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Identifying optimal combination regimens for therapy of Mycobacterium tuberculosis with an algorithmic approach: prospective predictions and validations. PLoS One. 2026; 21(2):e0324206. Louie A, Neely M, Kim S, Scanga CA, Flynn JL, Peloquin CA, Prideaux B, Schmidt S, Almoslem M, Yamada W, Drusano G. PMID: 41666210; PMCID: PMC12890097.
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Rising Role of Artificial Intelligence in Clinical Pharmacometrics and Model-Informed Precision Dosing in Pediatrics. J Pediatr Pharmacol Ther. 2026 Feb; 31(1):106-111. Mizuno T, Neely MN. PMID: 41675469; PMCID: PMC12888991.
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Pharmacokinetic-pharmacodynamic target attainment with continuous infusion piperacillin in patients admitted to the ICU with hospital-acquired pneumonia. Antimicrob Agents Chemother. 2026 Feb 04; 70(2):e0176025. Zurawska M, Valadez A, Harlan E, Williamson R, Scheetz MH, Neely MN, Yarnold PR, Kang M, Donnelly HK, Martinez F, Korth E, Medernach RL, Nozick SH, Hauser AR, Ozer EA, Diaz E, Misharin AV, Wunderink RG, Rhodes NJ. PMID: 41460103; PMCID: PMC12888853.
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Critical threshold target attainment rates for tazobactam combined with piperacillin among patients admitted to the ICU with hospital-acquired pneumonia. Antimicrob Agents Chemother. 2026 Feb 04; 70(2):e0176625. Williamson R, Zurawska M, Valadez A, Harlan E, Scheetz MH, Neely MN, Yarnold PR, Kang M, Donnelly HK, Martinez F, Korth E, Medernach RL, Nozick SH, Hauser AR, Ozer EA, Diaz E, Misharin AV, Wunderink RG, Rhodes NJ. PMID: 41460101; PMCID: PMC12888870.
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A Matched Case-Control Study to Evaluate Predicted Drug Exposures and Neutropenia during Valganciclovir Prophylaxis in Pediatric Solid Organ Transplant Recipients. Transpl Infect Dis. 2026 Jan-Feb; 28(1):e70146. Nguyen MT, Neely MN, Åsberg A, Boge CLK, Downes KJ. PMID: 41364029; PMCID: PMC12892838.
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Analyzing Pharmacodynamic Count Data That Rapidly Decrease to Zero. CPT Pharmacometrics Syst Pharmacol. 2026 Jan; 15(1):e70140. Yamada WM, Schumitzky A, Kryshchenko A, Otalvaro J, Kim S, Louie A, Drusano G, Neely MN. PMID: 41345802; PMCID: PMC12823320.
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A Nonparametric Population Pharmacokinetic Model of Selumetinib in Pediatric Patients Diagnosed With Neurofibromatosis-I or Plexiform Neurofibromas. CPT Pharmacometrics Syst Pharmacol. 2026 Jan; 15(1):e70156. Köllo Z, Kovács J, Neely MN, Vásárhelyi B, Brückner E, Szabo AJ, Garami M, Karvaly GB. PMID: 41321074; PMCID: PMC12823296.
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An Open-Source Framework for Virtual Bioequivalence Modeling and Clinical Trial Design. CPT Pharmacometrics Syst Pharmacol. 2025 Dec; 14(12):1932-1948. Hamadeh A, Pellowe M, Chelle P, Yeung CHT, Otalvaro J, Yamada W, Bartroff J, Kryshchenko A, Dallmann A, Solodenko J, Lippert J, Tsakalozou E, Neely M, Edginton A. PMID: 40990143; PMCID: PMC12706426.
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Adipocytes Impair Mitoxantrone Cytotoxicity Against Acute Lymphoblastic Leukemia. EJHaem. 2025 Oct; 6(5):e70140. Cohen M, Orgel E, Nevarez-Mejia J, Chen T, Neely M, Louie S, Mittelman SD. PMID: 40896243; PMCID: PMC12397950.
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Population pharmacokinetics of meropenem-vaborbactam in acutely ill hospitalized patients with various degrees of renal dysfunction including continuous renal replacement therapy. Antimicrob Agents Chemother. 2025 07 02; 69(7):e0010825. Reed G, Valadez A, Smith BJ, McCreary EK, Kline EG, Neely MN, Squires KM, Shields RK, Rhodes NJ. PMID: 40455008; PMCID: PMC12217465.
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Individual target pharmacokinetic/pharmacodynamic attainment rates among cefepime-treated patients admitted to the ICU with hospital-acquired pneumonia with and without ECMO. Antimicrob Agents Chemother. 2025 06 04; 69(6):e0010225. Valadez A, Zurawska M, Harlan E, Scheetz MH, Neely MN, Yarnold PR, Kang M, Korth E, Martinez F, Giblin B, Donnelly HK, Dedicatoria K, Medernach R, Nozick S, Hauser AR, Ozer EA, Diaz E, Misharin AV, Wunderink RG, Rhodes NJ. PMID: 40372025; PMCID: PMC12135513.
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Multiple Model Optimal Sampling Promotes Accurate Vancomycin Area-Under-the-Curve Estimation Using a Single Sample in Critically Ill Children. Ther Drug Monit. 2025 Jan 23; 47(4):512-519. Downes KJ, Sharova A, Malone J, Odom John AR, Zuppa AF, Neely MN. PMID: 39846757; PMCID: PMC12254021.
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Polymicrobial interactions influence Mycobacterium abscessus co-existence and biofilm forming capabilities. Front Microbiol. 2024; 15:1484510. Nandanwar N, Gu G, Gibson JE, Neely MN. PMID: 39654682; PMCID: PMC11627178.
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Safety, outcomes, and pharmacokinetics of isavuconazole as a treatment for invasive fungal diseases in pediatric patients: a non-comparative phase 2 trial. Antimicrob Agents Chemother. 2024 12 05; 68(12):e0048424. Segers H, Deville JG, Muller WJ, Manzanares A, Desai A, Neely M, Bordon V, Hanisch B, Lassaletta A, Fisher BT, Autmizguine J, Groll AH, Sinnar S, Croos-Dabrera R, Engelhardt M, Jones M, Kovanda LL, Arrieta AC. PMID: 39540734; PMCID: PMC11642194.
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Factors associated with tracheostomy-associated infection treatment: A multicenter observational study. Pediatr Pulmonol. 2024 Nov; 59(11):2761-2771. Morrison JM, Kono N, Rush M, Hahn A, Forster CS, Cogen JD, Thomson J, DeYoung SH, Bashiri S, Mack WJ, Neely MN, Simon TD, Russell CJ, Pediatric Research in Inpatient Settings Network. PMID: 38860585; PMCID: PMC11783139.
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Transcriptome profiles of macrophages upon infection by morphotypic smooth and rough variants of Mycobacterium abscessus. Microbes Infect. 2024 Jul-Aug; 26(5-6):105367. Nandanwar N, Gibson JE, Neely MN. PMID: 38782181.
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In-vitro and in-vivo assessment of nirmatrelvir penetration into CSF, central nervous system cells, tissues, and peripheral blood mononuclear cells. Sci Rep. 2024 05 10; 14(1):10709. Avedissian SN, Malik JR, Podany AT, Neely M, Rhodes NJ, Scarsi KK, Scheetz MH, Duryee MJ, Modebelu UO, Mykris TM, Winchester LC, Byrareddy SN, Fletcher CV. PMID: 38729980; PMCID: PMC11087525.
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RPEM: Randomized Monte Carlo parametric expectation maximization algorithm. CPT Pharmacometrics Syst Pharmacol. 2024 05; 13(5):759-780. Chen R, Schumitzky A, Kryshchenko A, Nieforth K, Tomashevskiy M, Hu S, Garreau R, Otalvaro J, Yamada W, Neely MN. PMID: 38622792; PMCID: PMC11098164.
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Modeling Pharmacokinetics in Individual Patients Using Therapeutic Drug Monitoring and Artificial Population Quasi-Models: A Study with Piperacillin. Pharmaceutics. 2024 Mar 04; 16(3). Karvaly GB, Vincze I, Neely MN, Zátroch I, Nagy Z, Kocsis I, Kopitkó C. PMID: 38543252; PMCID: PMC10975186.
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Genetic predisposition and high exposure to colistin in the early treatment period as independent risk factors for colistin-induced nephrotoxicity. Clin Transl Sci. 2024 03; 17(3):e13764. Mathew SK, Chapla A, Venkatesan P, Eriyat V, Aruldhas BW, Prabha R, Neely MN, Rao SV, Kandasamy S, Mathew BS. PMID: 38476095; PMCID: PMC10933594.
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Correction to: Training the next generation of pharmacometric modelers: a multisector perspective. J Pharmacokinet Pharmacodyn. 2024 Feb; 51(1):89. Bonate PL, Barrett JS, Ait-Oudhia S, Brundage R, Corrigan B, Duffull S, Gastonguay M, Karlsson MO, Kijima S, Krause A, Lovern M, Riggs MM, Neely M, Ouellet D, Plan EL, Rao GG, Standing J, Wilkins J, Zhu H. PMID: 37670078.
