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Cognitive profiles at presentation and subsequent cognitive decline and quality of life in Parkinson's disease. Alzheimers Dement. 2025 Dec; 21(12):e70912. Mirza SS, Duff-Canning S, Mapstone M, Fox S, Black SE, Binns MA, Breen DP, Fishman KN, Grimes DA, Lang AE, Levine B, McLaughlin PM, Troyer AK, Masellis M, Marras C. PMID: 41388800; PMCID: PMC12701370.
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Imaging and plasma biomarkers for pathological accumulation in Down syndrome. Brain. 2025 Nov 05. Wisch JK, Jiao Z, Kennedy JT, Cohen AD, Schlachetzki Z, Petersen M, Handen BL, Christian BT, Mapstone M, Rosas HD, Lai F, Lee JH, Krinsky-McHale SJ, Schmitt FA, Harp JP, Hom C, Lott IT, Hartley S, Zaman S, Ptomey L, Burns JM, Tudorascu D, Ibanez L, Rafii MS, Head E, Ances BM. PMID: 41205623; PMCID: PMC12917769.
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Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome. Alzheimers Dement. 2025 Sep; 21(9):e70679. Lao P, Edwards N, Flores-Aguilar L, Alshikho MJ, Smith A, LeMay R, Hahm J, Rizvi B, Tudorascu D, Rosas HD, Yassa M, Christian B, Mapstone M, Handen B, Alzheimer's Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators, Gutierrez J, Wilcock D, Head E, Brickman AM. PMID: 40951960; PMCID: PMC12434704.
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Longitudinal diffusion tensor imaging correlates with amyloid burden in Down syndrome. Alzheimers Dement. 2025 Aug; 21(8):e70572. LeMerise LG, Guerrero-Gonzalez J, McVea A, Zammit M, Kecskemeti S, Hartley S, Head E, Mapstone M, Handen B, Alexander A, Christian B, ABC-DS Investigators. PMID: 40779433; PMCID: PMC12333877.
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Genome-wide association of tau neuroimaging and plasma biomarkers in adults with Down syndrome. Alzheimers Dement. 2025 Jul; 21(7):e70398. Fan KH, Shi R, Cheema AN, Dang LT, Xicota L, Krinsky-McHale S, Aslam MM, Zafari N, Acharya V, Feingold E, Laymon CM, Cohen A, Handen BL, Christian BT, Head E, Mapstone ME, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS), Cruchaga C, Lee JH, Kamboh MI. PMID: 40667715; PMCID: PMC12264832.
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Joint spatial associations of amyloid beta and tau pathology in Down syndrome and preclinical Alzheimer's disease: Cross-sectional associations with early cognitive impairments. Alzheimers Dement. 2025 Jul; 21(7):e70424. Fu JF, Garimella A, Lapointe A, Aye WWT, Chen CD, Lee JH, Krinsky-McHale SJ, Zaman S, Lott IT, Hom C, Ances B, Head E, Mapstone M, Lai F, Handen BL, Laymon CM, Hartley SL, Christian BT, Rentz DM, Johnson KA, Rosas HD, Price JC, Alzheimer Biomarkers Consortium–Down Syndrome (ABC-DS). PMID: 40588723; PMCID: PMC12208798.
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Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study. Lancet Neurol. 2025 Jul; 24(7):591-600. Janelidze S, Collij LE, Mattsson-Carlgren N, Antill A, Laymon CM, Lott I, Rosas HD, Minhas DS, Luo W, Zaman S, Alzheimer's Biomarker Consortium–Down Syndrome investigators, Mapstone M, Head E, Lai F, Hartley SL, Ances BM, Krinsky-McHale SJ, Lee JH, Ossenkoppele R, Christian BT, Handen BL, Hansson O. PMID: 40541209; PMCID: PMC12174012.
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Genome-wide association analyses identify candidate loci for amyloid imaging and plasma biomarkers in adults with Down syndrome. Alzheimers Dement. 2025 Jul; 21(7):e70358. Aslam MM, Dang LT, Shi R, Fan KH, Cheema AN, Xicota L, Minhas D, Luo W, Zafari N, Acharya V, Feingold E, Krinsky-McHale S, Laymon CM, Cohen A, Handen BL, Christian BT, Head E, Mapstone ME, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS), Lee JH, Cruchaga C, Kamboh MI. PMID: 40667702; PMCID: PMC12265027.
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Physical activity as a resistance or resilience mechanism in Down syndrome Alzheimer's disease. Alzheimers Dement (N Y). 2025 Jul-Sep; 11(3):e70127. Fleming VL, Peven J, Helsel BC, Ptomey LT, Clina J, Barry A, Ances BM, Handen BL, Christian BT, Laymon C, Zammit M, Head E, Mapstone M, Okonkwo O, Hartley SL, Alzheimer Biomarkers Consortium – Down Syndrome. PMID: 40584896; PMCID: PMC12204845.
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Salivary levels of amyloid beta reflect brain amyloid beta burden in cognitively-normal older adults. J Prev Alzheimers Dis. 2025 Aug; 12(7):100216. Bamford AR, Adams JN, Kim S, Taylor LM, Tuteja N, McMillan LC, Sattari N, Chen IY, Chappel-Farley MG, Escalante Y, Lawrence AL, Meza NJ, Berisha DE, Dave A, Malhas R, Mapstone M, Mander BA, Yassa MA, Thomas EA. PMID: 40494737; PMCID: PMC12252581.
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PET-measured amyloid beta accumulates at an accelerated rate in Down syndrome compared to neurotypical populations. Alzheimers Dement. 2025 Jun; 21(6):e70357. McVea A, DiFilippo A, McLachlan M, Betcher B, Zammit M, Betthauser TJ, Converse A, Murali D, Stone C, Hartley S, Johnson S, Tudorascu DL, Laymon CM, Cohen AD, Minhas D, Luo W, Mathis C, Lao PJ, Ances B, Zaman S, Mapstone M, Head E, Handen BL, Christian BT, ABC-DS investigators. PMID: 40556306; PMCID: PMC12187968.
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Longitudinal study of body mass index in relation to Alzheimer's disease pathology and symptomatology in Down syndrome. Alzheimers Dement. 2025 Jun; 21(6):e70387. Fleming VL, Helsel BC, Ptomey LT, Handen BL, Krinsky-McHale SJ, Hom CL, Zammit M, Minhas D, Luo W, Laymon C, Lee JH, Lott I, Cohen A, Ances BM, Brickman AM, Pulsifer M, Clare ICH, Rosa HD, Lai F, Harp J, Schmitt F, Price J, Zaman SH, Head E, Mapstone M, Christian BT, Okonkwo O, Hartley SL, Alzheimer's Biomarkers Consortium–Down Syndrome. PMID: 40545561; PMCID: PMC12183108.
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Multiomic Evidence for a Unified Model of Alzheimer's Disease Etiology Linking Microglial Flux Capacity and Astrocyte-Neuron Metabolic Breakdown. bioRxiv. 2025 May 12. Paterson T, Rohrs J, Hohman TJ, Mapstone M, Meikle PJ, Kaddurah-Daouk R, Levey AI, Hood L, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer Disease Metabolomics Consortium, Funk CC. PMID: 40462904; PMCID: PMC12132299.
