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Comparative Genomics of Viral Genomes and Identification of Three Novel Viroporin-Like Superfamilies. Microb Physiol. 2026; 36(1):19-37. Wang J, Hendargo KJ, Kay Lam KJ, Trang Dao DN, Moreno-Hagelsieb G, Medrano-Soto A, Saier MH. PMID: 41411200; PMCID: PMC12937198.
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Investigating the Trans Effects of IS
1 Transposases on Intragenomic DNA Movements inEscherichia coli . Microb Physiol. 2026; 36(1):1-18. Ord JW, Zhang Z, Wu J, Smith S, Feng Z, Ancheta K, Garrido LF, Yao G, Gupta S, Lee ET, Saier MH. PMID: 41306025; PMCID: PMC12903888. -
Microbiome: Friend or Friendly Foe. Microb Physiol. 2025 Oct 03. Reddy LB, Saier MH. PMID: 41047836.
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Examining the Roles of Genomic Context and Endogenous Regulatory Elements on IS1 Transposition Within the Escherichia coli Genome. Int J Mol Sci. 2025 Aug 28; 26(17). Smith S, Zhang Z, Ho A, Karnani T, Ord J, Saier MH. PMID: 40943294; PMCID: PMC12428005.
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Key role of Desulfobacteraceae in C/S cycles of marine sediments is based on congeneric catabolic-regulatory networks. Sci Adv. 2025 Mar 07; 11(10):eads5631. Wöhlbrand L, Dörries M, Siani R, Medrano-Soto A, Schnaars V, Schumacher J, Hilbers C, Thies D, Kube M, Reinhardt R, Schloter M, Saier MH, Winklhofer M, Rabus R. PMID: 40053579; PMCID: PMC11887813.
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Transcriptional mechanism by which IS5 activates the fucAO operon in Escherichia coli. Nucleic Acids Res. 2025 Feb 27; 53(5). Zhou H, Zhang Z, Velo J, Huo J, Smith S, Ho A, Saier MH. PMID: 40066878; PMCID: PMC11894529.
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Cooperation and Competition Were Primary Driving Forces for Biological Evolution. Microb Physiol. 2025; 35(1):13-29. Saier MH. PMID: 39999802; PMCID: PMC11999638.
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Ligand interaction landscape of transcription factors and essential enzymes in E. coli. Cell. 2025 Mar 06; 188(5):1441-1455.e15. Peng H, Kotelnikov S, Egbert ME, Ofaim S, Stevens GC, Phanse S, Saccon T, Ignatov M, Dutta S, Istace Z, Moutaoufik MT, Aoki H, Kewalramani N, Sun J, Gong Y, Padhorny D, Poda G, Alekseenko A, Porter KA, Jones G, Rodionova I, Guo H, Pogoutse O, Datta S, Saier M, Crovella M, Vajda S, Moreno-Hagelsieb G, Parkinson J, Segre D, Babu M, Kozakov D, Emili A. PMID: 39862855.
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Investigating How Genomic Contexts Impact IS5 Transposition Within the Escherichia coli Genome. Microorganisms. 2024 Dec 16; 12(12). Onstead J, Zhang Z, Huo J, Ord JW, Smith S, Saier MH. PMID: 39770802; PMCID: PMC11677980.
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Health Benefits of Intermittent Fasting. Microb Physiol. 2024; 34(1):142-152. Reddy BL, Reddy VS, Saier MH. PMID: 38955141; PMCID: PMC11262566.
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The Pentameric Ligand-Gated Ion Channel Family: A New Member of the Voltage Gated Ion Channel Superfamily? Int J Mol Sci. 2024 May 03; 25(9). Dubey A, Baxter M, Hendargo KJ, Medrano-Soto A, Saier MH. PMID: 38732224; PMCID: PMC11084639.
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An Insider's Perspective about the Pathogenic Relevance of Gut Bacterial Transportomes. Microb Physiol. 2024; 34(1):133-141. Zafar H, Saier MH. PMID: 38636461; PMCID: PMC11283328.
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The effect of DNA-binding proteins on insertion sequence element transposition upstream of the bgl operon in Escherichia coli. Front Microbiol. 2024; 15:1388522. Kopkowski PW, Zhang Z, Saier MH. PMID: 38666260; PMCID: PMC11043490.
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Comprehensive Characterization of fucAO Operon Activation in Escherichia coli. Int J Mol Sci. 2024 Apr 02; 25(7). Zhang Z, Huo J, Velo J, Zhou H, Flaherty A, Saier MH. PMID: 38612757; PMCID: PMC11011485.
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Sequence Similarity among Structural Repeats in the Piezo Family of Mechanosensitive Ion Channels. Microb Physiol. 2023; 33(1):49-62. Hendargo KJ, Patel AO, Chukwudozie OS, Moreno-Hagelsieb G, Christen JA, Medrano-Soto A, Saier MH. PMID: 37321192; PMCID: PMC11283329.
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E. coli allantoinase is activated by the downstream metabolic enzyme, glycerate kinase, and stabilizes the putative allantoin transporter by direct binding. Sci Rep. 2023 05 05; 13(1):7345. Rodionova IA, Hosseinnia A, Kim S, Goodacre N, Zhang L, Zhang Z, Palsson B, Uetz P, Babu M, Saier MH. PMID: 37147430; PMCID: PMC10163214.
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Understanding the Relationship of the Human Bacteriome with COVID-19 Severity and Recovery. Cells. 2023 04 22; 12(9). Zafar H, Saier MH. PMID: 37174613; PMCID: PMC10177376.
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Histone-like nucleoid structuring (H-NS) protein silences the beta-glucoside (bgl) utilization operon in Escherichia coli by forming a DNA loop. Comput Struct Biotechnol J. 2022; 20:6287-6301. Lam KJK, Zhang Z, Saier MH. PMID: 36420159; PMCID: PMC9678765.
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Effects of Global and Specific DNA-Binding Proteins on Transcriptional Regulation of the E. coli bgl Operon. Int J Mol Sci. 2022 Sep 07; 23(18). Tran D, Zhang Z, Lam KJK, Saier MH. PMID: 36142257; PMCID: PMC9499468.
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Eating Animal Products, a Common Cause of Human Diseases. Microb Physiol. 2022; 32(5-6):146-157. Saier MH, Baird SM, Reddy BL, Kopkowski PW. PMID: 35952632; PMCID: PMC11330319.
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A systems approach discovers the role and characteristics of seven LysR type transcription factors in Escherichia coli. Sci Rep. 2022 05 04; 12(1):7274. Rodionova IA, Gao Y, Monk J, Hefner Y, Wong N, Szubin R, Lim HG, Rodionov DA, Zhang Z, Saier MH, Palsson BO. PMID: 35508583; PMCID: PMC9068703.
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Discovery and Characterization of the Phospholemman/SIMP/Viroporin Superfamily. Microb Physiol. 2022; 32(3-4):83-94. Tyler D, Hendargo KJ, Medrano-Soto A, Saier MH. PMID: 35152214; PMCID: PMC9355910.
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Insertion Sequence (IS) Element-Mediated Activating Mutations of the Cryptic Aromatic β-Glucoside Utilization (BglGFB) Operon Are Promoted by the Anti-Terminator Protein (BglG) in Escherichia coli. Int J Mol Sci. 2022 Jan 28; 23(3). Zhang Z, Zhou K, Tran D, Saier M. PMID: 35163427; PMCID: PMC8836124.
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Comparative Analyses of the Transport Proteins Encoded within the Genomes of nine Bifidobacterium Species. Microb Physiol. 2022; 32(1-2):30-44. Zafar H, Saier MH. PMID: 34555832; PMCID: PMC8940750.
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Identification of a transcription factor, PunR, that regulates the purine and purine nucleoside transporter punC in E. coli. Commun Biol. 2021 08 19; 4(1):991. Rodionova IA, Gao Y, Sastry A, Hefner Y, Lim HG, Rodionov DA, Saier MH, Palsson BO. PMID: 34413462; PMCID: PMC8376909.
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The Protein Interactome of Glycolysis in Escherichia coli. Proteomes. 2021 Apr 06; 9(2). Chowdhury S, Hepper S, Lodi MK, Saier MH, Uetz P. PMID: 33917325; PMCID: PMC8167557.
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Comparative population genomic analyses of transporters within the Asgard archaeal superphylum. PLoS One. 2021; 16(3):e0247806. Russum S, Lam KJK, Wong NA, Iddamsetty V, Hendargo KJ, Wang J, Dubey A, Zhang Y, Medrano-Soto A, Saier MH. PMID: 33770091; PMCID: PMC7997004.
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The SARS-Coronavirus Infection Cycle: A Survey of Viral Membrane Proteins, Their Functional Interactions and Pathogenesis. Int J Mol Sci. 2021 Jan 28; 22(3). Wong NA, Saier MH. PMID: 33525632; PMCID: PMC7865831.
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The Transporter Classification Database (TCDB): 2021 update. Nucleic Acids Res. 2021 01 08; 49(D1):D461-D467. Saier MH, Reddy VS, Moreno-Hagelsieb G, Hendargo KJ, Zhang Y, Iddamsetty V, Lam KJK, Tian N, Russum S, Wang J, Medrano-Soto A. PMID: 33170213; PMCID: PMC7778945.
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Gut Bacteroides species in health and disease. Gut Microbes. 2021 Jan-Dec; 13(1):1-20. Zafar H, Saier MH. PMID: 33535896; PMCID: PMC7872030.
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Comparative Genomics of the Transport Proteins of Ten Lactobacillus Strains. Genes (Basel). 2020 10 21; 11(10). Zafar H, Saier MH. PMID: 33096690; PMCID: PMC7593918.
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Protein-Protein Interactions in the Cytoplasmic Membrane of Escherichia coli: Influence of the Overexpression of Diverse Transporter-Encoding Genes on the Activities of PTS Sugar Uptake Systems. Microb Physiol. 2020; 30(1-6):36-49. Aboulwafa M, Zhang Z, Saier MH. PMID: 32998150; PMCID: PMC7717556.
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The Causal Relationship between Eating Animals and Viral Epidemics. Microb Physiol. 2020; 30(1-6):2-8. Reddy BL, Saier MHJ. PMID: 32957108; PMCID: PMC7573891.
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Expansion of the Transporter-Opsin-G protein-coupled receptor superfamily with five new protein families. PLoS One. 2020; 15(4):e0231085. Medrano-Soto A, Ghazi F, Hendargo KJ, Moreno-Hagelsieb G, Myers S, Saier MH. PMID: 32320418; PMCID: PMC7176098.
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Expansion of the Major Facilitator Superfamily (MFS) to include novel transporters as well as transmembrane-acting enzymes. Biochim Biophys Acta Biomembr. 2020 09 01; 1862(9):183277. Wang SC, Davejan P, Hendargo KJ, Javadi-Razaz I, Chou A, Yee DC, Ghazi F, Lam KJK, Conn AM, Madrigal A, Medrano-Soto A, Saier MH. PMID: 32205149; PMCID: PMC7939043.
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Protein:Protein interactions in the cytoplasmic membrane apparently influencing sugar transport and phosphorylation activities of the e. coli phosphotransferase system. PLoS One. 2019; 14(11):e0219332. Aboulwafa M, Zhang Z, Saier MH. PMID: 31751341; PMCID: PMC6872149.
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A Riboflavin Transporter in Bdellovibrio exovorous JSS. J Mol Microbiol Biotechnol. 2019; 29(1-6):27-34. Rodionova IA, Heidari Tajabadi F, Zhang Z, Rodionov DA, Saier MH. PMID: 31509826; PMCID: PMC7064401.
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Understanding the Genetic Code. J Bacteriol. 2019 08 01; 201(15). Saier MH. PMID: 31010904; PMCID: PMC6620406.
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Cryo-EM structure of OSCA1.2 from Oryza sativa elucidates the mechanical basis of potential membrane hyperosmolality gating. Proc Natl Acad Sci U S A. 2019 07 09; 116(28):14309-14318. Maity K, Heumann JM, McGrath AP, Kopcho NJ, Hsu PK, Lee CW, Mapes JH, Garza D, Krishnan S, Morgan GP, Hendargo KJ, Klose T, Rees SD, Medrano-Soto A, Saier MH, Piñeros M, Komives EA, Schroeder JI, Chang G, Stowell MHB. PMID: 31227607; PMCID: PMC6628804.
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Comparative genomics of the transportome of Ten Treponema species. Microb Pathog. 2019 Jul; 132:87-99. Buyuktimkin B, Zafar H, Saier MH. PMID: 31029716; PMCID: PMC7085940.
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Comparative genomics of transport proteins in seven Bacteroides species. PLoS One. 2018; 13(12):e0208151. Zafar H, Saier MH. PMID: 30517169; PMCID: PMC6281302.
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The uridylyltransferase GlnD and tRNA modification GTPase MnmE allosterically control Escherichia coli folylpoly-γ-glutamate synthase FolC. J Biol Chem. 2018 10 05; 293(40):15725-15732. Rodionova IA, Goodacre N, Do J, Hosseinnia A, Babu M, Uetz P, Saier MH. PMID: 30089654; PMCID: PMC6177579.
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Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases. PLoS One. 2018; 13(3):e0192851. Medrano-Soto A, Moreno-Hagelsieb G, McLaughlin D, Ye ZS, Hendargo KJ, Saier MH. PMID: 29579047; PMCID: PMC5868767.
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The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli. J Bacteriol. 2018 03 01; 200(5). Rodionova IA, Goodacre N, Babu M, Emili A, Uetz P, Saier MH. PMID: 29229699; PMCID: PMC5809692.
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Comparative Analyses of Transport Proteins Encoded within the Genomes of Bdellovibrio bacteriovorus HD100 and Bdellovibrio exovorus JSS. J Mol Microbiol Biotechnol. 2017; 27(6):332-349. Heidari Tajabadi F, Medrano-Soto A, Ahmadzadeh M, Salehi Jouzani G, Saier MH. PMID: 29212086; PMCID: PMC5823784.
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Global landscape of cell envelope protein complexes in Escherichia coli. Nat Biotechnol. 2018 01; 36(1):103-112. Babu M, Bundalovic-Torma C, Calmettes C, Phanse S, Zhang Q, Jiang Y, Minic Z, Kim S, Mehla J, Gagarinova A, Rodionova I, Kumar A, Guo H, Kagan O, Pogoutse O, Aoki H, Deineko V, Caufield JH, Holtzapple E, Zhang Z, Vastermark A, Pandya Y, Lai CC, El Bakkouri M, Hooda Y, Shah M, Burnside D, Hooshyar M, Vlasblom J, Rajagopala SV, Golshani A, Wuchty S, F Greenblatt J, Saier M, Uetz P, F Moraes T, Parkinson J, Emili A. PMID: 29176613; PMCID: PMC5922438.
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The Membrane Attack Complex/Perforin Superfamily. J Mol Microbiol Biotechnol. 2017; 27(4):252-267. Moreno-Hagelsieb G, Vitug B, Medrano-Soto A, Saier MH. PMID: 29145176; PMCID: PMC5796659.
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Hopping into a hot seat: Role of DNA structural features on IS5-mediated gene activation and inactivation under stress. PLoS One. 2017; 12(6):e0180156. Humayun MZ, Zhang Z, Butcher AM, Moshayedi A, Saier MH. PMID: 28666002; PMCID: PMC5493358.
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The phosphocarrier protein HPr of the bacterial phosphotransferase system globally regulates energy metabolism by directly interacting with multiple enzymes in Escherichia coli. J Biol Chem. 2017 08 25; 292(34):14250-14257. Rodionova IA, Zhang Z, Mehla J, Goodacre N, Babu M, Emili A, Uetz P, Saier MH. PMID: 28634232; PMCID: PMC5572926.
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Science, Innovation and the Future of Humanity. J Mol Microbiol Biotechnol. 2017; 27(2):128-132. Saier MH, Trevors JT. PMID: 28448972; PMCID: PMC5804353.
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Comparative genomic analyses of transport proteins encoded within the red algae Chondrus crispus, Galdieria sulphuraria, and Cyanidioschyzon merolae11. J Phycol. 2017 06; 53(3):503-521. Lee J, Ghosh S, Saier MH. PMID: 28328149; PMCID: PMC5591647.
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Environment-directed activation of the Escherichia coliflhDC operon by transposons. Microbiology (Reading). 2017 04; 163(4):554-569. Zhang Z, Kukita C, Humayun MZ, Saier MH. PMID: 28100305; PMCID: PMC5775904.
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Comparative genomics of transport proteins in probiotic and pathogenic Escherichia coli and Salmonella enterica strains. Microb Pathog. 2017 Jun; 107:106-115. Do J, Zafar H, Saier MH. PMID: 28344124; PMCID: PMC5591646.
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Transposon-mediated directed mutation in bacteria and eukaryotes. Front Biosci (Landmark Ed). 2017 03 01; 22(9):1458-1468. Saier MH, Kukita C, Zhang Z. PMID: 28199212; PMCID: PMC5820026.
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Difference distance map data of alternative crystal forms of UlaA. Data Brief. 2017 Feb; 10:198-201. Vastermark A, Driker A, Weng J, Li X, Wang J, Saier MH. PMID: 27995154; PMCID: PMC5154960.
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Characterization of the Tetraspan Junctional Complex (4JC) superfamily. Biochim Biophys Acta Biomembr. 2017 03; 1859(3):402-414. Chou A, Lee A, Hendargo KJ, Reddy VS, Shlykov MA, Kuppusamykrishnan H, Medrano-Soto A, Saier MH. PMID: 27916633; PMCID: PMC5292247.
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Transposon-mediated activation of the Escherichia coli glpFK operon is inhibited by specific DNA-binding proteins: Implications for stress-induced transposition events. Mutat Res. 2016 Nov - Dec; 793-794:22-31. Zhang Z, Saier MH. PMID: 27810619; PMCID: PMC5136330.
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The V-motifs facilitate the substrate capturing step of the PTS elevator mechanism. J Struct Biol. 2016 12; 196(3):496-502. Vastermark A, Driker A, Weng J, Li X, Wang J, Saier MH. PMID: 27720943; PMCID: PMC5118081.