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Association of piperacillin and vancomycin exposure on acute kidney injury during combination therapy. JAC Antimicrob Resist. 2024 Feb; 6(1):dlad157. Venugopalan V, Maranchick N, Hanai D, Hernandez YJ, Joseph Y, Gore A, Desear K, Peloquin C, Neely M, Felton T, Shoulders B, Alshaer M. PMID: 38259903; PMCID: PMC10801827.
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Time-dependent pharmacodynamics of amikacin on Mycobacterium abscessus growth and resistance emergence. Microbiol Spectr. 2024 Feb 06; 12(2):e0322223. Gibson JE, Nandanwar N, Neely MN. PMID: 38236037; PMCID: PMC10846206.
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Individual meropenem epithelial lining fluid and plasma PK/PD target attainment. Antimicrob Agents Chemother. 2023 12 14; 67(12):e0072723. Rohani R, Yarnold PR, Scheetz MH, Neely MN, Kang M, Donnelly HK, Dedicatoria K, Nozick SH, Medernach RL, Hauser AR, Ozer EA, Diaz E, Misharin AV, Wunderink RG, Rhodes NJ. PMID: 37975660; PMCID: PMC10720524.
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Training the next generation of pharmacometric modelers: a multisector perspective. J Pharmacokinet Pharmacodyn. 2024 02; 51(1):5-31. Bonate PL, Barrett JS, Ait-Oudhia S, Brundage R, Corrigan B, Duffull S, Gastonguay M, Karlsson MO, Kijima S, Krause A, Lovern M, Riggs MM, Neely M, Ouellet D, Plan EL, Rao GG, Standing J, Wilkins J, Zhu H. PMID: 37573528.
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Intravenous N-Acetylcysteine to Prevent Cisplatin-Induced Hearing Loss in Children: A Nonrandomized Controlled Phase I Trial. Clin Cancer Res. 2023 07 05; 29(13):2410-2418. Orgel E, Knight KR, Chi YY, Malvar J, Rushing T, Mena V, Eisenberg LS, Rassekh SR, Ross CJD, Scott EN, Neely M, Neuwelt EA, Muldoon LL, Freyer DR. PMID: 37134194; PMCID: PMC10330342.
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Double-Blind, Placebo-Controlled Study of Bezlotoxumab in Children Receiving Antibacterial Treatment for Clostridioides difficile Infection (MODIFY III). J Pediatric Infect Dis Soc. 2023 Jun 30; 12(6):334-341. Sferra TJ, Merta T, Neely M, Murta de Oliveira C, Lassaletta A, Fortuny Guasch C, Dorr MB, Winchell G, Su FH, Perko S, Fernsler D, Waskin H, Holden SR. PMID: 37389891; PMCID: PMC10312293.
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Optimizing Vancomycin Therapy in Critically Ill Children: A Population Pharmacokinetics Study to Inform Vancomycin Area under the Curve Estimation Using Novel Biomarkers. Pharmaceutics. 2023 Apr 25; 15(5). Downes KJ, Zuppa AF, Sharova A, Neely MN. PMID: 37242578; PMCID: PMC10220925.
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Variation in Treatment of Pediatric Tuberculosis Infection in Different Provider Settings. J Pediatr. 2023 08; 259:113419. Malhotra S, Dasgupta-Tsinikas S, Yumul J, Kaneta K, Lenz A, Kizzee R, Bihm D, Jung C, Neely M, Guevara RE, Higashi J, Bender JM. PMID: 37044372.
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Interchangeability of generic drugs for subpopulations: Bioequivalence simulation from a nonparametric PK model of gabapentin generic drugs. Br J Clin Pharmacol. 2024 Jul; 90(7):1576-1585. Glerum PJ, Yamada WM, Neely MN, Burger DM, Maliepaard M, Neef C. PMID: 36482842.
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Isavuconazole Pharmacokinetics and Pharmacodynamics in Children. Pharmaceutics. 2022 Dec 26; 15(1). Elhence H, Mongkolrattanothai K, Mohandas S, Neely MN. PMID: 36678704; PMCID: PMC9865364.
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A proof of concept reinforcement learning based tool for non parametric population pharmacokinetics workflow optimization. J Pharmacokinet Pharmacodyn. 2023 02; 50(1):33-43. Otalvaro JD, Yamada WM, Hernandez AM, Zuluaga AF, Chen R, Neely MN. PMID: 36478350; PMCID: PMC9938066.
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Assessment of flomoxef combined with amikacin in a hollow-fibre infection model for the treatment of neonatal sepsis in low- and middle-income healthcare settings. J Antimicrob Chemother. 2022 11 28; 77(12):3349-3357. Darlow CA, McEntee L, Johnson A, Farrington N, Unsworth J, Jimenez-Valverde A, Jagota B, Kolamunnage-Dona R, Da Costa RMA, Ellis S, Franceschi F, Sharland M, Neely M, Piddock L, Das S, Hope W. PMID: 36177766; PMCID: PMC9704437.
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Individual target pharmacokinetic/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia. J Antimicrob Chemother. 2022 10 28; 77(11):2956-2959. Rohani R, Scheetz MH, Donnelly HK, Donayre A, Kang M, Diaz E, Dedicatoria K, Hauser AR, Ozer EA, Nozick S, Qi C, Pawlowski AE, Neely MN, Misharin AV, Wunderink RG, Rhodes NJ, NU SCRIPT Study investigators. PMID: 35869779; PMCID: PMC10205601.
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Combination Therapy to Kill Mycobacterium tuberculosis in Its Nonreplicating Persister Phenotype. Antimicrob Agents Chemother. 2022 10 18; 66(10):e0069522. Yamada W, Kim S, Almoslem M, Kim S, Myrick J, Nole J, Duncanson B, Louie A, Peloquin CA, Schmidt S, Drusano GL, Neely M. PMID: 36165631; PMCID: PMC9578415.
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Model-Informed Rationale for Early Therapeutic Drug Monitoring of Colistin in Critically Ill Patients. J Clin Pharmacol. 2023 01; 63(1):57-65. Mathew SK, Rao SV, Prabha R, Neely MN, Mathew BS, Aruldhas BW, Veeraraghavan B, Kandasamy S. PMID: 35924629.
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Pharmacokinetic modelling of caspofungin to develop an extended dosing regimen in paediatric patients. J Antimicrob Chemother. 2022 07 28; 77(8):2209-2216. Gastine S, Hempel G, Neely MN, Walsh TJ, Groll AH. PMID: 35696555.
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Assessment of Antibiotic Pharmacokinetics, Molecular Biomarkers and Clinical Status in Critically Ill Adults Diagnosed with Community-Acquired Pneumonia and Receiving Intravenous Piperacillin/Tazobactam and Hydrocortisone over the First Five Days of Intensive Care: An Observational Study (STROBE Compliant). J Clin Med. 2022 Jul 16; 11(14). Vincze I, Czermann R, Nagy Z, Kovács M, Neely M, Farkas R, Kocsis I, Karvaly GB, Kopitkó C. PMID: 35887904; PMCID: PMC9324075.
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Flomoxef and fosfomycin in combination for the treatment of neonatal sepsis in the setting of highly prevalent antimicrobial resistance. J Antimicrob Chemother. 2022 04 27; 77(5):1334-1343. Darlow CA, Farrington N, Johnson A, McEntee L, Unsworth J, Jimenez-Valverde A, Kolamunnage-Dona R, Da Costa RMA, Ellis S, Franceschi F, Sharland M, Neely M, Piddock LJV, Das S, Hope W. PMID: 35170719; PMCID: PMC9047679.
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VP Shunt With Recurrent Malfunction in Two Pediatric Patients: Is the Hydrocephalus Truly Idiopathic? Pediatr Infect Dis J. 2022 04 01; 41(4):358-359. Precit MR, Enriquez C, Neely M, Smit M, Bender JM, Bard JD, Anand V, Mohandas S. PMID: 34260486.
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Optimal Practice for Vancomycin Therapeutic Drug Monitoring: Position Statement From the Anti-infectives Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Ther Drug Monit. 2022 02 01; 44(1):121-132. Reuter SE, Stocker SL, Alffenaar JC, Baldelli S, Cattaneo D, Jones G, Koch BCP, Kocic D, Mathew SK, Molinaro M, Neely M, Sandaradura I, Marriott DJE. PMID: 34882107.
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Evaluating the effect of clofazimine against Mycobacterium tuberculosis given alone or in combination with pretomanid, bedaquiline or linezolid. Int J Antimicrob Agents. 2022 Feb; 59(2):106509. Kim S, Louie A, Drusano GL, Almoslem M, Kim S, Myrick J, Nole J, Duncanson B, Peloquin CA, Scanga CA, Yamada W, Neely M, Schmidt S. PMID: 34958863.