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The Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS): A 10-year report. Alzheimers Dement. 2025 May; 21(5):e70294. Handen BL, Mapstone M, Hartley S, Andrews H, Christian B, Lee JH, Tudorascu D, Hom C, Ances BM, Zaman S, Krinsky-McHale S, Brickman AM, Rosas HD, Cohen A, Petersen M, O'Bryant S, Harp JP, Schmitt F, Ptomey L, Burns J, Lott IT, Lai F, Silverman W, Laymon C, Head E, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). PMID: 40371686; PMCID: PMC12079517.
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Modified Cued Recall Test: Longitudinal Analysis of Test Versions and Item Recall in Adults With Down Syndrome. J Intellect Disabil Res. 2025 Jul; 69(7):569-581. Schworer EK, Handen BL, Krinsky-McHale S, Hom CL, Clare ICH, Harp JP, Pulsifer MB, Mapstone M, Head E, Christian BT, Hartley SL, Alzheimer Biomarker Consortium-Down Syndrome. PMID: 40254895; PMCID: PMC12199718.
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Behavioral and psychological symptoms of dementia and Alzheimer's disease progression in Down syndrome. J Neurodev Disord. 2025 Apr 11; 17(1):19. Jenkins MR, Peven JC, Kubic L, Handen BL, Krinsky-McHale SJ, Hom CL, Lee A, Tudorascu DL, McLachlan M, Zammit M, Minhas D, Luo W, Laymon C, Lee JH, Lott I, Cohen A, Ances BM, Rosas HD, Lai F, Zaman SH, Head E, Mapstone M, Christian BT, Hartley SL, Alzheimer Biomarker Consortium - Down syndrome. PMID: 40217501; PMCID: PMC11987311.
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The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: Comparison of two radiotracers. Alzheimers Dement. 2025 Apr; 21(4):e70141. McLachlan M, Bettcher B, McVea A, DiFilippo A, Zammit M, LeMerise L, Rouanet J, Price J, Tudorascu D, Laymon C, Keator D, Lao P, Brickman AM, Fryer T, Hartley S, Ances BM, Rosas HD, Johnson S, Betthauser T, Stone CK, Zaman S, Handen B, Head E, Mapstone M, Christian BT, Investigators AD. PMID: 40189783; PMCID: PMC11972983.
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Longitudinal investigation of gait and Alzheimer's disease in adults with Down syndrome. Alzheimers Dement. 2025 Apr; 21(4):e70211. Barry A, Peven JC, Handen BL, Bolt D, Krinsky-McHale SJ, Hom CL, Clare ICH, Glueck A, Harp J, Schmitt F, Zammit M, Minhas D, Luo W, Laymon C, Price J, Lee JH, Lott I, Cohen A, Ances BM, Pulsifer M, Rosa HD, Lai F, Zaman SH, Head E, Mapstone M, Christian BT, Hartley SL, Alzheimer Biomarker Consortium - Down syndrome. PMID: 40289844; PMCID: PMC12035545.
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2024 VCP International Conference: Exploring multi-disciplinary approaches from basic science of valosin containing protein, an AAA+ ATPase protein, to the therapeutic advancement for VCP-associated multisystem proteinopathy. Neurobiol Dis. 2025 04; 207:106861. Peck A, Dadi A, Yavarow Z, Alfano LN, Anderson D, Arkin MR, Chou TF, D'Ambrosio ES, Diaz-Manera J, Dudley JP, Elder AG, Ghoshal N, Hart CE, Hart MM, Huryn DM, Johnson AE, Jones KB, Kimonis V, Kiskinis E, Lee EB, Lloyd TE, Mapstone M, Martin A, Meyer H, Mozaffar T, Onyike CU, Pfeffer G, Pindon A, Raman M, Richard I, Rubinsztein DC, Schiava M, Schütz AK, Shen PS, Southworth DR, Staffaroni AM, Taralio-Gravovac M, Weihl CC, Yao Q, Ye Y, Peck N. PMID: 40037468; PMCID: PMC11960434.
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Characterization of plasma AT(N) biomarkers among a racial and ethnically diverse community-based cohort: an HABS-HD study. Alzheimers Dement (N Y). 2025 Jan-Mar; 11(1):e70045. Petersen ME, Zhang F, Hall J, Brock C, Rissman RA, Como T, Julovich D, Mapstone M, Ances BM, Meeker K, Palmer R, Barber R, Mason D, Johnson L, Yaffe K, Toga AW, Cohen A, O'Bryant SE, HABS-HD Study Team. PMID: 39975470; PMCID: PMC11837735.
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A neuropathology case report of a woman with Down syndrome who remained cognitively stable: Implications for resilience to neuropathology. Alzheimers Dement. 2025 Feb; 21(2):e14479. Liou JJ, Lou J, Flores-Aguilar L, Nakagiri J, Yong W, Hom CL, Doran EW, Totoiu MO, Lott I, Mapstone M, Keator DB, Brickman AM, Wright ST, Nelson B, Lai F, Xicota L, Dang LT, Li J, Santini T, Mettenburg JM, Ikonomovic MD, Kofler J, Ibrahim T, Head E, Alzheimer Biomarker Consortium - Down Syndrome. PMID: 39868632; PMCID: PMC11851131.
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Association of mid-life cardiovascular risk with biomarkers of Alzheimer's disease, neurodegeneration, and white matter hyperintensities: Heart SCORE brain study. J Alzheimers Dis Rep. 2025 Jan-Dec; 9:25424823241299297. Saeed A, Chang Y, Swanson J, Vu M, Mapstone M, Villemagne VL, Snitz BE, Royse SK, Wang H, Lopresti B, Aizenstein HJ, Wu M, Kip K, Reis SE, Lopez O, Cohen A. PMID: 40034508; PMCID: PMC11864267.
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Decoding brain structure to stage Alzheimer's disease pathology in Down syndrome. Alzheimers Dement. 2025 Feb; 21(2):e14519. Kennedy JT, Wisch JK, Dincer A, Roman J, Gordon BA, Handen B, Benzinger TLS, Head E, Mapstone M, Christian BT, Tudorascu DL, Laymon CL, Hartley SL, Lao P, Brickman AM, Zaman SH, Ances BM, ABC-DS and DIAN Consortia. PMID: 39807622; PMCID: PMC11848172.
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Mid-life anti-inflammatory metabolites are inversely associated with long-term cardiovascular disease events. EBioMedicine. 2025 Feb; 112:105551. Saeed A, McKennan C, Duan J, Yang YN, Kip KE, Finegold D, Vu M, Swanson J, Lopez OL, Cohen A, Mapstone M, Yu B, Ballantyne CM, Reis SE. PMID: 39793479; PMCID: PMC11764641.
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The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: comparison of two radiotracers. medRxiv. 2024 Dec 06. McLachlan M, Bettcher B, McVea A, DiFillipo A, Zammit M, LeMerise L, Rouanet J, Price J, Tudorascu D, Laymon C, Keator D, Lao P, Brickman AM, Fryer T, Hartley S, Ances BM, Johnson S, Betthauser T, Stone CK, Zaman S, Handen B, Head E, Mapstone M, Christian BT. PMID: 39677434; PMCID: PMC11643166.
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Timeline to symptomatic Alzheimer's disease in people with Down syndrome as assessed by amyloid-PET and tau-PET: a longitudinal cohort study. Lancet Neurol. 2024 12; 23(12):1214-1224. Schworer EK, Zammit MD, Wang J, Handen BL, Betthauser T, Laymon CM, Tudorascu DL, Cohen AD, Zaman SH, Ances BM, Mapstone M, Head E, Christian BT, Hartley SL, Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS). PMID: 39577922; PMCID: PMC12207984.