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Analysis of 58 Families of Holins Using a Novel Program, PhyST. J Mol Microbiol Biotechnol. 2016; 26(6):381-388. Kuppusamykrishnan H, Chau LM, Moreno-Hagelsieb G, Saier MH. PMID: 27553295; PMCID: PMC5591648.
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Comparative analyses of transport proteins encoded within the genomes of Leptospira species. Microb Pathog. 2016 Sep; 98:118-31. Buyuktimkin B, Saier MH. PMID: 27296707; PMCID: PMC5317275.
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Time to Stop Holding the Elevator: A New Piece of the Transport Protein Mechanism Puzzle. Structure. 2016 06 07; 24(6):845-6. Vastermark A, Saier MH. PMID: 27276425; PMCID: PMC5899902.
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Transport protein evolution deduced from analysis of sequence, topology and structure. Curr Opin Struct Biol. 2016 06; 38:9-17. Saier MH. PMID: 27270239; PMCID: PMC5354534.
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Properties and Phylogeny of 76 Families of Bacterial and Eukaryotic Organellar Outer Membrane Pore-Forming Proteins. PLoS One. 2016; 11(4):e0152733. Reddy BL, Saier MH. PMID: 27064789; PMCID: PMC4827864.
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The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 04; 44(D1):D372-9. Saier MH, Reddy VS, Tsu BV, Ahmed MS, Li C, Moreno-Hagelsieb G. PMID: 26546518; PMCID: PMC4702804.
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Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs. PLoS One. 2015; 10(11):e0140569. Zhu C, Nigam KB, Date RC, Bush KT, Springer SA, Saier MH, Wu W, Nigam SK. PMID: 26536134; PMCID: PMC4633038.
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The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis. PLoS One. 2015; 10(10):e0137184. Tsu BV, Saier MH. PMID: 26474485; PMCID: PMC4608589.
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Comparative genomic analyses of transport proteins encoded within the genomes of Leptospira species. Microb Pathog. 2015 Nov; 88:52-64. Buyuktimkin B, Saier MH. PMID: 26247102; PMCID: PMC4601928.
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Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat. Database (Oxford). 2015; 2015:bav063. Babbitt PC, Bagos PG, Bairoch A, Bateman A, Chatonnet A, Chen MJ, Craik DJ, Finn RD, Gloriam D, Haft DH, Henrissat B, Holliday GL, Isberg V, Kaas Q, Landsman D, Lenfant N, Manning G, Nagano N, Srinivasan N, O'Donovan C, Pruitt KD, Sowdhamini R, Rawlings ND, Saier MH, Sharman JL, Spedding M, Tsirigos KD, Vastermark A, Vriend G. PMID: 26284514; PMCID: PMC4499208.
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The Bacterial Phosphotransferase System: New Frontiers 50 Years after Its Discovery. J Mol Microbiol Biotechnol. 2015; 25(2-3):73-8. Saier MH. PMID: 26159069; PMCID: PMC4512285.
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Control of Transposon-Mediated Directed Mutation by the Escherichia coli Phosphoenolpyruvate:Sugar Phosphotransferase System. J Mol Microbiol Biotechnol. 2015; 25(2-3):226-33. Saier MH, Zhang Z. PMID: 26159081; PMCID: PMC4511099.
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Key challenges for the creation and maintenance of specialist protein resources. Proteins. 2015 Jun; 83(6):1005-13. Holliday GL, Bairoch A, Bagos PG, Chatonnet A, Craik DJ, Finn RD, Henrissat B, Landsman D, Manning G, Nagano N, O'Donovan C, Pruitt KD, Rawlings ND, Saier M, Sowdhamini R, Spedding M, Srinivasan N, Vriend G, Babbitt PC, Bateman A. PMID: 25820941; PMCID: PMC4446195.
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Autism and our intestinal microbiota. J Mol Microbiol Biotechnol. 2015; 25(1):51-5. Reddy BL, Saier MH. PMID: 25792275.
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Conserved movement of TMS11 between occluded conformations of LacY and XylE of the major facilitator superfamily suggests a similar hinge-like mechanism. Proteins. 2015 Apr; 83(4):735-45. Västermark Å, Driker A, Li J, Saier MH. PMID: 25586173; PMCID: PMC4368487.
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The complexity, challenges and benefits of comparing two transporter classification systems in TCDB and Pfam. Brief Bioinform. 2015 Sep; 16(5):865-72. Chiang Z, Vastermark A, Punta M, Coggill PC, Mistry J, Finn RD, Saier MH. PMID: 25614388; PMCID: PMC4570203.
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Comparative genomic analysis of integral membrane transport proteins in ciliates. J Eukaryot Microbiol. 2015 Mar-Apr; 62(2):167-87. Kumar U, Saier MH. PMID: 25099884.
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Psychobiotics and their involvement in mental health. J Mol Microbiol Biotechnol. 2014; 24(4):211-4. Tang F, Reddy BL, Saier MH. PMID: 25196442.
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Holins in bacteria, eukaryotes, and archaea: multifunctional xenologues with potential biotechnological and biomedical applications. J Bacteriol. 2015 Jan 01; 197(1):7-17. Saier MH, Reddy BL. PMID: 25157079; PMCID: PMC4288690.
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Transposon-mediated directed mutation controlled by DNA binding proteins in Escherichia coli. Front Microbiol. 2014; 5:390. Saier MH, Zhang Z. PMID: 25136335; PMCID: PMC4117983.
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Expansion of the APC superfamily of secondary carriers. Proteins. 2014 Oct; 82(10):2797-811. Vastermark A, Wollwage S, Houle ME, Rio R, Saier MH. PMID: 25043943; PMCID: PMC4177346.
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Reliability of nine programs of topological predictions and their application to integral membrane channel and carrier proteins. J Mol Microbiol Biotechnol. 2014; 24(3):161-90. Reddy A, Cho J, Ling S, Reddy V, Shlykov M, Saier MH. PMID: 24992992; PMCID: PMC4125430.
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Regulation of crp gene expression by the catabolite repressor/activator, Cra, in Escherichia coli. J Mol Microbiol Biotechnol. 2014; 24(3):135-41. Zhang Z, Aboulwafa M, Saier MH. PMID: 24923415; PMCID: PMC4125524.
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Establishing homology between mitochondrial calcium uniporters, prokaryotic magnesium channels and chlamydial IncA proteins. Microbiology (Reading). 2014 Aug; 160(Pt 8):1679-1689. Lee A, Vastermark A, Saier MH. PMID: 24869855; PMCID: PMC4117221.
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Transport proteins promoting Escherichia coli pathogenesis. Microb Pathog. 2014 Jun-Jul; 71-72:41-55. Tang F, Saier MH. PMID: 24747185; PMCID: PMC4106412.
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Major facilitator superfamily porters, LacY, FucP and XylE of Escherichia coli appear to have evolved positionally dissimilar catalytic residues without rearrangement of 3-TMS repeat units. J Mol Microbiol Biotechnol. 2014; 24(2):82-90. Västermark A, Lunt B, Saier M. PMID: 24603210; PMCID: PMC4048653.
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Major Facilitator Superfamily (MFS) evolved without 3-transmembrane segment unit rearrangements. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):E1162-3. Västermark A, Saier MH. PMID: 24567407; PMCID: PMC3977298.
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The involvement of transport proteins in transcriptional and metabolic regulation. Curr Opin Microbiol. 2014 Apr; 18:8-15. Västermark A, Saier MH. PMID: 24513656; PMCID: PMC3999241.
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Genetic implication of a novel thiamine transporter in human hypertension. J Am Coll Cardiol. 2014 Apr 22; 63(15):1542-55. Zhang K, Huentelman MJ, Rao F, Sun EI, Corneveaux JJ, Schork AJ, Wei Z, Waalen J, Miramontes-Gonzalez JP, Hightower CM, Maihofer AX, Mahata M, Pastinen T, Ehret GB, International Consortium for Blood Pressure Genome-Wide Association Studies, Schork NJ, Eskin E, Nievergelt CM, Saier MH, O'Connor DT. PMID: 24509276; PMCID: PMC3992204.
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Comparative genomics of transport proteins in developmental bacteria: Myxococcus xanthus and Streptomyces coelicolor. BMC Microbiol. 2013 Dec 05; 13:279. Getsin I, Nalbandian GH, Yee DC, Vastermark A, Paparoditis PC, Reddy VS, Saier MH. PMID: 24304716; PMCID: PMC3924187.
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The transporter classification database. Nucleic Acids Res. 2014 Jan; 42(Database issue):D251-8. Saier MH, Reddy VS, Tamang DG, Västermark A. PMID: 24225317; PMCID: PMC3964967.
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Evolutionary relationship between 5+5 and 7+7 inverted repeat folds within the amino acid-polyamine-organocation superfamily. Proteins. 2014 Feb; 82(2):336-46. Västermark Å, Saier MH. PMID: 24038584.
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The transporter-opsin-G protein-coupled receptor (TOG) superfamily. FEBS J. 2013 Nov; 280(22):5780-800. Yee DC, Shlykov MA, Västermark A, Reddy VS, Arora S, Sun EI, Saier MH. PMID: 23981446; PMCID: PMC3832197.
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Comparative genomics of metabolic capacities of regulons controlled by cis-regulatory RNA motifs in bacteria. BMC Genomics. 2013 Sep 02; 14:597. Sun EI, Leyn SA, Kazanov MD, Saier MH, Novichkov PS, Rodionov DA. PMID: 24060102; PMCID: PMC3766115.
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Lipid dependencies, biogenesis and cytoplasmic micellar forms of integral membrane sugar transport proteins of the bacterial phosphotransferase system. Microbiology (Reading). 2013 Nov; 159(Pt 11):2213-2224. Aboulwafa M, Saier MH. PMID: 23985145; PMCID: PMC3836488.
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Bioinformatic analyses of integral membrane transport proteins encoded within the genome of the planctomycetes species, Rhodopirellula baltica. Biochim Biophys Acta. 2014 Jan; 1838(1 Pt B):193-215. Paparoditis P, Västermark A, Le AJ, Fuerst JA, Saier MH. PMID: 23969110; PMCID: PMC3905805.
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Microcompartments and protein machines in prokaryotes. J Mol Microbiol Biotechnol. 2013; 23(4-5):243-69. Saier MH. PMID: 23920489; PMCID: PMC3832201.
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Topological and phylogenetic analyses of bacterial holin families and superfamilies. Biochim Biophys Acta. 2013 Nov; 1828(11):2654-71. Reddy BL, Saier MH. PMID: 23856191; PMCID: PMC3788059.
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Evolutionary relationships of ATP-Binding Cassette (ABC) uptake porters. BMC Microbiol. 2013 May 06; 13:98. Zheng WH, Västermark Å, Shlykov MA, Reddy V, Sun EI, Saier MH. PMID: 23647830; PMCID: PMC3654945.
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Membranous organelles in bacteria. J Mol Microbiol Biotechnol. 2013; 23(1-2):5-12. Saier MH, Bogdanov MV. PMID: 23615191.
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Subcellular localization and logistics of integral membrane protein biogenesis in Escherichia coli. J Mol Microbiol Biotechnol. 2013; 23(1-2):24-34. Bogdanov M, Aboulwafa M, Saier MH. PMID: 23615193.
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Genetic engineering of the phosphocarrier protein NPr of the Escherichia coli phosphotransferase system selectively improves sugar uptake activity. J Biol Chem. 2012 Aug 24; 287(35):29931-9. Lopez-de Los Santos Y, Chan H, Cantu VA, Rettner R, Sanchez F, Zhang Z, Saier MH, Soberon X. PMID: 22767600; PMCID: PMC3436175.
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Transformative research: definitions, approaches and consequences. Theory Biosci. 2012 Jun; 131(2):117-23. Trevors JT, Pollack GH, Saier MH, Masson L. PMID: 22628127; PMCID: PMC3990254.
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The amino acid-polyamine-organocation superfamily. J Mol Microbiol Biotechnol. 2012; 22(2):105-13. Wong FH, Chen JS, Reddy V, Day JL, Shlykov MA, Wakabayashi ST, Saier MH. PMID: 22627175.
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The major facilitator superfamily (MFS) revisited. FEBS J. 2012 Jun; 279(11):2022-35. Reddy VS, Shlykov MA, Castillo R, Sun EI, Saier MH. PMID: 22458847; PMCID: PMC3425384.
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BioV Suite--a collection of programs for the study of transport protein evolution. FEBS J. 2012 Jun; 279(11):2036-46. Reddy VS, Saier MH. PMID: 22568782; PMCID: PMC3978091.
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Phylogenetic characterization of transport protein superfamilies: superiority of SuperfamilyTree programs over those based on multiple alignments. J Mol Microbiol Biotechnol. 2011; 21(3-4):83-96. Chen JS, Reddy V, Chen JH, Shlykov MA, Zheng WH, Cho J, Yen MR, Saier MH. PMID: 22286036; PMCID: PMC3290041.
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Did adaptive and directed mutation evolve to accelerate stress-induced evolutionary change? J Mol Microbiol Biotechnol. 2011; 21(1-2):5-7. Saier MH. PMID: 22248538.
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Transposon-mediated adaptive and directed mutations and their potential evolutionary benefits. J Mol Microbiol Biotechnol. 2011; 21(1-2):59-70. Zhang Z, Saier MH. PMID: 22248543; PMCID: PMC3697268.
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Bioinformatic characterization of the 4-Toluene Sulfonate Uptake Permease (TSUP) family of transmembrane proteins. Biochim Biophys Acta. 2012 Mar; 1818(3):703-17. Shlykov MA, Zheng WH, Chen JS, Saier MH. PMID: 22192777; PMCID: PMC3917603.
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Comparative analyses of transport proteins encoded within the genomes of Mycobacterium tuberculosis and Mycobacterium leprae. Biochim Biophys Acta. 2012 Mar; 1818(3):776-97. Youm J, Saier MH. PMID: 22179038; PMCID: PMC3425379.
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Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control. Genome Biol. 2011 Oct 17; 12(10):R100. Coyne RS, Hannick L, Shanmugam D, Hostetler JB, Brami D, Joardar VS, Johnson J, Radune D, Singh I, Badger JH, Kumar U, Saier M, Wang Y, Cai H, Gu J, Mather MW, Vaidya AB, Wilkes DE, Rajagopalan V, Asai DJ, Pearson CG, Findly RC, Dickerson HW, Wu M, Martens C, Van de Peer Y, Roos DS, Cassidy-Hanley DM, Clark TG. PMID: 22004680; PMCID: PMC3341644.
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Biophysical studies of the membrane-embedded and cytoplasmic forms of the glucose-specific Enzyme II of the E. coli phosphotransferase system (PTS). PLoS One. 2011; 6(9):e24088. Aboulwafa M, Saier MH. PMID: 21935376; PMCID: PMC3174158.
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Identifying relevant data for a biological database: handcrafted rules versus machine learning. IEEE/ACM Trans Comput Biol Bioinform. 2011 May-Jun; 8(3):851-7. Sehgal AK, Das S, Noto K, Saier MH, Elkan C. PMID: 21393656; PMCID: PMC3980937.
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Bioinformatic characterization of the trimeric intracellular cation-specific channel protein family. J Membr Biol. 2011 May; 241(2):77-101. Silverio AL, Saier MH. PMID: 21519847; PMCID: PMC3980945.
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Evolution of the oligopeptide transporter family. J Membr Biol. 2011 Mar; 240(2):89-110. Gomolplitinant KM, Saier MH. PMID: 21347612; PMCID: PMC3061005.
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A Vaccine Against Ignorance? Water Air Soil Pollut. 2011 Sep; 220(1-4):1-3. Trevors JT, Saier MH. PMID: 21949450; PMCID: PMC3153665.
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Pathways of transport protein evolution: recent advances. Biol Chem. 2011 Jan; 392(1-2):5-12. Lam VH, Lee JH, Silverio A, Chan H, Gomolplitinant KM, Povolotsky TL, Orlova E, Sun EI, Welliver CH, Saier MH. PMID: 21194372; PMCID: PMC4008129.
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Thermodynamic perspectives on genetic instructions, the laws of biology and diseased states. C R Biol. 2011 Jan; 334(1):1-5. Trevors JT, Saier MH. PMID: 21262480; PMCID: PMC4092032.
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The bacterial intimins and invasins: a large and novel family of secreted proteins. PLoS One. 2010 Dec 22; 5(12):e14403. Tsai JC, Yen MR, Castillo R, Leyton DL, Henderson IR, Saier MH. PMID: 21203509; PMCID: PMC3008723.
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The p-type ATPase superfamily. J Mol Microbiol Biotechnol. 2010; 19(1-2):5-104. Chan H, Babayan V, Blyumin E, Gandhi C, Hak K, Harake D, Kumar K, Lee P, Li TT, Liu HY, Lo TC, Meyer CJ, Stanford S, Zamora KS, Saier MH. PMID: 20962537.
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Functional Promiscuity of Homologues of the Bacterial ArsA ATPases. Int J Microbiol. 2010; 2010:187373. Castillo R, Saier MH. PMID: 20981284; PMCID: PMC2963123.
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The Legacy of Oil Spills. Water Air Soil Pollut. 2010 Sep; 211(1-4):1-3. Trevors JT, Saier MH. PMID: 20835295; PMCID: PMC3229911.
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Defense against cannibalism: the SdpI family of bacterial immunity/signal transduction proteins. J Membr Biol. 2010 Jun; 235(3):145-62. Povolotsky TL, Orlova E, Tamang DG, Saier MH. PMID: 20563570; PMCID: PMC2910880.
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The autoinducer-2 exporter superfamily. J Mol Microbiol Biotechnol. 2010; 18(4):195-205. Rettner RE, Saier MH. PMID: 20559013; PMCID: PMC3004238.
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Animal Ca2+ release-activated Ca2+ (CRAC) channels appear to be homologous to and derived from the ubiquitous cation diffusion facilitators. BMC Res Notes. 2010 Jun 03; 3:158. Matias MG, Gomolplitinant KM, Tamang DG, Saier MH. PMID: 20525303; PMCID: PMC2894845.
