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Grey matter volume reduction and its association with brain-enriched blood biomarkers in out-of-hospital cardiac arrest survivors. Sci Rep. 2025 Nov 26; 15(1):42219. Hollmén CC, Vorobyev V, Parkkola R, Posti JP, Saunavaara J, Laitio R, Arola O, Hynninen M, Bäcklund M, Blennow K, Zetterberg H, Martola J, Ylikoski E, Roine RO, Tiainen M, Scheinin H, Maze M, Vahlberg T, Laitio TT, Xe-HYPOTHECA Consortium. PMID: 41298726; PMCID: PMC12658190.
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Corrigendum to 'Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice' (Br J Anaesth 2020; 125: 298-307). Br J Anaesth. 2025 Dec; 135(6):1903-1904. Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M. PMID: 41062364; PMCID: PMC12799455.
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Emerging biomarkers of postoperative delirium at the intersection of neuroinflammation and neurodegeneration. Front Aging Neurosci. 2025; 17:1632947. Leng K, Maze M, Barreto Chang OL. PMID: 40951922; PMCID: PMC12426202.
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Alpha-2 adrenergic agonists in Anesthesiology. Seminars in Anesthesia. 2025; 15(1):27-40. Buttermann AE, Maze M. View Publication.
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Paradoxical increases in anterior cingulate cortex activity during nitrous oxide-induced analgesia reveal a signature of pain affect. Pain. 2025 Nov 01; 166(11):2576-2587. Weinrich JAP, Liu CD, Jewell ME, Andolina CR, Bernstein MX, Benitez J, Rodriguez-Rosado S, Braz JM, Maze M, Nemenov MI, Basbaum AI. PMID: 41037432.
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A comparison of large language model-generated and published perioperative neurocognitive disorder recommendations: a cross-sectional web-based analysis. Br J Anaesth. 2026 Apr; 136(4):1275-1286. Saxena S, Barreto Chang OL, Suppan M, Meco BC, Vacas S, Radtke F, Matot I, Devos A, Maze M, Gisselbaek M, Berger-Estilita J. PMID: 39922789.
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Effect of remimazolam besylate vs propofol on incidence of postoperative delirium in older patients undergoing hip surgery: a randomized noninferiority trial. Int J Surg. 2025 Jan 01; 111(1):1469-1472. Fang PP, Hu J, Wei QF, Liang YJ, Fan YG, Shen QY, Lu Y, Liu XS, Maze M, REMPPOD study collaborators. PMID: 38990287; PMCID: PMC11745690.
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Neuroprotective Effects of Inhaled Xenon Gas on Brain Structural Gray Matter Changes After Out-of-Hospital Cardiac Arrest Evaluated by Morphometric Analysis: A Substudy of the Randomized Xe-Hypotheca Trial. Neurocrit Care. 2025 Feb; 42(1):131-141. Hollmén C, Parkkola R, Vorobyev V, Saunavaara J, Laitio R, Arola O, Hynninen M, Bäcklund M, Martola J, Ylikoski E, Roine RO, Tiainen M, Scheinin H, Maze M, Vahlberg T, Laitio TT. PMID: 38982000.
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The role of cultural competency training to address health disparities in surgical settings. Br Med Bull. 2024 06 10; 150(1):42-59. Mora R, Maze M. PMID: 38465857.
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ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke. Clin Transl Med. 2024 04; 14(4):e1650. Pan JZ, Wang Z, Sun W, Pan P, Li W, Sun Y, Chen S, Lin A, Tan W, He L, Greene J, Yao V, An L, Liang R, Li Q, Yu J, Zhang L, Kyritsis N, Fernandez XD, Moncivais S, Mendoza E, Fung P, Wang G, Niu X, Du Q, Xiao Z, Chang Y, Lv P, Huie JR, Torres-Espin A, Ferguson AR, Hemmerle DD, Talbott JF, Weinstein PR, Pascual LU, Singh V, DiGiorgio AM, Saigal R, Whetstone WD, Manley GT, Dhall SS, Bresnahan JC, Maze M, Jiang X, Singhal NS, Beattie MS, Su H, Guan Z. PMID: 38649772; PMCID: PMC11035380.
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Clinical Use of Adrenergic Receptor Ligands in Acute Care Settings. Handb Exp Pharmacol. 2024; 285:617-637. Langnas E, Maze M. PMID: 38177400.
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Resolution of elevated interleukin-6 after surgery is associated with return of normal cognitive function. Br J Anaesth. 2023 10; 131(4):694-704. Taylor J, Wu JG, Kunkel D, Parker M, Rivera C, Casey C, Naismith S, Teixeira-Pinto A, Maze M, Pearce RA, Lennertz R, Sanders RD. PMID: 37385855; PMCID: PMC10925892.
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High Mobility Group Box 1 (HMGB1): Potential Target in Sepsis-Associated Encephalopathy. Cells. 2023 04 04; 12(7). DeWulf B, Minsart L, Verdonk F, Kruys V, Piagnerelli M, Maze M, Saxena S. PMID: 37048161; PMCID: PMC10093266.
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Paradoxical increases in anterior cingulate cortex activity during nitrous oxide-induced analgesia reveal a signature of pain affect. bioRxiv. 2023 Apr 03. Weinrich JA, Liu CD, Jewell ME, Andolina CR, Bernstein MX, Benitez J, Rodriguez-Rosado S, Braz JM, Maze M, Nemenov MI, Basbaum AI. PMID: 37066151; PMCID: PMC10104003.
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Involvement of KCa3.1 channel activity in immediate perioperative cognitive and neuroinflammatory outcomes. BMC Anesthesiol. 2023 03 16; 23(1):80. Saxena S, Nuyens V, Rodts C, Jamar K, Albert A, Seidel L, Cherkaoui-Malki M, Boogaerts JG, Wulff H, Maze M, Kruys V, Vamecq J. PMID: 36927341; PMCID: PMC10018926.
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Defining the role of Interleukin-6 for the development of perioperative neurocognitive disorders: Evidence from clinical and preclinical studies. Front Aging Neurosci. 2022; 14:1097606. Barreto Chang OL, Maze M. PMID: 36778590; PMCID: PMC9908597.
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Contribution of intraoperative electroencephalogram suppression to frailty-associated postoperative delirium: mediation analysis of a prospective surgical cohort. Br J Anaesth. 2023 02; 130(2):e263-e271. Fang PP, Shang ZX, Xu J, Hu J, Zhang SC, Fan YG, Lu Y, Liu XS, Maze M. PMID: 36503826.
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Longitudinal Profiling of Plasma Cytokines and Its Association With Postoperative Delirium in Elderly Patients Undergoing Major Lower Limb Surgery: A Prospective Observational Study. Anesth Analg. 2023 01 01; 136(1):34-42. Zhang Y, Hu J, Zuo W, He P, Xue Q, Feng X, Zhang Y, Maze M. PMID: 36534715.
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Comparison of the prognostic value of early-phase proton magnetic resonance spectroscopy and diffusion tensor imaging with serum neuron-specific enolase at 72 h in comatose survivors of out-of-hospital cardiac arrest-a substudy of the XeHypotheca trial. Neuroradiology. 2023 Feb; 65(2):349-360. Koskensalo K, Virtanen S, Saunavaara J, Parkkola R, Laitio R, Arola O, Hynninen M, Silvasti P, Nukarinen E, Martola J, Silvennoinen HM, Tiainen M, Roine RO, Scheinin H, Saraste A, Maze M, Vahlberg T, Laitio TT, XeHYPOTHECA Research Group. PMID: 36251060; PMCID: PMC9859870.
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Interleukin-6 trans-signalling in hippocampal CA1 neurones mediates perioperative neurocognitive disorders in mice. Br J Anaesth. 2022 12; 129(6):923-936. Hu J, Zhang Y, Huang C, Feng X, He S, Zhang Y, Maze M. PMID: 36253222.
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Plasma fibrinogen: An important piece of the COVID-19 ICU delirium puzzle? Med Hypotheses. 2022 Nov; 168:110953. Saxena S, Wery AR, Khelif A, Nisolle ML, Lelubre C, Maze M, Biston P, Piagnerelli M. PMID: 36158528; PMCID: PMC9489961.
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Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets. Annu Rev Pharmacol Toxicol. 2023 Jan 20; 63:321-340. Barreto Chang OL, Possin KL, Maze M. PMID: 36100220.
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Considerations for the implementation of machine learning into acute care settings. Br Med Bull. 2022 03 21; 141(1):15-32. Bishara A, Maze EH, Maze M. PMID: 35107127.
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Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia. Eur J Anaesthesiol. 2022 03 01; 39(3):296. Hu J, Zhang Y, Maze M. PMID: 35115467.
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Early postoperative risk prediction of neurocognitive decline. Br J Anaesth. 2022 Apr; 128(4):e266-e267. Saxena S, Rodts C, Nuyens V, Seidel L, Albert A, Boogaerts J, Kruys V, Maze M, Vamecq J. PMID: 35105461.
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Effect of Intraoperative Dexmedetomidine on Recovery of Gastrointestinal Function After Abdominal Surgery in Older Adults: A Randomized Clinical Trial. JAMA Netw Open. 2021 10 01; 4(10):e2128886. Lu Y, Fang PP, Yu YQ, Cheng XQ, Feng XM, Wong GTC, Maze M, Liu XS, POGF Study Collaborators. PMID: 34648009; PMCID: PMC8517746.
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Design of Clinical Trials Evaluating Sedation in Critically Ill Adults Undergoing Mechanical Ventilation: Recommendations From Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) Recommendation III. Crit Care Med. 2021 10 01; 49(10):1684-1693. Ward DS, Absalom AR, Aitken LM, Balas MC, Brown DL, Burry L, Colantuoni E, Coursin D, Devlin JW, Dexter F, Dworkin RH, Egan TD, Elliott D, Egerod I, Flood P, Fraser GL, Girard TD, Gozal D, Hopkins RO, Kress J, Maze M, Needham DM, Pandharipande P, Riker R, Sessler DI, Shafer SL, Shehabi Y, Spies C, Sun LS, Tung A, Urman RD. PMID: 33938718; PMCID: PMC8439670.
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High-Mobility Group Box-1 and Its Potential Role in Perioperative Neurocognitive Disorders. Cells. 2021 09 28; 10(10). Saxena S, Kruys V, De Jongh R, Vamecq J, Maze M. PMID: 34685561; PMCID: PMC8533835.
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Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest-A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial. Crit Care Explor. 2021 Aug; 3(8):e0502. Saraste A, Ballo H, Arola O, Laitio R, Airaksinen J, Hynninen M, Bäcklund M, Ylikoski E, Wennervirta J, Pietilä M, Roine RO, Harjola VP, Niiranen J, Korpi K, Varpula M, Scheinin H, Maze M, Vahlberg T, Laitio T. PMID: 34345828; PMCID: PMC8323798.
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The Role of Microglia in Perioperative Neuroinflammation and Neurocognitive Disorders. Front Aging Neurosci. 2021; 13:671499. Saxena S, Kruys V, Vamecq J, Maze M. PMID: 34122048; PMCID: PMC8193130.
