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Chronic companions: An updated national cross-sectional study of metabolic syndrome comorbidities in outpatient visits for hidradenitis suppurativa. PLoS One. 2025; 20(10):e0333010. Ma EJ, Roberts AM, Chou P, Katz A, Jeong CY, Nong Y, Ochoa MT, Armstrong AW. PMID: 41134833; PMCID: PMC12551858.
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COVID Curls: A Striking Change in Hair Texture Following COVID-19 Infection. Int J Trichology. 2024 Jan-Dec; 16(1-6):45-46. Khan S, Vecerek N, Ochoa MT, Adler BL. PMID: 40309360; PMCID: PMC12039786.
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Leprosy-Insufficient Evidence for Monthly Multidrug Therapy. JAMA Dermatol. 2024 Jul 01; 160(7):785. Adler BL, Harnisch JP, Ochoa MT. PMID: 38809538.
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Shared decision-making in psoriasis care: Evaluation of how patients' perception of clinicians' delivery of care changes by age and sex. PLoS One. 2024; 19(5):e0303058. Kikuchi R, Kingston P, Hao A, Sadrolashrafi K, Yamamoto RK, Tolson H, Bilimoria SN, Guo L, Yee D, Ochoa MT, Armstrong AW. PMID: 38728289; PMCID: PMC11086864.
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More on Autochthonous Leprosy in the United States. Reply. N Engl J Med. 2023 09 07; 389(10):963-964. Adler BL, Ochoa MT. PMID: 37672709.
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Autochthonous Leprosy in the United States. N Engl J Med. 2023 06 29; 388(26):2485-2487. Belzer A, Ochoa MT, Adler BL. PMID: 37379141.
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Mpox (Monkeypox) Clinical Pearls. Cutis. 2023 04; 111(4):170-171. Peterson H, Adler BL, Ochoa MT. PMID: 37289689.
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Impact of Mycobacterium leprae and Mycobacterium lepromatosis on immune reactions and clinical outcomes in Hansen's disease: A single-center retrospective analysis. J Am Acad Dermatol. 2023 Mar; 88(3):722-724. Khan S, Adler BL, Armstrong AW, Lahiri R, Ochoa MT. PMID: 36156303.
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Lucio phenomenon with concomitant necrotizing fasciitis and acute kidney injury. Dermatol Online J. 2022 Jun 15; 28(3). Norman T, Zikry J, Worswick S, Kim G, Ochoa MT. PMID: 36259803.
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Editorial: Strategies Played by Immune Cells and Mycobacteria in the Battle Between Antimicrobial Activity and Bacterial Survival. Front Immunol. 2022; 13:869692. Schmitz V, Jo EK, Ochoa MT, Teles RMB. PMID: 35309365; PMCID: PMC8924064.
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The cellular architecture of the antimicrobial response network in human leprosy granulomas. Nat Immunol. 2021 07; 22(7):839-850. Ma F, Hughes TK, Teles RMB, Andrade PR, de Andrade Silva BJ, Plazyo O, Tsoi LC, Do T, Wadsworth MH, Oulee A, Ochoa MT, Sarno EN, Iruela-Arispe ML, Klechevsky E, Bryson B, Shalek AK, Bloom BR, Gudjonsson JE, Pellegrini M, Modlin RL. PMID: 34168371; PMCID: PMC8579511.
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Diffuse cutaneous leishmaniasis and HIV co-infection: A case report and review of the literature. J Cutan Pathol. 2021 Jun; 48(6):802-806. Kassardjian AA, Yim KM, Rabi S, Liang TZ, Kim GH, Ochoa MT, Sattah MV, Ahronowitz IZ. PMID: 33611800.
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Isolation of Mycobacterium lepromatosis and Development of Molecular Diagnostic Assays to Distinguish Mycobacterium leprae and M. lepromatosis. Clin Infect Dis. 2020 11 05; 71(8):e262-e269. Sharma R, Singh P, McCoy RC, Lenz SM, Donovan K, Ochoa MT, Estrada-Garcia I, Silva-Miranda M, Jurado-Santa Cruz F, Balagon MF, Stryjewska B, Scollard DM, Pena MT, Lahiri R, Williams DL, Truman RW, Adams LB. PMID: 31732729; PMCID: PMC8189713.