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Transcriptional Regulation of the rsbV Promoter Controlling Stress Responses to Ethanol, Carbon Limitation, and Phosphorous Limitation in Bacillus subtilis. Int J Microbiol. 2010; 2010:263410. Choi SK, Saier MH. PMID: 20454630; PMCID: PMC2862951.
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In vitro phosphorylation of key metabolic enzymes from Bacillus subtilis: PrkC phosphorylates enzymes from different branches of basic metabolism. J Mol Microbiol Biotechnol. 2010; 18(3):129-40. Pietack N, Becher D, Schmidl SR, Saier MH, Hecker M, Commichau FM, Stülke J. PMID: 20389117.
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Bacterial Adaptor Membrane Fusion Proteins and the Structurally Dissimilar Outer Membrane Auxiliary Proteins Have Exchanged Central Domains in alpha-Proteobacteria. Int J Microbiol. 2010; 2010:589391. Xiao AY, Wang J, Saier MH. PMID: 20379386; PMCID: PMC2850547.
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Precise excision of IS5 from the intergenic region between the fucPIK and the fucAO operons and mutational control of fucPIK operon expression in Escherichia coli. J Bacteriol. 2010 Apr; 192(7):2013-9. Zhang Z, Yen MR, Saier MH. PMID: 20097855; PMCID: PMC2838058.
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Multidrug resistance: phylogenetic characterization of superfamilies of secondary carriers that include drug exporters. Methods Mol Biol. 2010; 637:47-64. Yen MR, Chen JS, Marquez JL, Sun EI, Saier MH. PMID: 20419429.
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Mathematics: The Basis for Quantitative Knowledge. Water Air Soil Pollut. 2010 Jun; 209(1-4):1-2. Trevors JT, Saier MH. PMID: 22247578; PMCID: PMC3252842.
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Education for Humanity. Water Air Soil Pollut. 2010 Feb; 206(1-4):1-2. Trevors JT, Saier MH. PMID: 22247577; PMCID: PMC3252885.
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Global Pollution: How Much Is Too Much? Water Air Soil Pollut. 2009 Nov; 204(1-4):1-3. Trevors JT, Saier MH. PMID: 19898672; PMCID: PMC3229874.
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A novel mechanism of transposon-mediated gene activation. PLoS Genet. 2009 Oct; 5(10):e1000689. Zhang Z, Saier MH. PMID: 19834539; PMCID: PMC2753651.
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Membrane porters of ATP-binding cassette transport systems are polyphyletic. J Membr Biol. 2009 Sep; 231(1):1-10. Wang B, Dukarevich M, Sun EI, Yen MR, Saier MH. PMID: 19806386.
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Bioinformatic analyses of transmembrane transport: novel software for deducing protein phylogeny, topology, and evolution. J Mol Microbiol Biotechnol. 2009; 17(4):163-76. Yen MR, Choi J, Saier MH. PMID: 19776645; PMCID: PMC2814153.
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Survival of the Fattest. Water Air Soil Pollut. 2009 Aug 20; 205(Suppl 1):107-109. Saier MH, Trevors JT. PMID: 20157349; PMCID: PMC2815294.
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A mechanism of transposon-mediated directed mutation. Mol Microbiol. 2009 Oct; 74(1):29-43. Zhang Z, Saier MH. PMID: 19682247; PMCID: PMC2973706.
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Bioinformatic characterization of p-type ATPases encoded within the fully sequenced genomes of 26 eukaryotes. J Membr Biol. 2009 Jun; 229(3):115-30. Thever MD, Saier MH. PMID: 19548020; PMCID: PMC2709905.
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Comprehensive analyses of transport proteins encoded within the genome of "Aromatoleum aromaticum" strain EbN1. J Membr Biol. 2009 May; 229(2):53-90. Tamang DG, Rabus R, Barabote RD, Saier MH. PMID: 19506936.
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The Transporter Classification Database: recent advances. Nucleic Acids Res. 2009 Jan; 37(Database issue):D274-8. Saier MH, Yen MR, Noto K, Tamang DG, Elkan C. PMID: 19022853; PMCID: PMC2686586.
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A genomic analysis of the archaeal system Ignicoccus hospitalis-Nanoarchaeum equitans. Genome Biol. 2008; 9(11):R158. Podar M, Anderson I, Makarova KS, Elkins JG, Ivanova N, Wall MA, Lykidis A, Mavromatis K, Sun H, Hudson ME, Chen W, Deciu C, Hutchison D, Eads JR, Anderson A, Fernandes F, Szeto E, Lapidus A, Kyrpides NC, Saier MH, Richardson PM, Rachel R, Huber H, Eisen JA, Koonin EV, Keller M, Stetter KO. PMID: 19000309; PMCID: PMC2614490.
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A stochastic automaton shows how enzyme assemblies may contribute to metabolic efficiency. BMC Syst Biol. 2008 Mar 25; 2:27. Amar P, Legent G, Thellier M, Ripoll C, Bernot G, Nystrom T, Saier MH, Norris V. PMID: 18366733; PMCID: PMC2322945.
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The bacterial chromosome. Crit Rev Biochem Mol Biol. 2008 Mar-Apr; 43(2):89-134. Saier MH. PMID: 18365861.
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Characterization of the E. coli glucose permease fused to the maltose-binding protein. J Basic Microbiol. 2008 Feb; 48(1):3-9. Aboulwafa M, Saier MH. PMID: 18247392.
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The phagosomal nutrient transporter (Pht) family. Microbiology (Reading). 2008 Jan; 154(Pt 1):42-53. Chen DE, Podell S, Sauer JD, Swanson MS, Saier MH. PMID: 18174124.
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Protein secretion and membrane insertion systems in bacteria and eukaryotic organelles. Adv Appl Microbiol. 2008; 65:141-97. Saier MH, Ma CH, Rodgers L, Tamang DG, Yen MR. PMID: 19026865.
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Comprehensive analysis of transport proteins encoded within the genome of Bdellovibrio bacteriovorus. Genomics. 2007 Oct; 90(4):424-46. Barabote RD, Rendulic S, Schuster SC, Saier MH. PMID: 17706914; PMCID: PMC3415317.
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Identification of regulatory network topological units coordinating the genome-wide transcriptional response to glucose in Escherichia coli. BMC Microbiol. 2007 Jun 08; 7:53. Gutierrez-Ríos RM, Freyre-Gonzalez JA, Resendis O, Collado-Vides J, Saier M, Gosset G. PMID: 17559662; PMCID: PMC1905917.
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Protein secretion and membrane insertion systems in gram-negative bacteria. J Membr Biol. 2006; 214(2):75-90. Saier MH. PMID: 17546510.
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Evolutionary origins of members of a superfamily of integral membrane cytochrome c biogenesis proteins. Biochim Biophys Acta. 2007 Sep; 1768(9):2164-81. Lee JH, Harvat EM, Stevens JM, Ferguson SJ, Saier MH. PMID: 17706591.
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Functional characterization of the heterooligomeric EbrAB multidrug efflux transporter of Bacillus subtilis. Biochemistry. 2007 May 01; 46(17):5218-25. Zhang Z, Ma C, Pornillos O, Xiu X, Chang G, Saier MH. PMID: 17417881.
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Combinatorial transcriptional control of the lactose operon of Escherichia coli. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):6043-8. Kuhlman T, Zhang Z, Saier MH, Hwa T. PMID: 17376875; PMCID: PMC1851613.
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Gap junctional proteins of animals: the innexin/pannexin superfamily. Prog Biophys Mol Biol. 2007 May-Jun; 94(1-2):5-14. Yen MR, Saier MH. PMID: 17507077; PMCID: PMC2592087.
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Functional taxonomy of bacterial hyperstructures. Microbiol Mol Biol Rev. 2007 Mar; 71(1):230-53. Norris V, den Blaauwen T, Cabin-Flaman A, Doi RH, Harshey R, Janniere L, Jimenez-Sanchez A, Jin DJ, Levin PA, Mileykovskaya E, Minsky A, Saier M, Skarstad K. PMID: 17347523; PMCID: PMC1847379.
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Transport capabilities of eleven gram-positive bacteria: comparative genomic analyses. Biochim Biophys Acta. 2007 Jun; 1768(6):1342-66. Lorca GL, Barabote RD, Zlotopolski V, Tran C, Winnen B, Hvorup RN, Stonestrom AJ, Nguyen E, Huang LW, Kim DS, Saier MH. PMID: 17490609; PMCID: PMC2592090.
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The bile/arsenite/riboflavin transporter (BART) superfamily. FEBS J. 2007 Feb; 274(3):612-29. Mansour NM, Sawhney M, Tamang DG, Vogl C, Saier MH. PMID: 17288550.
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Active transport in communication, protection and nutrition. J Mol Microbiol Biotechnol. 2007; 12(3-4):161-4. Saier MH. PMID: 17587865.
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In vitro interconversion of the soluble and membrane- integrated forms of the Escherichia coli glucose enzyme II of the phosphoenolpyruvate-dependent sugar-transporting phosphotransferase system. J Mol Microbiol Biotechnol. 2007; 12(3-4):263-8. Aboulwafa M, Saier MH. PMID: 17587874.
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Toward a hyperstructure taxonomy. Annu Rev Microbiol. 2007; 61:309-29. Norris V, den Blaauwen T, Doi RH, Harshey RM, Janniere L, Jiménez-Sánchez A, Jin DJ, Levin PA, Mileykovskaya E, Minsky A, Misevic G, Ripoll C, Saier M, Skarstad K, Thellier M. PMID: 17896876.
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Comparative genomics of the lactic acid bacteria. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15611-6. Makarova K, Slesarev A, Wolf Y, Sorokin A, Mirkin B, Koonin E, Pavlov A, Pavlova N, Karamychev V, Polouchine N, Shakhova V, Grigoriev I, Lou Y, Rohksar D, Lucas S, Huang K, Goodstein DM, Hawkins T, Plengvidhya V, Welker D, Hughes J, Goh Y, Benson A, Baldwin K, Lee JH, Díaz-Muñiz I, Dosti B, Smeianov V, Wechter W, Barabote R, Lorca G, Altermann E, Barrangou R, Ganesan B, Xie Y, Rawsthorne H, Tamir D, Parker C, Breidt F, Broadbent J, Hutkins R, O'Sullivan D, Steele J, Unlu G, Saier M, Klaenhammer T, Richardson P, Kozyavkin S, Weimer B, Mills D. PMID: 17030793; PMCID: PMC1622870.
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Are Megacities Sustainable? Water Air Soil Pollut. 2007; 178(1):1-3. Saier MH. PMID: 32214525; PMCID: PMC7088816.
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Protein-translocating trimeric autotransporters of gram-negative bacteria. J Bacteriol. 2006 Aug; 188(16):5655-67. Kim DS, Chao Y, Saier MH. PMID: 16885434; PMCID: PMC1540064.
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Are Megacities Sustainable? Water Air Soil Pollut. 2008; 191(1):1-3. Saier MH. PMID: 32214526; PMCID: PMC7088849.
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Extra domains in secondary transport carriers and channel proteins. Biochim Biophys Acta. 2006 Oct; 1758(10):1557-79. Barabote RD, Tamang DG, Abeywardena SN, Fallah NS, Fu JY, Lio JK, Mirhosseini P, Pezeshk R, Podell S, Salampessy ML, Thever MD, Saier MH. PMID: 16905115.
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Evolutionary appearance of H+-translocating pyrophosphatases. Microbiology (Reading). 2006 May; 152(Pt 5):1243-1247. Au KM, Barabote RD, Hu KY, Saier MH. PMID: 16622041.
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The iron/lead transporter superfamily of Fe/Pb2+ uptake systems. J Mol Microbiol Biotechnol. 2006; 11(1-2):1-9. Debut AJ, Dumay QC, Barabote RD, Saier MH. PMID: 16825785.
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The copper transporter (Ctr) family of Cu+ uptake systems. J Mol Microbiol Biotechnol. 2006; 11(1-2):10-9. Dumay QC, Debut AJ, Mansour NM, Saier MH. PMID: 16825786.
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The cecropin superfamily of toxic peptides. J Mol Microbiol Biotechnol. 2006; 11(1-2):94-103. Tamang DG, Saier MH. PMID: 16825792.
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Mechanism of CcpA-mediated glucose repression of the resABCDE operon of Bacillus subtilis. J Mol Microbiol Biotechnol. 2006; 11(1-2):104-10. Choi SK, Saier MH. PMID: 16825793.
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TCDB: the Transporter Classification Database for membrane transport protein analyses and information. Nucleic Acids Res. 2006 Jan 01; 34(Database issue):D181-6. Saier MH, Tran CV, Barabote RD. PMID: 16381841; PMCID: PMC1334385.
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The bioinformatic study of transmembrane molecular transport. J Mol Microbiol Biotechnol. 2006; 11(6):289-90. Saier MH, Ren Q. PMID: 17114892.
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Engineering transport protein function: theoretical and technical considerations using the sugar-transporting phosphotransferase system of Escherichia coli as a model system. J Mol Microbiol Biotechnol. 2006; 11(6):302-7. Soberón X, Saier MH. PMID: 17114894.
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Topological predictions for integral membrane permeases of the phosphoenolpyruvate:sugar phosphotransferase system. J Mol Microbiol Biotechnol. 2006; 11(6):345-60. Nguyen TX, Yen MR, Barabote RD, Saier MH. PMID: 17114898.
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Comparative genomic analyses of the bacterial phosphotransferase system. Microbiol Mol Biol Rev. 2005 Dec; 69(4):608-34. Barabote RD, Saier MH. PMID: 16339738; PMCID: PMC1306802.
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Catabolite repression and activation in Bacillus subtilis: dependency on CcpA, HPr, and HprK. J Bacteriol. 2005 Nov; 187(22):7826-39. Lorca GL, Chung YJ, Barabote RD, Weyler W, Schilling CH, Saier MH. PMID: 16267306; PMCID: PMC1280314.
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Regulation of sigL expression by the catabolite control protein CcpA involves a roadblock mechanism in Bacillus subtilis: potential connection between carbon and nitrogen metabolism. J Bacteriol. 2005 Oct; 187(19):6856-61. Choi SK, Saier MH. PMID: 16166551; PMCID: PMC1251575.
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The bestrophin family of anion channels: identification of prokaryotic homologues. Mol Membr Biol. 2005 Jul-Aug; 22(4):291-302. Hagen AR, Barabote RD, Saier MH. PMID: 16154901.
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Functional interactions between the carbon and iron utilization regulators, Crp and Fur, in Escherichia coli. J Bacteriol. 2005 Feb; 187(3):980-90. Zhang Z, Gosset G, Barabote R, Gonzalez CS, Cuevas WA, Saier MH. PMID: 15659676; PMCID: PMC545712.
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Evolution of the bacterial phosphotransferase system: from carriers and enzymes to group translocators. Biochem Soc Trans. 2005 Feb; 33(Pt 1):220-4. Saier MH, Hvorup RN, Barabote RD. PMID: 15667312.
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Bioinformatic analyses of bacterial HPr kinase/phosphorylase homologues. Res Microbiol. 2005 Apr; 156(3):443-51. Stonestrom A, Barabote RD, Gonzalez CF, Saier MH. PMID: 15808949.
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Lysophospholipid flipping across the Escherichia coli inner membrane catalyzed by a transporter (LplT) belonging to the major facilitator superfamily. J Biol Chem. 2005 Mar 25; 280(12):12028-34. Harvat EM, Zhang YM, Tran CV, Zhang Z, Frank MW, Rock CO, Saier MH. PMID: 15661733.
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Biochemical characterization of phosphoryl transfer involving HPr of the phosphoenolpyruvate-dependent phosphotransferase system in Treponema denticola, an organism that lacks PTS permeases. Biochemistry. 2005 Jan 18; 44(2):598-608. Gonzalez CF, Stonestrom AJ, Lorca GL, Saier MH. PMID: 15641785.
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Ser/Thr/Tyr protein phosphorylation in bacteria - for long time neglected, now well established. J Mol Microbiol Biotechnol. 2005; 9(3-4):125-31. Deutscher J, Saier MH. PMID: 16415586.
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Hypothesis: chemotaxis in Escherichia coli results from hyper-structure dynamics. J Mol Microbiol Biotechnol. 2005; 10(1):1-14. Cabin-Flaman A, Ripoll C, Saier MH, Norris V. PMID: 16491021.
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Probiotics and prebiotics in human health. J Mol Microbiol Biotechnol. 2005; 10(1):22-5. Saier MH, Mansour NM. PMID: 16491023.
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Regulation of pho regulon gene expression by the carbon control protein A, CcpA, in Bacillus subtilis. J Mol Microbiol Biotechnol. 2005; 10(1):40-50. Choi SK, Saier MH. PMID: 16491025.
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Beneficial bacteria and bioremediation. J Mol Microbiol Biotechnol. 2005; 9(2):63-4. Saier MH. PMID: 16319495.
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Genomic analyses of transport proteins in Ralstonia metallidurans. Comp Funct Genomics. 2005; 6(1-2):17-56. von Rozycki T, Nies DH, Saier MH. PMID: 18629293; PMCID: PMC2448597.
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Characterization of soluble enzyme II complexes of the Escherichia coli phosphotransferase system. J Bacteriol. 2004 Dec; 186(24):8453-62. Aboulwafa M, Saier MH. PMID: 15576795; PMCID: PMC532404.
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Topological analysis of integral membrane constituents of prokaryotic ABC efflux systems. Res Microbiol. 2005 Mar; 156(2):270-7. Khwaja M, Ma Q, Saier MH. PMID: 15748994.
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Sequence similarity between multidrug resistance efflux pumps of the ABC and RND superfamilies. Microbiology (Reading). 2004 Aug; 150(Pt 8):2493-2495. Kim SH, Chang AB, Saier MH. PMID: 15289545.
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The IUBMB-endorsed transporter classification system. Mol Biotechnol. 2004 Jul; 27(3):253-62. Busch W, Saier MH, International Union of Biochemistry and Molecular Biology (IUBMB). PMID: 15247498.