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Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia: A double-blind, randomised clinical trial. Eur J Anaesthesiol. 2021 Mar 01; 38(Suppl 1):S9-S17. Hu J, Zhu M, Gao Z, Zhao S, Feng X, Chen J, Zhang Y, Maze M. PMID: 33122571.
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Preoperative sedentary behavior is neither a risk factor for perioperative neurocognitive disorders nor associated with an increase in peripheral inflammation, a prospective observational cohort study. BMC Anesthesiol. 2020 11 14; 20(1):284. Saxena S, Rodts C, Nuyens V, Lazaron J, Sosnowski V, Verdonk F, Seidel L, Albert A, Boogaerts J, Kruys V, Maze M, Vamecq J. PMID: 33187477; PMCID: PMC7666527.
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Robert D. Sanders, B.Sc., M.B.B.S., Ph.D., F.R.C.A., Recipient of the 2020 James E. Cottrell, M.D., Presidential Scholar Award. Anesthesiology. 2020 10 01; 133(4):720-723. Pearce RA, Maze M. PMID: 32930726.
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Dexmedetomidine Exerts an Anti-inflammatory Effect via α2 Adrenoceptors to Prevent Lipopolysaccharide-induced Cognitive Decline in Mice. Anesthesiology. 2020 08; 133(2):393-407. Li R, Lai IK, Pan JZ, Zhang P, Maze M. PMID: 32482998; PMCID: PMC12902830.
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Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice. Br J Anaesth. 2020 09; 125(3):298-307. Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M. PMID: 32624183; PMCID: PMC7497028.
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Perioperative Neurocognitive Disorder: State of the Preclinical Science. Anesthesiology. 2020 01; 132(1):55-68. Eckenhoff RG, Maze M, Xie Z, Culley DJ, Goodlin SJ, Zuo Z, Wei H, Whittington RA, Terrando N, Orser BA, Eckenhoff MF. PMID: 31834869; PMCID: PMC6913778.
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Neuroprotective Properties of Xenon. Mol Neurobiol. 2020 Jan; 57(1):118-124. Maze M, Laitio T. PMID: 31758401.
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Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury. Br J Anaesth. 2019 12; 123(6):827-838. Gao J, Sun Z, Xiao Z, Du Q, Niu X, Wang G, Chang YW, Sun Y, Sun W, Lin A, Bresnahan JC, Maze M, Beattie MS, Pan JZ. PMID: 31623841; PMCID: PMC6883489.
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Impact of Dexmedetomidine on Long-term Outcomes After Noncardiac Surgery in Elderly: 3-Year Follow-up of a Randomized Controlled Trial. Ann Surg. 2019 08; 270(2):356-363. Zhang DF, Su X, Meng ZT, Li HL, Wang DX, Maze M, Ma D. PMID: 29742525.
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Protecting the Brain With Xenon Anesthesia for Neurosurgical Procedures. J Neurosurg Anesthesiol. 2019 Jan; 31(1):18-29. Rylova A, Maze M. PMID: 29470316.
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Specialised pro-resolving mediators: the magic bullet for perioperative neurocognitive disorders? Br J Anaesth. 2019 03; 122(3):292-294. Li R, Lai IK, Maze M. PMID: 30770043.
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Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group. Anesth Analg. 2018 12; 127(6):1406-1413. Berger M, Schenning KJ, Brown CH, Deiner SG, Whittington RA, Eckenhoff RG, Angst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, Ibinson J, Kline RP, Kofke A, Ma D, Mathew JP, Maze M, Orser BA, Price CC, Scott DA, Silbert B, Su D, Terrando N, Wang DS, Wei H, Xie Z, Zuo Z, Perioperative Neurotoxicity Working Group. PMID: 30303868; PMCID: PMC6309612.
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Diagnostic accuracy of leptospirosis whole-cell lateral flow assays: a systematic review and meta-analysis. Clin Microbiol Infect. 2019 Apr; 25(4):437-444. Maze MJ, Sharples KJ, Allan KJ, Rubach MP, Crump JA. PMID: 30472422; PMCID: PMC6456420.
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Restoring Order to Postoperative Neurocognitive Disorders. JAMA Neurol. 2018 05 01; 75(5):535-536. Saxena S, Uchida Y, Maze M. PMID: 29459976.
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Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein-induced Inflammation through a Vagomimetic Action in Mice. Anesthesiology. 2018 05; 128(5):921-931. Hu J, Vacas S, Feng X, Lutrin D, Uchida Y, Lai IK, Maze M. PMID: 29252509; PMCID: PMC6445386.
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Impact on the brain of the inflammatory response to surgery. Presse Med. 2018 Apr; 47(4 Pt 2):e73-e81. Saxena S, Maze M. PMID: 29656802; PMCID: PMC6445379.
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Past, present, and future of nitrous oxide. Br Med Bull. 2018 03 01; 125(1):103-119. Lew V, McKay E, Maze M. PMID: 29528367.
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Methods for Defining the Neuroprotective Properties of Xenon. Methods Enzymol. 2018; 602:273-288. Robel R, Caroccio P, Maze M. PMID: 29588034.
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The epidemiology of febrile illness in sub-Saharan Africa: implications for diagnosis and management. Clin Microbiol Infect. 2018 Aug; 24(8):808-814. Maze MJ, Bassat Q, Feasey NA, Mandomando I, Musicha P, Crump JA. PMID: 29454844; PMCID: PMC6057815.
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Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice. Br J Anaesth. 2018 Mar; 120(3):537-545. Hu J, Feng X, Valdearcos M, Lutrin D, Uchida Y, Koliwad SK, Maze M. PMID: 29452810; PMCID: PMC6200097.
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Exercise Prevents Enhanced Postoperative Neuroinflammation and Cognitive Decline and Rectifies the Gut Microbiome in a Rat Model of Metabolic Syndrome. Front Immunol. 2017; 8:1768. Feng X, Uchida Y, Koch L, Britton S, Hu J, Lutrin D, Maze M. PMID: 29321779; PMCID: PMC5732173.
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Perioperative management of the obese surgical patient. Br Med Bull. 2017 Dec 01; 124(1):135-155. Lang LH, Parekh K, Tsui BYK, Maze M. PMID: 29140418; PMCID: PMC5862330.
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Inhaled Xenon Attenuates Myocardial Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The Xe-Hypotheca Trial. J Am Coll Cardiol. 2017 Nov 28; 70(21):2652-2660. Arola O, Saraste A, Laitio R, Airaksinen J, Hynninen M, Bäcklund M, Ylikoski E, Wennervirta J, Pietilä M, Roine RO, Harjola VP, Niiranen J, Korpi K, Varpula M, Scheinin H, Maze M, Vahlberg T, Laitio T, Xe-HYPOTHECA Study Group. PMID: 29169472.
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The hip fracture surgery in elderly patients (HIPELD) study to evaluate xenon anaesthesia for the prevention of postoperative delirium: a multicentre, randomized clinical trial. Br J Anaesth. 2018 Jan; 120(1):127-137. Coburn M, Sanders RD, Maze M, Nguyên-Pascal ML, Rex S, Garrigues B, Carbonell JA, Garcia-Perez ML, Stevanovic A, Kienbaum P, Neukirchen M, Schaefer MS, Borghi B, van Oven H, Tognù A, Al Tmimi L, Eyrolle L, Langeron O, Capdevila X, Arnold GM, Schaller M, Rossaint R, HIPELD Study Investigators. PMID: 29397119.
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In Response. Anesth Analg. 2017 08; 125(2):695-696. Vacas S, Maze M. PMID: 28661919; PMCID: PMC5654546.
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The immune response of the human brain to abdominal surgery. Ann Neurol. 2017 Apr; 81(4):572-582. Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen LS, Zetterberg H, Erlandsson Harris H, Stridh P, Christensson E, Granström A, Schening A, Dymmel K, Knave N, Terrando N, Maze M, Borg J, Varrone A, Halldin C, Blennow K, Farde L, Eriksson LI. PMID: 28253549; PMCID: PMC12900553.
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Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice. JCI Insight. 2017 04 06; 2(7):e91229. Feng X, Valdearcos M, Uchida Y, Lutrin D, Maze M, Koliwad SK. PMID: 28405620; PMCID: PMC5374063.
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Neuroprotection and neurotoxicity in the developing brain: an update on the effects of dexmedetomidine and xenon. Neurotoxicol Teratol. 2017 Mar - Apr; 60:102-116. Alam A, Suen KC, Hana Z, Sanders RD, Maze M, Ma D. PMID: 28065636; PMCID: PMC12850681.
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Fragmented Sleep Enhances Postoperative Neuroinflammation but Not Cognitive Dysfunction. Anesth Analg. 2017 01; 124(1):270-276. Vacas S, Degos V, Maze M. PMID: 27755058.
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Initiating Mechanisms of Surgery-induced Memory Decline: The Role of HMGB1. J Clin Cell Immunol. 2016 Dec; 7(6). Vacas S, Maze M. PMID: 28674635; PMCID: PMC5493140.
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"A Time of Opportunity": Patient Safety and the Perioperative Surgical Home. Anesth Analg. 2016 12; 123(6):1348-1350. Garson LM, Vakharia S, Edwards AF, Maze M. PMID: 27644056.
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From Bench to Bedside and Back Again: A Personal Journey with Dexmedetomidine. Anesthesiology. 2016 09; 125(3):590-4. Maze M. PMID: 27348818; PMCID: PMC5394927.
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Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery. J Neuroinflammation. 2016 08 30; 13(1):211. Hirsch J, Vacas S, Terrando N, Yuan M, Sands LP, Kramer J, Bozic K, Maze MM, Leung JM. PMID: 27577265; PMCID: PMC5006595.
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Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. Lancet. 2016 Oct 15; 388(10054):1893-1902. Su X, Meng ZT, Wu XH, Cui F, Li HL, Wang DX, Zhu X, Zhu SN, Maze M, Ma D. PMID: 27542303.
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The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor. Anesth Analg. 2016 07; 123(1):206-12. Vacas S, McInrue E, Gropper MA, Maze M, Zak R, Lim E, Leung JM. PMID: 27159066; PMCID: PMC5493322.
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Therapeutic drug monitoring of isoniazid and rifampicin during anti-tuberculosis treatment in Auckland, New Zealand. Int J Tuberc Lung Dis. 2016 07; 20(7):955-60. Maze MJ, Paynter J, Chiu W, Hu R, Nisbet M, Lewis C. PMID: 27287650.
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Correction: Activation of α-7 Nicotinic Acetylcholine Receptor Reduces Ischemic Stroke Injury through Reduction of Pro-Inflammatory Macrophages and Oxidative Stress. PLoS One. 2016; 11(3):e0152218. Han Z, Shen F, He Y, Degos V, Camus M, Maze M, Young WL, Su H. PMID: 26986202; PMCID: PMC4795596.