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Parametric and Nonparametric Population Pharmacokinetic Models to Assess Probability of Target Attainment of Imipenem Concentrations in Critically Ill Patients. Pharmaceutics. 2021 Dec 16; 13(12). de Velde F, de Winter BCM, Neely MN, Strojil J, Yamada WM, Harbarth S, Huttner A, van Gelder T, Koch BCP, Muller AE. PMID: 34959451; PMCID: PMC8709176.
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Cefepime Precision Dosing Tool: from Standard to Precise Dose Using Nonparametric Population Pharmacokinetics. Antimicrob Agents Chemother. 2022 02 15; 66(2):e0204621. Alshaer MH, Goutelle S, Santevecchi BA, Shoulders BR, Venugopalan V, Cherabuddi K, Liu J, Kiel PJ, Roberts JA, Sime FB, Scheetz MH, Neely MN, Peloquin CA. PMID: 34902271; PMCID: PMC8846452.
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Parametric and Nonparametric Methods in Population Pharmacokinetics: Experts' Discussion on Use, Strengths, and Limitations. J Clin Pharmacol. 2022 02; 62(2):158-170. Goutelle S, Woillard JB, Buclin T, Bourguignon L, Yamada W, Csajka C, Neely M, Guidi M. PMID: 34713491.
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Growth medium and nitric oxide alter Mycobacterium abscessus morphotype and virulence. Microbiol Res. 2021 Dec; 253:126887. Nandanwar N, Gibson JE, Neely MN. PMID: 34628130.
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A pharmacokinetics-based approach to the monitoring of patient adherence to atorvastatin therapy. Pharmacol Res Perspect. 2021 10; 9(5):e00856. Karvaly GB, Karádi I, Vincze I, Neely MN, Trojnár E, Prohászka Z, Imreh É, Vásárhelyi B, Zsáry A. PMID: 34478238; PMCID: PMC8415218.
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Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships. Antimicrob Agents Chemother. 2021 09 17; 65(10):e0106021. Scheetz MH, Pais GM, Lodise TP, Tong SYC, Davis JS, O'Donnell JN, Liu J, Neely M, Prozialeck WC, Lamar PC, Rhodes NJ, Holland T, Avedissian SN. PMID: 34339278; PMCID: PMC8448150.
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Building Optimal Three-Drug Combination Chemotherapy Regimens To Eradicate Mycobacterium tuberculosis in Its Slow-Growth Acid Phase. Antimicrob Agents Chemother. 2021 09 17; 65(10):e0069321. Kim S, Yamada WM, Duncanson B, Nole J, Rogers S, Parker S, Bacci M, Mtchedlidze N, Peloquin CA, Louie A, Schmidt S, Drusano GL, Neely MN. PMID: 34339275; PMCID: PMC8451274.
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Editorial: In Memory of Roger Jelliffe, MD. Ther Drug Monit. 2021 08 01; 43(4):459-460. Neely MN. PMID: 33883522.
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To Estimate or to Forecast? Lessons From a Comparative Analysis of Four Bayesian Fitting Methods Based on Nonparametric Models. Ther Drug Monit. 2021 08 01; 43(4):461-471. Goutelle S, Alloux C, Bourguignon L, Van Guilder M, Neely M, Maire P. PMID: 34250963.
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Parental Perspectives on Immunizations: Impact of the COVID-19 Pandemic on Childhood Vaccine Hesitancy. J Community Health. 2022 02; 47(1):39-52. He K, Mack WJ, Neely M, Lewis L, Anand V. PMID: 34297272; PMCID: PMC8299444.
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Safety, Tolerability, and Population Pharmacokinetics of Intravenous and Oral Isavuconazonium Sulfate in Pediatric Patients. Antimicrob Agents Chemother. 2021 07 16; 65(8):e0029021. Arrieta AC, Neely M, Day JC, Rheingold SR, Sue PK, Muller WJ, Danziger-Isakov LA, Chu J, Yildirim I, McComsey GA, Frangoul HA, Chen TK, Statler VA, Steinbach WJ, Yin DE, Hamed K, Jones ME, Lademacher C, Desai A, Micklus K, Phillips DL, Kovanda LL, Walsh TJ. PMID: 34031051; PMCID: PMC8284446.
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The case for precision dosing: medical conservatism does not justify inaction. J Antimicrob Chemother. 2021 06 18; 76(7):1661-1665. Scheetz MH, Lodise TP, Downes KJ, Drusano G, Neely M. PMID: 33843994; PMCID: PMC8212772.
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Amikacin Combined with Fosfomycin for Treatment of Neonatal Sepsis in the Setting of Highly Prevalent Antimicrobial Resistance. Antimicrob Agents Chemother. 2021 06 17; 65(7):e0029321. Darlow CA, Docobo-Perez F, Farrington N, Johnson A, McEntee L, Unsworth J, Jimenez-Valverde A, Gastine S, Kolamunnage-Dona R, de Costa RMA, Ellis S, Franceschi F, Standing JF, Sharland M, Neely M, Piddock L, Das S, Hope W. PMID: 33972238; PMCID: PMC8373250.
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Dosage Individualization of Linezolid: Precision Dosing of Linezolid To Optimize Efficacy and Minimize Toxicity. Antimicrob Agents Chemother. 2021 05 18; 65(6). Luque S, Hope W, Sorli L, Muñoz-Bermudez R, Campillo N, Barceló-Vidal J, Álvarez-Lerma F, Horcajada JP, Masclans-Enviz JR, Neely M, Grau S. PMID: 33820765; PMCID: PMC8316043.
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Dose Fractionation of Moxifloxacin for Treatment of Tuberculosis: Impact of Dosing Interval and Elimination Half-Life on Microbial Kill and Resistance Suppression. Antimicrob Agents Chemother. 2021 03 18; 65(4). Drusano GL, Rogers S, Brown D, Peloquin CA, Neely M, Yamada W, Kim S, Almoslem M, Schmidt S, Louie A. PMID: 33468465; PMCID: PMC8097450.
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The Pharmacodynamic-Toxicodynamic Relationship of AUC and Cmax in Vancomycin-Induced Kidney Injury in an Animal Model. Antimicrob Agents Chemother. 2021 02 17; 65(3). Avedissian SN, Pais G, Liu J, O'Donnell JN, Lodise TP, Neely M, Prozialeck WC, Lamar PC, Becher L, Scheetz MH. PMID: 33318004; PMCID: PMC8092494.
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'Cost-benefit analysis comparing trough, two-level AUC, and Bayesian AUC dosing for vancomycin': authors' reply. Clin Microbiol Infect. 2021 06; 27(6):929-930. Lee BV, Fong G, Bolaris M, Neely M, Minejima E, Kang A, Lee G, Gong CL. PMID: 33524587.
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The Funnel: a Screening Technique for Identifying Optimal Two-Drug Combination Chemotherapy Regimens. Antimicrob Agents Chemother. 2021 01 20; 65(2). Drusano GL, Kim S, Almoslem M, Schmidt S, D'Argenio DZ, Myrick J, Duncanson B, Nole J, Brown D, Peloquin CA, Neely M, Yamada W, Louie A. PMID: 33199386; PMCID: PMC7848982.
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Effect of Body Fat on Population Pharmacokinetics of High-Dose Methotrexate in Pediatric Patients With Acute Lymphoblastic Leukemia. J Clin Pharmacol. 2021 06; 61(6):755-762. Orgel E, Nabais T, Douglas C, Mittelman SD, Neely M. PMID: 33314168.
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An Algorithm for Nonparametric Estimation of a Multivariate Mixing Distribution with Applications to Population Pharmacokinetics. Pharmaceutics. 2020 Dec 30; 13(1). Yamada WM, Neely MN, Bartroff J, Bayard DS, Burke JV, Guilder MV, Jelliffe RW, Kryshchenko A, Leary R, Tatarinova T, Schumitzky A. PMID: 33396749; PMCID: PMC7823953.
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Roger W. Jelliffe, MD, FCP, FAAPS: A World Leader in Population Pharmacokinetic and Pharmacodynamic Modeling and Model-Based Target Controlled Individualized Dosing. Clin Pharmacol Ther. 2021 01; 109(1):22-24. Neely MN, Vinks AA. PMID: 33616919.
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Cost-benefit analysis comparing trough, two-level AUC and Bayesian AUC dosing for vancomycin. Clin Microbiol Infect. 2021 Sep; 27(9):1346.e1-1346.e7. Lee BV, Fong G, Bolaris M, Neely M, Minejima E, Kang A, Lee G, Gong CL. PMID: 33221430.
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Developing New Drugs for Mycobacterium tuberculosis Therapy: What Information Do We Get from Preclinical Animal Models? Antimicrob Agents Chemother. 2020 11 17; 64(12). Drusano GL, Duncanson B, Scanga CA, Kim S, Schmidt S, Neely MN, Yamada WM, Vicchiarelli M, Peloquin CA, Louie A. PMID: 32958720; PMCID: PMC7674066.