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Transcriptome analysis of Crp-dependent catabolite control of gene expression in Escherichia coli. J Bacteriol. 2004 Jun; 186(11):3516-24. Gosset G, Zhang Z, Nayyar S, Cuevas WA, Saier MH. PMID: 15150239; PMCID: PMC415760.
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Phylogeny as a guide to structure and function of membrane transport proteins. Mol Membr Biol. 2004 May-Jun; 21(3):171-81. Chang AB, Lin R, Keith Studley W, Tran CV, Saier MH. PMID: 15204625.
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In silico and transcriptional analysis of carbohydrate uptake systems of Streptomyces coelicolor A3(2). J Bacteriol. 2004 Mar; 186(5):1362-73. Bertram R, Schlicht M, Mahr K, Nothaft H, Saier MH, Titgemeyer F. PMID: 14973030; PMCID: PMC344420.
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Evolution of bacterial type III protein secretion systems. Trends Microbiol. 2004 Mar; 12(3):113-5. Saier MH. PMID: 15001186.
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Sequence analyses of cyanobacterial bicarbonate transporters and their homologues. J Mol Microbiol Biotechnol. 2004; 7(3):102-8. von Rozycki T, Schultzel MA, Saier MH. PMID: 15263814.
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The principal chloroquine resistance protein of Plasmodium falciparum is a member of the drug/metabolite transporter superfamily. Microbiology (Reading). 2004 Jan; 150(Pt 1):1-3. Tran CV, Saier MH. PMID: 14702390.
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The YedZ family: possible heme binding proteins that can be fused to transporters and electron carriers. J Mol Microbiol Biotechnol. 2004; 8(3):129-40. von Rozycki T, Yen MR, Lende EE, Saier MH. PMID: 16088215.
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Carbonic anhydrases fused to anion transporters of the SulP family: evidence for a novel type of bicarbonate transporter. J Mol Microbiol Biotechnol. 2004; 8(3):169-76. Felce J, Saier MH. PMID: 16088218.
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Biofilm-defective mutants of Bacillus subtilis. J Mol Microbiol Biotechnol. 2004; 8(3):177-88. Chagneau C, Saier MH. PMID: 16088219.
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The ion transporter superfamily. Biochim Biophys Acta. 2003 Dec 03; 1618(1):79-92. Prakash S, Cooper G, Singhi S, Saier MH. PMID: 14643936.
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Dependency of sugar transport and phosphorylation by the phosphoenolpyruvate-dependent phosphotransferase system on membranous phosphatidylethanolamine in Escherichia coli: studies with a pssA mutant lacking phosphatidylserine synthase. Arch Microbiol. 2004 Jan; 181(1):26-34. Aboulwafa M, Hvorup R, Saier MH. PMID: 14634719.
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Type II protein secretion and its relationship to bacterial type IV pili and archaeal flagella. Microbiology (Reading). 2003 Nov; 149(Pt 11):3051-3072. Peabody CR, Chung YJ, Yen MR, Vidal-Ingigliardi D, Pugsley AP, Saier MH. PMID: 14600218.
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The tripartite tricarboxylate transporter (TTT) family. Res Microbiol. 2003 Sep; 154(7):457-65. Winnen B, Hvorup RN, Saier MH. PMID: 14499931.
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Molecular modeling of the bacterial outer membrane receptor energizer, ExbBD/TonB, based on homology with the flagellar motor, MotAB. Biochim Biophys Acta. 2003 Aug 07; 1614(2):201-10. Zhai YF, Heijne W, Saier MH. PMID: 12896813.
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Sequence and phylogenetic analyses of 4 TMS junctional proteins of animals: connexins, innexins, claudins and occludins. J Membr Biol. 2003 Jul 01; 194(1):59-76. Hua VB, Chang AB, Tchieu JH, Kumar NM, Nielsen PA, Saier MH. PMID: 14502443.
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A transporter of Escherichia coli specific for L- and D-methionine is the prototype for a new family within the ABC superfamily. Arch Microbiol. 2003 Aug; 180(2):88-100. Zhang Z, Feige JN, Chang AB, Anderson IJ, Brodianski VM, Vitreschak AG, Gelfand MS, Saier MH. PMID: 12819857.
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Tracing pathways of transport protein evolution. Mol Microbiol. 2003 Jun; 48(5):1145-56. Saier MH. PMID: 12787345.
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Identification of the L-aspartate transporter in Bacillus subtilis. J Bacteriol. 2003 May; 185(10):3218-22. Lorca G, Winnen B, Saier MH. PMID: 12730183; PMCID: PMC154055.
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The ascorbate transporter of Escherichia coli. J Bacteriol. 2003 Apr; 185(7):2243-50. Zhang Z, Aboulwafa M, Smith MH, Saier MH. PMID: 12644495; PMCID: PMC151508.
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Soluble sugar permeases of the phosphotransferase system in Escherichia coli: evidence for two physically distinct forms of the proteins in vivo. Mol Microbiol. 2003 Apr; 48(1):131-41. Aboulwafa M, Saier M. PMID: 12657050.
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Protein secretion systems of Pseudomonas aeruginosa and P fluorescens. Biochim Biophys Acta. 2003 Apr 01; 1611(1-2):223-33. Ma Q, Zhai Y, Schneider JC, Ramseier TM, Saier MH. PMID: 12659964.
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The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily. Eur J Biochem. 2003 Mar; 270(5):799-813. Hvorup RN, Winnen B, Chang AB, Jiang Y, Zhou XF, Saier MH. PMID: 12603313.
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Studies on the Escherichia coli glucose-specific permease, PtsG, with a point mutation in its N-terminal amphipathic leader sequence. Microbiology (Reading). 2003 Mar; 149(Pt 3):763-771. Aboulwafa M, Chung YJ, Wai HH, Saier MH. PMID: 12634344.
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The general protein secretory pathway: phylogenetic analyses leading to evolutionary conclusions. Biochim Biophys Acta. 2003 Jan 10; 1609(1):115-25. Cao TB, Saier MH. PMID: 12507766.
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Reversing transmembrane electron flow: the DsbD and DsbB protein families. J Mol Microbiol Biotechnol. 2003; 5(3):133-49. Kimball RA, Martin L, Saier MH. PMID: 12766342.
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Web-based programs for the display and analysis of transmembrane alpha-helices in aligned protein sequences. J Mol Microbiol Biotechnol. 2003; 5(1):1-6. Zhou X, Yang NM, Tran CV, Hvorup RN, Saier MH. PMID: 12673055.
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An automated program to screen databases for members of protein families. J Mol Microbiol Biotechnol. 2003; 5(1):7-10. Zhou X, Hvorup RN, Saier MH. PMID: 12673056.
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The IUBMB-endorsed transporter classification system. Methods Mol Biol. 2003; 227:21-36. Busch W, Saier MH. PMID: 12824641.
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The urea transporter (UT) family: bioinformatic analyses leading to structural, functional, and evolutionary predictions. Recept Channels. 2003; 9(6):345-52. Minocha R, Studley K, Saier MH. PMID: 14698962.
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Bioinformatic analyses of the bacterial L-ascorbate phosphotransferase system permease family. J Mol Microbiol Biotechnol. 2003; 6(3-4):191-205. Hvorup R, Chang AB, Saier MH. PMID: 15153772.
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Dependency of sugar transport and phosphorylation by the phosphoenolpyruvate-dependent phosphotransferase system on membranous phosphatidyl glycerol in Escherichia coli: studies with a pgsA mutant lacking phosphatidyl glycerophosphate synthase. Res Microbiol. 2002 Dec; 153(10):667-77. Aboulwafa M, Saier MH. PMID: 12558186.
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Sequence similarity between the channel-forming domains of voltage-gated ion channel proteins and the C-terminal domains of secondary carriers of the major facilitator superfamily. Microbiology (Reading). 2002 Dec; 148(Pt 12):3760-2. Hvorup RN, Saier MH. PMID: 12480878.
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Domain analysis of transcriptional regulators bearing PTS regulatory domains. Res Microbiol. 2002 Oct; 153(8):519-26. Greenberg DB, Stülke J, Saier MH. PMID: 12437213.
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The beta-barrel finder (BBF) program, allowing identification of outer membrane beta-barrel proteins encoded within prokaryotic genomes. Protein Sci. 2002 Sep; 11(9):2196-207. Zhai Y, Saier MH. PMID: 12192075; PMCID: PMC2373602.
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Phylogeny of phosphoryl transfer proteins of the phosphoenolpyruvate-dependent sugar-transporting phosphotransferase system. Res Microbiol. 2002 Sep; 153(7):405-15. Hu KY, Saier MH. PMID: 12405346.
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Discovering lactic acid bacteria by genomics. Antonie Van Leeuwenhoek. 2002 Aug; 82(1-4):29-58. Klaenhammer T, Altermann E, Arigoni F, Bolotin A, Breidt F, Broadbent J, Cano R, Chaillou S, Deutscher J, Gasson M, van de Guchte M, Guzzo J, Hartke A, Hawkins T, Hols P, Hutkins R, Kleerebezem M, Kok J, Kuipers O, Lubbers M, Maguin E, McKay L, Mills D, Nauta A, Overbeek R, Pel H, Pridmore D, Saier M, van Sinderen D, Sorokin A, Steele J, O'Sullivan D, de Vos W, Weimer B, Zagorec M, Siezen R. PMID: 12369195.
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A simple sensitive program for detecting internal repeats in sets of multiply aligned homologous proteins. J Mol Microbiol Biotechnol. 2002 Jul; 4(4):375-7. Zhai Y, Saier MH. PMID: 12125818.
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Protein-translocating outer membrane porins of Gram-negative bacteria. Biochim Biophys Acta. 2002 May 03; 1562(1-2):6-31. Yen MR, Peabody CR, Partovi SM, Zhai Y, Tseng YH, Saier MH. PMID: 11988218.
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Overexpression of the Escherichia coli sugE gene confers resistance to a narrow range of quaternary ammonium compounds. J Bacteriol. 2002 May; 184(9):2543-5. Chung YJ, Saier MH. PMID: 11948170; PMCID: PMC135002.
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Sec61beta--a component of the archaeal protein secretory system. Trends Biochem Sci. 2002 Apr; 27(4):170-1. Kinch LN, Saier MH, Grishin NV. PMID: 11943537.
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Voltage-gated H+ channels associated with human phagocyte superoxide-generating NADPH oxidases: sequence comparisons, structural predictions, and phylogenetic analyses. Mol Membr Biol. 2002 Apr-Jun; 19(2):137-47. Kimball RA, Saier MH. PMID: 12126231.
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Sequence and phylogenetic analyses of the twin-arginine targeting (Tat) protein export system. Arch Microbiol. 2002 Jun; 177(6):441-50. Yen MR, Tseng YH, Nguyen EH, Wu LF, Saier MH. PMID: 12029389.
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Regulation of carbon utilization by sulfur availability in Escherichia coli and Salmonella typhimurium. Microbiology (Reading). 2002 Jan; 148(Pt 1):123-131. Quan JA, Schneider BL, Paulsen IT, Yamada M, Kredich NM, Saier MH. PMID: 11782505.
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The ubiquitous ThrE family of putative transmembrane amino acid efflux transporters. Res Microbiol. 2002 Jan-Feb; 153(1):19-25. Yen MR, Tseng YH, Simic P, Sahm H, Eggeling L, Saier MH. PMID: 11881894.
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The transporter classification (TC) system, 2002. Crit Rev Biochem Mol Biol. 2002; 37(5):287-337. Busch W, Saier MH. PMID: 12449427.
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The EcoCyc Database. Nucleic Acids Res. 2002 Jan 01; 30(1):56-8. Karp PD, Riley M, Saier M, Paulsen IT, Collado-Vides J, Paley SM, Pellegrini-Toole A, Bonavides C, Gama-Castro S. PMID: 11752253; PMCID: PMC99147.
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Transport capabilities encoded within the Bacillus subtilis genome. J Mol Microbiol Biotechnol. 2002 Jan; 4(1):37-67. Saier MH, Goldman SR, Maile RR, Moreno MS, Weyler W, Yang N, Paulsen IT. PMID: 11763970.
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A web-based Tree View (TV) program for the visualization of phylogenetic trees. J Mol Microbiol Biotechnol. 2002 Jan; 4(1):69-70. Zhai Y, Tchieu J, Saier MH. PMID: 11763971.
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Hyperstructures, genome analysis and I-cells. Acta Biotheor. 2002; 50(4):357-73. Amar P, Ballet P, Barlovatz-Meimon G, Benecke A, Bernot G, Bouligand Y, Bourguine P, Delaplace F, Delosme JM, Demarty M, Fishov I, Fourmentin-Guilbert J, Fralick J, Giavitto JL, Gleyse B, Godin C, Incitti R, Képès F, Lange C, Le Sceller L, Loutellier C, Michel O, Molina F, Monnier C, Natowicz R, Norris V, Orange N, Pollard H, Raine D, Ripoll C, Rouviere-Yaniv J, Saier M, Soler P, Tambourin P, Thellier M, Tracqui P, Ussery D, Vincent JC, Vannier JP, Wiggins P, Zemirline A. PMID: 12675536.
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Conjugal type IV macromolecular transfer systems of Gram-negative bacteria: organismal distribution, structural constraints and evolutionary conclusions. Microbiology (Reading). 2001 Dec; 147(Pt 12):3201-14. Cao TB, Saier MH. PMID: 11739753.
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Phylogenetic and structural analyses of the oxa1 family of protein translocases. FEMS Microbiol Lett. 2001 Nov 13; 204(2):223-31. Yen MR, Harley KT, Tseng YH, Saier MH. PMID: 11731127.
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Maize Yellow Stripe1, an iron-phytosiderophore uptake transporter, is a member of the oligopeptide transporter (OPT) family. Microbiology (Reading). 2001 Nov; 147(Pt 11):2881-3. Yen MR, Tseng YH, Saier MH. PMID: 11700339.
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A web-based program (WHAT) for the simultaneous prediction of hydropathy, amphipathicity, secondary structure and transmembrane topology for a single protein sequence. J Mol Microbiol Biotechnol. 2001 Oct; 3(4):501-2. Zhai Y, Saier MH. PMID: 11545267.
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The complete phosphotransferase system in Escherichia coli. J Mol Microbiol Biotechnol. 2001 Jul; 3(3):329-46. Tchieu JH, Norris V, Edwards JS, Saier MH. PMID: 11361063.
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An evolutionary alternative system for aryl beta-glucosides assimilation in bacteria. J Mol Microbiol Biotechnol. 2001 Jul; 3(3):467-70. Faure D, Saier MH, Vanderleyden J. PMID: 11361080.
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The drug/metabolite transporter superfamily. Eur J Biochem. 2001 Jul; 268(13):3620-39. Jack DL, Yang NM, Saier MH. PMID: 11432728.
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The bacterial phosphotransferase system: structure, function, regulation and evolution. J Mol Microbiol Biotechnol. 2001 Jul; 3(3):325-7. Saier MH. PMID: 11361062.
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Phylogeny of multidrug transporters. Semin Cell Dev Biol. 2001 Jun; 12(3):205-13. Saier MH, Paulsen IT. PMID: 11428913.
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NMR structure of cysteinyl-phosphorylated enzyme IIB of the N,N'-diacetylchitobiose-specific phosphoenolpyruvate-dependent phosphotransferase system of Escherichia coli. J Mol Biol. 2001 May 18; 308(5):993-1009. Ab E, Schuurman-Wolters GK, Nijlant D, Dijkstra K, Saier MH, Robillard GT, Scheek RM. PMID: 11352587.
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Genes involved in control of galactose uptake in Lactobacillus brevis and reconstitution of the regulatory system in Bacillus subtilis. J Bacteriol. 2001 May; 183(10):3224-36. Djordjevic GM, Tchieu JH, Saier MH. PMID: 11325952; PMCID: PMC95224.
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Homologues of archaeal rhodopsins in plants, animals and fungi: structural and functional predications for a putative fungal chaperone protein. Biochim Biophys Acta. 2001 Apr 02; 1511(2):206-23. Zhai Y, Heijne WH, Smith DW, Saier MH. PMID: 11286964.
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Comparative genomics of microbial drug efflux systems. J Mol Microbiol Biotechnol. 2001 Apr; 3(2):145-50. Paulsen IT, Chen J, Nelson KE, Saier MH. PMID: 11321566.
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A web-based program for the prediction of average hydropathy, average amphipathicity and average similarity of multiply aligned homologous proteins. J Mol Microbiol Biotechnol. 2001 Apr; 3(2):285-6. Zhai Y, Saier MH. PMID: 11321584.
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Catabolite repression mediated by the CcpA protein in Bacillus subtilis: novel modes of regulation revealed by whole-genome analyses. Mol Microbiol. 2001 Mar; 39(5):1366-81. Moreno MS, Schneider BL, Maile RR, Weyler W, Saier MH. PMID: 11251851.
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SMR-type multidrug resistance pumps. Curr Opin Drug Discov Devel. 2001 Mar; 4(2):237-45. Chung YJ, Saier MH. PMID: 11378963.
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Size comparisons among integral membrane transport protein homologues in bacteria, Archaea, and Eucarya. J Bacteriol. 2001 Feb; 183(3):1012-21. Chung YJ, Krueger C, Metzgar D, Saier MH. PMID: 11208800; PMCID: PMC94969.
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Evolution of transport proteins. Genet Eng (N Y). 2001; 23:1-10. Saier MH. PMID: 11570098.
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Whole genome analyses of transporters in spirochetes: Borrelia burgdorferi and Treponema pallidum. J Mol Microbiol Biotechnol. 2000 Oct; 2(4):393-9. Saier MH, Paulsen IT. PMID: 11075911.
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GRASP-DNA: a web application to screen prokaryotic genomes for specific DNA-binding sites and repeat motifs. J Mol Microbiol Biotechnol. 2000 Oct; 2(4):495-500. Schilling CH, Held L, Torre M, Saier MH. PMID: 11075923.