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Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial. JAMA. 2016 Mar 15; 315(11):1120-8. Laitio R, Hynninen M, Arola O, Virtanen S, Parkkola R, Saunavaara J, Roine RO, Grönlund J, Ylikoski E, Wennervirta J, Bäcklund M, Silvasti P, Nukarinen E, Tiainen M, Saraste A, Pietilä M, Airaksinen J, Valanne L, Martola J, Silvennoinen H, Scheinin H, Harjola VP, Niiranen J, Korpi K, Varpula M, Inkinen O, Olkkola KT, Maze M, Vahlberg T, Laitio T. PMID: 26978207.
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Will Xenon Be a Valuable Addition in Perioperative and Critical Care Settings? Anesth Analg. 2016 Mar; 122(3):593-596. Maze M, Pirracchio R. PMID: 26891385.
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Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. Lancet Neurol. 2016 02; 15(2):145-153. Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deierl A, Fagiolo G, Franks NP, Griffiths J, Hajnal J, Juszczak E, Kapetanakis B, Linsell L, Maze M, Omar O, Strohm B, Tusor N, Edwards AD. PMID: 26708675; PMCID: PMC4710577.
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Preclinical neuroprotective actions of xenon and possible implications for human therapeutics: a narrative review. Can J Anaesth. 2016 Feb; 63(2):212-26. Maze M. PMID: 26507536.
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Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome. Brain Behav Immun. 2015 Nov; 50:203-208. Gambús PL, Trocóniz IF, Feng X, Gimenez-Milá M, Mellado R, Degos V, Vacas S, Maze M. PMID: 26164200; PMCID: PMC4631699.
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Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome. PLoS One. 2015; 10(5):e0126906. Feng X, Maze M, Koch LG, Britton SL, Hellman J. PMID: 25978669; PMCID: PMC4433232.
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Immune cell expression of GABAA receptors and the effects of diazepam on influenza infection. J Neuroimmunol. 2015 May 15; 282:97-103. Sanders RD, Grover V, Goulding J, Godlee A, Gurney S, Snelgrove R, Ma D, Singh S, Maze M, Hussell T. PMID: 25903735.
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Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice. Mol Med. 2015 Mar 17; 20:667-75. Terrando N, Yang T, Ryu JK, Newton PT, Monaco C, Feldmann M, Ma D, Akassoglou K, Maze M. PMID: 25365546; PMCID: PMC4398668.
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In reply. Anesthesiology. 2014 Dec; 121(6):1353-4. Vacas S, Degos V, Maze M. PMID: 25405302.
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Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress. PLoS One. 2014; 9(8):e105711. Han Z, Shen F, He Y, Degos V, Camus M, Maze M, Young WL, Su H. PMID: 25157794; PMCID: PMC4144901.
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Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture. J Neurochem. 2014 Nov; 131(4):498-508. Han Z, Li L, Wang L, Degos V, Maze M, Su H. PMID: 25040630; PMCID: PMC4221541.
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Endoglin deficiency impairs stroke recovery. Stroke. 2014 Jul; 45(7):2101-6. Shen F, Degos V, Chu PL, Han Z, Westbroek EM, Choi EJ, Marchuk D, Kim H, Lawton MT, Maze M, Young WL, Su H. PMID: 24876084; PMCID: PMC4118747.
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High-mobility group box 1 protein initiates postoperative cognitive decline by engaging bone marrow-derived macrophages. Anesthesiology. 2014 May; 120(5):1160-7. Vacas S, Degos V, Tracey KJ, Maze M. PMID: 24162463; PMCID: PMC3999217.
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Bundled payments in total joint arthroplasty: targeting opportunities for quality improvement and cost reduction. Clin Orthop Relat Res. 2014 Jan; 472(1):188-93. Bozic KJ, Ward L, Vail TP, Maze M. PMID: 23649225; PMCID: PMC3889448.
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Take off, landing, and fly anesthesia. PLoS Genet. 2013; 9(9):e1003788. Sanders RD, Maze M. PMID: 24039612; PMCID: PMC3764188.
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Feasibility and cardiac safety of inhaled xenon in combination with therapeutic hypothermia following out-of-hospital cardiac arrest. Crit Care Med. 2013 Sep; 41(9):2116-24. Arola OJ, Laitio RM, Roine RO, Grönlund J, Saraste A, Pietilä M, Airaksinen J, Perttilä J, Scheinin H, Olkkola KT, Maze M, Laitio TT. PMID: 23896830.
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Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice. Crit Care Med. 2013 Jul; 41(7):1627-36. Sanders RD, Godlee A, Fujimori T, Goulding J, Xin G, Salek-Ardakani S, Snelgrove RJ, Ma D, Maze M, Hussell T. PMID: 23478657; PMCID: PMC5774585.
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Bone fracture exacerbates murine ischemic cerebral injury. Anesthesiology. 2013 Jun; 118(6):1362-72. Degos V, Maze M, Vacas S, Hirsch J, Guo Y, Shen F, Jun K, van Rooijen N, Gressens P, Young WL, Su H. PMID: 23438676; PMCID: PMC3987811.
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Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome. Anesthesiology. 2013 May; 118(5):1098-105. Feng X, Degos V, Koch LG, Britton SL, Zhu Y, Vacas S, Terrando N, Nelson J, Su X, Maze M. PMID: 23353794; PMCID: PMC5530762.
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The neuroinflammatory response of postoperative cognitive decline. Br Med Bull. 2013; 106:161-78. Vacas S, Degos V, Feng X, Maze M. PMID: 23558082; PMCID: PMC4990823.
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G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration. Ann Neurol. 2013 May; 73(5):667-78. Degos V, Peineau S, Nijboer C, Kaindl AM, Sigaut S, Favrais G, Plaisant F, Teissier N, Gouadon E, Lombet A, Saliba E, Collingridge GL, Maze M, Nicoletti F, Heijnen C, Mantz J, Kavelaars A, Gressens P. PMID: 23494575; PMCID: PMC3837433.
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Sleep and Anesthesia - Common mechanisms of action. Sleep Med Clin. 2013 Mar; 8(1):1-9. Vacas S, Kurien P, Maze M. PMID: 28747855; PMCID: PMC5524381.
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Depletion of bone marrow-derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction. Anesthesiology. 2013 Mar; 118(3):527-36. Degos V, Vacas S, Han Z, van Rooijen N, Gressens P, Su H, Young WL, Maze M. PMID: 23426204; PMCID: PMC3779063.
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Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Mol Med. 2013 Feb 08; 18:1481-90. Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M. PMID: 23296426; PMCID: PMC3576477.
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Parenteral fluids do not affect pulmonary immune responses to influenza or susceptibility to secondary bacterial pneumonia in mice. Influenza Other Respir Viruses. 2013 Nov; 7(6):895-9. Sanders RD, Godlee A, Goulding JC, Ma D, Maze M, Hussell T. PMID: 23279978; PMCID: PMC4634233.
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Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage. Anesthesiology. 2012 Dec; 117(6):1262-75. Sheng SP, Lei B, James ML, Lascola CD, Venkatraman TN, Jung JY, Maze M, Franks NP, Pearlstein RD, Sheng H, Warner DS. PMID: 23143806.
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Noradrenergic trespass in anesthetic and sedative states. Anesthesiology. 2012 Nov; 117(5):945-7. Sanders RD, Maze M. PMID: 23042229.
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The Hip Fracture Surgery in Elderly Patients (HIPELD) study: protocol for a randomized, multicenter controlled trial evaluating the effect of xenon on postoperative delirium in older patients undergoing hip fracture surgery. Trials. 2012 Sep 27; 13:180. Coburn M, Sanders RD, Maze M, Rossaint R, HIPELD Investigators. PMID: 23016882; PMCID: PMC3488510.
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Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia. PLoS One. 2012; 7(5):e37020. Yang T, Zhuang L, Rei Fidalgo AM, Petrides E, Terrando N, Wu X, Sanders RD, Robertson NJ, Johnson MR, Maze M, Ma D. PMID: 22615878; PMCID: PMC3355162.
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Independent preoperative predictors of outcomes in orthopedic and vascular surgery: the influence of time interval between an acute coronary syndrome or stroke and the operation. Ann Surg. 2012 May; 255(5):901-7. Sanders RD, Bottle A, Jameson SS, Mozid A, Aylin P, Edger L, Ma D, Reed MR, Walters M, Lees KR, Maze M. PMID: 22504189.
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Reprogramming of the infant brain by surgery with general anesthesia. Mayo Clin Proc. 2012 Feb; 87(2):110-3. Culley DJ, Maze M, Crosby G. PMID: 22305023; PMCID: PMC3497865.
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Resolving postoperative neuroinflammation and cognitive decline. Ann Neurol. 2011 Dec; 70(6):986-995. Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M. PMID: 22190370; PMCID: PMC4556354.
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Sedation & immunomodulation. Anesthesiol Clin. 2011 Dec; 29(4):687-706. Sanders RD, Hussell T, Maze M. PMID: 22078917.
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N-(Imidazolidin-2-ylidene)-1-arylmethanamine oxides: synthesis, structure and pharmacological evaluation. Arch Pharm (Weinheim). 2012 Jan; 345(1):33-42. Saczewski J, Hudson A, Laird S, Rybczynska A, Boblewski K, Lehmann A, Ma D, Maze M, Watts H, Gdaniec M. PMID: 22083875.
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Xenon pretreatment may prevent early memory decline after isoflurane anesthesia and surgery in mice. PLoS One. 2011; 6(11):e26394. Vizcaychipi MP, Lloyd DG, Wan Y, Palazzo MG, Maze M, Ma D. PMID: 22073162; PMCID: PMC3207823.
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Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain. Neurobiol Dis. 2012 Feb; 45(2):743-50. Shu Y, Zhou Z, Wan Y, Sanders RD, Li M, Pac-Soo CK, Maze M, Ma D. PMID: 22075165.
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Perioperative cognitive decline in the aging population. Mayo Clin Proc. 2011 Sep; 86(9):885-93. Terrando N, Brzezinski M, Degos V, Eriksson LI, Kramer JH, Leung JM, Miller BL, Seeley WW, Vacas S, Weiner MW, Yaffe K, Young WL, Xie Z, Maze M. PMID: 21878601; PMCID: PMC3257991.
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Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop. J Pediatr. 2011 Nov; 159(5):851-858.e1. Higgins RD, Raju T, Edwards AD, Azzopardi DV, Bose CL, Clark RH, Ferriero DM, Guillet R, Gunn AJ, Hagberg H, Hirtz D, Inder TE, Jacobs SE, Jenkins D, Juul S, Laptook AR, Lucey JF, Maze M, Palmer C, Papile L, Pfister RH, Robertson NJ, Rutherford M, Shankaran S, Silverstein FS, Soll RF, Thoresen M, Walsh WF, Eunice Kennedy Shriver National Institute of Child Health and Human Development Hypothermia Workshop. PMID: 21875719; PMCID: PMC3263823.
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Anticipating and managing postoperative delirium and cognitive decline in adults. BMJ. 2011 Jul 20; 343:d4331. Sanders RD, Pandharipande PP, Davidson AJ, Ma D, Maze M. PMID: 21775401.