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Supporting Precision Dosing in Drug Labeling. Clin Pharmacol Ther. 2021 01; 109(1):37-41. Neely M, Onufrak N, Scheetz MH, Avedissian S, Lakota E, Deitchman AN, Gonzalez D. PMID: 33111328.
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Nonparametric Methods in Population Pharmacokinetics. J Clin Pharmacol. 2022 02; 62(2):142-157. Goutelle S, Woillard JB, Neely M, Yamada W, Bourguignon L. PMID: 33103785.
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Building Optimal Three-Drug Combination Chemotherapy Regimens. Antimicrob Agents Chemother. 2020 10 20; 64(11). Drusano GL, Neely MN, Kim S, Yamada WM, Schmidt S, Duncanson B, Nole J, Mtchedlidze N, Peloquin CA, Louie A. PMID: 32900682; PMCID: PMC7577121.
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Population Pharmacokinetics and Target Attainment of Cefepime in Critically Ill Patients and Guidance for Initial Dosing. Antimicrob Agents Chemother. 2020 08 20; 64(9). Al-Shaer MH, Neely MN, Liu J, Cherabuddi K, Venugopalan V, Rhodes NJ, Klinker K, Scheetz MH, Peloquin CA. PMID: 32601155; PMCID: PMC7449216.
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Caspofungin Weight-Based Dosing Supported by a Population Pharmacokinetic Model in Critically Ill Patients. Antimicrob Agents Chemother. 2020 08 20; 64(9). Märtson AG, van der Elst KCM, Veringa A, Zijlstra JG, Beishuizen A, van der Werf TS, Kosterink JGW, Neely M, Alffenaar JW. PMID: 32660990; PMCID: PMC7449215.
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Pharmacodynamic Evaluation of Plasma and Epithelial Lining Fluid Exposures of Amikacin against Pseudomonas aeruginosa in a Dynamic In Vitro Hollow-Fiber Infection Model. Antimicrob Agents Chemother. 2020 08 20; 64(9). Heffernan AJ, Sime FB, Sarovich DS, Neely M, Guerra-Valero Y, Naicker S, Cottrell K, Harris P, Andrews KT, Ellwood D, Wallis SC, Lipman J, Grimwood K, Roberts JA. PMID: 32660986; PMCID: PMC7449155.
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Intra-individual Pharmacokinetic Variability of Intravenous Busulfan in Hematopoietic Stem Cell-Transplanted Children. Clin Pharmacokinet. 2020 08; 59(8):1049-1061. Marsit H, Philippe M, Neely M, Rushing T, Bertrand Y, Ducher M, Leclerc V, Guitton J, Bleyzac N, Goutelle S. PMID: 32157629.
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Development of Population and Bayesian Models for Applied Use in Patients Receiving Cefepime. Clin Pharmacokinet. 2020 08; 59(8):1027-1036. Liu J, Neely M, Lipman J, Sime F, Roberts JA, Kiel PJ, Avedissian SN, Rhodes NJ, Scheetz MH. PMID: 32140940; PMCID: PMC7222999.
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Population Pharmacokinetics of Imipenem in Critically Ill Patients: A Parametric and Nonparametric Model Converge on CKD-EPI Estimated Glomerular Filtration Rate as an Impactful Covariate. Clin Pharmacokinet. 2020 07; 59(7):885-898. de Velde F, de Winter BCM, Neely MN, Yamada WM, Koch BCP, Harbarth S, von Dach E, van Gelder T, Huttner A, Mouton JW, COMBACTE-NET consortium. PMID: 31956969; PMCID: PMC7329758.
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Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper. Intensive Care Med. 2020 06; 46(6):1127-1153. Abdul-Aziz MH, Alffenaar JC, Bassetti M, Bracht H, Dimopoulos G, Marriott D, Neely MN, Paiva JA, Pea F, Sjovall F, Timsit JF, Udy AA, Wicha SG, Zeitlinger M, De Waele JJ, Roberts JA, Infection Section of European Society of Intensive Care Medicine (ESICM), Pharmacokinetic/pharmacodynamic and Critically Ill Patient Study Groups of European Society of Clini, Infectious Diseases Group of International Association of Therapeutic Drug Monitoring and Clinical T, Infections in the ICU and Sepsis Working Group of International Society of Antimicrobial Chemotherap. PMID: 32383061; PMCID: PMC7223855.
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How to design a study to evaluate therapeutic drug monitoring in infectious diseases? Clin Microbiol Infect. 2020 Aug; 26(8):1008-1016. Märtson AG, Sturkenboom MGG, Stojanova J, Cattaneo D, Hope W, Marriott D, Patanwala AE, Peloquin CA, Wicha SG, van der Werf TS, Tängdén T, Roberts JA, Neely MN, Alffenaar JC. PMID: 32205294.
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Development of a methodology to make individual estimates of the precision of liquid chromatography-tandem mass spectrometry drug assay results for use in population pharmacokinetic modeling and the optimization of dosage regimens. PLoS One. 2020; 15(3):e0229873. Karvaly GB, Neely MN, Kovács K, Vincze I, Vásárhelyi B, Jelliffe RW. PMID: 32134971; PMCID: PMC7058336.
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Therapeutic Drug Monitoring Can Improve Linezolid Dosing Regimens in Current Clinical Practice: A Review of Linezolid Pharmacokinetics and Pharmacodynamics. Ther Drug Monit. 2020 02; 42(1):83-92. Rao GG, Konicki R, Cattaneo D, Alffenaar JW, Marriott DJE, Neely M, IATDMCT Antimicrobial Scientific Committee. PMID: 31652190.
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Use of Simulation Strategies to Predict Subtherapeutic Meropenem Exposure Caused by Augmented Renal Clearance in Critically Ill Pediatric Patients With Sepsis. J Pediatr Pharmacol Ther. 2020; 25(5):413-422. Avedissian SN, Skochko SM, Le J, Hingtgen S, Harvey H, Capparelli EV, Richardson A, Momper J, Mak RH, Neely M, Bradley JS. PMID: 32641911; PMCID: PMC7337137.
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Nonparametric Population Pharmacokinetic Modeling of Isoniazid in Colombian Patients With Tuberculosis. Ther Drug Monit. 2019 12; 41(6):719-725. Rodriguez CA, Zuluaga AF, Neely MN, Sierra Y, Morales-Gutierrez J, Zapata J, Zapata JD, Naranjo TW, Agudelo Y. PMID: 31725693.
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In vitro antimicrobial combination testing of and evolution of resistance to the first-in-class spiropyrimidinetrione zoliflodacin combined with six therapeutically relevant antimicrobials for Neisseria gonorrhoeae. J Antimicrob Chemother. 2019 12 01; 74(12):3521-3529. Foerster S, Drusano G, Golparian D, Neely M, Piddock LJV, Alirol E, Unemo M. PMID: 31730160.
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Development and Implementation of Electronic Health Record-Integrated Model-Informed Clinical Decision Support Tools for the Precision Dosing of Drugs. Clin Pharmacol Ther. 2020 01; 107(1):129-135. Vinks AA, Peck RW, Neely M, Mould DR. PMID: 31621071.
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Development of Chronic Pseudomonas aeruginosa-Positive Respiratory Cultures in Children with Tracheostomy. Lung. 2019 12; 197(6):811-817. Russell CJ, Simon TD, Neely MN. PMID: 31673781; PMCID: PMC6934374.
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Update in antibiotic therapy in intensive care unit: report from the 2019 Nîmes International Symposium. Anaesth Crit Care Pain Med. 2019 12; 38(6):647-656. Leone M, Roberts JA, Bassetti M, Bouglé A, Lavigne JP, Legrand M, Neely M, Paiva JA, Payen D, Rello J, Roger C, Sjövall F, Jung B. PMID: 31606548.
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Optimizing Gentamicin Dosing in Pediatrics Using Monte Carlo Simulations. Pediatr Infect Dis J. 2019 04; 38(4):390-395. Alsultan A, Abouelkheir M, Elsharawy Y, Alkoraishi A, Osman R, Neely MN, Mansy W, Algahtani S. PMID: 30882729.
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Software for Dosage Individualization of Voriconazole: a Prospective Clinical Study. Antimicrob Agents Chemother. 2019 04; 63(4). Hope W, Johnstone G, Cicconi S, Felton T, Goodwin J, Whalley S, Santoyo-Castelazo A, Ramos-Martin V, Lestner J, Credidio L, Dane A, Carr DF, Pirmohamed M, Salim R, Neely M. PMID: 30670416; PMCID: PMC6496160.
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Early Use of Anti-influenza Medications in Hospitalized Children With Tracheostomy. Pediatrics. 2019 03; 143(3). Miyakawa R, Barreto NB, Kato RM, Neely MN, Russell CJ. PMID: 30814271; PMCID: PMC6398370.
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Activity of Moxifloxacin against Mycobacterium tuberculosis in Acid Phase and Nonreplicative-Persister Phenotype Phase in a Hollow-Fiber Infection Model. Antimicrob Agents Chemother. 2018 12; 62(12). Louie A, Duncanson B, Myrick J, Maynard M, Nole J, Brown D, Schmidt S, Neely M, Scanga CA, Peloquin C, Drusano GL. PMID: 30249693; PMCID: PMC6256764.