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Functional genomic studies of dihydroxyacetone utilization in Escherichia coli. Microbiology (Reading). 2000 Oct; 146 ( Pt 10):2343-2344. Paulsen IT, Reizer J, Jin RZ, Lin ECC, Saier MH. PMID: 11021910.
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The amoebapore superfamily. Biochim Biophys Acta. 2000 Sep 18; 1469(2):87-99. Zhai Y, Saier MH. PMID: 10998571.
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Vectorial metabolism and the evolution of transport systems. J Bacteriol. 2000 Sep; 182(18):5029-35. Saier MH. PMID: 10960084; PMCID: PMC94648.
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Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31; 406(6799):959-64. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV. PMID: 10984043.
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Microbial genome analyses: comparative transport capabilities in eighteen prokaryotes. J Mol Biol. 2000 Aug 04; 301(1):75-100. Paulsen IT, Nguyen L, Sliwinski MK, Rabus R, Saier MH. PMID: 10926494.
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Families of transmembrane transporters selective for amino acids and their derivatives. Microbiology (Reading). 2000 Aug; 146 ( Pt 8):1775-1795. Saier MH. PMID: 10931885.
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The amino acid/polyamine/organocation (APC) superfamily of transporters specific for amino acids, polyamines and organocations. Microbiology (Reading). 2000 Aug; 146 ( Pt 8):1797-1814. Jack DL, Paulsen IT, Saier MH. PMID: 10931886.
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Families of proteins forming transmembrane channels. J Membr Biol. 2000 Jun 01; 175(3):165-80. Saier MH. PMID: 10833527.
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A functional-phylogenetic classification system for transmembrane solute transporters. Microbiol Mol Biol Rev. 2000 Jun; 64(2):354-411. Saier MH. PMID: 10839820; PMCID: PMC98997.
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Phylogenetic analyses of the constituents of Type III protein secretion systems. J Mol Microbiol Biotechnol. 2000 Apr; 2(2):125-44. Nguyen L, Paulsen IT, Tchieu J, Hueck CJ, Saier MH. PMID: 10939240.
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A novel ubiquitous family of putative efflux transporters. J Mol Microbiol Biotechnol. 2000 Apr; 2(2):195-8. Harley KT, Saier MH. PMID: 10939244.
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A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins. J Bacteriol. 2000 Apr; 182(8):2311-3. Jack DL, Storms ML, Tchieu JH, Paulsen IT, Saier MH. PMID: 10735877; PMCID: PMC111283.
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Membrane-fusion protein homologues in gram-positive bacteria. Mol Microbiol. 2000 Apr; 36(2):516-7. Harley KT, Djordjevic GM, Tseng TT, Saier MH. PMID: 10792737.
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Families of transmembrane sugar transport proteins. Mol Microbiol. 2000 Feb; 35(4):699-710. Saier MH. PMID: 10692148.
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The EcoCyc and MetaCyc databases. Nucleic Acids Res. 2000 Jan 01; 28(1):56-9. Karp PD, Riley M, Saier M, Paulsen IT, Paley SM, Pellegrini-Toole A. PMID: 10592180; PMCID: PMC102475.
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Novel phosphotransferase system genes revealed by genome analysis - the complete complement of PTS proteins encoded within the genome of Bacillus subtilis. Microbiology (Reading). 1999 Dec; 145 ( Pt 12):3419-3429. Reizer J, Bachem S, Reizer A, Arnaud M, Saier MH, Stülke J. PMID: 10627040.
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TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters. Microbiology (Reading). 1999 Dec; 145 ( Pt 12):3431-3445. Rabus R, Jack DL, Kelly DJ, Saier MH. PMID: 10627041.
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New glycoprotein-associated amino acid transporters. J Membr Biol. 1999 Dec 01; 172(3):181-92. Verrey F, Jack DL, Paulsen IT, Saier MH, Pfeiffer R. PMID: 10568788.
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Paralogous genes encoding transport proteins in microbial genomes. Res Microbiol. 1999 Nov-Dec; 150(9-10):689-99. Saier MH, Paulsen IT. PMID: 10673007.
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The major facilitator superfamily. J Mol Microbiol Biotechnol. 1999 Nov; 1(2):257-79. Saier MH, Beatty JT, Goffeau A, Harley KT, Heijne WH, Huang SC, Jack DL, Jähn PS, Lew K, Liu J, Pao SS, Paulsen IT, Tseng TT, Virk PS. PMID: 10943556.
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Modular assembly of voltage-gated channel proteins: a sequence analysis and phylogenetic study. J Mol Microbiol Biotechnol. 1999 Nov; 1(2):281-7. Nelson RD, Kuan G, Saier MH, Montal M. PMID: 10943557.
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Novel phosphotransferase systems revealed by bacterial genome analysis: the complete repertoire of pts genes in Pseudomonas aeruginosa. J Mol Microbiol Biotechnol. 1999 Nov; 1(2):289-93. Reizer J, Reizer A, Lagrou MJ, Folger KR, Stover CK, Saier MH. PMID: 10943558.
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The LysE superfamily: topology of the lysine exporter LysE of Corynebacterium glutamicum, a paradyme for a novel superfamily of transmembrane solute translocators. J Mol Microbiol Biotechnol. 1999 Nov; 1(2):327-36. Vrljic M, Garg J, Bellmann A, Wachi S, Freudl R, Malecki MJ, Sahm H, Kozina VJ, Eggeling L, Saier MH, Eggeling L, Saier MH. PMID: 10943564.
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Genome archeology leading to the characterization and classification of transport proteins. Curr Opin Microbiol. 1999 Oct; 2(5):555-61. Saier MH. PMID: 10508720.
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Enzyme I(Ntr) from Escherichia coli. A novel enzyme of the phosphoenolpyruvate-dependent phosphotransferase system exhibiting strict specificity for its phosphoryl acceptor, NPr. J Biol Chem. 1999 Sep 10; 274(37):26185-91. Rabus R, Reizer J, Paulsen I, Saier MH. PMID: 10473571.
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Is FatP a long-chain fatty acid transporter? Mol Microbiol. 1999 Aug; 33(3):670-2. Saier MH, Kollman JM. PMID: 10417658.
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The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins. J Mol Microbiol Biotechnol. 1999 Aug; 1(1):107-25. Tseng TT, Gratwick KS, Kollman J, Park D, Nies DH, Goffeau A, Saier MH. PMID: 10941792.
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The Escherichia coli ABC transporters: an update. Mol Microbiol. 1999 May; 32(4):887-9. Dassa E, Hofnung M, Paulsen IT, Saier MH. PMID: 10361292.
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A hybrid response regulator possessing a PEP-dependent phosphorylation domain. Microbiology (Reading). 1999 May; 145 ( Pt 5):987-989. Reizer J, Schneider B, Reizer A, Saier MH. PMID: 10376812.
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Mutations that confer resistance to 2-deoxyglucose reduce the specific activity of hexokinase from Myxococcus xanthus. J Bacteriol. 1999 Apr; 181(7):2225-35. Youderian P, Lawes MC, Creighton C, Cook JC, Saier MH. PMID: 10094702; PMCID: PMC93637.
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Flexible programs for the prediction of average amphipathicity of multiply aligned homologous proteins: application to integral membrane transport proteins. Mol Membr Biol. 1999 Apr-Jun; 16(2):173-9. Le T, Tseng TT, Saier MH. PMID: 10417982.
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Metabolite-induced metabolons: the activation of transporter-enzyme complexes by substrate binding. Mol Microbiol. 1999 Mar; 31(5):1592-5. Norris V, Gascuel P, Guespin-Michel J, Ripoll C, Saier MH. PMID: 10200976.
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Phylogenetic characterization of novel transport protein families revealed by genome analyses. Biochim Biophys Acta. 1999 Feb 25; 1422(1):1-56. Saier MH, Eng BH, Fard S, Garg J, Haggerty DA, Hutchinson WJ, Jack DL, Lai EC, Liu HJ, Nusinew DP, Omar AM, Pao SS, Paulsen IT, Quan JA, Sliwinski M, Tseng TT, Wachi S, Young GB. PMID: 10082980.
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The amino acid/auxin:proton symport permease family. Biochim Biophys Acta. 1999 Jan 08; 1415(2):306-22. Young GB, Jack DL, Smith DW, Saier MH. PMID: 9889387.
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A functional-phylogenetic system for the classification of transport proteins. J Cell Biochem. 1999; Suppl 32-33:84-94. Saier MH. PMID: 10629107.
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Eukaryotic transmembrane solute transport systems. Int Rev Cytol. 1999; 190:61-136. Saier MH. PMID: 10331239.
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Phylogenetic analyses of proton-translocating transhydrogenases. Microb Comp Genomics. 1999; 4(3):173-86. Studley WK, Yamaguchi M, Hatefi Y, Saier MH. PMID: 10587945.
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CHR, a novel family of prokaryotic proton motive force-driven transporters probably containing chromate/sulfate antiporters. J Bacteriol. 1998 Nov; 180(21):5799-802. Nies DH, Koch S, Wachi S, Peitzsch N, Saier MH. PMID: 9791139; PMCID: PMC107648.
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Sequence analyses and phylogenetic characterization of the ZIP family of metal ion transport proteins. J Membr Biol. 1998 Nov 01; 166(1):1-7. Eng BH, Guerinot ML, Eide D, Saier MH. PMID: 9784581.
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Unique regulation of carbohydrate chemotaxis in Bacillus subtilis by the phosphoenolpyruvate-dependent phosphotransferase system and the methyl-accepting chemotaxis protein McpC. J Bacteriol. 1998 Sep; 180(17):4475-80. Garrity LF, Schiel SL, Merrill R, Reizer J, Saier MH, Ordal GW. PMID: 9721285; PMCID: PMC107457.
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Genome sequencing and informatics: new tools for biochemical discoveries. Plant Physiol. 1998 Aug; 117(4):1129-33. Saier MH. PMID: 9701568; PMCID: PMC1539184.
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Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae. FEBS Lett. 1998 Jun 23; 430(1-2):116-25. Paulsen IT, Sliwinski MK, Nelissen B, Goffeau A, Saier MH. PMID: 9678606.
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The glucitol permease of Escherichia coli: a tripartite permease of the phosphotransferase system. Microbiology (Reading). 1998 Jun; 144(6):1463-1464. Reizer J, Reizer A, Yamada M, Saier MH. PMID: 33789396.
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The three-dimensional structure of the nitrogen regulatory protein IIANtr from Escherichia coli. J Mol Biol. 1998 May 29; 279(1):245-55. Bordo D, van Monfort RL, Pijning T, Kalk KH, Reizer J, Saier MH, Dijkstra BW. PMID: 9636714.
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High-resolution solution structure of Bacillus subtilis IIAglc. Proteins. 1998 May 15; 31(3):258-70. Chen Y, Case DA, Reizer J, Saier MH, Wright PE. PMID: 9593197.
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Microbial genome analyses: global comparisons of transport capabilities based on phylogenies, bioenergetics and substrate specificities. J Mol Biol. 1998 Apr 03; 277(3):573-92. Paulsen IT, Sliwinski MK, Saier MH. PMID: 9533881.
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Multiple mechanisms controlling carbon metabolism in bacteria. Biotechnol Bioeng. 1998 Apr 20-May 5; 58(2-3):170-4. Saier MH. PMID: 10191387.
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Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria. FASEB J. 1998 Mar; 12(3):265-74. Saier MH, Paulsen IT, Sliwinski MK, Pao SS, Skurray RA, Nikaido H. PMID: 9506471.
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A novel protein kinase that controls carbon catabolite repression in bacteria. Mol Microbiol. 1998 Mar; 27(6):1157-69. Reizer J, Hoischen C, Titgemeyer F, Rivolta C, Rabus R, Stülke J, Karamata D, Saier MH, Hillen W. PMID: 9570401.
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Major facilitator superfamily. Microbiol Mol Biol Rev. 1998 Mar; 62(1):1-34. Pao SS, Paulsen IT, Saier MH. PMID: 9529885; PMCID: PMC98904.
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CcpB, a novel transcription factor implicated in catabolite repression in Bacillus subtilis. J Bacteriol. 1998 Feb; 180(3):491-7. Chauvaux S, Paulsen IT, Saier MH. PMID: 9457849; PMCID: PMC106913.
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Characterization of glucose-specific catabolite repression-resistant mutants of Bacillus subtilis: identification of a novel hexose:H+ symporter. J Bacteriol. 1998 Feb; 180(3):498-504. Paulsen IT, Chauvaux S, Choi P, Saier MH. PMID: 9457850; PMCID: PMC106914.
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Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya. Adv Microb Physiol. 1998; 40:81-136. Saier MH. PMID: 9889977.
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Demonstration of protein-protein interaction specificity by NMR chemical shift mapping. Protein Sci. 1997 Dec; 6(12):2624-7. Rajagopal P, Waygood EB, Reizer J, Saier MH, Klevit RE. PMID: 9416611; PMCID: PMC2143627.
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A family of gram-negative bacterial outer membrane factors that function in the export of proteins, carbohydrates, drugs and heavy metals from gram-negative bacteria. FEMS Microbiol Lett. 1997 Nov 01; 156(1):1-8. Paulsen IT, Park JH, Choi PS, Saier MH. PMID: 9368353.
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Is the ribulose monophosphate pathway widely distributed in bacteria? Microbiology (Reading). 1997 Aug; 143 ( Pt 8):2519-2520. Reizer J, Reizer A, Saier MH. PMID: 9274005.
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Computer-based analyses of the protein constituents of transport systems catalysing export of complex carbohydrates in bacteria. Microbiology (Reading). 1997 Aug; 143 ( Pt 8):2685-2699. Paulsen IT, Beness AM, Saier MH. PMID: 9274022.
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Multiple phosphorylation of SacY, a Bacillus subtilis transcriptional antiterminator negatively controlled by the phosphotransferase system. J Biol Chem. 1997 Jul 04; 272(27):17230-7. Tortosa P, Aymerich S, Lindner C, Saier MH, Reizer J, Le Coq D. PMID: 9202047.
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A novel family of channel-forming, autotransporting, bacterial virulence factors. Mol Membr Biol. 1997 Jul-Sep; 14(3):113-23. Loveless BJ, Saier MH. PMID: 9394291.
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Modular multidomain phosphoryl transfer proteins of bacteria. Curr Opin Struct Biol. 1997 Jun; 7(3):407-15. Reizer J, Saier MH. PMID: 9204284.
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Nonplastid eukaryotic response regulators have a monophyletic origin and evolved from their bacterial precursors in parallel with their cognate sensor kinases. J Mol Evol. 1997 Jun; 44(6):605-13. Pao GM, Saier MH. PMID: 9169552.
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HatA and HatR, implicated in the uptake of inorganic carbon in Synechocystis PCC6803, contain WD40 domains. Mol Microbiol. 1997 Apr; 24(1):229-30. Dagnall BH, Saier MH. PMID: 9140979.
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A novel family of ubiquitous heavy metal ion transport proteins. J Membr Biol. 1997 Mar 15; 156(2):99-103. Paulsen IT, Saier MH. PMID: 9075641.
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Cra-mediated regulation of Escherichia coli adenylate cyclase. Microbiology (Reading). 1997 Mar; 143 ( Pt 3):785-792. Crasnier-Mednansky M, Park MC, Studley WK, Saier MH. PMID: 9084162.
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The structure of an energy-coupling protein from bacteria, IIBcellobiose, reveals similarity to eukaryotic protein tyrosine phosphatases. Structure. 1997 Feb 15; 5(2):217-25. van Montfort RL, Pijning T, Kalk KH, Reizer J, Saier MH, Thunnissen MM, Robillard GT, Dijkstra BW. PMID: 9032081.
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Characterization of a novel transporter family that includes multiple Escherichia coli gluconate transporters and their homologues. FEMS Microbiol Lett. 1997 Feb 15; 147(2):233-8. Peekhaus N, Tong S, Reizer J, Saier MH, Murray E, Conway T. PMID: 9119199.
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The NMR side-chain assignments and solution structure of enzyme IIBcellobiose of the phosphoenolpyruvate-dependent phosphotransferase system of Escherichia coli. Protein Sci. 1997 Feb; 6(2):304-14. Ab E, Schuurman-Wolters G, Reizer J, Saier MH, Dijkstra K, Scheek RM, Robillard GT. PMID: 9041631; PMCID: PMC2143641.
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A bacterial model system for understanding multi-drug resistance. Microb Drug Resist. 1997; 3(4):289-95. Saier MH, Paulsen IT, Matin A. PMID: 9442481.
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Characterization of a family of bacterial response regulator aspartyl-phosphate (RAP) phosphatases. Microb Comp Genomics. 1997; 2(2):103-11. Reizer J, Reizer A, Perego M, Saier MH. PMID: 9689219.
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Multidrug-resistant transport proteins in yeast: complete inventory and phylogenetic characterization of yeast open reading frames with the major facilitator superfamily. Yeast. 1997 Jan; 13(1):43-54. Goffeau A, Park J, Paulsen IT, Jonniaux JL, Dinh T, Mordant P, Saier MH. PMID: 9046086.
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Novel phosphotransferase-encoding genes revealed by analysis of the Escherichia coli genome: a chimeric gene encoding an Enzyme I homologue that possesses a putative sensory transduction domain. Gene. 1996 Nov 28; 181(1-2):103-8. Reizer J, Reizer A, Merrick MJ, Plunkett G, Rose DJ, Saier MH. PMID: 8973315.
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L-histidinol selectively modulates daunomycin toxicity in normal and tumorigenic kidney epithelial cells. Anticancer Res. 1996 Nov-Dec; 16(6B):3629-33. Warrington RC, Fang WD, Zhang L, Shieh M, Saier MH. PMID: 9042233.
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Proposed topology of the glucitol permeases of Escherichia coli and Clostridium acetobutylicum. Curr Microbiol. 1996 Nov; 33(5):331-3. Reizer J, Mitchell WJ, Minton N, Brehm J, Reizer A, Saier MH. PMID: 8875915.