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ER Stress Regulates Immunosuppressive Function of Myeloid Derived Suppressor Cells in Leprosy that Can Be Overcome in the Presence of IFN-γ. iScience. 2020 May 22; 23(5):101050. Kelly-Scumpia KM, Choi A, Shirazi R, Bersabe H, Park E, Scumpia PO, Ochoa MT, Yu J, Ma F, Pellegrini M, Modlin RL. PMID: 32339990; PMCID: PMC7190750.
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Characterization and Outcomes of Patients With Hansen Disease Treated at the Los Angeles County Hospital. JAMA Dermatol. 2019 Oct 01; 155(10):1190-1192. Chow M, Shue L, Sierro T, Tran K, Vaccaro S, Ochoa MT. PMID: 31389979; PMCID: PMC6686763.
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The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy. PLoS Negl Trop Dis. 2019 07; 13(7):e0007589. R Andrade P, Mehta M, Lu J, M B Teles R, Montoya D, O Scumpia P, Nunes Sarno E, Ochoa MT, Ma F, Pellegrini M, Modlin RL. PMID: 31344041; PMCID: PMC6684084.
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IL-1β Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells. J Immunol. 2019 08 15; 203(4):911-921. Weiss DI, Ma F, Merleev AA, Maverakis E, Gilliet M, Balin SJ, Bryson BD, Ochoa MT, Pellegrini M, Bloom BR, Modlin RL. PMID: 31235553; PMCID: PMC6684376.
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Sorafenib Toxicity Mimicking Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome J Drugs Dermatol. 2019 May 01; 18(5):468-469. Salame N, Chow ML, Ochoa MT, Compoginis G, Crew AB. PMID: 31141856.
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Autophagy links antimicrobial activity with antigen presentation in Langerhans cells. JCI Insight. 2019 04 18; 4(8). Dang AT, Teles RM, Liu PT, Choi A, Legaspi A, Sarno EN, Ochoa MT, Parvatiyar K, Cheng G, Gilliet M, Bloom BR, Modlin RL. PMID: 30996142; PMCID: PMC6538337.
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IL-26 contributes to host defense against intracellular bacteria. J Clin Invest. 2019 04 02; 129(5):1926-1939. Dang AT, Teles RM, Weiss DI, Parvatiyar K, Sarno EN, Ochoa MT, Cheng G, Gilliet M, Bloom BR, Modlin RL. PMID: 30939123; PMCID: PMC6486355.
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Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria. Sci Immunol. 2018 08 31; 3(26). Balin SJ, Pellegrini M, Klechevsky E, Won ST, Weiss DI, Choi AW, Hakimian J, Lu J, Ochoa MT, Bloom BR, Lanier LL, Stenger S, Modlin RL. PMID: 30171080; PMCID: PMC6431239.
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Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy. JCI Insight. 2016 09 22; 1(15):e88843. Inkeles MS, Teles RM, Pouldar D, Andrade PR, Madigan CA, Lopez D, Ambrose M, Noursadeghi M, Sarno EN, Rea TH, Ochoa MT, Iruela-Arispe ML, Swindell WR, Ottenhoff TH, Geluk A, Bloom BR, Pellegrini M, Modlin RL. PMID: 27699251; PMCID: PMC5033757.
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S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages. PLoS Pathog. 2016 06; 12(6):e1005705. Realegeno S, Kelly-Scumpia KM, Dang AT, Lu J, Teles R, Liu PT, Schenk M, Lee EY, Schmidt NW, Wong GC, Sarno EN, Rea TH, Ochoa MT, Pellegrini M, Modlin RL. PMID: 27355424; PMCID: PMC4927120.
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Thomas Herald Rea, MD (1929-2016). Lepr Rev. 2016 Mar; 87(1):130-1. Ochoa MT, Vaccaro S, Jerskey R, Mora H, Peng D, Modlin RL. PMID: 27255071.
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IL-27 Suppresses Antimicrobial Activity in Human Leprosy. J Invest Dermatol. 2015 Oct; 135(10):2410-2417. Teles RMB, Kelly-Scumpia KM, Sarno EN, Rea TH, Ochoa MT, Cheng G, Modlin RL. PMID: 26030183; PMCID: PMC4567935.