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Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice. Crit Care. 2011 Jun 24; 15(3):R153. Gu J, Sun P, Zhao H, Watts HR, Sanders RD, Terrando N, Xia P, Maze M, Ma D. PMID: 21702944; PMCID: PMC3219027.
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Xenon augmented hypothermia reduces early lactate/N-acetylaspartate and cell death in perinatal asphyxia. Ann Neurol. 2011 Jul; 70(1):133-50. Faulkner S, Bainbridge A, Kato T, Chandrasekaran M, Kapetanakis AB, Hristova M, Liu M, Evans S, De Vita E, Kelen D, Sanders RD, Edwards AD, Maze M, Cady EB, Raivich G, Robertson NJ. PMID: 21674582.
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Systemic inflammation enhances surgery-induced cognitive dysfunction in mice. Neurosci Lett. 2011 Jul 01; 498(1):63-6. Fidalgo AR, Cibelli M, White JP, Nagy I, Maze M, Ma D. PMID: 21575676.
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Heat shock protein 72 overexpression prevents early postoperative memory decline after orthopedic surgery under general anesthesia in mice. Anesthesiology. 2011 Apr; 114(4):891-900. Vizcaychipi MP, Xu L, Barreto GE, Ma D, Maze M, Giffard RG. PMID: 21317632; PMCID: PMC3063324.
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A clinically relevant model of perinatal global ischemic brain damage in rats. Brain Res. 2011 Apr 06; 1383:317-23. Yang T, Zhuang L, Terrando N, Wu X, Jonhson MR, Maze M, Ma D. PMID: 21281606.
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Nucleic Acid Amplification of the opa Gene for Detection of Neisseria gonorrhoeae: experience from a diagnostic laboratory. J Clin Microbiol. 2011 Mar; 49(3):1128-9. Maze MJ, Young S, Creighton J, Anderson T, Werno A. PMID: 21248091; PMCID: PMC3067690.
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Contribution of sedative-hypnotic agents to delirium via modulation of the sleep pathway. Can J Anaesth. 2011 Feb; 58(2):149-56. Sanders RD, Maze M. PMID: 21170622; PMCID: PMC3033507.
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Cognitive decline following major surgery is associated with gliosis, β-amyloid accumulation, and τ phosphorylation in old mice. Crit Care Med. 2010 Nov; 38(11):2190-8. Wan Y, Xu J, Meng F, Bao Y, Ge Y, Lobo N, Vizcaychipi MP, Zhang D, Gentleman SM, Maze M, Ma D. PMID: 20711073.
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Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20518-22. Terrando N, Monaco C, Ma D, Foxwell BM, Feldmann M, Maze M. PMID: 21041647; PMCID: PMC2996666.
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Role of interleukin-1beta in postoperative cognitive dysfunction. Ann Neurol. 2010 Sep; 68(3):360-8. Cibelli M, Fidalgo AR, Terrando N, Ma D, Monaco C, Feldmann M, Takata M, Lever IJ, Nanchahal J, Fanselow MS, Maze M. PMID: 20818791; PMCID: PMC4836445.
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Xenon pretreatment attenuates anesthetic-induced apoptosis in the developing brain in comparison with nitrous oxide and hypoxia. Anesthesiology. 2010 Aug; 113(2):360-8. Shu Y, Patel SM, Pac-Soo C, Fidalgo AR, Wan Y, Maze M, Ma D. PMID: 20613483.
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Preconditioning and postinsult therapies for perinatal hypoxic-ischemic injury at term. Anesthesiology. 2010 Jul; 113(1):233-49. Sanders RD, Manning HJ, Robertson NJ, Ma D, Edwards AD, Hagberg H, Maze M. PMID: 20526192.
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Effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells. Exp Biol Med (Maywood). 2010 Jul; 235(7):886-91. Rizvi M, Jawad N, Li Y, Vizcaychipi MP, Maze M, Ma D. PMID: 20472713.
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The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. Crit Care. 2010; 14(3):R88. Terrando N, Rei Fidalgo A, Vizcaychipi M, Cibelli M, Ma D, Monaco C, Feldmann M, Maze M. PMID: 20470406; PMCID: PMC2911722.
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Nitrous oxide discretely up-regulates nNOS and p53 in neonatal rat brain. Minerva Anestesiol. 2010 Jun; 76(6):420-4. Cattano D, Valleggi S, Abramo A, Forfori F, Maze M, Giunta F. PMID: 20473255.
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Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial. Crit Care. 2010; 14(2):R38. Pandharipande PP, Sanders RD, Girard TD, McGrane S, Thompson JL, Shintani AK, Herr DL, Maze M, Ely EW, MENDS investigators. PMID: 20233428; PMCID: PMC2887145.
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Role of transient receptor potential and acid-sensing ion channels in peripheral inflammatory pain. Anesthesiology. 2010 Mar; 112(3):729-41. White JP, Cibelli M, Rei Fidalgo A, Paule CC, Noormohamed F, Urban L, Maze M, Nagy I. PMID: 20179512.
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Noble gas xenon is a novel adenosine triphosphate-sensitive potassium channel opener. Anesthesiology. 2010 Mar; 112(3):623-30. Bantel C, Maze M, Trapp S. PMID: 20179498; PMCID: PMC2935677.
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Argon neuroprotection. Crit Care. 2010; 14(1):117. Sanders RD, Ma D, Maze M. PMID: 20236500; PMCID: PMC2875517.
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Neuroinflammation and postoperative cognitive dysfunction: can anaesthesia be therapeutic? Eur J Anaesthesiol. 2010 Jan; 27(1):3-5. Sanders RD, Maze M. PMID: 19996712.
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Xenon preconditioning confers neuroprotection regardless of gender in a mouse model of transient middle cerebral artery occlusion. Neuroscience. 2010 Feb 03; 165(3):874-81. Limatola V, Ward P, Cattano D, Gu J, Giunta F, Maze M, Ma D. PMID: 19895874.
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Does correcting the numbers improve long-term outcome? Anesthesiology. 2009 Sep; 111(3):475-7. Sanders RD, Maze M. PMID: 19672169.
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Sedation improves early outcome in severely septic Sprague Dawley rats. Crit Care. 2009; 13(4):R136. Qiao H, Sanders RD, Ma D, Wu X, Maze M. PMID: 19691839; PMCID: PMC2750194.
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Sedation & immunomodulation. Crit Care Clin. 2009 Jul; 25(3):551-70, ix. Sanders RD, Hussell T, Maze M. PMID: 19576530.
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Neuroprotection (and lack of neuroprotection) afforded by a series of noble gases in an in vitro model of neuronal injury. Neurosci Lett. 2009 Sep 04; 460(3):232-6. Jawad N, Rizvi M, Gu J, Adeyi O, Tao G, Maze M, Ma D. PMID: 19500647.
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Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Anesthesiology. 2009 May; 110(5):1077-85. Sanders RD, Xu J, Shu Y, Januszewski A, Halder S, Fidalgo A, Sun P, Hossain M, Ma D, Maze M. PMID: 19352168.
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Neuronal preconditioning by inhalational anesthetics: evidence for the role of plasmalemmal adenosine triphosphate-sensitive potassium channels. Anesthesiology. 2009 May; 110(5):986-95. Bantel C, Maze M, Trapp S. PMID: 19352153; PMCID: PMC2930813.
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The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse. J Neurosci. 2009 Feb 18; 29(7):2177-87. Zecharia AY, Nelson LE, Gent TC, Schumacher M, Jurd R, Rudolph U, Brickley SG, Maze M, Franks NP. PMID: 19228970; PMCID: PMC6666350.
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Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation. J Am Soc Nephrol. 2009 Apr; 20(4):713-20. Ma D, Lim T, Xu J, Tang H, Wan Y, Zhao H, Hossain M, Maxwell PH, Maze M. PMID: 19144758; PMCID: PMC2663824.
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Xenon and sevoflurane protect against brain injury in a neonatal asphyxia model. Anesthesiology. 2008 Nov; 109(5):782-9. Luo Y, Ma D, Ieong E, Sanders RD, Yu B, Hossain M, Maze M. PMID: 18946288.
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Xenon up-regulates several genes that are not up-regulated by nitrous oxide. J Neurosurg Anesthesiol. 2008 Oct; 20(4):226-32. Valleggi S, Cavazzana AO, Bernardi R, Ma D, Natale G, Maze M, Cattano D, Davide C, Giunta F. PMID: 18812885.
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Biologic effects of nitrous oxide: a mechanistic and toxicologic review. Anesthesiology. 2008 Oct; 109(4):707-22. Sanders RD, Weimann J, Maze M. PMID: 18813051.
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Balancing paediatric anaesthesia: preclinical insights into analgesia, hypnosis, neuroprotection, and neurotoxicity. Br J Anaesth. 2008 Nov; 101(5):597-609. Sanders RD, Ma D, Brooks P, Maze M. PMID: 18796440.
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General anesthetics induce apoptotic neurodegeneration in the neonatal rat spinal cord. Anesth Analg. 2008 Jun; 106(6):1708-11. Sanders RD, Xu J, Shu Y, Fidalgo A, Ma D, Maze M. PMID: 18499598.
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Role of endogenous sleep-wake and analgesic systems in anesthesia. J Comp Neurol. 2008 Jun 01; 508(4):648-62. Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB. PMID: 18383504; PMCID: PMC4924624.
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Expecting the unexpected. Anesth Analg. 2008 Jun; 106(6):1605-6. Talke PO, Maze M. PMID: 18499586.
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Xenon induces transcription of ADNP in neonatal rat brain. Neurosci Lett. 2008 Aug 08; 440(3):217-21. Cattano D, Valleggi S, Ma D, Kastsiuchenka O, Abramo A, Sun P, Cavazzana AO, Natale G, Maze M, Giunta F. PMID: 18571851.
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The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury. Crit Care Med. 2008 Feb; 36(2):588-95. Coburn M, Maze M, Franks NP. PMID: 18216607.
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Taking the lead in research into postoperative cognitive dysfunction. Anesthesiology. 2008 Jan; 108(1):1-2. Maze M, Cibelli M, Grocott HP. PMID: 18156872.
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Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 2007 Dec 12; 298(22):2644-53. Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, Shintani AK, Thompson JL, Jackson JC, Deppen SA, Stiles RA, Dittus RS, Bernard GR, Ely EW. PMID: 18073360.
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Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology. Anesthesiology. 2007 Nov; 107(5):756-67. Dickinson R, Peterson BK, Banks P, Simillis C, Martin JC, Valenzuela CA, Maze M, Franks NP. PMID: 18073551.
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Translational research: addressing problems facing the anesthesiologist. Anesth Analg. 2007 Oct; 105(4):899-901. Sanders RD, Maze M. PMID: 17898363.
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Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis. J Biol Chem. 2007 Jul 20; 282(29):20977-90. Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson R, Maze M, Franks NP. PMID: 17548360.