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Mimetics of L-histidinol which selectively modulate daunomycin toxicity in normal and tumorigenic epithelial cells. Anticancer Res. 1996 Nov-Dec; 16(6B):3635-9. Warrington RC, Fang WD, Zhang L, Shieh M, Saier MH. PMID: 9042234.
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Cooperative interaction between Cra and Fnr in the regulation of the cydAB operon of Escherichia coli. Curr Microbiol. 1996 Oct; 33(4):270-4. Ramseier TM, Chien SY, Saier MH. PMID: 8824175.
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Involvement of the central loop of the lactose permease of Escherichia coli in its allosteric regulation by the glucose-specific enzyme IIA of the phosphoenolpyruvate-dependent phosphotransferase system. J Bacteriol. 1996 Oct; 178(20):6082-6. Hoischen C, Levin J, Pitaknarongphorn S, Reizer J, Saier MH. PMID: 8830713; PMCID: PMC178473.
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Phylogenetic characterization of the MIP family of transmembrane channel proteins. J Membr Biol. 1996 Oct; 153(3):171-80. Park JH, Saier MH. PMID: 8849412.
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Plant sucrose:H+ symporters are homologous to the melibiose permease of Escherichia coli. Mol Microbiol. 1996 Oct; 22(2):390-1. Naderi S, Saier MH. PMID: 8930923.
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Catabolite repression resistance of gnt operon expression in Bacillus subtilis conferred by mutation of His-15, the site of phosphoenolpyruvate-dependent phosphorylation of the phosphocarrier protein HPr. J Bacteriol. 1996 Sep; 178(18):5480-6. Reizer J, Bergstedt U, Galinier A, Küster E, Saier MH, Hillen W, Steinmetz M, Deutscher J. PMID: 8808939; PMCID: PMC178371.
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Regulation of competence development and sugar utilization in Haemophilus influenzae Rd by a phosphoenolpyruvate:fructose phosphotransferase system. Mol Microbiol. 1996 Sep; 21(5):941-52. Macfadyen LP, Dorocicz IR, Reizer J, Saier MH, Redfield RJ. PMID: 8885265.
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In vitro reconstitution of transcriptional antitermination by the SacT and SacY proteins of Bacillus subtilis. J Biol Chem. 1996 Aug 02; 271(31):18966-72. Arnaud M, Débarbouillé M, Rapoport G, Saier MH, Reizer J. PMID: 8702561.
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Phylogenetic characterization of the epithelial Na+ channel (ENaC) family. Mol Membr Biol. 1996 Jul-Sep; 13(3):149-57. Le T, Saier MH. PMID: 8905643.
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Regulatory interactions controlling carbon metabolism: an overview. Res Microbiol. 1996 Jul-Sep; 147(6-7):439-47. Saier MH. PMID: 9084753.
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Inducer exclusion and the regulation of sugar transport. Res Microbiol. 1996 Jul-Sep; 147(6-7):482-9. Saier MH, Crasnier M. PMID: 9084759.
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Structural and phylogenetic analysis of the MotA and MotB families of bacterial flagellar motor proteins. Res Microbiol. 1996 Jun; 147(5):317-32. Nguyen CC, Saier MH. PMID: 8763618.
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The catabolite repressor/activator (Cra) protein of enteric bacteria. J Bacteriol. 1996 Jun; 178(12):3411-7. Saier MH, Ramseier TM. PMID: 8655535; PMCID: PMC178107.
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Regulation of sugar uptake via the phosphoenolpyruvate-dependent phosphotransferase systems in Bacillus subtilis and Lactococcus lactis is mediated by ATP-dependent phosphorylation of seryl residue 46 in HPr. J Bacteriol. 1996 Jun; 178(12):3557-63. Ye JJ, Saier MH. PMID: 8655554; PMCID: PMC178126.
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Novel PTS proteins revealed by bacterial genome sequencing: a unique fructose-specific phosphoryl transfer protein with two HPr-like domains in Haemophilus influenzae. Res Microbiol. 1996 May; 147(4):209-15. Reizer J, Reizer A, Saier MH. PMID: 8763608.
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Cyclic AMP-independent catabolite repression in bacteria. FEMS Microbiol Lett. 1996 May 01; 138(2-3):97-103. Saier MH. PMID: 9026456.
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Function of the duplicated IIB domain and oligomeric structure of the fructose permease of Escherichia coli. J Biol Chem. 1996 Apr 26; 271(17):9997-10003. Charbit A, Reizer J, Saier MH. PMID: 8626640.
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Inducer expulsion and the occurrence of an HPr(Ser-P)-activated sugar-phosphate phosphatase in Enterococcus faecalis and Streptococcus pyogenes. Microbiology (Reading). 1996 Mar; 142 ( Pt 3):585-592. Ye JJ, Minarcik J, Saier MH. PMID: 8868433.
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The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs. Mol Microbiol. 1996 Mar; 19(6):1167-75. Paulsen IT, Skurray RA, Tam R, Saier MH, Turner RJ, Weiner JH, Goldberg EB, Grinius LL. PMID: 8730859.
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sigma54-dependent transcription of the Pseudomonas putida xylS operon is influenced by the IIANtr protein of the phosphotransferase system in Escherichia coli. Res Microbiol. 1996 Mar-Apr; 147(3):129-32. Du Y, Holtel A, Reizer J, Saier MH. PMID: 8761731.
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Phylogenetic, structural and functional characteristics of the Na-K-Cl cotransporter family. J Membr Biol. 1996 Feb; 149(3):161-8. Park JH, Saier MH. PMID: 8801348.
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Novel phosphotransferase genes revealed by bacterial genome sequencing: a gene cluster encoding a putative N-acetylgalactosamine metabolic pathway in Escherichia coli. Microbiology (Reading). 1996 Feb; 142 ( Pt 2):231-250. Reizer J, Ramseier TM, Reizer A, Charbit A, Saier MH. PMID: 8932697.
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Identification of a site in the phosphocarrier protein, HPr, which influences its interactions with sugar permeases of the bacterial phosphotransferase system: kinetic analyses employing site-specific mutants. J Bacteriol. 1996 Feb; 178(4):1126-33. Koch S, Sutrina SL, Wu LF, Reizer J, Schnetz K, Rak B, Saier MH. PMID: 8576048; PMCID: PMC177775.
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Catabolite repression and inducer control in Gram-positive bacteria. Microbiology (Reading). 1996 Feb; 142 ( Pt 2):217-230. Saier MH, Chauvaux S, Cook GM, Deutscher J, Paulsen IT, Reizer J, Ye JJ. PMID: 8932696.
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Frur mediates catabolite activation of pyruvate kinase (pykF) gene expression in Escherichia coli. J Bacteriol. 1996 Jan; 178(1):280-3. Bledig SA, Ramseier TM, Saier MH. PMID: 8550429; PMCID: PMC177650.
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Identification of an anaerobically induced phosphoenolpyruvate-dependent fructose-specific phosphotransferase system and evidence for the Embden-Meyerhof glycolytic pathway in the heterofermentative bacterium Lactobacillus brevis. J Bacteriol. 1996 Jan; 178(1):314-6. Saier MH, Ye JJ, Klinke S, Nino E. PMID: 8550437; PMCID: PMC177658.
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Phylogenetic approaches to the identification and characterization of protein families and superfamilies. Microb Comp Genomics. 1996; 1(3):129-50. Saier MH. PMID: 9689209.
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Novel phosphotransferase system genes revealed by bacterial genome analysis: the complete complement of pts genes in mycoplasma genitalium. Microb Comp Genomics. 1996; 1(3):151-64. Reizer J, Paulsen IT, Reizer A, Titgemeyer F, Saier MH. PMID: 9689210.
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Phylogenetic analyses of the homologous transmembrane channel-forming proteins of the F0F1-ATPases of bacteria, chloroplasts and mitochondria. Microbiology (Reading). 1996 Jan; 142 ( Pt 1):17-32. Blair A, Ngo L, Park J, Paulsen IT, Saier MH. PMID: 8581162.
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A simple flexible program for the computational analysis of amino acyl residue distribution in proteins: application to the distribution of aromatic versus aliphatic hydrophobic amino acids in transmembrane alpha-helical spanners of integral membrane transport proteins. J Comput Biol. 1996; 3(1):185-90. Tsang S, Saier MH. PMID: 8697235.
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Phylogenetic, structural and functional analyses of the LacI-GalR family of bacterial transcription factors. FEBS Lett. 1995 Dec 18; 377(2):98-102. Nguyen CC, Saier MH. PMID: 8543068.
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Phosphorylation of serine-46 in HPr, a key regulatory protein in bacteria, results in stabilization of its solution structure. Protein Sci. 1995 Dec; 4(12):2478-86. Pullen K, Rajagopal P, Branchini BR, Huffine ME, Reizer J, Saier MH, Scholtz JM, Klevit RE. PMID: 8580838; PMCID: PMC2143046.
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Properties of two sugar phosphate phosphatases from Streptococcus bovis and their potential involvement in inducer expulsion. J Bacteriol. 1995 Dec; 177(23):7007-9. Cook GM, Ye JJ, Russell JB, Saier MH. PMID: 7592500; PMCID: PMC177575.
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Phylogenetic analysis of the putative phosphorylation domain in the pyruvate kinase of Bacillus stearothermophilus. Res Microbiol. 1995 Nov-Dec; 146(9):713-9. Nguyen CC, Saier MH. PMID: 8584793.
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The DAG family of glycosyl hydrolases combines two previously identified protein families. Biochem J. 1995 Oct 01; 311 ( Pt 1):349-50. Dagnall BH, Paulsen IT, Saier MH. PMID: 7575475; PMCID: PMC1136158.
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Regulation of the lactose phosphotransferase system of Streptococcus bovis by glucose: independence of inducer exclusion and expulsion mechanisms. Microbiology (Reading). 1995 Sep; 141 ( Pt 9):2261-9. Cook GM, Kearns DB, Russell JB, Reizer J, Saier MH. PMID: 7496538.
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Glucose metabolism in 'Sphingomonas elodea': pathway engineering via construction of a glucose-6-phosphate dehydrogenase insertion mutant. Microbiology (Reading). 1995 Sep; 141 ( Pt 9):2339-50. Vartak NB, Lin CC, Cleary JM, Fagan MJ, Saier MH. PMID: 7496544.
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cAMP-cAMP receptor protein complex: five binding sites in the control region of the Escherichia coli mannitol operon. Microbiology (Reading). 1995 Aug; 141 ( Pt 8):1901-1907. Ramseier TM, Saier MH. PMID: 7551052.
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Purification and characterization of a small membrane-associated sugar phosphate phosphatase that is allosterically activated by HPr(Ser(P)) of the phosphotransferase system in Lactococcus lactis. J Biol Chem. 1995 Jul 14; 270(28):16740-4. Ye JJ, Saier MH. PMID: 7622485.
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Protein phosphorylation and regulation of carbon metabolism in gram-negative versus gram-positive bacteria. Trends Biochem Sci. 1995 Jul; 20(7):267-71. Saier MH, Chauvaux S, Deutscher J, Reizer J, Ye JJ. PMID: 7667879.
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In vitro binding of the CcpA protein of Bacillus megaterium to cis-acting catabolite responsive elements (CREs) of gram-positive bacteria. FEMS Microbiol Lett. 1995 Jun 15; 129(2-3):207-13. Ramseier TM, Reizer J, Küster E, Hillen W, Saier MH. PMID: 7607401.
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The global regulatory protein FruR modulates the direction of carbon flow in Escherichia coli. Mol Microbiol. 1995 Jun; 16(6):1157-69. Ramseier TM, Bledig S, Michotey V, Feghali R, Saier MH. PMID: 8577250.
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CarRS of Azospirillum brasilense is homologous to a large family of aldehyde dehydrogenases rather than to two-component regulators. Res Microbiol. 1995 Jun; 146(5):425-9. Ramseier TM, Inui M, Saier MH. PMID: 8525059.
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Phylogenetic characterization of the ubiquitous electron transfer flavoprotein families ETF-alpha and ETF-beta. Res Microbiol. 1995 Jun; 146(5):397-404. Tsai MH, Saier MH. PMID: 8525056.
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Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases. Res Microbiol. 1995 May; 146(4):271-8. Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH. PMID: 7569321.
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Allosteric regulation of the glucose:H+ symporter of Lactobacillus brevis: cooperative binding of glucose and HPr(ser-P). J Bacteriol. 1995 Apr; 177(7):1900-2. Ye JJ, Saier MH. PMID: 7896720; PMCID: PMC176825.
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Novel phosphotransferase system genes revealed by bacterial genome analysis--a gene cluster encoding a unique Enzyme I and the proteins of a fructose-like permease system. Microbiology (Reading). 1995 Apr; 141 ( Pt 4):961-71. Reizer J, Reizer A, Saier MH. PMID: 7773398.
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Topological and segmental phylogenetic analyses of the anion exchanger (band 3) family of transporters. Mol Membr Biol. 1995 Apr-Jun; 12(2):193-200. Espanol MJ, Saier MH. PMID: 7795710.
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Differential codon usage: a safeguard against inappropriate expression of specialized genes? FEBS Lett. 1995 Mar 27; 362(1):1-4. Saier MH. PMID: 7535249.
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Novel proteins of the phosphotransferase system encoded within the rpoN operon of Escherichia coli. Enzyme IIANtr affects growth on organic nitrogen and the conditional lethality of an erats mutant. J Biol Chem. 1995 Mar 03; 270(9):4822-39. Powell BS, Court DL, Inada T, Nakamura Y, Michotey V, Cui X, Reizer A, Saier MH, Reizer J. PMID: 7876255.
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Effect of the FruR regulator on transcription of the pts operon in Escherichia coli. J Biol Chem. 1995 Feb 10; 270(6):2489-96. Ryu S, Ramseier TM, Michotey V, Saier MH, Garges S. PMID: 7852310.
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Sorbose-1-P reductase (SorE) and the glucitol-6-P dehydrogenase (SorD) of the Klebsiella pneumoniae L-sorbose operon belong to the zinc-dependent dehydrogenase family and the short chain alcohol dehydrogenase family, respectively. Res Microbiol. 1995 Feb; 146(2):183-4. Reizer J, Reizer A, Saier MH. PMID: 7652212.
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Response regulators of bacterial signal transduction systems: selective domain shuffling during evolution. J Mol Evol. 1995 Feb; 40(2):136-54. Pao GM, Saier MH. PMID: 7699720.
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Cooperative binding of lactose and the phosphorylated phosphocarrier protein HPr(Ser-P) to the lactose/H+ symport permease of Lactobacillus brevis. Proc Natl Acad Sci U S A. 1995 Jan 17; 92(2):417-21. Ye JJ, Saier MH. PMID: 7831302; PMCID: PMC42751.
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Identification and characterization of phosphoenolpyruvate:fructose phosphotransferase systems in three Streptomyces species. Microbiology (Reading). 1995 Jan; 141 ( Pt 1):51-8. Titgemeyer F, Walkenhorst J, Reizer J, Stuiver MH, Cui X, Saier MH. PMID: 7894719.
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Nucleotide sequence of the region between crr and cysM in Salmonella typhimurium: five novel ORFs including one encoding a putative transcriptional regulator of the phosphotransferase system. DNA Seq. 1995; 5(3):145-52. Titgemeyer F, Reizer J, Reizer A, Tang J, Parr TR, Saier MH. PMID: 7612925.
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Regulation of 2-deoxyglucose phosphate accumulation in Lactococcus lactis vesicles by metabolite-activated, ATP-dependent phosphorylation of serine-46 in HPr of the phosphotransferase system. Microbiology (Reading). 1994 Dec; 140 ( Pt 12):3421-9. Ye JJ, Reizer J, Saier MH. PMID: 7881559.
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The N-terminal, putative, mitochondrial targeting domain of the mitochondrial genome maintenance protein (MGM1) in yeast is homologous to the bacterial ribonuclease inhibitor, barstar. Mol Biol Evol. 1994 Nov; 11(6):964-5. Pao GM, Saier MH. PMID: 7815934.
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Bacterial protein kinases that recognize tertiary rather than primary structure? Res Microbiol. 1994 Nov-Dec; 145(9):647-50. Saier MH. PMID: 7746953.
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Evolutionary relationships between sugar kinases and transcriptional repressors in bacteria. Microbiology (Reading). 1994 Sep; 140 ( Pt 9):2349-54. Titgemeyer F, Reizer J, Reizer A, Saier MH. PMID: 7952186.
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Analysis of a cis-active sequence mediating catabolite repression in gram-positive bacteria. Res Microbiol. 1994 Sep; 145(7):503-18. Hueck CJ, Hillen W, Saier MH. PMID: 7855437.
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The bacterial phosphotransferase system: new frontiers 30 years later. Mol Microbiol. 1994 Sep; 13(5):755-64. Saier MH, Reizer J. PMID: 7815935.
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Mechanism of catabolite repression of tryptophanase synthesis in Escherichia coli. Microbiology (Reading). 1994 Aug; 140 ( Pt 8):2125-34. Isaacs H, Chao D, Yanofsky C, Saier MH. PMID: 7921262.
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A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria. J Bacteriol. 1994 Jul; 176(13):3825-31. Dinh T, Paulsen IT, Saier MH. PMID: 8021163; PMCID: PMC205578.
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A functional superfamily of sodium/solute symporters. Biochim Biophys Acta. 1994 Jun 29; 1197(2):133-66. Reizer J, Reizer A, Saier MH. PMID: 8031825.
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Crystallization of enzyme IIB of the cellobiose-specific phosphotransferase system of Escherichia coli. J Mol Biol. 1994 Jun 17; 239(4):588-90. van Montfort RL, Pijning T, Kalk KH, Schuurman-Wolters GK, Reizer J, Saier MH, Robillard G, Dijkstra BW. PMID: 8006971.
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Regulation of the glucose:H+ symporter by metabolite-activated ATP-dependent phosphorylation of HPr in Lactobacillus brevis. J Bacteriol. 1994 Jun; 176(12):3484-92. Ye JJ, Neal JW, Cui X, Reizer J, Saier MH. PMID: 8206825; PMCID: PMC205535.