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The Combination of Fosfomycin plus Meropenem Is Synergistic for Pseudomonas aeruginosa PAO1 in a Hollow-Fiber Infection Model. Antimicrob Agents Chemother. 2018 12; 62(12). Drusano GL, Neely MN, Yamada WM, Duncanson B, Brown D, Maynard M, Vicchiarelli M, Louie A. PMID: 30249700; PMCID: PMC6256766.
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Pharmacometric Modeling and Simulation Is Essential to Pediatric Clinical Pharmacology. J Clin Pharmacol. 2018 10; 58 Suppl 10:S73-S85. Neely M, Bayard D, Desai A, Kovanda L, Edginton A. PMID: 30248199.
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Maximal concentration of intravenous busulfan as a determinant of veno-occlusive disease: a pharmacokinetic-pharmacodynamic analysis in 293 hematopoietic stem cell transplanted children. Bone Marrow Transplant. 2019 03; 54(3):448-457. Philippe M, Neely M, Rushing T, Bertrand Y, Bleyzac N, Goutelle S. PMID: 30108322.
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Linezolid Kills Acid-Phase and Nonreplicative-Persister-Phase Mycobacterium tuberculosis in a Hollow-Fiber Infection Model. Antimicrob Agents Chemother. 2018 08; 62(8). Drusano GL, Myrick J, Maynard M, Nole J, Duncanson B, Brown D, Schmidt S, Neely M, Scanga CA, Peloquin C, Louie A. PMID: 29866864; PMCID: PMC6105790.
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Pharmacokinetic/Pharmacodynamic Determinants of Vancomycin Efficacy in Enterococcal Bacteremia. Antimicrob Agents Chemother. 2018 03; 62(3). Jumah MTB, Vasoo S, Menon SR, De PP, Neely M, Teng CB. PMID: 29263057; PMCID: PMC5826144.
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Interchangeability of Generic Drugs: A Nonparametric Pharmacokinetic Model of Gabapentin Generic Drugs. Clin Pharmacol Ther. 2018 11; 104(5):966-973. Glerum PJ, Yu Y, Yamada WM, Neely MN, Maliepaard M, Burger DM, Neef C. PMID: 29330847; PMCID: PMC6220931.
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Prospective Trial on the Use of Trough Concentration versus Area under the Curve To Determine Therapeutic Vancomycin Dosing. Antimicrob Agents Chemother. 2018 02; 62(2). Neely MN, Kato L, Youn G, Kraler L, Bayard D, van Guilder M, Schumitzky A, Yamada W, Jones B, Minejima E. PMID: 29203493; PMCID: PMC5786789.
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Length of Stay and Hospital Revisit After Bacterial Tracheostomy-Associated Respiratory Tract Infection Hospitalizations. Hosp Pediatr. 2018 Jan 16. Russell CJ, Mamey MR, Koh JY, Schrager SM, Neely MN, Wu S. PMID: 29339536; PMCID: PMC5790296.
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Risk factors for hospitalizations due to bacterial respiratory tract infections after tracheotomy. Pediatr Pulmonol. 2018 03; 53(3):349-357. Russell CJ, Thurm C, Hall M, Simon TD, Neely MN, Berry JG. PMID: 29314789; PMCID: PMC5815950.
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Pharmacodynamics of teicoplanin against MRSA. J Antimicrob Chemother. 2017 Dec 01; 72(12):3382-3389. Ramos-Martín V, Johnson A, McEntee L, Farrington N, Padmore K, Cojutti P, Pea F, Neely MN, Hope WW. PMID: 28962026.
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The effect of medication nonadherence on progression-free survival among patients with renal cell carcinoma. Cancer Manag Res. 2017; 9:731-739. Shafrin J, Sullivan J, Chou JW, Neely MN, Doan JF, Maclean JR. PMID: 29238223; PMCID: PMC5713701.
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Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin. Mol Cancer Res. 2017 12; 15(12):1704-1713. Sheng X, Parmentier JH, Tucci J, Pei H, Cortez-Toledo O, Dieli-Conwright CM, Oberley MJ, Neely M, Orgel E, Louie SG, Mittelman SD. PMID: 29117945; PMCID: PMC5726435.
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Sofosbuvir (SOF) Suppresses Ledipasvir (LDV)-resistant Mutants during SOF/LDV Combination Therapy against Genotype 1b Hepatitis C Virus (HCV). Sci Rep. 2017 10 31; 7(1):14421. Brown AN, Liu L, Rodriquez JL, Zhao L, Schuster L, Li E, Wang GP, Neely MN, Yamada W, Drusano GL. PMID: 29089577; PMCID: PMC5663921.
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Tools for the Individualized Therapy of Teicoplanin for Neonates and Children. Antimicrob Agents Chemother. 2017 10; 61(10). Ramos-Martín V, Neely MN, Padmore K, Peak M, Beresford MW, Turner MA, Paulus S, López-Herce J, Hope WW. PMID: 28760897; PMCID: PMC5610524.
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Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation. Front Pharmacol. 2017; 8:358. Woillard JB, Mourad M, Neely M, Capron A, van Schaik RH, van Gelder T, Lloberas N, Hesselink DA, Marquet P, Haufroid V, Elens L. PMID: 28642710; PMCID: PMC5462973.
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Pharmacodynamics of Isavuconazole for Invasive Mold Disease: Role of Galactomannan for Real-Time Monitoring of Therapeutic Response. Clin Infect Dis. 2017 Jun 01; 64(11):1557-1563. Kovanda LL, Kolamunnage-Dona R, Neely M, Maertens J, Lee M, Hope WW. PMID: 28472247; PMCID: PMC5434340.
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Pseudomonas aeruginosa and post-tracheotomy bacterial respiratory tract infection readmissions. Pediatr Pulmonol. 2017 09; 52(9):1212-1218. Russell CJ, Simon TD, Mamey MR, Newth CJL, Neely MN. PMID: 28440922; PMCID: PMC5561001.
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Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future. Clin Pharmacol Ther. 2017 May; 101(5):646-656. Darwich AS, Ogungbenro K, Vinks AA, Powell JR, Reny JL, Marsousi N, Daali Y, Fairman D, Cook J, Lesko LJ, McCune JS, Knibbe C, de Wildt SN, Leeder JS, Neely M, Zuppa AF, Vicini P, Aarons L, Johnson TN, Boiani J, Rostami-Hodjegan A. PMID: 28182269.
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A Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics. Clin Pharmacokinet. 2017 04; 56(4):435-447. Philippe M, Neely M, Bertrand Y, Bleyzac N, Goutelle S. PMID: 27585476.
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Correction for Rhodes et al., Evaluation of Vancomycin Exposures Associated with Elevations in Novel Urinary Biomarkers of Acute Kidney Injury in Vancomycin-Treated Rats. Antimicrob Agents Chemother. 2017 04; 61(4). Rhodes NJ, Prozialeck WC, Lodise TP, Venkatesan N, O'Donnell JN, Pais G, Cluff C, Lamar PC, Neely MN, Gulati A, Scheetz MH. PMID: 28341810; PMCID: PMC5365701.
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Is continuous infusion of imipenem always the best choice? Int J Antimicrob Agents. 2017 Mar; 49(3):348-354. Suchánková H, Lipš M, Urbánek K, Neely MN, Strojil J. PMID: 28189734.
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Immune reactivity after adenoviral-mediated aquaporin-1 cDNA transfer to human parotid glands. Oral Dis. 2017 Apr; 23(3):337-346. Alevizos I, Zheng C, Cotrim AP, Goldsmith CM, McCullagh L, Berkowitz T, Strobl SL, Malyguine A, Kopp WC, Chiorini JA, Nikolov NP, Neely M, Illei GG, Baum BJ. PMID: 27886428; PMCID: PMC5340570.
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Scalpels not hammers: The way forward for precision drug prescription. Clin Pharmacol Ther. 2017 03; 101(3):368-372. Neely M. PMID: 27984653.
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Experiment design for nonparametric models based on minimizing Bayes Risk: application to voriconazole¹. J Pharmacokinet Pharmacodyn. 2017 04; 44(2):95-111. Bayard DS, Neely M. PMID: 27909942; PMCID: PMC5376526.
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The Brief Case: Neonatal Meningitis Caused by Listeria monocytogenes Diagnosed by Multiplex Molecular Panel. J Clin Microbiol. 2016 12; 54(12):2846-2849. Anand V, Holmen J, Neely M, Pannaraj PS, Dien Bard J. PMID: 27881634; PMCID: PMC5121369.
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Closing the Brief Case: Neonatal Meningitis Caused by Listeria monocytogenes Diagnosed by Multiplex Molecular Panel. J Clin Microbiol. 2016 12; 54(12):3075. Anand V, Holmen J, Neely M, Pannaraj PS, Dien Bard J. PMID: 27881637; PMCID: PMC5121407.