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Blood biomarkers in Down syndrome: Facilitating Alzheimer's disease detection and monitoring. Alzheimers Dement. 2025 Jan; 21(1):e14364. Petersen ME, Flores-Aguilar L, Head E, Montoliu-Gaya L, Strydom A, Pape SE, Fortea J, Ashton NJ, Udeh-Momoh C, O'Bryant SE, German D, Despa F, Mapstone M, Zetterberg H. PMID: 39535517; PMCID: PMC11782192.
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The mediating role of plasma glial fibrillary acidic protein in amyloid and tau pathology in Down's syndrome. Alzheimers Dement. 2025 Jan; 21(1):e14359. Boerwinkle AH, Wisch JK, Handen BL, Head E, Mapstone M, Rafii MS, O'Bryant SE, Krinsky-McHale SJ, Lai F, Rosas HD, Zaman S, Lott IT, Tudorascu D, Zammit M, Brickman AM, Lee JH, Ances BM, Alzheimer's Biomarker Consortium-Down Syndrome. PMID: 39535359; PMCID: PMC11782213.
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The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome. EBioMedicine. 2024 Dec; 110:105433. Xicota L, Dang LT, Lee A, Krinsky-McHale S, Pang D, Melilli L, O'Bryant S, Henson RL, Laymon C, Lai F, Rosas HD, Ances B, Lott I, Hom C, Christian B, Hartley S, Zaman S, Head E, Mapstone M, Jin Z, Silverman W, Schupf N, Handen B, Lee JH, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). PMID: 39500037; PMCID: PMC11570228.
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Cerebrovascular disease is associated with Alzheimer's plasma biomarker concentrations in adults with Down syndrome. Brain Commun. 2024; 6(5):fcae331. Edwards NC, Lao PJ, Alshikho MJ, Ericsson OM, Rizvi B, Petersen ME, O'Bryant S, Aguilar LF, Simoes S, Mapstone M, Tudorascu DL, Janelidze S, Hansson O, Handen BL, Christian BT, Lee JH, Lai F, Rosas HD, Zaman S, Lott IT, Yassa MA, Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators , Gutierrez J, Wilcock DM, Head E, Brickman AM. PMID: 39403075; PMCID: PMC11472828.
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Cognitive decline and political leadership. Politics Life Sci. 2024; 43(2):185-197. Gong S, Hu ZP, Ghaemi SN, Min D, Mapstone M, Sanbar SS, Berenji M, Rosenberg S, Phoenix D, Fisher M. PMID: 39291658.
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The amyloid beta 42/38 ratio as a plasma biomarker of early memory deficits in cognitively unimpaired older adults. Neurobiol Aging. 2024 12; 144:12-18. Bamford AR, Adams JN, Kim S, McMillan LC, Malhas R, Mapstone M, Hitt BD, Yassa MA, Thomas EA. PMID: 39241563; PMCID: PMC11706698.
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Amyloid age and tau PET timeline to symptomatic Alzheimer's disease in Down syndrome. medRxiv. 2024 Aug 09. Schworer EK, Zammit MD, Wang J, Handen BL, Betthauser T, Laymon CM, Tudorascu DL, Cohen AD, Zaman SH, Ances BM, Mapstone M, Head E, Klunk WE, Christian BT, Hartley SL, Alzheimer Biomarker Consortium – Down Syndrome (ABC-DS). PMID: 39211859; PMCID: PMC11361254.
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A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable. medRxiv. 2024 Jun 03. Liou JJ, Lou J, Nakagiri J, Yong W, Hom CL, Doran EW, Totoiu M, Lott I, Mapstone M, Keator DB, Brickman AM, Wright S, Nelson B, Lai F, Xicota L, Dang LT, Li J, Santini T, Mettenburg JM, Ikonomovic MD, Kofler J, Ibrahim T, Head E, Alzheimer Biomarker Consortium - Down Syndrome. PMID: 38883742; PMCID: PMC11177914.
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Cerebrovascular disease emerges with age and Alzheimer's disease in adults with Down syndrome. Sci Rep. 2024 05 29; 14(1):12334. Lao P, Edwards N, Flores-Aguilar L, Alshikho M, Rizvi B, Tudorascu D, Rosas HD, Yassa M, Christian BT, Mapstone M, Handen B, Zimmerman ME, Gutierrez J, Wilcock D, Head E, Brickman AM. PMID: 38811657; PMCID: PMC11137035.
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A pathway linking pulse pressure to dementia in adults with Down syndrome. Brain Commun. 2024; 6(3):fcae157. Rizvi B, Lao PJ, Sathishkumar M, Taylor L, Queder N, McMillan L, Edwards NC, Keator DB, Doran E, Hom C, Nguyen D, Rosas HD, Lai F, Schupf N, Gutierrez J, Silverman W, Lott IT, Mapstone M, Wilcock DM, Head E, Yassa MA, Brickman AM. PMID: 38764776; PMCID: PMC11099660.
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Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study. Lancet Neurol. 2024 May; 23(5):500-510. Wisch JK, McKay NS, Boerwinkle AH, Kennedy J, Flores S, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O'Bryant SE, Price JC, Laymon CM, Krinsky-McHale SJ, Lai F, Rosas HD, Hartley SL, Zaman S, Lott IT, Tudorascu D, Zammit M, Brickman AM, Lee JH, Bird TD, Cohen A, Chrem P, Daniels A, Chhatwal JP, Cruchaga C, Ibanez L, Jucker M, Karch CM, Day GS, Lee JH, Levin J, Llibre-Guerra J, Li Y, Lopera F, Roh JH, Ringman JM, Supnet-Bell C, van Dyck CH, Xiong C, Wang G, Morris JC, McDade E, Bateman RJ, Benzinger TLS, Gordon BA, Ances BM, Alzheimer's Biomarker Consortium-Down syndrome, Dominantly Inherited Alzheimer Network. PMID: 38631766; PMCID: PMC11209765.
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Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome. Alzheimers Dement (Amst). 2024 Apr-Jun; 16(2):e12582. Schworer EK, Handen BL, Petersen M, O'Bryant S, Peven JC, Tudorascu DL, Lee L, Krinsky-McHale SJ, Hom CL, Clare ICH, Christian BT, Schupf N, Lee JH, Head E, Mapstone M, Lott I, Ances BM, Zaman S, Brickman AM, Lai F, Rosas HD, Hartley SL, Alzheimer Biomarker Consortium-Down Syndrome. PMID: 38623384; PMCID: PMC11016818.
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A critical appraisal of blood-based biomarkers for Alzheimer's disease. Ageing Res Rev. 2024 04; 96:102290. Lista S, Mapstone M, Caraci F, Emanuele E, López-Ortiz S, Martín-Hernández J, Triaca V, Imbimbo C, Gabelle A, Mielke MM, Nisticò R, Santos-Lozano A, Imbimbo BP. PMID: 38580173.
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Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hAβ-KI) mice. Alzheimers Dement. 2024 07; 20(7):4935-4950. Dunham SJB, Avelar-Barragan J, Rothman JA, Adams ED, Faraci G, Forner S, Kawauchi S, Tenner AJ, Green KN, LaFerla FM, MacGregor GR, Mapstone M, Whiteson KL. PMID: 38572865; PMCID: PMC11247698.