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T lymphocyte density and distribution in human colorectal mucosa, and inefficiency of current cell isolation protocols. PLoS One. 2015; 10(4):e0122723. Preza GC, Yang OO, Elliott J, Anton PA, Ochoa MT. PMID: 25856343; PMCID: PMC4391713.
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Recognizing and managing the immunologic reactions in leprosy. J Am Acad Dermatol. 2014 Oct; 71(4):795-803. Kamath S, Vaccaro SA, Rea TH, Ochoa MT. PMID: 24767732.
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Antigen-presenting cell candidates for HIV-1 transmission in human distal colonic mucosa defined by CD207 dendritic cells and CD209 macrophages. AIDS Res Hum Retroviruses. 2014 Mar; 30(3):241-9. Preza GC, Tanner K, Elliott J, Yang OO, Anton PA, Ochoa MT. PMID: 24134315; PMCID: PMC3938918.
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NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy. Nat Med. 2012 Mar 25; 18(4):555-63. Schenk M, Krutzik SR, Sieling PA, Lee DJ, Teles RM, Ochoa MT, Komisopoulou E, Sarno EN, Rea TH, Graeber TG, Kim S, Cheng G, Modlin RL. PMID: 22447076; PMCID: PMC3348859.
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Mobile teledermatology: As doctors and patients are increasingly mobile, technology keeps us connected. Skinmed. 2011 Jul-Aug; 9(4):231-8. Farshidi D, Craft N, Ochoa MT. PMID: 21980708.
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A role for interleukin-5 in promoting increased immunoglobulin M at the site of disease in leprosy. Immunology. 2010 Nov; 131(3):405-14. Ochoa MT, Teles R, Haas BE, Zaghi D, Li H, Sarno EN, Rea TH, Modlin RL, Lee DJ. PMID: 20561085; PMCID: PMC2996561.
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Human immunodeficiency virus and leishmaniasis. J Glob Infect Dis. 2010 Sep; 2(3):248-57. Ezra N, Ochoa MT, Craft N. PMID: 20927287; PMCID: PMC2946682.
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Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy. Infect Immun. 2010 Nov; 78(11):4634-43. Teles RM, Krutzik SR, Ochoa MT, Oliveira RB, Sarno EN, Modlin RL. PMID: 20713631; PMCID: PMC2976321.
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New World cutaneous leishmaniasis: current challenges in diagnosis and parenteral treatment. J Am Acad Dermatol. 2011 Mar; 64(3):587-92. Zaghi D, Panosian C, Gutierrez MA, Gregson A, Taylor E, Ochoa MT. PMID: 20494480.
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Integrated pathways for neutrophil recruitment and inflammation in leprosy. J Infect Dis. 2010 Feb 15; 201(4):558-69. Lee DJ, Li H, Ochoa MT, Tanaka M, Carbone RJ, Damoiseaux R, Burdick A, Sarno EN, Rea TH, Modlin RL. PMID: 20070238; PMCID: PMC2811231.
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Divergence of macrophage phagocytic and antimicrobial programs in leprosy. Cell Host Microbe. 2009 Oct 22; 6(4):343-53. Montoya D, Cruz D, Teles RM, Lee DJ, Ochoa MT, Krutzik SR, Chun R, Schenk M, Zhang X, Ferguson BG, Burdick AE, Sarno EN, Rea TH, Hewison M, Adams JS, Cheng G, Modlin RL. PMID: 19837374; PMCID: PMC2764558.
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Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma. Clin Cancer Res. 2009 Oct 01; 15(19):6267-76. Ribas A, Comin-Anduix B, Chmielowski B, Jalil J, de la Rocha P, McCannel TA, Ochoa MT, Seja E, Villanueva A, Oseguera DK, Straatsma BR, Cochran AJ, Glaspy JA, Hui L, Marincola FM, Wang E, Economou JS, Gomez-Navarro J. PMID: 19789309; PMCID: PMC2765061.
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Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. J Clin Invest. 2008 Aug; 118(8):2917-28. Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL. PMID: 18636118; PMCID: PMC2467381.
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"Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages. J Invest Dermatol. 2008 Sep; 128(9):2225-31. Ochoa MT, Loncaric A, Krutzik SR, Becker TC, Modlin RL. PMID: 18337829; PMCID: PMC2682223.