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Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain. Anesthesiology. 2007 Apr; 106(4):746-53. Ma D, Williamson P, Januszewski A, Nogaro MC, Hossain M, Ong LP, Shu Y, Franks NP, Maze M. PMID: 17413912.
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Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology. 2007 Mar; 106(3):436-43. Wan Y, Xu J, Ma D, Zeng Y, Cibelli M, Maze M. PMID: 17325501.
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Special issue on postoperative cognitive dysfunction: selected reports from the journal-sponsored symposium. Anesthesiology. 2007 Mar; 106(3):418-20. Maze M, Todd MM. PMID: 17325497.
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Postoperative cognitive dysfunction after noncardiac surgery: a systematic review. Anesthesiology. 2007 Mar; 106(3):572-90. Newman S, Stygall J, Hirani S, Shaefi S, Maze M. PMID: 17325517.
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Alpha2-adrenoceptor agonists. Curr Opin Investig Drugs. 2007 Jan; 8(1):25-33. Sanders RD, Maze M. PMID: 17263182.
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Adrenergic and cholinergic compounds. Handb Exp Pharmacol. 2007; (177):251-64. Sanders RD, Maze M. PMID: 17087126.
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The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study. Anesth Analg. 2006 Dec; 103(6):1459-63. Sakamoto S, Nakao S, Masuzawa M, Inada T, Maze M, Franks NP, Shingu K. PMID: 17122223.
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Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models. Neurosci Lett. 2006 Dec 01; 409(2):128-33. Rajakumaraswamy N, Ma D, Hossain M, Sanders RD, Franks NP, Maze M. PMID: 17052852.
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Molecular mechanisms transducing the anesthetic, analgesic, and organ-protective actions of xenon. Anesthesiology. 2006 Jul; 105(1):187-97. Preckel B, Weber NC, Sanders RD, Maze M, Schlack W. PMID: 16810011.
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The role of the craniospinal nerves in mediating the antinociceptive effect of transcranial electrostimulation in the rat. Anesth Analg. 2006 Jun; 102(6):1775-80. Nekhendzy V, Davies MF, Lemmens HJ, Maze M. PMID: 16717325.
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A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management. Anesthesiology. 2006 May; 104(5):1040-6. Holdcroft A, Maze M, Doré C, Tebbs S, Thompson S. PMID: 16645457.
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Feasibility and safety of delivering xenon to patients undergoing coronary artery bypass graft surgery while on cardiopulmonary bypass: phase I study. Anesthesiology. 2006 Mar; 104(3):458-65. Lockwood GG, Franks NP, Downie NA, Taylor KM, Maze M. PMID: 16508392.
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Xenon preconditioning reduces brain damage from neonatal asphyxia in rats. J Cereb Blood Flow Metab. 2006 Feb; 26(2):199-208. Ma D, Hossain M, Pettet GK, Luo Y, Lim T, Akimov S, Sanders RD, Franks NP, Maze M. PMID: 16034370.
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Expansion of gas bubbles by nitrous oxide and xenon. Anesthesiology. 2006 Feb; 104(2):299-302. Benavides R, Maze M, Franks NP. PMID: 16436849.
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Alpha-2 agonists: can they modify the outcomes in the Postanesthesia Care Unit? Curr Drug Targets. 2005 Nov; 6(7):749-54. Pandharipande P, Ely EW, Maze M. PMID: 16305453.
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Anaesthesia induced neuroprotection. Best Pract Res Clin Anaesthesiol. 2005 Sep; 19(3):461-74. Sanders RD, Ma D, Maze M. PMID: 16013694.
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Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Ann Neurol. 2005 Aug; 58(2):182-93. Ma D, Hossain M, Chow A, Arshad M, Battson RM, Sanders RD, Mehmet H, Edwards AD, Franks NP, Maze M. PMID: 16049939.
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Xenon and the inflammatory response to cardiopulmonary bypass in the rat. J Cardiothorac Vasc Anesth. 2005 Aug; 19(4):488-93. Clark JA, Ma D, Homi HM, Maze M, Grocott HP. PMID: 16085255.
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Xenon: from stranger to guardian. Curr Opin Anaesthesiol. 2005 Aug; 18(4):405-11. Sanders RD, Maze M. PMID: 16534266.
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Isoflurane exerts antinociceptive and hypnotic properties at all ages in Fischer rats. Br J Anaesth. 2005 Sep; 95(3):393-9. Sanders RD, Patel N, Hossain M, Ma D, Maze M. PMID: 15994850.
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Dexmedetomidine exerts dose-dependent age-independent antinociception but age-dependent hypnosis in Fischer rats. Anesth Analg. 2005 May; 100(5):1295-1302. Sanders RD, Giombini M, Ma D, Ohashi Y, Hossain M, Fujinaga M, Maze M. PMID: 15845672.
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Xenon: elemental anaesthesia in clinical practice. Br Med Bull. 2004; 71:115-35. Sanders RD, Ma D, Maze M. PMID: 15728132.
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alpha2-Adrenoceptor agonists: shedding light on neuroprotection? Br Med Bull. 2004; 71:77-92. Ma D, Rajakumaraswamy N, Maze M. PMID: 15684247.
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Dexmedetomidine and opioid interactions: defining the role of dexmedetomidine for intensive care unit sedation. Anesthesiology. 2004 Nov; 101(5):1059-61. Maze M, Angst MS. PMID: 15505438.
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Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype. Eur J Pharmacol. 2004 Oct 11; 502(1-2):87-97. Ma D, Hossain M, Rajakumaraswamy N, Arshad M, Sanders RD, Franks NP, Maze M. PMID: 15464093.
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Comparative analgesic and mental effects of increasing plasma concentrations of dexmedetomidine and alfentanil in humans. Anesthesiology. 2004 Sep; 101(3):744-52. Angst MS, Ramaswamy B, Davies MF, Maze M. PMID: 15329600.
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Dexmedetomidine: another arrow for the clinician's quiver. Anesthesiology. 2004 Sep; 101(3):568-70. Ebert T, Maze M. PMID: 15329580.
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Rested and refreshed after anesthesia? Overlapping neurobiologic mechanisms of sleep and anesthesia. Anesthesiology. 2004 Jun; 100(6):1341-2. Nelson LE, Franks NP, Maze M. PMID: 15166550.
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Xenon exerts age-independent antinociception in Fischer rats. Anesthesiology. 2004 May; 100(5):1313-8. Ma D, Sanders RD, Halder S, Rajakumaraswamy N, Franks NP, Maze M. PMID: 15114234.
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Attentional effects of noradrenaline vary with arousal level: selective activation of thalamic pulvinar in humans. Neuroimage. 2004 May; 22(1):315-22. Coull JT, Jones ME, Egan TD, Frith CD, Maze M. PMID: 15110021.
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Dexmedetomidine enhances analgesic action of nitrous oxide: mechanisms of action. Anesthesiology. 2004 Apr; 100(4):894-904. Dawson C, Ma D, Chow A, Maze M. PMID: 15087625.
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The antinociceptive effect of transcranial electrostimulation with combined direct and alternating current in freely moving rats. Anesth Analg. 2004 Mar; 98(3):730-7, table of contents. Nekhendzy V, Fender CP, Davies MF, Lemmens HJ, Kim MS, Bouley DM, Maze M. PMID: 14980928.
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Xenon: no stranger to anaesthesia. Br J Anaesth. 2003 Nov; 91(5):709-17. Sanders RD, Franks NP, Maze M. PMID: 14570795.
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The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice. Anesthesiology. 2003 Oct; 99(4):876-81. Homi HM, Yokoo N, Ma D, Warner DS, Franks NP, Maze M, Grocott HP. PMID: 14508320.
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Brain stem opioidergic and GABAergic neurons mediate the antinociceptive effect of nitrous oxide in Fischer rats. Anesthesiology. 2003 Oct; 99(4):947-54. Ohashi Y, Guo T, Orii R, Maze M, Fujinaga M. PMID: 14508330.
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Corticotropin-releasing factor mediates the antinociceptive action of nitrous oxide in rats. Anesthesiology. 2003 Sep; 99(3):708-15. Sawamura S, Obara M, Takeda K, Maze M, Hanaoka K. PMID: 12960557.
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Combination of xenon and isoflurane produces a synergistic protective effect against oxygen-glucose deprivation injury in a neuronal-glial co-culture model. Anesthesiology. 2003 Sep; 99(3):748-51. Ma D, Hossain M, Rajakumaraswamy N, Franks NP, Maze M. PMID: 12960563.
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GABAergic interneurons at supraspinal and spinal levels differentially modulate the antinociceptive effect of nitrous oxide in Fischer rats. Anesthesiology. 2003 May; 98(5):1223-30. Orii R, Ohashi Y, Halder S, Giombini M, Maze M, Fujinaga M. PMID: 12717145.
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Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat. Anesthesiology. 2003 Mar; 98(3):690-8. Ma D, Yang H, Lynch J, Franks NP, Maze M, Grocott HP. PMID: 12606913.
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The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology. 2003 Feb; 98(2):428-36. Nelson LE, Lu J, Guo T, Saper CB, Franks NP, Maze M. PMID: 12552203.
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Evaluation of high fidelity patient simulator in assessment of performance of anaesthetists. Br J Anaesth. 2003 Jan; 90(1):43-7. Weller JM, Bloch M, Young S, Maze M, Oyesola S, Wyner J, Dob D, Haire K, Durbridge J, Walker T, Newble D. PMID: 12488377.
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Evidence for the involvement of spinal cord alpha1 adrenoceptors in nitrous oxide-induced antinociceptive effects in Fischer rats. Anesthesiology. 2002 Dec; 97(6):1458-65. Orii R, Ohashi Y, Guo T, Nelson LE, Hashimoto T, Maze M, Fujinaga M. PMID: 12459672.
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Nitrous oxide exerts age-dependent antinociceptive effects in Fischer rats. Pain. 2002 Nov; 100(1-2):7-18. Ohashi Y, Stowell JM, Nelson LE, Hashimoto T, Maze M, Fujinaga M. PMID: 12435454.
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Neuroprotective and neurotoxic properties of the 'inert' gas, xenon. Br J Anaesth. 2002 Nov; 89(5):739-46. Ma D, Wilhelm S, Maze M, Franks NP. PMID: 12393773.
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The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nat Neurosci. 2002 Oct; 5(10):979-84. Nelson LE, Guo TZ, Lu J, Saper CB, Franks NP, Maze M. PMID: 12195434.
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Effects of xenon on in vitro and in vivo models of neuronal injury. Anesthesiology. 2002 Jun; 96(6):1485-91. Wilhelm S, Ma D, Maze M, Franks NP. PMID: 12170064.
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Meperidine exerts agonist activity at the alpha(2B)-adrenoceptor subtype. Anesthesiology. 2002 Jun; 96(6):1420-6. Takada K, Clark DJ, Davies MF, Tonner PH, Krause TK, Bertaccini E, Maze M. PMID: 12170055.
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Neurobiology of nitrous oxide-induced antinociceptive effects. Mol Neurobiol. 2002 Apr; 25(2):167-89. Fujinaga M, Maze M. PMID: 11936558.