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The Abca7V1613M variant reduces Aβ generation, plaque load, and neuronal damage. Alzheimers Dement. 2024 07; 20(7):4914-4934. Butler CA, Mendoza Arvilla A, Milinkeviciute G, Da Cunha C, Kawauchi S, Rezaie N, Liang HY, Javonillo D, Thach A, Wang S, Collins S, Walker A, Shi KX, Neumann J, Gomez-Arboledas A, Henningfield CM, Hohsfield LA, Mapstone M, Tenner AJ, LaFerla FM, Mortazavi A, MacGregor GR, Green KN. PMID: 38506634; PMCID: PMC11247689.
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Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease. Alzheimers Dement. 2024 04; 20(4):2670-2679. Xicota L, Cosentino S, Vardarajan B, Mayeux R, Perls TT, Andersen SL, Zmuda JM, Thyagarajan B, Yashin A, Wojczynski MK, Krinsky-McHale S, Handen BL, Christian BT, Head E, Mapstone ME, Schupf N, Lee JH, Barral S, Long-Life Family Study (LLFS), Alzheimer's Disease Genetic Consortium (ADGC), Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS). PMID: 38380866; PMCID: PMC11032545.
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Neurofilament light chain concentration mediates the association between regional medial temporal lobe structure and memory in adults with Down syndrome. Alzheimers Dement (Amst). 2024 Jan-Mar; 16(1):e12542. DiProspero N, Sathishkumar M, Janecek J, Smith A, McMillan L, Petersen M, Tustison N, Keator DB, Doran E, Hom CL, Nguyen D, Andrews H, Krinsky-McHale S, Brickman AM, Rosas HD, Lai F, Head E, Mapstone M, Silverman W, Lott IT, O'Bryant S, Yassa MA. PMID: 38348178; PMCID: PMC10859879.
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Cerebrovascular disease drives Alzheimer plasma biomarker concentrations in adults with Down syndrome. medRxiv. 2023 Nov 30. Edwards NC, Lao PJ, Alshikho MJ, Ericsson OM, Rizvi B, Petersen ME, O'Bryant S, Flores-Aguilar L, Simoes S, Mapstone M, Tudorascu DL, Janelidze S, Hansson O, Handen BL, Christian BT, Lee JH, Lai F, Rosas HD, Zaman S, Lott IT, Yassa MA, Gutierrez J, Wilcock DM, Head E, Brickman AM. PMID: 38076904; PMCID: PMC10705616.
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Pathways linking pulse pressure to dementia in adults with Down syndrome. medRxiv. 2023 Oct 26. Rizvi B, Lao PJ, Sathishkumar M, Taylor L, Queder N, McMillan L, Edwards N, Keator DB, Doran E, Hom C, Nguyen D, Rosas HD, Lai F, Schupf N, Gutierrez J, Silverman W, Lott IT, Mapstone M, Wilcock DM, Head E, Yassa MA, Brickman AM. PMID: 37961444; PMCID: PMC10635215.
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Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome. Alzheimers Dement. 2024 02; 20(2):1038-1049. Gorijala P, Aslam MM, Dang LT, Xicota L, Fernandez MV, Sung YJ, Fan KH, Feingold E, Surace EI, Chhatwal JP, Hom CL, Dominantly Inherited Alzheimer Network (DIAN), the Alzheimer's Disease Neuroimaging Initiative (ADNI, NIA-LOAD family study, for the Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS) Investigator, Hartley SL, Hassenstab J, Perrin RJ, Mapstone M, Zaman SH, Ances BM, Kamboh MI, Lee JH, Cruchaga C. PMID: 37855447; PMCID: PMC10916941.
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Predictors of Cognitive Change in Parkinson Disease: A 2-year Follow-up Study. Alzheimer Dis Assoc Disord. 2023 Oct-Dec 01; 37(4):335-342. Gasca-Salas C, Duff-Canning S, McArthur E, Armstrong MJ, Fox S, Meaney CA, Tang-Wai DF, Gill D, Eslinger PJ, Zadikoff C, Marshall FJ, Mapstone M, Chou KL, Persad C, Litvan I, Mast BT, Gerstenecker AT, Weintraub S, Marras C. PMID: 37615480.
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Plasma NT1-tau and Aβ42 correlate with age and cognitive function in two large Down syndrome cohorts. Alzheimers Dement. 2023 12; 19(12):5755-5764. Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O'Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E, Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) investigators. PMID: 37438872; PMCID: PMC10784408.
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Integrative metabolomics science in Alzheimer's disease: Relevance and future perspectives. Ageing Res Rev. 2023 08; 89:101987. Lista S, González-Domínguez R, López-Ortiz S, González-Domínguez Á, Menéndez H, Martín-Hernández J, Lucia A, Emanuele E, Centonze D, Imbimbo BP, Triaca V, Lionetto L, Simmaco M, Cuperlovic-Culf M, Mill J, Li L, Mapstone M, Santos-Lozano A, Nisticò R. PMID: 37343679; PMCID: PMC12450062.
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Plasma NT1-tau and Aβ 42 correlate with age and cognitive function in two large Down syndrome cohorts. medRxiv. 2023 Mar 10. Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O'Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E, Alzheimer’s Biomarker Consortium – Down Syndrome (ABC-DS) investigators. PMID: 36945447; PMCID: PMC10029060.
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Weight Loss and Alzheimer's Disease in Down Syndrome. J Alzheimers Dis. 2023; 91(3):1215-1227. Fleming V, Helsel BC, Ptomey LT, Rosas HD, Handen B, Laymon C, Christian BT, Head E, Mapstone M, Lai F, Krinsky-McHale S, Zaman S, Ances BM, Lee JH, Hartley SL, Alzheimer’s Biomarker Consortium –Down Syndrome (ABC-DS) Consortium. PMID: 36565120; PMCID: PMC9940268.
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Timing of Alzheimer's Disease by Intellectual Disability Level in Down Syndrome. J Alzheimers Dis. 2023; 95(1):213-225. Hartley SL, Fleming V, Schworer EK, Peven J, Handen BL, Krinsky-McHale S, Hom C, Lee L, Tudorascu DL, Laymon C, Minhas D, Luo W, Cohen A, Zaman S, Ances BM, Mapstone M, Head E, Lai F, Rosas HD, Klunk W, Christian B, Alzheimer Biomarker Consortium-Down Syndrome. PMID: 37482997; PMCID: PMC10578224.
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Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study. Lancet Neurol. 2023 01; 22(1):55-65. Boerwinkle AH, Gordon BA, Wisch J, Flores S, Henson RL, Butt OH, McKay N, Chen CD, Benzinger TLS, Fagan AM, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O'Bryant S, Lai F, Rosas HD, Lee JH, Silverman W, Brickman AM, Chhatwal JP, Cruchaga C, Perrin RJ, Xiong C, Hassenstab J, McDade E, Bateman RJ, Ances BM, Alzheimer's Biomarker Consortium-Down Syndrome, Dominantly Inherited Alzheimer Network. PMID: 36517172; PMCID: PMC9979840.
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Longitudinal Analysis of the Microbiome and Metabolome in the 5xfAD Mouse Model of Alzheimer's Disease. mBio. 2022 12 20; 13(6):e0179422. Dunham SJB, McNair KA, Adams ED, Avelar-Barragan J, Forner S, Mapstone M, Whiteson KL. PMID: 36468884; PMCID: PMC9765021.
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Associations between saliva and plasma cytokines in cognitively normal, older adults. Aging Clin Exp Res. 2023 Jan; 35(1):117-126. Parkin GM, Kim S, Mikhail A, Malhas R, McMillan L, Hollearn M, Granger DA, Mapstone M, Yassa MA, Thomas EA. PMID: 36319939; PMCID: PMC9816252.