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LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells. J Immunol. 2007 Dec 15; 179(12):8128-36. Lee DJ, Sieling PA, Ochoa MT, Krutzik SR, Guo B, Hernandez M, Rea TH, Cheng G, Colonna M, Modlin RL. PMID: 18056355; PMCID: PMC2650749.
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Activation of human CD4+ T cells by targeting MHC class II epitopes to endosomal compartments using human CD1 tail sequences. Immunology. 2007 Dec; 122(4):522-31. Niazi KR, Ochoa MT, Sieling PA, Rooke NE, Peter AK, Mollahan P, Dickey M, Rabizadeh S, Rea TH, Modlin RL. PMID: 17635609; PMCID: PMC2266034.
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Regulation of human T-cell homing receptor expression in cutaneous bacterial infection. Immunology. 2007 Apr; 120(4):518-25. Sieling PA, Legaspi A, Ochoa MT, Rea TH, Modlin RL. PMID: 17343614; PMCID: PMC2265905.
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Functional characterization of a T-cell receptor BV6+ T-cell clone derived from a leprosy lesion. Immunology. 2007 Mar; 120(3):354-61. Sabet S, Ochoa MT, Sieling PA, Rea TH, Modlin RL. PMID: 17140401; PMCID: PMC2265884.
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TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response. J Immunol. 2006 Jul 01; 177(1):298-305. Renn CN, Sanchez DJ, Ochoa MT, Legaspi AJ, Oh CK, Liu PT, Krutzik SR, Sieling PA, Cheng G, Modlin RL. PMID: 16785525.
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Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation. J Immunol. 2006 Mar 15; 176(6):3536-47. Hornell TM, Burster T, Jahnsen FL, Pashine A, Ochoa MT, Harding JJ, Macaubas C, Lee AW, Modlin RL, Mellins ED. PMID: 16517722.
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Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006 Mar 24; 311(5768):1770-3. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL. PMID: 16497887.
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TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med. 2005 Jun; 11(6):653-60. Krutzik SR, Tan B, Li H, Ochoa MT, Liu PT, Sharfstein SE, Graeber TG, Sieling PA, Liu YJ, Rea TH, Bloom BR, Modlin RL. PMID: 15880118; PMCID: PMC1409736.
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Mohs' micrographic surgery of a proliferating trichilemmal tumor in a young black man. Dermatol Surg. 2005 Mar; 31(3):359-63. Tierney E, Ochoa MT, Rudkin G, Soriano TT. PMID: 15841643.
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Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science. 2003 Sep 12; 301(5639):1527-30. Bleharski JR, Li H, Meinken C, Graeber TG, Ochoa MT, Yamamura M, Burdick A, Sarno EN, Wagner M, Röllinghoff M, Rea TH, Colonna M, Stenger S, Bloom BR, Eisenberg D, Modlin RL. PMID: 12970564.
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Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Nat Med. 2003 May; 9(5):525-32. Krutzik SR, Ochoa MT, Sieling PA, Uematsu S, Ng YW, Legaspi A, Liu PT, Cole ST, Godowski PJ, Maeda Y, Sarno EN, Norgard MV, Brennan PJ, Akira S, Rea TH, Modlin RL. PMID: 12692544.
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Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue. Immunology. 2003 Jan; 108(1):10-5. Ochoa MT, Legaspi AJ, Hatziris Z, Godowski PJ, Modlin RL, Sieling PA. PMID: 12519297; PMCID: PMC1782859.
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Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol. 2002 Aug 01; 169(3):1535-41. Kim J, Ochoa MT, Krutzik SR, Takeuchi O, Uematsu S, Legaspi AJ, Brightbill HD, Holland D, Cunliffe WJ, Akira S, Sieling PA, Godowski PJ, Modlin RL. PMID: 12133981; PMCID: PMC4636337.
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Signaling lymphocytic activation molecule expression and regulation in human intracellular infection correlate with Th1 cytokine patterns. J Immunol. 2001 Nov 15; 167(10):5719-24. García VE, Quiroga MF, Ochoa MT, Ochoa L, Pasquinelli V, Fainboim L, Olivares LM, Valdez R, Sordelli DO, Aversa G, Modlin RL, Sieling PA. PMID: 11698444.