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Isoflurane and nociception: spinal alpha2A adrenoceptors mediate antinociception while supraspinal alpha1 adrenoceptors mediate pronociception. Anesthesiology. 2002 Feb; 96(2):367-74. Kingery WS, Agashe GS, Guo TZ, Sawamura S, Davies MF, Clark JD, Kobilka BK, Maze M. PMID: 11818770.
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Capsaicin sensitive afferents mediate the development of heat hyperalgesia and hindpaw edema after sciatic section in rats. Neurosci Lett. 2002 Jan 18; 318(1):39-43. Kingery WS, Agashe GS, Guo TZ, Davies MF, Clark JD, Maze M. PMID: 11786220.
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Developmental variation in nitrous oxide-induced c-fos expression in Fischer rat spinal cord. Anesthesiology. 2002 Jan; 96(1):249-51. Hashimoto T, Ohashi Y, Nelson LE, Maze M, Fujinaga M. PMID: 11753029.
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Fetuses, fentanyl, and the stress response: signals from the beginnings of pain? Anesthesiology. 2001 Oct; 95(4):823-5. Anand KJ, Maze M. PMID: 11605918.
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New agents for sedation in the intensive care unit. Crit Care Clin. 2001 Oct; 17(4):881-97. Maze M, Scarfini C, Cavaliere F. PMID: 11762266.
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Glucocorticoid inhibition of neuropathic limb edema and cutaneous neurogenic extravasation. Brain Res. 2001 Sep 21; 913(2):140-8. Kingery WS, Guo T, Agashe GS, Davies MF, Clark JD, Maze M. PMID: 11549377.
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Pharmacology of nitrous oxide. Best Practice & Research Clinical Anaesthesiology. 2001; 15(3):339-348. Maze M, Fujinaga M. View Publication.
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Nitrous oxide activates GABAergic neurons in the spinal cord in Fischer rats. Anesthesiology. 2001 Aug; 95(2):463-9. Hashimoto T, Maze M, Ohashi Y, Fujinaga M. PMID: 11506121.
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Sedative but not analgesic alpha2 agonist tolerance is blocked by NMDA receptor and nitric oxide synthase inhibitors. Anesthesiology. 2001 Jul; 95(1):184-91. Davies MF, Reid K, Guo TZ, Agashe GS, Amin YK, Maze M. PMID: 11465557.
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Glucocorticoid inhibition of neuropathic hyperalgesia and spinal Fos expression. Anesth Analg. 2001 Feb; 92(2):476-82. Kingery WS, Agashe GS, Sawamura S, Davies MF, Clark JD, Maze M. PMID: 11159254.
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Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of [alpha]2B adrenoceptors. J Neurosci. 2000 Dec 15; 20(24):9242-51. Sawamura S, Kingery WS, Davies MF, Agashe GS, Clark JD, Kobilka BK, Hashimoto T, Maze M. PMID: 11125002; PMCID: PMC6773006.
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Controversial issues in adult and paediatric ambulatory anaesthesia: is there a role for alpha-2 agonists in conscious sedation in adults and paediatric ambulatory surgical practice? Curr Opin Anaesthesiol. 2000 Dec; 13(6):619-24. Wilhelm S, Maze M. PMID: 17016365.
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Clinical uses of alpha2 -adrenergic agonists. Anesthesiology. 2000 Nov; 93(5):1345-9. Kamibayashi T, Maze M. PMID: 11046225.
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Nitrous oxide lacks the antinociceptive effect on the tail flick test in newborn rats. Anesth Analg. 2000 Jul; 91(1):6-10. Fujinaga M, Doone R, Davies MF, Maze M. PMID: 10866878.
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Alpha2 adrenoceptors in pain modulation: which subtype should be targeted to produce analgesia? Anesthesiology. 2000 Apr; 92(4):934-6. Maze M, Fujinaga M. PMID: 10754610.
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Recent advances in understanding the actions and toxicity of nitrous oxide. Anaesthesia. 2000 Apr; 55(4):311-4. Maze M, Fujinaga M. PMID: 10781114.
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The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice. Pain. 2000 Apr; 85(3):345-358. Kingery WS, Guo TZ, Davies FM, Limbird L, Maze M. PMID: 10781908.
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Strain differences in the antinociceptive effect of nitrous oxide on the tail flick test in rats. Anesth Analg. 2000 Jan; 90(1):195-9. Fender C, Fujinaga M, Maze M. PMID: 10625003.
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Dexmedetomidine: Viewpoints. Drugs. 2000; 59:269-270. Maze M, Talke P, Hassan E.
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The analgesic action of nitrous oxide is dependent on the release of norepinephrine in the dorsal horn of the spinal cord. Anesthesiology. 1999 Nov; 91(5):1401-7. Zhang C, Davies MF, Guo TZ, Maze M. PMID: 10551592.
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Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds. Pain. 1999 Apr; 80(3):555-566. Kingery WS, Castellote JM, Maze M. PMID: 10342417.
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Nitrous oxide produces antinociceptive response via alpha2B and/or alpha2C adrenoceptor subtypes in mice. Anesthesiology. 1999 Feb; 90(2):470-6. Guo TZ, Davies MF, Kingery WS, Patterson AJ, Limbird LE, Maze M. PMID: 9952154.
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Are cholinergic pathways involved in the anesthetic response to alpha2 agonists. Toxicol Lett. 1998 Nov 23; 100-101:17-22. Buttermann AE, Reid K, Maze M. PMID: 10049139.
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The analgesic potency of dexmedetomidine is enhanced after nerve injury: a possible role for peripheral alpha2-adrenoceptors. Anesth Analg. 1998 Oct; 87(4):941-8. Poree LR, Guo TZ, Kingery WS, Maze M. PMID: 9768799.
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Chronic desipramine treatment desensitizes the rat to anesthetic and antinociceptive effects of the alpha2-adrenergic agonist dexmedetomidine. Anesthesiology. 1998 Jun; 88(6):1634-42. Guo TZ, Reid K, Davies MF, Nacif-Coelho C, Rabin BC, Gonzalez F, Maze M. PMID: 9637658.
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Colchicine treatment of the sciatic nerve reduces neurogenic extravasation, but does not affect nociceptive thresholds or collateral sprouting in neuropathic or normal rats. Pain. 1998 Jan; 74(1):11-20. Kingery SW, Guo ZT, Poree RL, Maze M. PMID: 9514555.
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In vivo mutation of the alpha 2A-adrenergic receptor by homologous recombination reveals the role of this receptor subtype in multiple physiological processes. Adv Pharmacol. 1998; 42:493-6. MacMillan LB, Lakhlani PP, Hein L, Piascik M, Guo TZ, Lovinger D, Maze M, Limbird LE. PMID: 9327947.
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Nifedipine, an L-type calcium channel blocker, restores the hypnotic response in rats made tolerant to the alpha-2 adrenergic agonist dexmedetomidine. J Pharmacol Exp Ther. 1997 Dec; 283(3):993-9. Reid K, Guo TZ, Davies MF, Maze M. PMID: 9399968.
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"Exciting" aspects of opiate receptor signal transduction. Anesthesiology. 1997 Nov; 87(5):1032-3. Maze M. PMID: 9366451.
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Why does insensitivity to opioid narcotics develop? Anesthesiology. 1997 Nov; 87(5):1033-4. Maze M. PMID: 9366452.
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Opiate receptors in the periaqueductal gray mediate analgesic effect of nitrous oxide in rats. Eur J Pharmacol. 1997 Oct 08; 336(2-3):137-41. Fang F, Guo TZ, Davies MF, Maze M. PMID: 9384225.
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Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Proc Natl Acad Sci U S A. 1997 Sep 02; 94(18):9950-5. Lakhlani PP, MacMillan LB, Guo TZ, McCool BA, Lovinger DM, Maze M, Limbird LE. PMID: 9275232; PMCID: PMC23306.
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Alpha-2 adrenergic agonists. Can J Anaesth. 1997 May; 44(5 Pt 2):R13-22. Kamibayashi T, Harasawa K, Maze M. PMID: 9196836.
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Dissociation of hypnotic-anesthetic actions of alpha 2 agonists from cyclic AMP in the rat. Pharmacol Biochem Behav. 1997 May-Jun; 57(1-2):23-9. Rabin BC, Guo TZ, Maze M. PMID: 9164550.
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Chronic treatment with dexmedetomidine desensitizes alpha 2-adrenergic signal transduction. Pharmacol Biochem Behav. 1997 May-Jun; 57(1-2):63-71. Reid K, Hayashi Y, Hsu J, Maguire PA, Rabin BC, Guo TZ, Maze M. PMID: 9164555.
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Molecular Pharmacology of alpha-2 adrenoceptors; relevance to anesthesia. Anesthesiology Clinics of North America. 1997; 1:1-26. Mizobe T; Maze M.
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Antinociceptive response to nitrous oxide is mediated by supraspinal opiate and spinal alpha 2 adrenergic receptors in the rat. Anesthesiology. 1996 Oct; 85(4):846-52. Guo TZ, Poree L, Golden W, Stein J, Fujinaga M, Maze M. PMID: 8873555.
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Sympatholytic and minimum anesthetic concentration-sparing responses are preserved in rats rendered tolerant to the hypnotic and analgesic action of dexmedetomidine, a selective alpha(2)-adrenergic agonist. Anesthesiology. 1996 Sep; 85(3):565-73. Rabin BC, Reid K, Guo TZ, Gustafsson E, Zhang C, Maze M. PMID: 8853087.
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Antisense technology reveals the alpha2A adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat. J Clin Invest. 1996 Sep 01; 98(5):1076-80. Mizobe T, Maghsoudi K, Sitwala K, Tianzhi G, Ou J, Maze M. PMID: 8787667; PMCID: PMC507526.
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Hypnotic and analgesic effects of the alpha 2-adrenergic agonist dexmedetomidine in morphine-tolerant rats. Anesth Analg. 1996 Sep; 83(3):606-10. Hayashi Y, Guo TZ, Maze M. PMID: 8780290.
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Perioperative use of alpha-2 adrenergic agonists. Current Opinion in Anaesthesiology. 1996; 9(4):323-327. Kamibayashi T, Maze M.
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Dexmedetomidine does not attenuate increases in excitatory amino acids after transient global ischemia in the rabbit. J Neurosurg Anesthesiol. 1996 Jul; 8(3):230-6. Kim HK, Zornow MH, Strnat MA, Maze M. PMID: 8803836.
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Role of serotonergic neurotransmission in the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. Eur J Pharmacol. 1996 Jun 13; 306(1-3):51-9. Rabin BC, Guo TZ, Gregg K, Maze M. PMID: 8813614.
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Dexmedetomidine injection into the locus ceruleus produces antinociception. Anesthesiology. 1996 Apr; 84(4):873-81. Guo TZ, Jiang JY, Buttermann AE, Maze M. PMID: 8638842.