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A Nonparametric Pharmacokinetic Approach to Determine the Optimal Dosing Regimen for 30-Minute and 3-Hour Meropenem Infusions in Critically Ill Patients. Ther Drug Monit. 2016 10; 38(5):593-9. Mathew SK, Mathew BS, Neely MN, Naik GS, Prabha R, Jacob GG, K S, Fleming DH. PMID: 27454665.
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Evaluation of Vancomycin Exposures Associated with Elevations in Novel Urinary Biomarkers of Acute Kidney Injury in Vancomycin-Treated Rats. Antimicrob Agents Chemother. 2016 10; 60(10):5742-51. Rhodes NJ, Prozialeck WC, Lodise TP, Venkatesan N, O'Donnell JN, Pais G, Cluff C, Lamar PC, Neely MN, Gulati A, Scheetz MH. PMID: 27431226; PMCID: PMC5038238.
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Dosage Adjustments Related to Young or Old Age and Organ Impairment. J Clin Pharmacol. 2016 12; 56(12):1461-1473. Burris JF, Tortorici MA, Mandic M, Neely M, Reed MD. PMID: 27539787.
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Population pharmacokinetics and pharmacodynamics of teicoplanin in neonates: making better use of C-reactive protein to deliver individualized therapy. J Antimicrob Chemother. 2016 11; 71(11):3168-3178. Ramos-Martín V, Neely MN, McGowan P, Siner S, Padmore K, Peak M, Beresford MW, Turner MA, Paulus S, Hope WW. PMID: 27543654; PMCID: PMC5079301.
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Accurately Achieving Target Busulfan Exposure in Children and Adolescents With Very Limited Sampling and the BestDose Software. Ther Drug Monit. 2016 06; 38(3):332-42. Neely M, Philippe M, Rushing T, Fu X, van Guilder M, Bayard D, Schumitzky A, Bleyzac N, Goutelle S. PMID: 26829600; PMCID: PMC4864122.
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Voriconazole pharmacokinetics following HSCT: results from the BMT CTN 0101 trial. J Antimicrob Chemother. 2016 08; 71(8):2234-40. Hope WW, Walsh TJ, Goodwin J, Peloquin CA, Howard A, Kurtzberg J, Mendizabal A, Confer DL, Bulitta J, Baden LR, Neely MN, Wingard JR, Blood and Marrow Transplant Clinical Trials Network. PMID: 27121401; PMCID: PMC4954923.
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Drug monitoring and individual dose optimization of antimicrobial drugs: oxazolidinones. Expert Opin Drug Metab Toxicol. 2016 May; 12(5):533-44. Cattaneo D, Alffenaar JW, Neely M. PMID: 26982718.
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Pharmacodynamics of Voriconazole in Children: Further Steps along the Path to True Individualized Therapy. Antimicrob Agents Chemother. 2016 Apr; 60(4):2336-42. Huurneman LJ, Neely M, Veringa A, Docobo Pérez F, Ramos-Martin V, Tissing WJ, Alffenaar JW, Hope W. PMID: 26833158; PMCID: PMC4808208.
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An exploratory analysis of the ability of a cefepime trough concentration greater than 22 mg/L to predict neurotoxicity. J Infect Chemother. 2016 Feb; 22(2):78-83. Rhodes NJ, Kuti JL, Nicolau DP, Neely MN, Nicasio AM, Scheetz MH. PMID: 26712584.
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Defining Clinical Exposures of Cefepime for Gram-Negative Bloodstream Infections That Are Associated with Improved Survival. Antimicrob Agents Chemother. 2015 Dec 14; 60(3):1401-10. Rhodes NJ, Kuti JL, Nicolau DP, Van Wart S, Nicasio AM, Liu J, Lee BJ, Neely MN, Scheetz MH. PMID: 26666929; PMCID: PMC4775983.
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Plasma and intracellular exposure to ganciclovir in adult renal transplant recipients: is there an association with haematological toxicity? J Antimicrob Chemother. 2016 Feb; 71(2):484-9. Billat PA, Woillard JB, Essig M, Sauvage FL, Picard N, Alain S, Neely M, Marquet P, Saint-Marcoux F. PMID: 26538506.
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Improved Tacrolimus Target Concentration Achievement Using Computerized Dosing in Renal Transplant Recipients--A Prospective, Randomized Study. Transplantation. 2015 Oct; 99(10):2158-66. Størset E, Åsberg A, Skauby M, Neely M, Bergan S, Bremer S, Midtvedt K. PMID: 25886918; PMCID: PMC4591080.
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Characterisation of a multidrug-resistant meningitic Escherichia coli strain (O75:K1:H5) isolated from an infant that is sensitive to memantine, a newly identified host-directed antimicrobial drug. Int J Antimicrob Agents. 2015 Nov; 46(5):598-600. Wang S, He X, Yu JY, Neely M, Zhang L, Peng L, Shi X, Li X, Wang S, Cao H, Gai Z, Huang SH. PMID: 26387615.
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Population modeling and simulation study of the pharmacokinetics and antituberculosis pharmacodynamics of isoniazid in lungs. Antimicrob Agents Chemother. 2015 Sep; 59(9):5181-9. Lalande L, Bourguignon L, Bihari S, Maire P, Neely M, Jelliffe R, Goutelle S. PMID: 26077251; PMCID: PMC4538517.
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Describing Assay Precision-Reciprocal of Variance Is Correct, Not CV Percent: Its Use Should Significantly Improve Laboratory Performance. Ther Drug Monit. 2015 Jun; 37(3):389-94. Jelliffe RW, Schumitzky A, Bayard D, Fu X, Neely M. PMID: 25970509; PMCID: PMC4435937.
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Simultaneous plasma and genital pharmacokinetics and pharmacodynamics of atazanavir and efavirenz in HIV-infected women starting therapy. J Clin Pharmacol. 2015 Jul; 55(7):798-808. Neely M, Louie S, Xu J, Anthony P, Thuvamontolrat K, Mordwinkin N, Kovacs A. PMID: 25683232; PMCID: PMC4461473.
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Optimal timing of oral fosfomycin administration for pre-prostate biopsy prophylaxis. J Antimicrob Chemother. 2015 Jul; 70(7):2068-73. Rhodes NJ, Gardiner BJ, Neely MN, Grayson ML, Ellis AG, Lawrentschuk N, Frauman AG, Maxwell KM, Zembower TR, Scheetz MH. PMID: 25802286.
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Achieving target voriconazole concentrations more accurately in children and adolescents. Antimicrob Agents Chemother. 2015; 59(6):3090-7. Neely M, Margol A, Fu X, van Guilder M, Bayard D, Schumitzky A, Orbach R, Liu S, Louie S, Hope W. PMID: 25779580; PMCID: PMC4432122.
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Influence of renal function estimation on pharmacokinetic modeling of vancomycin in elderly patients. Antimicrob Agents Chemother. 2015; 59(6):2986-94. Glatard A, Bourguignon L, Jelliffe RW, Maire P, Neely MN, Goutelle S. PMID: 25753640; PMCID: PMC4432143.
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Combination treatment with meropenem plus levofloxacin is synergistic against Pseudomonas aeruginosa infection in a murine model of pneumonia. J Infect Dis. 2015 Apr 15; 211(8):1326-33. Louie A, Liu W, VanGuilder M, Neely MN, Schumitzky A, Jelliffe R, Fikes S, Kurhanewicz S, Robbins N, Brown D, Baluya D, Drusano GL. PMID: 25362196; PMCID: PMC4447837.
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Pharmacokinetic tools for the dose adjustment of ciclosporin in haematopoietic stem cell transplant patients. Br J Clin Pharmacol. 2014 Oct; 78(4):836-46. Woillard JB, Lebreton V, Neely M, Turlure P, Girault S, Debord J, Marquet P, Saint-Marcoux F. PMID: 24698009; PMCID: PMC4239977.
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Multiday administration of ivermectin is effective in reducing alcohol intake in mice at doses shown to be safe in humans. Neuroreport. 2014 Sep 10; 25(13):1018-23. Yardley MM, Neely M, Huynh N, Asatryan L, Louie SG, Alkana RL, Davies DL. PMID: 25004078; PMCID: PMC4126080.
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A population pharmacokinetic modeling approach shows that serum penicillin G concentrations are below inhibitory concentrations by two weeks after benzathine penicillin G injection in the majority of young adults. Antimicrob Agents Chemother. 2014 Nov; 58(11):6735-41. Neely M, Kaplan EL, Blumer JL, Faix DJ, Broderick MP. PMID: 25182635; PMCID: PMC4249386.
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Analysis of combination drug therapy to develop regimens with shortened duration of treatment for tuberculosis. PLoS One. 2014; 9(7):e101311. Drusano GL, Neely M, Van Guilder M, Schumitzky A, Brown D, Fikes S, Peloquin C, Louie A. PMID: 25003557; PMCID: PMC4086932.