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Bacterial sensor kinase/response regulator systems: an introduction. Res Microbiol. 1994 Jun-Aug; 145(5-6):349-55. Saier MH. PMID: 7855419.
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Loss of protein kinase-catalyzed phosphorylation of HPr, a phosphocarrier protein of the phosphotransferase system, by mutation of the ptsH gene confers catabolite repression resistance to several catabolic genes of Bacillus subtilis. J Bacteriol. 1994 Jun; 176(11):3336-44. Deutscher J, Reizer J, Fischer C, Galinier A, Saier MH, Steinmetz M. PMID: 8195089; PMCID: PMC205505.
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Response regulators: structure, function and evolution. Res Microbiol. 1994 Jun-Aug; 145(5-6):356-62. Pao GM, Tam R, Lipschitz LS, Saier MH. PMID: 7855420.
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In vitro asymmetric binding of the pleiotropic regulatory protein, FruR, to the ace operator controlling glyoxylate shunt enzyme synthesis. J Biol Chem. 1994 May 27; 269(21):14885-91. Cortay JC, Nègre D, Scarabel M, Ramseier TM, Vartak NB, Reizer J, Saier MH, Cozzone AJ. PMID: 8195118.
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Sequence of the fruB gene of Escherichia coli encoding the diphosphoryl transfer protein (DTP) of the phosphoenolpyruvate: sugar phosphotransferase system. FEMS Microbiol Lett. 1994 May 01; 118(1-2):159-62. Reizer J, Reizer A, Kornberg HL, Saier MH. PMID: 8013873.
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Phylogenetic relationships among bacteriorhodopsins. Res Microbiol. 1994 May; 145(4):273-85. Kuan G, Saier MH. PMID: 7997641.
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A novel zinc-binding motif found in two ubiquitous deaminase families. Protein Sci. 1994 May; 3(5):853-6. Reizer J, Buskirk S, Bairoch A, Reizer A, Saier MH. PMID: 8061614; PMCID: PMC2142716.
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Inhibition of the phosphoenolpyruvate:lactose phosphotransferase system and activation of a cytoplasmic sugar-phosphate phosphatase in Lactococcus lactis by ATP-dependent metabolite-activated phosphorylation of serine 46 in the phosphocarrier protein HPr. J Biol Chem. 1994 Apr 22; 269(16):11837-44. Ye JJ, Reizer J, Cui X, Saier MH. PMID: 8163482.
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Functional characterization of the Escherichia coli glycerol facilitator, GlpF, in Xenopus oocytes. J Biol Chem. 1994 Apr 22; 269(16):11869-72. Maurel C, Reizer J, Schroeder JI, Chrispeels MJ, Saier MH. PMID: 7512955.
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ATP-dependent phosphorylation of serine-46 in the phosphocarrier protein HPr regulates lactose/H+ symport in Lactobacillus brevis. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):3102-6. Ye JJ, Reizer J, Cui X, Saier MH. PMID: 8159711; PMCID: PMC43523.
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Computer-aided analyses of transport protein sequences: gleaning evidence concerning function, structure, biogenesis, and evolution. Microbiol Rev. 1994 Mar; 58(1):71-93. Saier MH. PMID: 8177172; PMCID: PMC372954.
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Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport. Mol Microbiol. 1994 Mar; 11(5):841-7. Saier MH, Tam R, Reizer A, Reizer J. PMID: 8022262.
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Novel phosphotransferase system genes revealed by bacterial genome analysis: unique, putative fructose- and glucoside-specific systems. Protein Sci. 1994 Mar; 3(3):440-50. Reizer J, Michotey V, Reizer A, Saier MH. PMID: 8019415; PMCID: PMC2142697.
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Enzyme IIBcellobiose of the phosphoenol-pyruvate-dependent phosphotransferase system of Escherichia coli: backbone assignment and secondary structure determined by three-dimensional NMR spectroscopy. Protein Sci. 1994 Feb; 3(2):282-90. Ab E, Schuurman-Wolters GK, Saier MH, Reizer J, Jacuinod M, Roepstorff P, Dijkstra K, Scheek RM, Robillard GT. PMID: 8003964; PMCID: PMC2142798.
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Proteins of the phosphoenolpyruvate:sugar phosphotransferase system in Streptomyces: possible involvement in the regulation of antibiotic production. Res Microbiol. 1994 Feb; 145(2):89-92. Titgemeyer F, Walkenhorst J, Cui X, Reizer J, Saier MH. PMID: 8090996.
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The mannitol repressor (MtlR) of Escherichia coli. J Bacteriol. 1994 Feb; 176(3):840-7. Figge RM, Ramseier TM, Saier MH. PMID: 8300537; PMCID: PMC205122.
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Protein uptake into E. coli during Bdellovibrio infection. A process of reverse secretion? FEBS Lett. 1994 Jan 03; 337(1):14-7. Saier MH. PMID: 8276104.
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Regulation of the raffinose permease of Escherichia coli by the glucose-specific enzyme IIA of the phosphoenolpyruvate:sugar phosphotransferase system. J Bacteriol. 1994 Jan; 176(2):543-6. Titgemeyer F, Mason RE, Saier MH. PMID: 8288553; PMCID: PMC205084.
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P-type ATPases of eukaryotes and bacteria: sequence analyses and construction of phylogenetic trees. J Mol Evol. 1994 Jan; 38(1):57-99. Fagan MJ, Saier MH. PMID: 8151716.
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Classification and function prediction of proteins using diagnostic amino acid patterns. Methods Mol Biol. 1994; 25:295-305. Reizer A, Saier MH, Reizer J. PMID: 8004172.
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Convergence and divergence in the evolution of transport proteins. Bioessays. 1994 Jan; 16(1):23-9. Saier MH. PMID: 7511376.
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DNA sequence of a gene in Escherichia coli encoding a putative tripartite transcription factor with receiver, ATPase and DNA binding domains. DNA Seq. 1994; 5(1):17-24. Ramseier TM, Figge RM, Saier MH. PMID: 7894055.
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In vitro binding of the pleiotropic transcriptional regulatory protein, FruR, to the fru, pps, ace, pts and icd operons of Escherichia coli and Salmonella typhimurium. J Mol Biol. 1993 Nov 05; 234(1):28-44. Ramseier TM, Nègre D, Cortay JC, Scarabel M, Cozzone AJ, Saier MH. PMID: 8230205.
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Presence of protein constituents of the gram-positive bacterial phosphotransferase regulatory system in Acholeplasma laidlawii. J Bacteriol. 1993 Oct; 175(20):6599-604. Hoischen C, Dijkstra A, Rottem S, Reizer J, Saier MH. PMID: 8407837; PMCID: PMC206771.
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Expansion of the mitochondrial carrier family. Res Microbiol. 1993 Oct; 144(8):671-2. Kuan J, Saier MH. PMID: 8140286.
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Structural and evolutionary relationships between two families of bacterial extracytoplasmic chaperone proteins which function cooperatively in fimbrial assembly. Res Microbiol. 1993 Sep; 144(7):507-27. Van Rosmalen M, Saier MH. PMID: 7906046.
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Exopolyphosphate phosphatase and guanosine pentaphosphate phosphatase belong to the sugar kinase/actin/hsp 70 superfamily. Trends Biochem Sci. 1993 Jul; 18(7):247-8. Reizer J, Reizer A, Saier MH, Bork P, Sander C. PMID: 8212131.
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Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria. Microbiol Rev. 1993 Jun; 57(2):320-46. Tam R, Saier MH. PMID: 8336670; PMCID: PMC372912.
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A diverse transketolase family that includes the RecP protein of Streptococcus pneumoniae, a protein implicated in genetic recombination. Res Microbiol. 1993 Jun; 144(5):341-7. Reizer J, Reizer A, Bairoch A, Saier MH. PMID: 8248627.
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Identification of a phosphoenolpyruvate:fructose phosphotransferase system (fructose-1-phosphate forming) in Listeria monocytogenes. J Bacteriol. 1993 May; 175(9):2758-61. Mitchell WJ, Reizer J, Herring C, Hoischen C, Saier MH. PMID: 8478337; PMCID: PMC204581.
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Sequence analyses and evolutionary relationships among the energy-coupling proteins Enzyme I and HPr of the bacterial phosphoenolpyruvate: sugar phosphotransferase system. Protein Sci. 1993 Apr; 2(4):506-21. Reizer J, Hoischen C, Reizer A, Pham TN, Saier MH. PMID: 7686067; PMCID: PMC2142364.
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A bacterial periplasmic receptor homologue with catalytic activity: cyclohexadienyl dehydratase of Pseudomonas aeruginosa is homologous to receptors specific for polar amino acids. Res Microbiol. 1993 Mar-Apr; 144(3):165-9. Tam R, Saier MH. PMID: 8210673.
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Mapping of the binding interfaces of the proteins of the bacterial phosphotransferase system, HPr and IIAglc. Biochemistry. 1993 Jan 12; 32(1):32-7. Chen Y, Reizer J, Saier MH, Fairbrother WJ, Wright PE. PMID: 8418852.
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Introduction: protein phosphorylation and signal transduction in bacteria. J Cell Biochem. 1993 Jan; 51(1):1-6. Saier MH. PMID: 8381788.
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Regulatory interactions involving the proteins of the phosphotransferase system in enteric bacteria. J Cell Biochem. 1993 Jan; 51(1):62-8. Saier MH. PMID: 8432744.
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The MIP family of integral membrane channel proteins: sequence comparisons, evolutionary relationships, reconstructed pathway of evolution, and proposed functional differentiation of the two repeated halves of the proteins. Crit Rev Biochem Mol Biol. 1993; 28(3):235-57. Reizer J, Reizer A, Saier MH. PMID: 8325040.
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Characterization of the gcd gene from Escherichia coli K-12 W3110 and regulation of its expression. J Bacteriol. 1993 Jan; 175(2):568-71. Yamada M, Asaoka S, Saier MH, Yamada Y. PMID: 8419307; PMCID: PMC196176.
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The mitochondrial carrier family of transport proteins: structural, functional, and evolutionary relationships. Crit Rev Biochem Mol Biol. 1993; 28(3):209-33. Kuan J, Saier MH. PMID: 8325039.
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A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport. Trends Biochem Sci. 1993 Jan; 18(1):13-20. Marger MD, Saier MH. PMID: 8438231.
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Mammalian integral membrane receptors are homologous to facilitators and antiporters of yeast, fungi, and eubacteria. Protein Sci. 1993 Jan; 2(1):20-30. Reizer J, Finley K, Kakuda D, MacLeod CL, Reizer A, Saier MH. PMID: 8382989; PMCID: PMC2142299.
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Membrane insertion of the mannitol permease of Escherichia coli occurs under conditions of impaired SecA function. J Biol Chem. 1992 Dec 05; 267(34):24523-32. Werner PK, Saier MH, Müller M. PMID: 1447197.
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Structural and evolutionary relationships among the immunophilins: two ubiquitous families of peptidyl-prolyl cis-trans isomerases. FASEB J. 1992 Dec; 6(15):3410-20. Trandinh CC, Pao GM, Saier MH. PMID: 1464374.
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Transport proteins in bacteria: common themes in their design. Science. 1992 Nov 06; 258(5084):936-42. Nikaido H, Saier MH. PMID: 1279804.
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A new subfamily of bacterial ABC-type transport systems catalyzing export of drugs and carbohydrates. Protein Sci. 1992 Oct; 1(10):1326-32. Reizer J, Reizer A, Saier MH. PMID: 1303751; PMCID: PMC2142109.
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Solution structure of the phosphocarrier protein HPr from Bacillus subtilis by two-dimensional NMR spectroscopy. Protein Sci. 1992 Oct; 1(10):1363-76. Wittekind M, Rajagopal P, Branchini BR, Reizer J, Saier MH, Klevit RE. PMID: 1303754; PMCID: PMC2142093.
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The putative Na+/H+ antiporter (NapA) of Enterococcus hirae is homologous to the putative K+/H+ antiporter (KefC) of Escherichia coli. FEMS Microbiol Lett. 1992 Jul 01; 73(1-2):161-3. Reizer J, Reizer A, Saier MH. PMID: 1325937.
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The bacterial phosphotransferase system as a potential vehicle for the entry of novel antibiotics. Res Microbiol. 1992 Jun; 143(5):443-7. Parr TR, Saier MH. PMID: 1448620.
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A proposed link between nitrogen and carbon metabolism involving protein phosphorylation in bacteria. Protein Sci. 1992 Jun; 1(6):722-6. Reizer J, Reizer A, Saier MH, Jacobson GR. PMID: 1304914; PMCID: PMC2142240.
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Backbone dynamics of the Bacillus subtilis glucose permease IIA domain determined from 15N NMR relaxation measurements. Biochemistry. 1992 May 12; 31(18):4394-406. Stone MJ, Fairbrother WJ, Palmer AG, Reizer J, Saier MH, Wright PE. PMID: 1316146.
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Assignment of the aliphatic 1H and 13C resonances of the Bacillus subtilis glucose permease IIA domain using double- and triple-resonance heteronuclear three-dimensional NMR spectroscopy. Biochemistry. 1992 May 12; 31(18):4413-25. Fairbrother WJ, Palmer AG, Rance M, Reizer J, Saier MH, Wright PE. PMID: 1581296.
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Functional interactions between proteins of the phosphoenolpyruvate:sugar phosphotransferase systems of Bacillus subtilis and Escherichia coli. J Biol Chem. 1992 May 05; 267(13):9158-69. Reizer J, Sutrina SL, Wu LF, Deutscher J, Reddy P, Saier MH. PMID: 1577753.
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Horizontal transfer of a phosphatase gene as evidence for mosaic structure of the Salmonella genome. EMBO J. 1992 Apr; 11(4):1309-16. Groisman EA, Saier MH, Ochman H. PMID: 1339343; PMCID: PMC556579.
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Structure of the histidine-containing phosphocarrier protein HPr from Bacillus subtilis at 2.0-A resolution. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2499-503. Herzberg O, Reddy P, Sutrina S, Saier MH, Reizer J, Kapadia G. PMID: 1549615; PMCID: PMC48686.
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Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system. J Bacteriol. 1992 Mar; 174(5):1433-8. Saier MH, Reizer J. PMID: 1537788; PMCID: PMC206537.
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Properties of phosphorylated protein intermediates of the bacterial phosphoenolpyruvate:sugar phosphotransferase system. Biochem Cell Biol. 1992 Mar-Apr; 70(3-4):242-6. Anderson JW, Waygood EB, Saier MH, Reizer J. PMID: 1515124.
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Possible problems with the protein sequence comparison program FASTA. Trends Biochem Sci. 1992 Feb; 17(2):60. Reizer J, Saier MH, Reizer A. PMID: 1566329.
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Low resolution solution structure of the Bacillus subtilis glucose permease IIA domain derived from heteronuclear three-dimensional NMR spectroscopy. FEBS Lett. 1992 Jan 20; 296(2):148-52. Fairbrother WJ, Gippert GP, Reizer J, Saier MH, Wright PE. PMID: 1733770.
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Effect of Bdellovibrio bacteriovorus infection on the phosphoenolpyruvate:sugar phosphotransferase system in Escherichia coli: evidence for activation of cytoplasmic proteolysis. Res Microbiol. 1992 Jan; 143(1):5-14. Romo AJ, Ruby EG, Saier MH. PMID: 1322553.
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Crystallization and preliminary X-ray analysis of the lactose-specific phosphocarrier protein IIAlac of the phosphoenolpyruvate: sugar phosphotransferase system from Staphylococcus aureus. J Mol Biol. 1991 Dec 20; 222(4):857-9. Celikel R, Dai XP, Stewart GC, Sutrina SL, Saier MH, Xuong NH, Reizer J. PMID: 1762152.
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A multiplicity of potential carbon catabolite repression mechanisms in prokaryotic and eukaryotic microorganisms. New Biol. 1991 Dec; 3(12):1137-47. Saier MH. PMID: 1667478.
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Sequence and evolution of the FruR protein of Salmonella typhimurium: a pleiotropic transcriptional regulatory protein possessing both activator and repressor functions which is homologous to the periplasmic ribose-binding protein. Res Microbiol. 1991 Nov-Dec; 142(9):951-63. Vartak NB, Reizer J, Reizer A, Gripp JT, Groisman EA, Wu LF, Tomich JM, Saier MH. PMID: 1805309.
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Differences in codon usage among genes encoding proteins of different function in Rhodobacter capsulatus. Res Microbiol. 1991 Nov-Dec; 142(9):943-9. Wu LF, Saier MH. PMID: 1805308.
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Crystallization of the IIA domain of the glucose permease of Bacillus subtilis. J Mol Biol. 1991 Oct 20; 221(4):1079-80. Kapadia G, Chen CC, Reddy P, Saier MH, Reizer J, Herzberg O. PMID: 1942043.
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Structure of the IIA domain of the glucose permease of Bacillus subtilis at 2.2-A resolution. Biochemistry. 1991 Oct 08; 30(40):9583-94. Liao DI, Kapadia G, Reddy P, Saier MH, Reizer J, Herzberg O. PMID: 1911744.
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Insertion of the mannitol permease into the membrane of Escherichia coli. Possible involvement of an N-terminal amphiphilic sequence. J Biol Chem. 1991 Sep 25; 266(27):17863-71. Yamada Y, Chang YY, Daniels GA, Wu LF, Tomich JM, Yamada M, Saier MH. PMID: 1917927.
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Evolutionary relationships among the permease proteins of the bacterial phosphoenolpyruvate: sugar phosphotransferase system. Construction of phylogenetic trees and possible relatedness to proteins of eukaryotic mitochondria. J Mol Evol. 1991 Aug; 33(2):179-93. Reizer A, Pao GM, Saier MH. PMID: 1920454.
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Polypeptide backbone resonance assignments and secondary structure of Bacillus subtilis enzyme IIIglc determined by two-dimensional and three-dimensional heteronuclear NMR spectroscopy. Biochemistry. 1991 Jul 16; 30(28):6896-907. Fairbrother WJ, Cavanagh J, Dyson HJ, Palmer AG, Sutrina SL, Reizer J, Saier MH, Wright PE. PMID: 1906345.