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Detection of Brain Tau Pathology in Down Syndrome Using Plasma Biomarkers. JAMA Neurol. 2022 08 01; 79(8):797-807. Janelidze S, Christian BT, Price J, Laymon C, Schupf N, Klunk WE, Lott I, Silverman W, Rosas HD, Zaman S, Mapstone M, Lai F, Ances BM, Handen BL, Hansson O. PMID: 35789365; PMCID: PMC9257682.
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Joint-label fusion brain atlases for dementia research in Down syndrome. Alzheimers Dement (Amst). 2022; 14(1):e12324. Queder N, Phelan MJ, Taylor L, Tustison N, Doran E, Hom C, Nguyen D, Lai F, Pulsifer M, Price J, Kreisl WC, Rosas HD, Krinsky-McHale S, Brickman AM, Yassa MA, Schupf N, Silverman W, Lott IT, Head E, Mapstone M, Keator DB, Alzheimer's Biomarkers Consortium. PMID: 35634535; PMCID: PMC9131930.
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A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer's disease. Geroscience. 2022 06; 44(3):1525-1550. Macciardi F, Giulia Bacalini M, Miramontes R, Boattini A, Taccioli C, Modenini G, Malhas R, Anderlucci L, Gusev Y, Gross TJ, Padilla RM, Fiandaca MS, Head E, Guffanti G, Federoff HJ, Mapstone M. PMID: 35585302; PMCID: PMC9213607.
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Beyond amyloid: Immune, cerebrovascular, and metabolic contributions to Alzheimer disease in people with Down syndrome. Neuron. 2022 07 06; 110(13):2063-2079. Martini AC, Gross TJ, Head E, Mapstone M. PMID: 35472307; PMCID: PMC9262826.
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Impact of the COVID-19 pandemic on daily life, mood, and behavior of adults with Down syndrome. Disabil Health J. 2022 07; 15(3):101278. Hartley SL, Fleming V, Piro-Gambetti B, Cohen A, Ances BM, Yassa MA, Brickman AM, Handen BL, Head E, Mapstone M, Christian BT, Lott IT, Doran E, Zaman S, Krinsky-McHale S, Schmitt FA, Hom C, Schupf N, ABC-DS Group. PMID: 35256308; PMCID: PMC8849846.
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TGFβ Drives Metabolic Perturbations during Epithelial Mesenchymal Transition in Pancreatic Cancer: TGFβ Induced EMT in PDAC. Cancers (Basel). 2021 Dec 09; 13(24). Rajagopal MU, Bansal S, Kaur P, Jain SK, Altadil T, Hinzman CP, Li Y, Moulton J, Singh B, Bansal S, Chauthe SK, Singh R, Banerjee PP, Mapstone M, Fiandaca MS, Federoff HJ, Unger K, Smith JP, Cheema AK. PMID: 34944824; PMCID: PMC8699757.
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A blood screening tool for detecting mild cognitive impairment and Alzheimer's disease among community-dwelling Mexican Americans and non-Hispanic Whites: A method for increasing representation of diverse populations in clinical research. Alzheimers Dement. 2022 01; 18(1):77-87. O'Bryant SE, Zhang F, Petersen M, Hall JR, Johnson LA, Yaffe K, Mason D, Braskie M, Barber RA, Rissman RA, Mapstone M, Mielke MM, Toga AW, HABLE Study Team. PMID: 34057802; PMCID: PMC8936163.
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Omics sciences for systems biology in Alzheimer's disease: State-of-the-art of the evidence. Ageing Res Rev. 2021 08; 69:101346. Hampel H, Nisticò R, Seyfried NT, Levey AI, Modeste E, Lemercier P, Baldacci F, Toschi N, Garaci F, Perry G, Emanuele E, Valenzuela PL, Lucia A, Urbani A, Sancesario GM, Mapstone M, Corbo M, Vergallo A, Lista S, Alzheimer Precision Medicine Initiative (APMI). PMID: 33915266.
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Plasma Sphingomyelins in Late-Onset Alzheimer's Disease. J Alzheimers Dis. 2021; 83(3):1161-1171. Fote G, Wu J, Mapstone M, Macciardi F, Fiandaca MS, Federoff HJ. PMID: 34397408; PMCID: PMC9788856.
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Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer's Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome. J Alzheimers Dis. 2021; 79(2):671-681. Petersen ME, Rafii MS, Zhang F, Hall J, Julovich D, Ances BM, Schupf N, Krinsky-McHale SJ, Mapstone M, Silverman W, Lott I, Klunk W, Head E, Christian B, Foroud T, Lai F, Diana Rosas H, Zaman S, Wang MC, Tycko B, Lee JH, Handen B, Hartley S, Fortea J, O'Bryant S, Alzheimer’s Biomarker Consortium –Down Syndrome (ABC-DS). PMID: 33337378; PMCID: PMC8273927.
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The AT(N) framework for Alzheimer's disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12062. Rafii MS, Ances BM, Schupf N, Krinsky-McHale SJ, Mapstone M, Silverman W, Lott I, Klunk W, Head E, Christian B, Lai F, Rosas HD, Zaman S, Petersen ME, Strydom A, Fortea J, Handen B, O'Bryant S. PMID: 33134477; PMCID: PMC7588820.
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Cognitively supernormal older adults maintain a unique structural connectome that is resistant to Alzheimer's pathology. Neuroimage Clin. 2020; 28:102413. Chen Q, Baran TM, Rooks B, O'Banion MK, Mapstone M, Zhang Z, Lin F, Alzheimer's Disease Neuroimaging Initiative. PMID: 32971466; PMCID: PMC7511768.
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The Alzheimer's Biomarker Consortium-Down Syndrome: Rationale and methodology. Alzheimers Dement (Amst). 2020; 12(1):e12065. Handen BL, Lott IT, Christian BT, Schupf N, OBryant S, Mapstone M, Fagan AM, Lee JH, Tudorascu D, Wang MC, Head E, Klunk W, Ances B, Lai F, Zaman S, Krinsky-McHale S, Brickman AM, Rosas HD, Cohen A, Andrews H, Hartley S, Silverman W, Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS). PMID: 32775597; PMCID: PMC7396809.
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Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study. Alzheimers Dement (Amst). 2020; 12(1):e12039. Petersen ME, Zhang F, Schupf N, Krinsky-McHale SJ, Hall J, Mapstone M, Cheema A, Silverman W, Lott I, Rafii MS, Handen B, Klunk W, Head E, Christian B, Foroud T, Lai F, Rosas HD, Zaman S, Ances BM, Wang MC, Tycko B, Lee JH, O'Bryant S, Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). PMID: 32626817; PMCID: PMC7327223.
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Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome. Alzheimers Dement (Amst). 2020; 12(1):e12028. Mapstone M, Gross TJ, Macciardi F, Cheema AK, Petersen M, Head E, Handen BL, Klunk WE, Christian BT, Silverman W, Lott IT, Schupf N, Alzheimer's Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators. PMID: 32258359; PMCID: PMC7131985.
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A Community-Based Study Identifying Metabolic Biomarkers of Mild Cognitive Impairment and Alzheimer's Disease Using Artificial Intelligence and Machine Learning. J Alzheimers Dis. 2020; 78(4):1381-1392. Yilmaz A, Ustun I, Ugur Z, Akyol S, Hu WT, Fiandaca MS, Mapstone M, Federoff H, Maddens M, Graham SF. PMID: 33164929.