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Innovative approaches to optimizing the delivery of vancomycin in individual patients. Adv Drug Deliv Rev. 2014 Nov 20; 77:50-7. Pai MP, Neely M, Rodvold KA, Lodise TP. PMID: 24910345.
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Individualization of piperacillin dosing for critically ill patients: dosing software to optimize antimicrobial therapy. Antimicrob Agents Chemother. 2014 Jul; 58(7):4094-102. Felton TW, Roberts JA, Lodise TP, Van Guilder M, Boselli E, Neely MN, Hope WW. PMID: 24798288; PMCID: PMC4068511.
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Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions. Lancet Infect Dis. 2014 Jun; 14(6):498-509. Roberts JA, Abdul-Aziz MH, Lipman J, Mouton JW, Vinks AA, Felton TW, Hope WW, Farkas A, Neely MN, Schentag JJ, Drusano G, Frey OR, Theuretzbacher U, Kuti JL, International Society of Anti-Infective Pharmacology and the Pharmacokinetics and Pharmacodynamics S. PMID: 24768475; PMCID: PMC4181663.
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Population pharmacokinetics of a single intramuscular administration of tulathromycin in adult desert tortoises (Gopherus agassizii). J Vet Pharmacol Ther. 2014 Oct; 37(5):500-7. Kinney ME, Lamberski N, Wack R, Foster R, Neely M, Tell L, Gehring R. PMID: 24611596.
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The Case for Using Higher Doses of First Line Anti-Tuberculosis Drugs to Optimize Efficacy. Curr Pharm Des. 2014; 20(39):6191-206. Goutelle S, Bourguignon L, Maire P, Jelliffe RW, Neely MN. PMID: 25190098.
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Effect of protease inhibitors on steady-state pharmacokinetics of oral norethindrone contraception in HIV-infected women. J Acquir Immune Defic Syndr. 2014 Jan 01; 65(1):72-7. Atrio J, Stanczyk FZ, Neely M, Cherala G, Kovacs A, Mishell DR. PMID: 24025339; PMCID: PMC3946363.
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NPEST: a nonparametric method and a database for transcription start site prediction. Quant Biol. 2013 Dec; 1(4):261-271. Tatarinova T, Kryshchenko A, Triska M, Hassan M, Murphy D, Neely M, Schumitzky A. PMID: 25197613; PMCID: PMC4156414.
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Are vancomycin trough concentrations adequate for optimal dosing? Antimicrob Agents Chemother. 2014; 58(1):309-16. Neely MN, Youn G, Jones B, Jelliffe RW, Drusano GL, Rodvold KA, Lodise TP. PMID: 24165176; PMCID: PMC3910745.
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New algorithm for valganciclovir dosing in pediatric solid organ transplant recipients. Pediatr Transplant. 2014 Feb; 18(1):103-11. Åsberg A, Bjerre A, Neely M. PMID: 24152053; PMCID: PMC3880615.
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Inclusion of CYP3A5 genotyping in a nonparametric population model improves dosing of tacrolimus early after transplantation. Transpl Int. 2013 Dec; 26(12):1198-207. Åsberg A, Midtvedt K, van Guilder M, Størset E, Bremer S, Bergan S, Jelliffe R, Hartmann A, Neely MN. PMID: 24118301; PMCID: PMC3852421.
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Pharmacodynamic target attainment for various ceftazidime dosing schemes in high-flux hemodialysis. Antimicrob Agents Chemother. 2013 Dec; 57(12):5854-9. Loo AS, Neely M, Anderson EJ, Ghossein C, McLaughlin MM, Scheetz MH. PMID: 24018264; PMCID: PMC3837845.
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Impact of Bolus dosing versus continuous infusion of Piperacillin and Tazobactam on the development of antimicrobial resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2013 Dec; 57(12):5811-9. Felton TW, Goodwin J, O'Connor L, Sharp A, Gregson L, Livermore J, Howard SJ, Neely MN, Hope WW. PMID: 24002098; PMCID: PMC3837869.
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Use of nucleoside reverse transcriptase inhibitor-only regimens in HIV-infected children and adolescents. Pediatr Infect Dis J. 2013 Sep; 32(9):e370-6. Neely M, Rutstein R, Del Bianco G, Heresi G, Barton T, Wiznia A, Wiegand R, Wheeling T, Bohannon B, Dominguez K, LEGACY Consortium. PMID: 24008749; PMCID: PMC3766529.
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Pharmacodynamics of liposomal amphotericin B and flucytosine for cryptococcal meningoencephalitis: safe and effective regimens for immunocompromised patients. J Infect Dis. 2013 Jul 15; 208(2):351-61. O'Connor L, Livermore J, Sharp AD, Goodwin J, Gregson L, Howard SJ, Felton TW, Schwartz JA, Neely MN, Harrison TS, Perfect JR, Hope WW. PMID: 23599314; PMCID: PMC3685229.
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Two general methods for population pharmacokinetic modeling: non-parametric adaptive grid and non-parametric Bayesian. J Pharmacokinet Pharmacodyn. 2013 Apr; 40(2):189-99. Tatarinova T, Neely M, Bartroff J, van Guilder M, Yamada W, Bayard D, Jelliffe R, Leary R, Chubatiuk A, Schumitzky A. PMID: 23404393; PMCID: PMC3630269.
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Software for dosage individualization of voriconazole for immunocompromised patients. Antimicrob Agents Chemother. 2013 Apr; 57(4):1888-94. Hope WW, Vanguilder M, Donnelly JP, Blijlevens NM, Brüggemann RJ, Jelliffe RW, Neely MN. PMID: 23380734; PMCID: PMC3623322.
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Population pharmacokinetic and pharmacodynamic modeling for assessing risk of bisphosphonate-related osteonecrosis of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Feb; 115(2):224-32. Sedghizadeh PP, Jones AC, LaVallee C, Jelliffe RW, Le AD, Lee P, Kiss A, Neely M. PMID: 23246224; PMCID: PMC3545087.
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From pediatric covariate model to semiphysiological function for maturation: part I-extrapolation of a covariate model from morphine to Zidovudine. CPT Pharmacometrics Syst Pharmacol. 2012 Oct 03; 1:e9. Krekels EH, Neely M, Panoilia E, Tibboel D, Capparelli E, Danhof M, Mirochnick M, Knibbe CA. PMID: 23887364; PMCID: PMC3603431.
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Quantification by energy dispersive x-ray spectroscopy of alendronate in the diseased jaw bone of patients with bisphosphonate-related jaw osteonecrosis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Oct; 114(4):480-6. Schaudinn C, Gorur A, Webster P, Jones AC, Neely M, Jelliffe RW, Le AD, Sedghizadeh PP. PMID: 22986243.
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Accurate detection of outliers and subpopulations with Pmetrics, a nonparametric and parametric pharmacometric modeling and simulation package for R. Ther Drug Monit. 2012 Aug; 34(4):467-76. Neely MN, van Guilder MG, Yamada WM, Schumitzky A, Jelliffe RW. PMID: 22722776; PMCID: PMC3394880.
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Antiviral therapy of two patients with chromosomally-integrated human herpesvirus-6A presenting with cognitive dysfunction. J Clin Virol. 2012 Sep; 55(1):40-5. Montoya JG, Neely MN, Gupta S, Lunn MR, Loomis KS, Pritchett JC, Polsky B, Medveczky PG. PMID: 22770640.
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High dose of darunavir in treatment-experienced HIV-infected adolescent results in virologic suppression and improved CD4 cell count. Ther Drug Monit. 2012 Jun; 34(3):237-41. Rakhmanina NY, Neely MN, Capparelli EV. PMID: 22549499; PMCID: PMC3354040.
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More codeine fatalities after tonsillectomy in North American children. Pediatrics. 2012 May; 129(5):e1343-7. Kelly LE, Rieder M, van den Anker J, Malkin B, Ross C, Neely MN, Carleton B, Hayden MR, Madadi P, Koren G. PMID: 22492761.
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Population pharmacokinetic analysis and pharmacogenetics of raltegravir in HIV-positive and healthy individuals. Antimicrob Agents Chemother. 2012 Jun; 56(6):2959-66. Arab-Alameddine M, Fayet-Mello A, Lubomirov R, Neely M, di Iulio J, Owen A, Boffito M, Cavassini M, Günthard HF, Rentsch K, Buclin T, Aouri M, Telenti A, Decosterd LA, Rotger M, Csajka C, Swiss HIV Cohort Study Group. PMID: 22371894; PMCID: PMC3370715.
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Comparison of four renal function estimation equations for pharmacokinetic modeling of gentamicin in geriatric patients. Antimicrob Agents Chemother. 2012 Apr; 56(4):1862-9. Charhon N, Neely MN, Bourguignon L, Maire P, Jelliffe RW, Goutelle S. PMID: 22290966; PMCID: PMC3318363.