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Arrangement of transmembrane domains in adrenergic receptors. Similarity to bacteriorhodopsin. J Biol Chem. 1996 Feb 02; 271(5):2387-9. Mizobe T, Maze M, Lam V, Suryanarayana S, Kobilka BK. PMID: 8576196.
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Alpha-2 adrenergic modulation of sleep: time-of-day-dependent pharmacodynamic profiles of dexmedetomidine and clonidine in the rat. J Pharmacol Exp Ther. 1995 Oct; 275(1):263-73. Seidel WF, Maze M, Dement WC, Edgar DM. PMID: 7562559.
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Role of pertussis toxin-sensitive G-proteins in the analgesic and anesthetic actions of alpha 2-adrenergic agonists in the rat. Anesthesiology. 1995 Oct; 83(4):816-22. Hayashi Y, Rabin BC, Guo TZ, Maze M. PMID: 7574062.
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Desensitization to the behavioral effects of alpha 2-adrenergic agonists in rats. Anesthesiology. 1995 Apr; 82(4):954-62. Hayashi Y, Guo TZ, Maze M. PMID: 7717568.
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Alpha 2-adrenoceptor agonists and anesthesia. Int Anesthesiol Clin. 1995; 33(1):81-102. Mizobe T, Maze M. PMID: 7635559.
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Anaesthetic and analgesic action of alpha-2 adrenoceptor agonists. Pharmacology Communications. 1995; 6:175-182. Maze M, Poree L, Rabin BC.
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Perturbation of ion channel conductance alters the hypnotic response to the alpha 2-adrenergic agonist dexmedetomidine in the locus coeruleus of the rat. Anesthesiology. 1994 Dec; 81(6):1527-34. Nacif-Coelho C, Correa-Sales C, Chang LL, Maze M. PMID: 7992922.
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Chronic administration of an alpha 2 adrenergic agonist desensitizes rats to the anesthetic effects of dexmedetomidine. Pharmacol Biochem Behav. 1994 Jan; 47(1):171-5. Reid K, Hayashi Y, Guo TZ, Correa-Sales C, Nacif-Coelho C, Maze M. PMID: 7906889.
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Cardiopulmonary and behavioral responses to computer-driven infusion of detomidine in standing horses. Am J Vet Res. 1993 Dec; 54(12):2075-82. Daunt DA, Dunlop CI, Chapman PL, Shafer SL, Ruskoaho H, Vakkuri O, Hodgson DS, Tyler LM, Maze M. PMID: 8116941.
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The alpha 2 adrenergic agonist, dexmedetomidine, selectively attenuates ischemia-induced increases in striatal norepinephrine concentrations. Brain Res. 1993 Nov 12; 627(2):325-9. Matsumoto M, Zornow MH, Rabin BC, Maze M. PMID: 7905353.
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Implementation of a radioreceptor assay for dexmedetomidine. Pharmacol Toxicol. 1993 Nov; 73(5):254-6. Salonen M, Maze M. PMID: 7906879.
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Neuroprotection by the alpha 2-adrenoreceptor agonist dexmedetomidine in a focal model of cerebral ischemia. Anesthesiology. 1993 Aug; 79(2):306-12. Maier C, Steinberg GK, Sun GH, Zhi GT, Maze M. PMID: 8102042.
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Alpha 2 adrenoceptor agonists and anaesthesia. Br J Anaesth. 1993 Jul; 71(1):108-18. Hayashi Y, Maze M. PMID: 8102063.
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The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology. 1993 May; 78(5):813-20. Dyck JB, Maze M, Haack C, Vuorilehto L, Shafer SL. PMID: 8098190.
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Computer-controlled infusion of intravenous dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology. 1993 May; 78(5):821-8. Dyck JB, Maze M, Haack C, Azarnoff DL, Vuorilehto L, Shafer SL. PMID: 8098191.
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Dexmedetomidine decreases cerebral blood flow velocity in humans. J Cereb Blood Flow Metab. 1993 Mar; 13(2):350-3. Zornow MH, Maze M, Dyck JB, Shafer SL. PMID: 8094720.
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Role of imidazoline-preferring receptors in the genesis of epinephrine-induced arrhythmias in halothane-anesthetized dogs. Anesthesiology. 1993 Mar; 78(3):524-30. Hayashi Y, Kamibayashi T, Maze M, Yamatodani A, Sumikawa K, Kuro M, Yoshiya I. PMID: 7681269.
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Molecular Pharmacology of alpha-2 adrenergic receptors. Anesthetic Pharmacology Review. 1993; 1:233-237. Maze M, Scheinin M.
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Effects of intravenous dexmedetomidine in humans. I. Sedation, ventilation, and metabolic rate. Anesthesiology. 1992 Dec; 77(6):1125-33. Belleville JP, Ward DS, Bloor BC, Maze M. PMID: 1361310.
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Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changes. Anesthesiology. 1992 Dec; 77(6):1134-42. Bloor BC, Ward DS, Belleville JP, Maze M. PMID: 1361311.
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Pertussis toxin-mediated ribosylation of G proteins blocks the hypnotic response to an alpha 2-agonist in the locus coeruleus of the rat. Pharmacol Biochem Behav. 1992 Nov; 43(3):723-7. Correa-Sales C, Reid K, Maze M. PMID: 1360160.
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A hypnotic response to dexmedetomidine, an alpha 2 agonist, is mediated in the locus coeruleus in rats. Anesthesiology. 1992 Jun; 76(6):948-52. Correa-Sales C, Rabin BC, Maze M. PMID: 1350889.
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Ventilatory effects of clonidine alone and in the presence of alfentanil, in human volunteers. Anesthesiology. 1992 Jun; 76(6):899-905. Jarvis DA, Duncan SR, Segal IS, Maze M. PMID: 1599110.
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Synergistic interaction between alpha 2-adrenergic agonists and benzodiazepines in rats. Anesthesiology. 1992 Jun; 76(6):1004-11. Salonen M, Reid K, Maze M. PMID: 1350887.
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Activation of alpha-1 adrenergic receptors modulates the control of left/right sidedness in rat embryos. Dev Biol. 1992 Apr; 150(2):419-21. Fujinaga M, Maze M, Hoffman BB, Baden JM. PMID: 1348038.
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Clinical interactions with alpha-2-adrenergic agonists in anesthetic practice. J Clin Anesth. 1992 Mar-Apr; 4(2):164-72. Salonen MA, Kanto JH, Maze M. PMID: 1348621.
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Dexmedetomidine synergism with midazolam in the elevated plus-maze test in rats. Psychopharmacology (Berl). 1992; 108(1-2):229-34. Salonen M, Onaivi ES, Maze M. PMID: 1357706.
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Mechanism of antiarrhythmic effect of dexmedetomidine on epinephrine-induced arrhythmias (Correspondence; Peer-Reviewed). Anesthesiology. 1991; 75(6):1116-1117. Hayashi Y, Sumikawa K, Maze M. View Publication.
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Functional effects of activation of alpha-1 adrenoceptors by dexmedetomidine: in vivo and in vitro studies. J Pharmacol Exp Ther. 1991 Dec; 259(3):1147-52. Schwinn DA, Correa-Sales C, Page SO, Maze M. PMID: 1684815.
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A comparison of etomidate and thiopental anesthesia for cardioversion. J Cardiothorac Vasc Anesth. 1991 Dec; 5(6):563-5. Ford SR, Maze M, Gaba DM. PMID: 1768819.
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Isoflurane and an alpha 2-adrenoceptor agonist suppress nociceptive neurotransmission in neonatal rat spinal cord. Anesthesiology. 1991 Sep; 75(3):489-98. Savola MK, Woodley SJ, Maze M, Kendig JJ. PMID: 1716080.
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Effects of dexmedetomidine, a novel imidazole sedative-anesthetic agent, on adrenal steroidogenesis: in vivo and in vitro studies. Anesth Analg. 1991 Aug; 73(2):204-8. Maze M, Virtanen R, Daunt D, Banks SJ, Stover EP, Feldman D. PMID: 1649559.
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Central alpha 1-adrenoceptor stimulation functionally antagonizes the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. Anesthesiology. 1991 Aug; 75(2):252-6. Guo TZ, Tinklenberg J, Oliker R, Maze M. PMID: 1677547.
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Dexmedetomidine prevents epinephrine-induced arrhythmias through stimulation of central alpha 2 adrenoceptors in halothane-anesthetized dogs. Anesthesiology. 1991 Jul; 75(1):113-7. Hayashi Y, Sumikawa K, Maze M, Yamatodani A, Kamibayashi T, Kuro M, Yoshiya I. PMID: 1676567.
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Attenuation of central alpha 2 adrenergic action in diabetic rats. Pharmacol Biochem Behav. 1991 Jun; 39(2):383-7. Guo TZ, Maze B, Maze M. PMID: 1682948.
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The alpha 2-adrenoceptor agonist dexmedetomidine increases the apparent potency of the volatile anesthetic isoflurane in rats in vivo and in hippocampal slice in vitro. Brain Res. 1991 May 10; 548(1-2):23-8. Savola MK, MacIver MB, Doze VA, Kendig JJ, Maze M. PMID: 1678296.
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Alpha-2 adrenoceptor agonists: defining the role in clinical anesthesia. Anesthesiology. 1991 Mar; 74(3):581-605. Maze M, Tranquilli W. PMID: 1672060.
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Clinical efficacy of oral-transdermal clonidine combinations during the perioperative period. Anesthesiology. 1991 Feb; 74(2):220-5. Segal IS, Jarvis DJ, Duncan SR, White PF, Maze M. PMID: 1990896.
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Alpha 2-adrenoceptors inhibit a nociceptive response in neonatal rat spinal cord. Eur J Pharmacol. 1991 Jan 10; 192(2):293-300. Kendig JJ, Savola MK, Woodley SJ, Maze M. PMID: 1674474.
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Analysis of anesthetic action on the potassium channels of the Shaker mutant of Drosophila. Ann N Y Acad Sci. 1991; 625:532-9. Tinklenberg JA, Segal IS, Guo TZ, Maze M. PMID: 1905502.
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Role of signal transduction in anesthetic action. Alpha 2 adrenergic agonists. Ann N Y Acad Sci. 1991; 625:409-22. Maze M, Regan JW. PMID: 1711813.
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Modulating role of dopamine on anesthetic requirements. Eur J Pharmacol. 1990 Sep 04; 186(1):9-15. Segal IS, Walton JK, Irwin I, DeLanney LE, Ricaurte GA, Langston JW, Maze M. PMID: 2282937.
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Pertussis toxin and 4-aminopyridine differentially affect the hypnotic-anesthetic action of dexmedetomidine and pentobarbital. Anesthesiology. 1990 Aug; 73(2):304-7. Doze VA, Chen BX, Tinklenberg JA, Segal IS, Maze M. PMID: 1974396.
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Transmembrane signalling and the holy grail of anesthesia. Anesthesiology. 1990 Jun; 72(6):959-61. Maze M. PMID: 2161622.