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Identify a shared neural circuit linking multiple neuropsychiatric symptoms with Alzheimer's pathology. Brain Imaging Behav. 2019 Feb; 13(1):53-64. Wang X, Ren P, Mapstone M, Conwell Y, Porsteinsson AP, Foxe JJ, Raizada RDS, Lin F, and the Alzheimer’s Disease Neuroimaging Initiative. PMID: 28913718; PMCID: PMC5854501.
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Longitudinal Functional Brain Mapping in Supernormals. Cereb Cortex. 2019 01 01; 29(1):242-252. Wang X, Ren P, Baran TM, Raizada RDS, Mapstone M, Lin F, Alzheimer’s Disease Neuroimaging Initiative. PMID: 29186360; PMCID: PMC6294410.
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Blood-based systems biology biomarkers for next-generation clinical trials in Alzheimer's disease . Dialogues Clin Neurosci. 2019; 21(2):177-191. Hampel H, Vergallo A, Afshar M, Akman-Anderson L, Arenas J, Benda N, Batrla R, Broich K, Caraci F, Cuello AC, Emanuele E, Haberkamp M, Kiddle SJ, Lucía A, Mapstone M, Verdooner SR, Woodcock J, Lista S. PMID: 31636492; PMCID: PMC6787542.
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Potential Metabolomic Linkage in Blood between Parkinson's Disease and Traumatic Brain Injury. Metabolites. 2018 Sep 07; 8(3). Fiandaca MS, Gross TJ, Johnson TM, Hu MT, Evetts S, Wade-Martins R, Merchant-Borna K, Bazarian J, Cheema AK, Mapstone M, Federoff HJ. PMID: 30205491; PMCID: PMC6161135.
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Temporospatial components of brain ERPs as biomarkers for Alzheimer's disease. Alzheimers Dement (Amst). 2018; 10:604-614. Chapman RM, Gardner MN, Klorman R, Mapstone M, Porsteinsson AP, Antonsdottir IM, Kamalyan L. PMID: 30417070; PMCID: PMC6215980.
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Differentiation of Alzheimer's disease based on local and global parameters in personalized Virtual Brain models. Neuroimage Clin. 2018; 19:240-251. Zimmermann J, Perry A, Breakspear M, Schirner M, Sachdev P, Wen W, Kochan NA, Mapstone M, Ritter P, McIntosh AR, Solodkin A. PMID: 30035018; PMCID: PMC6051478.
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Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls. PLoS One. 2018; 13(4):e0195318. Fiandaca MS, Mapstone M, Mahmoodi A, Gross T, Macciardi F, Cheema AK, Merchant-Borna K, Bazarian J, Federoff HJ. PMID: 29677216; PMCID: PMC5909890.
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Precision pharmacology for Alzheimer's disease. Pharmacol Res. 2018 04; 130:331-365. Hampel H, Vergallo A, Aguilar LF, Benda N, Broich K, Cuello AC, Cummings J, Dubois B, Federoff HJ, Fiandaca M, Genthon R, Haberkamp M, Karran E, Mapstone M, Perry G, Schneider LS, Welikovitch LA, Woodcock J, Baldacci F, Lista S, Alzheimer Precision Medicine Initiative (APMI). PMID: 29458203; PMCID: PMC8505114.
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Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development. Curr Top Med Chem. 2018; 18(11):883-895. Gross T, Mapstone M, Miramontes R, Padilla R, Cheema AK, Macciardi F, Federoff HJ, Fiandaca MS. PMID: 29992885.
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Metabolomic biomarkers of pancreatic cancer: a meta-analysis study. Oncotarget. 2017 Sep 15; 8(40):68899-68915. Mehta KY, Wu HJ, Menon SS, Fallah Y, Zhong X, Rizk N, Unger K, Mapstone M, Fiandaca MS, Federoff HJ, Cheema AK. PMID: 28978166; PMCID: PMC5620306.
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Combination antiretroviral therapy improves cognitive performance and functional connectivity in treatment-naïve HIV-infected individuals. J Neurovirol. 2017 10; 23(5):704-712. Zhuang Y, Qiu X, Wang L, Ma Q, Mapstone M, Luque A, Weber M, Tivarus M, Miller E, Arduino RC, Zhong J, Schifitto G. PMID: 28791662; PMCID: PMC5655604.
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Apolipoprotein E genotype impact on memory and attention in older persons: the moderating role of personality phenotype. Int J Geriatr Psychiatry. 2018 02; 33(2):332-339. Chapman BP, Benedict RHB, Lin F, Roy S, Porteinsson A, Szigeti K, Federoff H, Mapstone M. PMID: 28612377.
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Communicating mild cognitive impairment diagnoses with and without amyloid imaging. Alzheimers Res Ther. 2017 May 04; 9(1):35. Grill JD, Apostolova LG, Bullain S, Burns JM, Cox CG, Dick M, Hartley D, Kawas C, Kremen S, Lingler J, Lopez OL, Mapstone M, Pierce A, Rabinovici G, Roberts JS, Sajjadi SA, Teng E, Karlawish J. PMID: 28472970; PMCID: PMC5418690.
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Personality and Performance in Specific Neurocognitive Domains Among Older Persons. Am J Geriatr Psychiatry. 2017 Aug; 25(8):900-908. Chapman BP, Benedict RH, Lin F, Roy S, Federoff HJ, Mapstone M. PMID: 28456386; PMCID: PMC5647872.
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Biomarker validation: Methods and matrix matter. Alzheimers Dement. 2017 05; 13(5):608-609. Mapstone M, Cheema AK, Zhong X, Fiandaca MS, Federoff HJ. PMID: 28010950.
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What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer's disease. Neurobiol Aging. 2017 03; 51:148-155. Mapstone M, Lin F, Nalls MA, Cheema AK, Singleton AB, Fiandaca MS, Federoff HJ. PMID: 27939698; PMCID: PMC5985530.
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The cingulate cortex of older adults with excellent memory capacity. Cortex. 2017 01; 86:83-92. Lin F, Ren P, Mapstone M, Meyers SP, Porsteinsson A, Baran TM, Alzheimer's Disease Neuroimaging Initiative. PMID: 27930899; PMCID: PMC5253250.
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Longitudinal Alteration of Intrinsic Brain Activity in the Striatum in Mild Cognitive Impairment. J Alzheimers Dis. 2016 07 25; 54(1):69-78. Ren P, Lo RY, Chapman BP, Mapstone M, Porsteinsson A, Lin F, Alzheimer’s Disease Neuroimaging Initiative. PMID: 27472880; PMCID: PMC5003682.
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Cognitive and Neural Effects of Vision-Based Speed-of-Processing Training in Older Adults with Amnestic Mild Cognitive Impairment: A Pilot Study. J Am Geriatr Soc. 2016 06; 64(6):1293-8. Lin F, Heffner KL, Ren P, Tivarus ME, Brasch J, Chen DG, Mapstone M, Porsteinsson AP, Tadin D. PMID: 27321608; PMCID: PMC4916855.
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Academic Dysfunction After a Concussion Among US High School and College Students. Am J Public Health. 2016 07; 106(7):1247-53. Wasserman EB, Bazarian JJ, Mapstone M, Block R, van Wijngaarden E. PMID: 27196651; PMCID: PMC4984778.
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ERP C250 shows the elderly (cognitively normal, Alzheimer's disease) store more stimuli in short-term memory than Young Adults do. Clin Neurophysiol. 2016 06; 127(6):2423-35. Chapman RM, Gardner MN, Mapstone M, Klorman R, Porsteinsson AP, Dupree HM, Antonsdottir IM, Kamalyan L. PMID: 27178862; PMCID: PMC4959798.