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Relevance of pharmacokinetic and pharmacodynamic modeling to clinical care of critically ill patients. Curr Pharm Biotechnol. 2011 Dec; 12(12):2044-61. Bulitta JB, Landersdorfer CB, Forrest A, Brown SV, Neely MN, Tsuji BT, Louie A. PMID: 21554212.
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Obesity and its impact on drug therapy: are we ready for this change? Clin Pharmacokinet. 2011 Dec 01; 50(12):825-6. Neely M, Louie S. PMID: 22087869.
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Posaconazole for chronic refractory coccidioidal meningitis. Clin Infect Dis. 2011 Dec; 53(12):1252-4. Schein R, Homans J, Larsen RA, Neely M. PMID: 21987729.
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Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patients. Biol Blood Marrow Transplant. 2012 May; 18(5):731-8. Florescu DF, Pergam SA, Neely MN, Qiu F, Johnston C, Way S, Sande J, Lewinsohn DA, Guzman-Cottrill JA, Graham ML, Papanicolaou G, Kurtzberg J, Rigdon J, Painter W, Mommeja-Marin H, Lanier R, Anderson M, van der Horst C. PMID: 21963623; PMCID: PMC3608125.
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Comment: assessment of vancomycin dosing and subsequent serum concentrations in pediatric patients. Ann Pharmacother. 2011 Sep; 45(9):1171-2. Goutelle S, Neely M, Bleyzac N. PMID: 21862712.
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CYP3A5, ABCB1, and SLCO1B1 polymorphisms and pharmacokinetics and virologic outcome of lopinavir/ritonavir in HIV-infected children. Ther Drug Monit. 2011 Aug; 33(4):417-24. Rakhmanina NY, Neely MN, Van Schaik RH, Gordish-Dressman HA, Williams KD, Soldin SJ, van den Anker JN. PMID: 21743379; PMCID: PMC3139013.
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Nonparametric population modeling and Bayesian analysis. Pharmacol Res. 2011 Oct; 64(4):426. Jelliffe R, Neely M, Schumitzky A, Bayard D, Van Guilder M, Botnen A, Bustad A, Laing D, Yamada W, Bartroff J, Tatarinova T. PMID: 21699981.
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Incidence and predictors of invasive candidiasis associated with candidaemia in children. Mycoses. 2011 Mar; 54(2):146-53. Festekjian A, Neely M. PMID: 19821906; PMCID: PMC2888996.
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Pharmacokinetic optimization of antiretroviral therapy in children and adolescents. Clin Pharmacokinet. 2011 Mar; 50(3):143-89. Neely MN, Rakhmanina NY. PMID: 21294595.
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Increased clearance of morphine in sickle cell disease: implications for pain management. J Pain. 2011 May; 12(5):531-8. Darbari DS, Neely M, van den Anker J, Rana S. PMID: 21277838; PMCID: PMC3086992.
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Psychological factors, beliefs about medication, and adherence of youth with human immunodeficiency virus in a multisite directly observed therapy pilot study. J Adolesc Health. 2011 Jun; 48(6):637-40. Garvie PA, Flynn PM, Belzer M, Britto P, Hu C, Graham B, Neely M, McSherry GD, Spector SA, Gaur AH, Pediatric AIDS Clinical Trials Group (PACTG) P1036B Team. PMID: 21575827; PMCID: PMC3096841.
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Pharmacokinetics and pharmacogenomics of once-daily raltegravir and atazanavir in healthy volunteers. Antimicrob Agents Chemother. 2010 Nov; 54(11):4619-25. Neely M, Decosterd L, Fayet A, Lee JS, Margol A, Kanani M, di Iulio J, von Schoen-Angerer T, Jelliffe R, Calmy A. PMID: 20823282; PMCID: PMC2976128.
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Directly observed therapy (DOT) for nonadherent HIV-infected youth: lessons learned, challenges ahead. AIDS Res Hum Retroviruses. 2010 Sep; 26(9):947-53. Gaur AH, Belzer M, Britto P, Garvie PA, Hu C, Graham B, Neely M, McSherry G, Spector SA, Flynn PM, Pediatric AIDS Clinical Trials Group P1036B Team. PMID: 20707731; PMCID: PMC2957634.
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Can therapeutic drug monitoring improve pharmacotherapy of HIV infection in adolescents? Ther Drug Monit. 2010 Jun; 32(3):273-81. Rakhmanina NY, van den Anker JN, Soldin SJ, van Schaik RH, Mordwinkin N, Neely MN. PMID: 20445485; PMCID: PMC2886015.
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Practical, individualized dosing: 21st century therapeutics and the clinical pharmacometrician. J Clin Pharmacol. 2010 Jul; 50(7):842-7. Neely M, Jelliffe R. PMID: 20154293.
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Comment on: Pharmacokinetics and 48 week efficacy of low-dose lopinavir/ritonavir in HIV-infected children. J Antimicrob Chemother. 2010 Apr; 65(4):808-9; author reply 809-10. Neely MN, Rakhmanina NY. PMID: 20086000.
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Voriconazole pharmacokinetics and pharmacodynamics in children. Clin Infect Dis. 2010 Jan 01; 50(1):27-36. Neely M, Rushing T, Kovacs A, Jelliffe R, Hoffman J. PMID: 19951112; PMCID: PMC2803104.
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Managing treatment-experienced pediatric and adolescent HIV patients: role of darunavir. Ther Clin Risk Manag. 2009 Jun; 5(3):595-615. Neely M, Kovacs A. PMID: 19707276; PMCID: PMC2724190.
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Population pharmacokinetics of lopinavir predict suboptimal therapeutic concentrations in treatment-experienced human immunodeficiency virus-infected children. Antimicrob Agents Chemother. 2009 Jun; 53(6):2532-8. Rakhmanina N, van den Anker J, Baghdassarian A, Soldin S, Williams K, Neely MN. PMID: 19258274; PMCID: PMC2687254.
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Pharmacokinetics and safety of caspofungin in older infants and toddlers. Antimicrob Agents Chemother. 2009 Apr; 53(4):1450-6. Neely M, Jafri HS, Seibel N, Knapp K, Adamson PC, Bradshaw SK, Strohmaier KM, Sun P, Bi S, Dockendorf MF, Stone JA, Kartsonis NA. PMID: 19114680; PMCID: PMC2663098.
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Practical therapeutic drug management in HIV-infected patients: use of population pharmacokinetic models supplemented by individualized Bayesian dose optimization. J Clin Pharmacol. 2008 Sep; 48(9):1081-91. Neely M, Jelliffe R. PMID: 18635757; PMCID: PMC2724306.
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Cervical shedding of HIV-1 RNA among women with low levels of viremia while receiving highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2007 Jan 01; 44(1):38-42. Neely MN, Benning L, Xu J, Strickler HD, Greenblatt RM, Minkoff H, Young M, Bremer J, Levine AM, Kovacs A. PMID: 17106279; PMCID: PMC3126662.
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Pharmacokinetics, safety, and tolerability of caspofungin in children and adolescents. Antimicrob Agents Chemother. 2005 Nov; 49(11):4536-45. Walsh TJ, Adamson PC, Seibel NL, Flynn PM, Neely MN, Schwartz C, Shad A, Kaplan SL, Roden MM, Stone JA, Miller A, Bradshaw SK, Li SX, Sable CA, Kartsonis NA. PMID: 16251293; PMCID: PMC1280172.
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Management of antiretroviral therapy in neonates, children, and adolescents. Curr HIV/AIDS Rep. 2004 Jun; 1(2):97-104. Neely M, Kovacs A. PMID: 16091229.
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Management of Antiretroviral Therapy in Neonates, Children, and Adolescents. Curr Infect Dis Rep. 2003 Dec; 5(6):521-530. Neely M, Kovacs A. PMID: 14642195.
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Effect of chloroquine on human immunodeficiency virus (HIV) vertical transmission. Afr Health Sci. 2003 Aug; 3(2):61-7. Neely M, Kalyesubula I, Bagenda D, Myers C, Olness K. PMID: 12913796; PMCID: PMC2141601.
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Pharmacokinetic characteristics of caspofungin in two pediatric liver transplant patients. Curr Ther Res Clin Exp. 2003 Feb; 64(2):127-36. Neely M, Blumer J. PMID: 24944361; PMCID: PMC4053026.
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Infection control in pediatric hospitals. Curr Opin Infect Dis. 2001 Aug; 14(4):449-53. Neely M, Toltzis P. PMID: 11964864.
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Organ heavy-metal accumulation during parenteral nutrition is associated with pathologic abnormalities in rats. Nutrition. 2001 Jul-Aug; 17(7-8):600-6. Buchman AL, Neely M, Grossie VB, Truong L, Lykissa E, Ahn C. PMID: 11448580.
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Fluconazole prophylaxis in the very low birth weight infant: not ready for prime time. Pediatrics. 2001 Feb; 107(2):404-5. Neely MN, Schreiber JR. PMID: 11158475.
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The exciting future of antifungal therapy. Eur J Clin Microbiol Infect Dis. 2000 Dec; 19(12):897-914. Neely MN, Ghannoum MA. PMID: 11205627.
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