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Treatment failure in children in a randomized clinical trial with 10 and 20 days of meglumine antimonate for cutaneous leishmaniasis due to Leishmania viannia species. Am J Trop Med Hyg. 2001 Mar-Apr; 64(3-4):187-93. Palacios R, Osorio LE, Grajalew LF, Ochoa MT. PMID: 11442216.
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Induction of direct antimicrobial activity through mammalian toll-like receptors. Science. 2001 Feb 23; 291(5508):1544-7. Thoma-Uszynski S, Stenger S, Takeuchi O, Ochoa MT, Engele M, Sieling PA, Barnes PF, Rollinghoff M, Bolcskei PL, Wagner M, Akira S, Norgard MV, Belisle JT, Godowski PJ, Bloom BR, Modlin RL. PMID: 11222859.
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T-cell release of granulysin contributes to host defense in leprosy. Nat Med. 2001 Feb; 7(2):174-9. Ochoa MT, Stenger S, Sieling PA, Thoma-Uszynski S, Sabet S, Cho S, Krensky AM, Rollinghoff M, Nunes Sarno E, Burdick AE, Rea TH, Modlin RL. PMID: 11175847.
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Role of granulysin in immunity to leprosy. Lepr Rev. 2000 Dec; 71 Suppl:S115; discussion S115-6. Ochoa MT, Thoma-Uszynski S, Sieling PA, Sabet S, Cho S, Krensky AM, Burdick A, Rea TH, Modlin RL. PMID: 11201866.
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Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10. J Immunol. 2000 Oct 01; 165(7):3804-10. Thoma-Uszynski S, Kiertscher SM, Ochoa MT, Bouis DA, Norgard MV, Miyake K, Godowski PJ, Roth MD, Modlin RL. PMID: 11034386.
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Evidence for human CD4+ T cells in the CD1-restricted repertoire: derivation of mycobacteria-reactive T cells from leprosy lesions. J Immunol. 2000 May 01; 164(9):4790-6. Sieling PA, Ochoa MT, Jullien D, Leslie DS, Sabet S, Rosat JP, Burdick AE, Rea TH, Brenner MB, Porcelli SA, Modlin RL. PMID: 10779786.
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Positive IgG Western blot for Borrelia burgdorferi in Colombia. Mem Inst Oswaldo Cruz. 1999 Jul-Aug; 94(4):499-503. Palacios R, Osorio LE, Giraldo LE, Torres AJ, Philipp MT, Ochoa MT. PMID: 10446009.
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IL-18 promotes type 1 cytokine production from NK cells and T cells in human intracellular infection. J Immunol. 1999 May 15; 162(10):6114-21. García VE, Uyemura K, Sieling PA, Ochoa MT, Morita CT, Okamura H, Kurimoto M, Rea TH, Modlin RL. PMID: 10229854.
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Mucosal leishmaniasis due to Leishmania (Viannia) panamensis in Colombia: clinical characteristics. Am J Trop Med Hyg. 1998 Jul; 59(1):49-52. Osorio LE, Castillo CM, Ochoa MT. PMID: 9684627.
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Treatment of cutaneous leishmaniasis in Colombia with dapsone. Lancet. 1998 Feb 14; 351(9101):498-9. Osorio LE, Palacios R, Chica ME, Ochoa MT. PMID: 9482449.
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Changes in expression of signal transduction proteins in T lymphocytes of patients with leprosy. Infect Immun. 1998 Feb; 66(2):499-504. Zea AH, Ochoa MT, Ghosh P, Longo DL, Alvord WG, Valderrama L, Falabella R, Harvey LK, Saravia N, Moreno LH, Ochoa AC. PMID: 9453602; PMCID: PMC107934.
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Lepromatous and tuberculoid leprosy: clinical presentation and cytokine responses. Int J Dermatol. 1996 Nov; 35(11):786-90. Ochoa MT, Valderrama L, Ochoa A, Zea A, Escobar CE, Moreno LH, Falabella R. PMID: 8915730.
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A yeast-derived antigen from Paracoccidioides brasiliensis useful for serologic testing. Sabouraudia. 1985 Feb; 23(1):23-9. Restrepo A, Cano LE, Ochoa MT. PMID: 3922069.
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