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Mental Fatigability and Heart Rate Variability in Mild Cognitive Impairment. Am J Geriatr Psychiatry. 2016 05; 24(5):374-8. Lin F, Ren P, Cotton K, Porsteinsson A, Mapstone M, Heffner KL. PMID: 26905050; PMCID: PMC4846469.
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Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer's Disease. Front Neurol. 2015; 6:237. Fiandaca MS, Zhong X, Cheema AK, Orquiza MH, Chidambaram S, Tan MT, Gresenz CR, FitzGerald KT, Nalls MA, Singleton AB, Mapstone M, Federoff HJ. PMID: 26617567; PMCID: PMC4642213.
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Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study. Lancet Neurol. 2015 Oct; 14(10):1002-9. Nalls MA, McLean CY, Rick J, Eberly S, Hutten SJ, Gwinn K, Sutherland M, Martinez M, Heutink P, Williams NM, Hardy J, Gasser T, Brice A, Price TR, Nicolas A, Keller MF, Molony C, Gibbs JR, Chen-Plotkin A, Suh E, Letson C, Fiandaca MS, Mapstone M, Federoff HJ, Noyce AJ, Morris H, Van Deerlin VM, Weintraub D, Zabetian C, Hernandez DG, Lesage S, Mullins M, Conley ED, Northover CA, Frasier M, Marek K, Day-Williams AG, Stone DJ, Ioannidis JP, Singleton AB, Parkinson's Disease Biomarkers Program and Parkinson's Progression Marker Initiative investigators. PMID: 26271532; PMCID: PMC4575273.
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Critical periods after stroke study: translating animal stroke recovery experiments into a clinical trial. Front Hum Neurosci. 2015; 9:231. Dromerick AW, Edwardson MA, Edwards DF, Giannetti ML, Barth J, Brady KP, Chan E, Tan MT, Tamboli I, Chia R, Orquiza M, Padilla RM, Cheema AK, Mapstone ME, Fiandaca MS, Federoff HJ, Newport EL. PMID: 25972803; PMCID: PMC4413691.
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Memory timeline: Brain ERP C250 (not P300) is an early biomarker of short-term storage. Brain Res. 2015 Apr 16; 1604:74-83. Chapman RM, Gardner MN, Mapstone M, Dupree HM, Antonsdottir IM. PMID: 25641043; PMCID: PMC4524323.
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Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study. Alzheimers Dement. 2015 Jun; 11(6):600-7.e1. Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, Abner EL, Petersen RC, Federoff HJ, Miller BL, Goetzl EJ. PMID: 25130657; PMCID: PMC4329112.
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Longitudinal effects of metabolic syndrome on Alzheimer and vascular related brain pathology. Dement Geriatr Cogn Dis Extra. 2014 May; 4(2):184-94. Lin F, Lo RY, Cole D, Ducharme S, Chen DG, Mapstone M, Porsteinsson A, Alzheimer's Disease Neuroimaging Initiative. PMID: 25337075; PMCID: PMC4187257.
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The critical need for defining preclinical biomarkers in Alzheimer's disease. Alzheimers Dement. 2014 Jun; 10(3 Suppl):S196-212. Fiandaca MS, Mapstone ME, Cheema AK, Federoff HJ. PMID: 24924671.
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Evaluation of objective and perceived mental fatigability in older adults with vascular risk. J Psychosom Res. 2014 Jun; 76(6):458-64. Lin F, Roiland R, Heffner K, Johnson M, Chen DG, Mapstone M. PMID: 24840140; PMCID: PMC4033905.
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Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med. 2014 Apr; 20(4):415-8. Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, MacArthur LH, Hall WJ, Fisher SG, Peterson DR, Haley JM, Nazar MD, Rich SA, Berlau DJ, Peltz CB, Tan MT, Kawas CH, Federoff HJ. PMID: 24608097; PMCID: PMC5360460.
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Fatigability disrupts cognitive processes' regulation of inflammatory reactivity in old age. Am J Geriatr Psychiatry. 2014 Dec; 22(12):1544-54. Lin F, Roiland R, Polesskaya O, Chapman B, Johnson M, Brasch J, Chen DG, Mapstone M. PMID: 24388221; PMCID: PMC4048650.
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The impact of AD drug treatments on event-related potentials as markers of disease conversion. Curr Alzheimer Res. 2013 Sep; 10(7):732-41. Chapman RM, Porsteinsson AP, Gardner MN, Mapstone M, McCrary JW, Sandoval TC, Guillily MD, Reilly LA, DeGrush E. PMID: 23905997; PMCID: PMC4021490.
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Poor Aerobic Fitness May Contribute to Cognitive Decline in HIV-infected Older Adults. Aging Dis. 2013; 4(6):311-9. Mapstone M, Hilton TN, Yang H, Guido JJ, Luque AE, Hall WJ, Dewhurst S, Shah K. PMID: 24307964; PMCID: PMC3843648.
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Frequency of mentally stimulating activities modifies the relationship between cardiovascular reactivity and executive function in old age. Am J Geriatr Psychiatry. 2014 Nov; 22(11):1210-21. Lin F, Heffner K, Mapstone M, Chen DG, Porsteisson A. PMID: 23891367; PMCID: PMC3900591.
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Impact of mild cognitive impairment on health-related quality of life in Parkinson's disease. Dement Geriatr Cogn Disord. 2013; 36(1-2):67-75. Reginold W, Duff-Canning S, Meaney C, Armstrong MJ, Fox S, Rothberg B, Zadikoff C, Kennedy N, Gill D, Eslinger P, Marshall F, Mapstone M, Chou KL, Persad C, Litvan I, Mast B, Tang-Wai D, Lang AE, Marras C. PMID: 23774742.
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Measuring mild cognitive impairment in patients with Parkinson's disease. Mov Disord. 2013 May; 28(5):626-33. Marras C, Armstrong MJ, Meaney CA, Fox S, Rothberg B, Reginold W, Tang-Wai DF, Gill D, Eslinger PJ, Zadikoff C, Kennedy N, Marshall FJ, Mapstone M, Chou KL, Persad C, Litvan I, Mast BT, Gerstenecker AT, Weintraub S, Duff-Canning S. PMID: 23520128; PMCID: PMC4524474.
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C145 as a short-latency electrophysiological index of cognitive compensation in Alzheimer's disease. J Alzheimers Dis. 2013; 33(1):55-68. Chapman RM, Porsteinsson AP, Gardner MN, Mapstone M, McCrary JW, Sandoval TC, Guillily MD, DeGrush E, Reilly LA. PMID: 22886016; PMCID: PMC3576817.
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Neurophysiological correlates of motor and working memory performance following subthalamic nucleus stimulation. J Cogn Neurosci. 2013 Jan; 25(1):37-48. Selzler K, Burack M, Bender R, Mapstone M. PMID: 23198889.
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Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease. Am J Geriatr Psychiatry. 2012 Dec; 20(12):1026-35. Dar-Nimrod I, Chapman BP, Franks P, Robbins J, Porsteinsson A, Mapstone M, Duberstein PR. PMID: 23079898; PMCID: PMC4184145.
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Longitudinal relationships between subjective fatigue, cognitive function, and everyday functioning in old age. Int Psychogeriatr. 2013 Feb; 25(2):275-85. Lin F, Chen DG, Vance DE, Ball KK, Mapstone M. PMID: 23083533; PMCID: PMC3552486.