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Adrenergic characteristics of the pulmonary artery "barorefelex". Journal of Applied Cardiology. 1990; 5(5):339-347. De Campli WM, Baldwin JC, Hagberg RC, Gaba DM, Maze M.
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The role of alpha-2 agonists in anesthesia. Advances in Anesthesia. 1990; 8:115-156. Maze M.
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Dexmedetomidine, acting through central alpha-2 adrenoceptors, prevents opiate-induced muscle rigidity in the rat. Anesthesiology. 1989 Aug; 71(2):242-9. Weinger MB, Segal IS, Maze M. PMID: 2569282.
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Dexmedetomidine produces a hypnotic-anesthetic action in rats via activation of central alpha-2 adrenoceptors. Anesthesiology. 1989 Jul; 71(1):75-9. Doze VA, Chen BX, Maze M. PMID: 2568769.
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Dexmedetomidine decreases halothane anesthetic requirements in rats. Acta Vet Scand Suppl. 1989; 85:55-9. Segal IS, Vickery RG, Maze M. PMID: 2571278.
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Pharmacologic characterization of the receptor mediating the hypnotic action of dexmedetomidine. Acta Vet Scand Suppl. 1989; 85:61-4. Doze V, Chen BX, Li Z, Maze M. PMID: 2571279.
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Action of the stereoisomers of medetomidine, in halothane-anesthetized dogs. Acta Vet Scand Suppl. 1989; 85:71-6. Vickery RG, Maze M. PMID: 2571281.
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Anesthesia and ion channel function in the autonomic nervous system. Int Anesthesiol Clin. 1989; 27(4):248-58. Maze M. PMID: 2480335.
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Dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic alpha 2 adrenergic receptor. Anesthesiology. 1988 Dec; 69(6):818-23. Segal IS, Vickery RG, Walton JK, Doze VA, Maze M. PMID: 2848424.
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Anesthetic and hemodynamic effects of the stereoisomers of medetomidine, an alpha 2-adrenergic agonist, in halothane-anesthetized dogs. Anesth Analg. 1988 Jul; 67(7):611-5. Vickery RG, Sheridan BC, Segal IS, Maze M. PMID: 2898219.
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Mechanism for desensitization of beta-adrenergic receptor-stimulated lipolysis in adipocytes from rats harboring pheochromocytoma. Endocrinology. 1988 Jul; 123(1):528-33. Prokocimer PG, Maze M, Vickery RG, Hoffman BB. PMID: 2838264.
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Anesthetic and hemodynamic effects of the alpha 2-adrenergic agonist, azepexole, in isoflurane-anesthetized dogs. Anesthesiology. 1988 May; 68(5):689-94. Maze M, Vickery RG, Merlone SC, Gaba DM. PMID: 2897174.
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Mechanism of halothane-induced inhibition of isoproterenol-stimulated lipolysis in isolated rat adipocytes. Mol Pharmacol. 1988 Mar; 33(3):338-43. Prokocimer PG, Maze M, Vickery RG, Kraemer FB, Gandjei R, Hoffman BB. PMID: 3352597.
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L-phenylisopropyladenosine (L-PIA) diminishes halothane anesthetic requirements and decreases noradrenergic neurotransmission in rats. Life Sci. 1988; 42(14):1355-60. Birch BD, Louie GL, Vickery RG, Gaba DM, Maze M. PMID: 2832674.
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Perioperative changes in adrenergic responsiveness: Effects of anesthetics on adrenoceptor effector mechanisms. Neurology and Neurobiology. 1988; (42C):461-468. Maze M, Prokocimer PG, Marty JM, Syrota A, Seto M, Kraemer FB, Hoffman BB.
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Clonidine and other alpha2 adrenergic agonists: strategies for the rational use of these novel anesthetic agents. J Clin Anesth. 1988; 1(2):146-57. Maze M, Segal IS, Bloor BC. PMID: 2908485.
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Clonidine reduces halothane MAC in rats. Anesthesiology. 1987 Nov; 67(5):868-9. Maze M, Birch B, Vickery RG. PMID: 3674509.
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Role of the sympathetic nervous system in the maintenance of hypertension in rats harboring pheochromocytoma. J Pharmacol Exp Ther. 1987 Jun; 241(3):870-4. Prokocimer PG, Maze M, Hoffman BB. PMID: 3598906.
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Halothane hepatotoxicity in Fischer 344 rats pretreated with isoniazid. Toxicol Appl Pharmacol. 1987 Mar 15; 87(3):411-9. Rice SA, Maze M, Smith CM, Kosek JC, Mazze RI. PMID: 3564016.
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Pulmonary and systemic hemodynamic effects of central venous and left atrial sympathomimetic drug administration in the dog. J Cardiothorac Anesth. 1987 Feb; 1(1):29-35. Pearl RG, Maze M, Rosenthal MH. PMID: 2979068.
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Halothane anesthetic requirements are not affected by aminophylline treatment in rats and dogs. Anesthesiology. 1986 Dec; 65(6):637-41. Nicholls EA, Louie GL, Prokocimer PG, Maze M. PMID: 3789436.
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Aminophylline shortens thiopental sleep-time and enhances noradrenergic neurotransmission in rats. Brain Res. 1986 Sep 24; 383(1-2):377-81. Louie GL, Prokocimer PG, Nicholls EA, Maze M. PMID: 3021279.
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Epinephrine arrhythmogenicity is enhanced by acute, but not chronic, aminophylline administration during halothane anesthesia in dogs. Anesthesiology. 1986 Jul; 65(1):13-8. Prokocimer PG, Nicholls E, Gaba DM, Maze M. PMID: 3729049.
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Alpha 1-adrenergic blockade raises epinephrine-arrhythmia threshold in halothane-anesthetized dogs in a dose-dependent fashion. Anesthesiology. 1985 Dec; 63(6):611-5. Maze M, Hayward E, Gaba DM. PMID: 2865913.
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Effects of volatile anesthetics or fentanyl on hepatic function in cirrhotic rats. Anesth Analg. 1985 Dec; 64(12):1183-8. Baden JM, Kundomal YR, Luttropp ME, Maze M, Kosek JC. PMID: 4061900.
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Epinephrine infusion induces hyporesponsiveness of vascular smooth muscle. Life Sci. 1985 Oct 28; 37(17):1571-8. Maze M, Spiss CK, Tsujimoto G, Hoffman BB. PMID: 2997566.
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Antiarrhythmic effect of verapamil may be independent of calcium channel blockade. Anesthesiology. 1985 Aug; 63(2):233. Metz S, Maze M. PMID: 4025881.
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A multicenter study of the epidemiology of hepatitis B in anesthesia residents. Anesth Analg. 1985 Jul; 64(7):672-6. Berry AJ, Isaacson IJ, Kane MA, Schatz GC, Clark BT, Beaupre P, Derrer S, Kapur P, Thompson J, Martin D, et al. PMID: 3160260.
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Postcountershock myocardial damage after pretreatment with adrenergic and calcium channel antagonists in halothane-anesthetized dogs. Anesthesiology. 1985 May; 62(5):610-4. Gaba DM, Metz S, Maze M. PMID: 3994026.
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Halothane concentration does not alter the threshold for epinephrine-induced arrhythmias in dogs. Anesthesiology. 1985 Apr; 62(4):470-4. Metz S, Maze M. PMID: 3985403.
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[Adrenoreceptors]. Anaesthesist. 1985 Jan; 34(1):1-10. Spiss CK, Maze M. PMID: 2983584.
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Prolonged hyporesponsiveness of vascular smooth muscle contraction after halothane anesthesia in rabbits. Anesth Analg. 1985 Jan; 64(1):1-6. Spiss CK, Smith CM, Tsujimoto G, Hoffman BB, Maze M. PMID: 2981487.
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Halothane anesthesia does not exacerbate hepatic dysfunction in cirrhotic rats. Anesthesiology. 1985 Jan; 62(1):1-5. Maze M, Smith CM, Baden JM. PMID: 3966663.
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Halothane-epinephrine arrhythmias and adrenergic responsiveness after chronic imipramine administration in dogs. Anesth Analg. 1984 Sep; 63(9):825-8. Spiss CK, Smith CM, Maze M. PMID: 6465577.
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A multicenter study of the prevalence of hepatitis B viral serologic markers in anesthesia personnel. Anesth Analg. 1984 Aug; 63(8):738-42. Berry AJ, Isaacson IJ, Kane MA, Schatz GC, Bastron RD, Maze M, Spiss CK, Rizk SF, Ronai AK, Kimovec MA. PMID: 6465559.
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Alpha-adrenergic responsiveness correlates with epinephrine dose for arrhythmias during halothane anesthesia in dogs. Anesth Analg. 1984 Mar; 63(3):297-300. Spiss CK, Maze M, Smith CM. PMID: 6322614.
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Identification of receptor mechanism mediating epinephrine-induced arrhythmias during halothane anesthesia in the dog. Anesthesiology. 1983 Oct; 59(4):322-6. Maze M, Smith CM. PMID: 6137172.
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Verapamil decreases MAC for halothane in dogs. Anesthesiology. 1983 Oct; 59(4):327-9. Maze M, Mason DM, Kates RE. PMID: 6614542.
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Etiology and treatment of halothane-induced arrhythmias. Clinics in Anaesthesiology. 1983; 1(2):301-322. Maze M, Mason DM. View Publication.
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Prednisolone enhances aminopeptidase turnover in adult rat small intestine. Biochim Biophys Acta. 1982 Dec 17; 719(3):464-73. Scott J, Maze M, Peters TJ. PMID: 7150654.
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Clinical implications of membrane receptor function in anesthesia. Anesthesiology. 1981 Aug; 55(2):160-71. Maze M. PMID: 6114685.
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Intestinal brush border aminooligopeptidases: cytosol precursors of the membrane enzyme. Biochemistry. 1980 May 27; 19(11):2351-8. Maze M, Gray GM. PMID: 7387977.
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Beta-receptor blockade following the use of eye drops. Anesthesiology. 1980 Apr; 52(4):369-70. Samuels SI, Maze M. PMID: 7362061.
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Clinical trial of four pancreatic scanning agents. Br J Radiol. 1978 Mar; 51(603):206-9. Agnew JE, Maze M. PMID: 343862.
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Pancreatic scanning. Br J Radiol. 1976 Dec; 49(588):979-95. Agnew JE, Maze M, Mitchell CJ. PMID: 793672.
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Letter: Uptake of 67Ga in space-occupying lesions in the liver. J Nucl Med. 1975 May; 16(5):443-4. Maze M, Wood J. PMID: 1195003.
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Proceedings: 67Ga citrate liver scanning: evaluation of its use in 80 patients and evidence of intrahepatic distribution by autoradiography. Gut. 1974 Apr; 15(4):342. James O, Wood J, Maze M, Gayotto LC, Williams HS, Sherlock S. PMID: 4365511.
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Involuntary muscle involvement in dystrophia myotonica. Case report. S Afr Med J. 1973 Oct 20; 47(41):1947-50. Maze M, Novis BH, Lurie BB, Bank S. PMID: 4748660.
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