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The meaning of a "hippo" response on the Montreal Cognitive Assessment in Parkinson's disease. Parkinsonism Relat Disord. 2013 Apr; 19(4):463-5. Armstrong MJ, Duff-Canning S, Tang-Wai DF, Fox S, Zadikoff C, Kennedy N, Gill D, Eslinger PJ, Mapstone M, Chou KL, Persad C, Litvan I, Mast BT, Marras C. PMID: 23036511.
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Trajectories of combined laboratory- and real world-based speed of processing in community-dwelling older adults. J Gerontol B Psychol Sci Soc Sci. 2013 May; 68(3):364-73. Lin F, Chen DG, Vance D, Mapstone M. PMID: 22967505; PMCID: PMC3627655.
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Roles of Education and IQ in Cognitive Reserve in Parkinson's Disease-Mild Cognitive Impairment. Dement Geriatr Cogn Dis Extra. 2012 Jan; 2(1):343-52. Armstrong MJ, Naglie G, Duff-Canning S, Meaney C, Gill D, Eslinger PJ, Zadikoff C, Mapstone M, Chou KL, Persad C, Litvan I, Mast BT, Fox S, Tang-Wai DF, Marras C. PMID: 22962558; PMCID: PMC3435526.
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The pill questionnaire in a nondemented Parkinson's disease population. Mov Disord. 2012 Sep 01; 27(10):1308-11. Reginold W, Armstrong MJ, Duff-Canning S, Lang A, Tang-Wai D, Fox S, Rothberg B, Zadikoff C, Kennedy N, Gill D, Eslinger P, Mapstone M, Chou K, Persad C, Litvan I, Mast B, Marras C. PMID: 22865587.
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Reconciling subjective memory complaints with objective memory performance in the menopausal transition. Menopause. 2012 Jul; 19(7):735-41. Weber MT, Mapstone M, Staskiewicz J, Maki PM. PMID: 22415562; PMCID: PMC3773730.
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Effect of leisure activities on inflammation and cognitive function in an aging sample. Arch Gerontol Geriatr. 2012 May-Jun; 54(3):e398-404. Lin F, Friedman E, Quinn J, Chen DG, Mapstone M. PMID: 22377120; PMCID: PMC3331938.
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Gene by neuroticism interaction and cognitive function among older adults. Int J Geriatr Psychiatry. 2012 Nov; 27(11):1147-54. Dar-Nimrod I, Chapman BP, Robbins JA, Porsteinsson A, Mapstone M, Duberstein PR. PMID: 23042108; PMCID: PMC3466473.
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Women have farther to fall: gender differences between normal elderly and Alzheimer's disease in verbal memory engender better detection of Alzheimer's disease in women. J Int Neuropsychol Soc. 2011 Jul; 17(4):654-62. Chapman RM, Mapstone M, Gardner MN, Sandoval TC, McCrary JW, Guillily MD, Reilly LA, DeGrush E. PMID: 21486518; PMCID: PMC3387297.
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Diagnosis of Alzheimer's disease using neuropsychological testing improved by multivariate analyses. J Clin Exp Neuropsychol. 2010 Oct; 32(8):793-808. Chapman RM, Mapstone M, Porsteinsson AP, Gardner MN, McCrary JW, DeGrush E, Reilly LA, Sandoval TC, Guillily MD. PMID: 20358452; PMCID: PMC2896992.
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Predicting conversion from mild cognitive impairment to Alzheimer's disease using neuropsychological tests and multivariate methods. J Clin Exp Neuropsychol. 2011 Feb; 33(2):187-99. Chapman RM, Mapstone M, McCrary JW, Gardner MN, Porsteinsson A, Sandoval TC, Guillily MD, Degrush E, Reilly LA. PMID: 20711906; PMCID: PMC3048956.
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Approaching objects cause confusion in patients with Alzheimer's disease regarding their direction of self-movement. Brain. 2010 Sep; 133(9):2690-701. Mapstone M, Duffy CJ. PMID: 20647265; PMCID: PMC2948814.
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Cognitive Dimensions in Alzheimer's Disease, Mild Cognitive Impairment, and Normal Elderly: Developing a Common Metric. Open Geriatr Med J. 2010 Jan 28; 3(10):1-10. Chapman RM, Mapstone M, McCrary JW, Gardner MN, Bachus LE, Degrush E, Reilly LA, Sandoval TC, Guillily MD. PMID: 20717503; PMCID: PMC2922059.
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Memory complaints and memory performance in the menopausal transition. Menopause. 2009 Jul-Aug; 16(4):694-700. Weber M, Mapstone M. PMID: 19276998.
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The effect of modafinil on cognitive function in breast cancer survivors. Cancer. 2009 Jun 15; 115(12):2605-16. Kohli S, Fisher SG, Tra Y, Adams MJ, Mapstone ME, Wesnes KA, Roscoe JA, Morrow GR. PMID: 19309747; PMCID: PMC2796482.
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Distinct mechanisms of impairment in cognitive ageing and Alzheimer's disease. Brain. 2008 Jun; 131(Pt 6):1618-29. Mapstone M, Dickerson K, Duffy CJ. PMID: 18385184.
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Cue integration for the perception and control of self-movement in ageing and Alzheimer's disease. Brain. 2006 Nov; 129(Pt 11):2931-44. Mapstone M, Logan D, Duffy CJ. PMID: 17071922.
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What are we seeing? Is posterior cortical atrophy just Alzheimer disease? Neurology. 2006 Feb 14; 66(3):300-1. Tang-Wai D, Mapstone M. PMID: 16476924.
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Does extracorporeal circulation harm the brain? Neurology. 2005 Oct 11; 65(7):978-9. Smith WS, Mapstone M. PMID: 16217045.
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The "zoom lens" of focal attention in visual search: changes in aging and Alzheimer's disease. Cortex. 2005 Aug; 41(4):512-9. Rösler A, Mapstone M, Hays-Wicklund A, Gitelman DR, Weintraub S. PMID: 16042027.
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A visuospatial variant of mild cognitive impairment: getting lost between aging and AD. Neurology. 2003 Mar 11; 60(5):802-8. Mapstone M, Steffenella TM, Duffy CJ. PMID: 12629237.
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Cerebral hemispheric specialization for spatial attention: spatial distribution of search-related eye fixations in the absence of neglect. Neuropsychologia. 2003; 41(10):1396-409. Mapstone M, Weintraub S, Nowinski C, Kaptanoglu G, Gitelman DR, Mesulam MM. PMID: 12757911.
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Dynamic allocation of attention in aging and Alzheimer disease: uncoupling of the eye and mind. Arch Neurol. 2001 Sep; 58(9):1443-7. Mapstone M, Rösler A, Hays A, Gitelman DR, Weintraub S. PMID: 11559317.
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[Beyond "successful aging: Rembrandt in his self-portraits]. Psychiatr Prax. 2001 Mar; 28(2):88-90. Rösler A, Hofmann M, Mackenzie M, Harris A, Mapstone M. PMID: 11305165.
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Alterations of visual search strategy in Alzheimer's disease and aging. Neuropsychology. 2000 Jul; 14(3):398-408. Rösler A, Mapstone ME, Hays AK, Mesulam MM, Rademaker A, Gitelman DR, Weintraub S. PMID: 10928743.
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Dopamine agonists reorient visual exploration away from the neglected hemispace. Neurology. 1998 Nov; 51(5):1395-8. Grujic Z, Mapstone M, Gitelman DR, Johnson N, Weintraub S, Hays A, Kwasnica C, Harvey R, Mesulam MM. PMID: 9818867.
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