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Nucleotide sequence of the Rhodobacter capsulatus fruK gene, which encodes fructose-1-phosphate kinase: evidence for a kinase superfamily including both phosphofructokinases of Escherichia coli. J Bacteriol. 1991 May; 173(10):3117-27. Wu LF, Reizer A, Reizer J, Cai B, Tomich JM, Saier MH. PMID: 1850730; PMCID: PMC207905.
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Analysis of the gluconate (gnt) operon of Bacillus subtilis. Mol Microbiol. 1991 May; 5(5):1081-9. Reizer A, Deutscher J, Saier MH, Reizer J. PMID: 1659648.
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Evolution of the MIP family of integral membrane transport proteins. Mol Microbiol. 1991 Jan; 5(1):33-7. Pao GM, Wu LF, Johnson KD, Höfte H, Chrispeels MJ, Sweet G, Sandal NN, Saier MH. PMID: 2014003.
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Regulation of the maltose transport system of Escherichia coli by the glucose-specific enzyme III of the phosphoenolpyruvate-sugar phosphotransferase system. Characterization of inducer exclusion-resistant mutants and reconstitution of inducer exclusion in proteoliposomes. J Biol Chem. 1990 Dec 05; 265(34):21005-10. Dean DA, Reizer J, Nikaido H, Saier MH. PMID: 2250006.
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Nucleotide sequence of the fruA gene, encoding the fructose permease of the Rhodobacter capsulatus phosphotransferase system, and analyses of the deduced protein sequence. J Bacteriol. 1990 Dec; 172(12):7167-78. Wu LF, Saier MH. PMID: 2254279; PMCID: PMC210842.
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Physiological studies on regulation of glycerol utilization by the phosphoenolpyruvate:sugar phosphotransferase system in Enterococcus faecalis. J Bacteriol. 1990 Dec; 172(12):6741-8. Romano AH, Saier MH, Harriott OT, Reizer J. PMID: 2123855; PMCID: PMC210788.
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The cellobiose permease of Escherichia coli consists of three proteins and is homologous to the lactose permease of Staphylococcus aureus. Res Microbiol. 1990 Nov-Dec; 141(9):1061-7. Reizer J, Reizer A, Saier MH. PMID: 2092358.
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Domain shuffling during evolution of the proteins of the bacterial phosphotransferase system. Res Microbiol. 1990 Nov-Dec; 141(9):1033-8. Saier MH, Reizer J. PMID: 2092356.
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Corrected sequence of the mannitol (mtl) operon in Escherichia coli. Mol Microbiol. 1990 Nov; 4(11):2003-6. Jiang W, Wu LF, Tomich J, Saier MH, Niehaus WG. PMID: 1964486.
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The Na+/pantothenate symporter (PanF) of Escherichia coli is homologous to the Na+/proline symporter (PutP) of E. coli and the Na+/glucose symporters of mammals. Res Microbiol. 1990 Nov-Dec; 141(9):1069-72. Reizer J, Reizer A, Saier MH. PMID: 1965458.
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The glucose permease of Bacillus subtilis is a single polypeptide chain that functions to energize the sucrose permease. J Biol Chem. 1990 Oct 25; 265(30):18581-9. Sutrina SL, Reddy P, Saier MH, Reizer J. PMID: 2120236.
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Regulation of bacterial physiological processes by three types of protein phosphorylating systems. Trends Biochem Sci. 1990 Oct; 15(10):391-5. Saier MH, Wu LF, Reizer J. PMID: 2251731.
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Physiological consequences of the complete loss of phosphoryl-transfer proteins HPr and FPr of the phosphoenolpyruvate:sugar phosphotransferase system and analysis of fructose (fru) operon expression in Salmonella typhimurium. J Bacteriol. 1990 Sep; 172(9):5459-69. Feldheim DA, Chin AM, Nierva CT, Feucht BU, Cao YW, Xu YF, Sutrina SL, Saier MH. PMID: 2203752; PMCID: PMC213213.
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Identification of catalytic residues in the beta-glucoside permease of Escherichia coli by site-specific mutagenesis and demonstration of interdomain cross-reactivity between the beta-glucoside and glucose systems. J Biol Chem. 1990 Aug 15; 265(23):13464-71. Schnetz K, Sutrina SL, Saier MH, Rak B. PMID: 2199437.
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Evolution of permease diversity and energy-coupling mechanisms with special reference to the bacterial phosphotransferase system. Biochim Biophys Acta. 1990 Jul 25; 1018(2-3):248-51. Saier MH, Wu LF, Baker ME, Sweet G, Reizer A, Reizer J. PMID: 2168212.
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On the evolutionary origins of the bacterial phosphoenolpyruvate:sugar phosphotransferase system. Mol Microbiol. 1990 Jul; 4(7):1219-22. Wu LF, Saier MH. PMID: 2172696.
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Structure and evolution of a multidomain multiphosphoryl transfer protein. Nucleotide sequence of the fruB(HI) gene in Rhodobacter capsulatus and comparisons with homologous genes from other organisms. J Mol Biol. 1990 Jun 20; 213(4):687-703. Wu LF, Tomich JM, Saier MH. PMID: 2193161.
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Crystallization of the Bacillus subtilis histidine-containing phosphocarrier protein HPr and of some of its site-directed mutants. J Mol Biol. 1990 Mar 05; 212(1):1-2. Kapadia G, Reizer J, Sutrina SL, Saier MH, Reddy P, Herzberg O. PMID: 2108249.
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Mechanism of sugar transport and phosphorylation via permeases of the bacterial phosphotransferase system: catalytic residues in the beta-glucoside-specific permease as defined by site-specific mutagenesis. Res Microbiol. 1990 Mar-Apr; 141(3):368-74. Sutrina SL, Schnetz K, Rak B, Saier MH. PMID: 2281195.
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Evolution of permease diversity and energy-coupling mechanisms: an introduction. Res Microbiol. 1990 Mar-Apr; 141(3):281-6. Saier MH. PMID: 2281190.
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A common ancestor for bovine lens fiber major intrinsic protein, soybean nodulin-26 protein, and E. coli glycerol facilitator. Cell. 1990 Jan 26; 60(2):185-6. Baker ME, Saier MH. PMID: 2404610.
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Nucleotide sequence and expression of the gutQ gene within the glucitol operon of Escherichia coli. DNA Seq. 1990; 1(2):141-5. Yamada M, Yamada Y, Saier MH. PMID: 2134185.
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Salmonella virulence: new clues to intramacrophage survival. Trends Biochem Sci. 1990 Jan; 15(1):30-3. Groisman EA, Saier MH. PMID: 2180148.
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Common structural changes accompany the functional inactivation of HPr by seryl phosphorylation or by serine to aspartate substitution. Biochemistry. 1989 Dec 26; 28(26):9908-12. Wittekind M, Reizer J, Deutscher J, Saier MH, Klevit RE. PMID: 2515891.
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Metabolite-sensitive, ATP-dependent, protein kinase-catalyzed phosphorylation of HPr, a phosphocarrier protein of the phosphotransferase system in gram-positive bacteria. Biochimie. 1989 Sep-Oct; 71(9-10):989-96. Reizer J, Deutscher J, Saier MH. PMID: 2557095.
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Insertion of proteins into bacterial membranes: mechanism, characteristics, and comparisons with the eucaryotic process. Microbiol Rev. 1989 Sep; 53(3):333-66. Saier MH, Werner PK, Müller M. PMID: 2677637; PMCID: PMC372740.
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Involvement of the bacterial phosphotransferase system in diverse mechanisms of transcriptional regulation. Res Microbiol. 1989 Jul-Aug; 140(6):349-52. Saier MH. PMID: 2616889.
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Mechanistic and physiological consequences of HPr(ser) phosphorylation on the activities of the phosphoenolpyruvate:sugar phosphotransferase system in gram-positive bacteria: studies with site-specific mutants of HPr. EMBO J. 1989 Jul; 8(7):2111-20. Reizer J, Sutrina SL, Saier MH, Stewart GC, Peterkofsky A, Reddy P. PMID: 2507315; PMCID: PMC401104.
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Current studies on the bacterial phosphotransferase system in the Saier laboratory (La Jolla, California, summer, 1988). FEMS Microbiol Rev. 1989 Jun; 5(1-2):183-92. Saier MH. PMID: 2699248.
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Altered transcriptional patterns affecting several metabolic pathways in strains of Salmonella typhimurium which overexpress the fructose regulon. J Bacteriol. 1989 May; 171(5):2424-34. Chin AM, Feldheim DA, Saier MH. PMID: 2496106; PMCID: PMC209917.
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Protein phosphorylation and allosteric control of inducer exclusion and catabolite repression by the bacterial phosphoenolpyruvate: sugar phosphotransferase system. Microbiol Rev. 1989 Mar; 53(1):109-20. Saier MH. PMID: 2651862; PMCID: PMC372719.
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Membrane incorporation and induction of secondary structure of synthetic peptides corresponding to the N-terminal signal sequences of the glucitol and mannitol permeases of Escherichia coli. J Biol Chem. 1989 Feb 15; 264(5):2587-92. Tamm LK, Tomich JM, Saier MH. PMID: 2644265.
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Partial nucleotide sequence of the pts operon in Salmonella typhimurium: comparative analyses in five bacterial genera. Mol Microbiol. 1989 Jan; 3(1):113-8. Schnierow BJ, Yamada M, Saier MH. PMID: 2497295.
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Bacterial proteins with N-terminal leader sequences resembling mitochondrial targeting sequences of eukaryotes. Biochimie. 1988 Dec; 70(12):1743-8. Saier MH, Yamada M, Suda K, Erni B, Rak B, Lengeler J, Stewart GC, Waygood EB, Rapoport G. PMID: 3150678.
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Positive and negative regulators for glucitol (gut) operon expression in Escherichia coli. J Mol Biol. 1988 Oct 05; 203(3):569-83. Yamada M, Saier MH. PMID: 3062173.
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Effects of 5-azacytidine, sodium butyrate, and phorbol esters on amino acid transport system A in a kidney epithelial cell line, MDCK: evidence for multiple mechanisms of regulation. J Cell Physiol. 1988 Oct; 137(1):117-24. Boerner P, Saier MH. PMID: 2459137.
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[Coordinate control of cell growth and transport functions in a kidney cell line]. Naturwissenschaften. 1988 Sep; 75(9):451-7. Saier MH, Deutscher J. PMID: 3226436.
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Neutral amino acid transport systems in animal cells: potential targets of oncogene action and regulators of cellular growth. J Membr Biol. 1988 Aug; 104(1):1-20. Saier MH, Daniels GA, Boerner P, Lin J. PMID: 3054116.
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Statistical and functional analyses of viral and cellular proteins with N-terminal amphipathic alpha-helices with large hydrophobic moments: importance to macromolecular recognition and organelle targeting. J Bacteriol. 1988 May; 170(5):2296-300. Saier MH, McCaldon P. PMID: 3360744; PMCID: PMC211121.
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Nucleotide sequence of the mannitol (mtl) operon in Escherichia coli. Mol Microbiol. 1988 May; 2(3):405-12. Davis T, Yamada M, Elgort M, Saier MH. PMID: 3135464.
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Purification and characterization of the fructose-inducible HPr-like protein, FPr, and the fructose-specific enzyme III of the phosphoenolpyruvate: sugar phosphotransferase system of Salmonella typhimurium. J Biol Chem. 1988 Apr 15; 263(11):5061-9. Sutrina SL, Chin AM, Esch F, Saier MH. PMID: 3281935.
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Properties of a Tn5 insertion mutant defective in the structural gene (fruA) of the fructose-specific phosphotransferase system of Rhodobacter capsulatus and cloning of the fru regulon. J Bacteriol. 1988 Apr; 170(4):1698-703. Daniels GA, Drews G, Saier MH. PMID: 2832374; PMCID: PMC211019.
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Inducer expulsion in Streptococcus pyogenes: properties and mechanism of the efflux reaction. J Bacteriol. 1988 Apr; 170(4):1874-7. Sutrina SL, Reizer J, Saier MH. PMID: 3280553; PMCID: PMC211044.
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Sugar permeases of the bacterial phosphoenolpyruvate-dependent phosphotransferase system: sequence comparisons. FASEB J. 1988 Mar 01; 2(3):199-208. Saier MH, Yamada M, Erni B, Suda K, Lengeler J, Ebner R, Argos P, Rak B, Schnetz K, Lee CA, et al. PMID: 2832233.
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Genetic analyses of the mannitol permease of Escherichia coli: isolation and characterization of a transport-deficient mutant which retains phosphorylation activity. J Bacteriol. 1988 Mar; 170(3):1290-6. Manayan R, Tenn G, Yee HB, Desai JD, Yamada M, Saier MH. PMID: 3277953; PMCID: PMC210905.
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The phosphoenolpyruvate:sugar phosphotransferase system in gram-positive bacteria: properties, mechanism, and regulation. Crit Rev Microbiol. 1988; 15(4):297-338. Reizer J, Saier MH, Deutscher J, Grenier F, Thompson J, Hengstenberg W. PMID: 3060316.
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Regulation of gluconeogenesis by the glucitol enzyme III of the phosphotransferase system in Escherichia coli. J Bacteriol. 1987 Dec; 169(12):5416-22. Yamada M, Feucht BU, Saier MH. PMID: 2824435; PMCID: PMC213966.
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Physical and genetic characterization of the glucitol operon in Escherichia coli. J Bacteriol. 1987 Jul; 169(7):2990-4. Yamada M, Saier MH. PMID: 3036766; PMCID: PMC212338.
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Physiology and biophysics of chloride and cation cotransport across cell membranes. Fed Proc. 1987 May 15; 46(7):2377-94. Lauf PK, McManus TJ, Haas M, Forbush B, Duhm J, Flatman PW, Saier MH, Russell JM. PMID: 3552736.
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Glucitol-specific enzymes of the phosphotransferase system in Escherichia coli. Nucleotide sequence of the gut operon. J Biol Chem. 1987 Apr 25; 262(12):5455-63. Yamada M, Saier MH. PMID: 3553176.
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HPr/HPr-P phosphoryl exchange reaction catalyzed by the mannitol specific enzyme II of the bacterial phosphotransferase system. J Biol Chem. 1987 Feb 25; 262(6):2636-41. Sutrina SL, Waygood EB, Grenier FC, Saier MH. PMID: 3102473.
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Evidence for regulation of gluconeogenesis by the fructose phosphotransferase system in Salmonella typhimurium. J Bacteriol. 1987 Feb; 169(2):897-9. Chin AM, Feucht BU, Saier MH. PMID: 3542978; PMCID: PMC211866.
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Genetic expression of enzyme I activity of the phosphoenolpyruvate:sugar phosphotransferase system in ptsHI deletion strains of Salmonella typhimurium. J Bacteriol. 1987 Feb; 169(2):894-6. Chin AM, Sutrina S, Feldheim DA, Saier MH. PMID: 3542977; PMCID: PMC211865.
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Mechanism and regulation of phosphate transport in Streptococcus pyogenes. J Bacteriol. 1987 Jan; 169(1):297-302. Reizer J, Saier MH. PMID: 3539921; PMCID: PMC211767.
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Polarity of neutral amino acid transport and characterization of a broad specificity transport activity in a kidney epithelial cell line, MDCK. J Biol Chem. 1986 Oct 25; 261(30):13957-62. Boerner P, Evans-Laying M, U HS, Saier MH. PMID: 3771512.
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Sodium entry pathways in renal epithelial cell lines. Miner Electrolyte Metab. 1986; 12(1):42-50. Saier MH, Boerner P, Grenier FC, McRoberts JA, Rindler MJ, Taub M, U HS. PMID: 2421147.
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The bacterial phosphotransferase system: kinetic characterization of the glucose, mannitol, glucitol, and N-acetylglucosamine systems. J Cell Biochem. 1986; 31(2):97-105. Grenier FC, Waygood EB, Saier MH. PMID: 3015992.
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Bacterial phosphotransferase system: regulation of the glucose and mannose enzymes II by sulfhydryl oxidation. Biochemistry. 1985 Aug 27; 24(18):4872-6. Grenier FC, Waygood EB, Saier MH. PMID: 3907693.
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Evidence for covalently cross-linked dimers and trimers of enzyme I of the Escherichia coli phosphotransferase system. J Bacteriol. 1985 Jul; 163(1):243-7. Grenier FC, Reizer J, Waygood EB, Saier MH. PMID: 3891729; PMCID: PMC219104.
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Allosteric regulation of glycerol kinase by enzyme IIIglc of the phosphotransferase system in Escherichia coli and Salmonella typhimurium. J Bacteriol. 1985 May; 162(2):810-6. Novotny MJ, Frederickson WL, Waygood EB, Saier MH. PMID: 2985549; PMCID: PMC218925.
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Identification of the phosphocarrier protein enzyme IIIgut: essential component of the glucitol phosphotransferase system in Salmonella typhimurium. J Bacteriol. 1985 Mar; 161(3):1017-22. Grenier FC, Hayward I, Novotny MJ, Leonard JE, Saier MH. PMID: 3882659; PMCID: PMC215000.
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Adaptive regulatory control of System A transport activity in a kidney epithelial cell line (MDCK) and in a transformed variant (MDCK-T1). J Cell Physiol. 1985 Feb; 122(2):308-15. Boerner P, Saier MH. PMID: 3968188.
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Hormonal regulation of the System A amino acid transport adaptive response mechanism in a kidney epithelial cell line (MDCK). J Cell Physiol. 1985 Feb; 122(2):316-22. Boerner P, Saier MH. PMID: 3881463.
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Characterization of chemically and virally transformed variants of Madin-Darby canine kidney (MDCK) epithelial cells. J Cell Physiol. 1985 Feb; 122(2):299-307. U HS, Boerner P, Rindler MJ, Chuman L, Saier MH. PMID: 2981894.
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Evidence for the evolutionary relatedness of the proteins of the bacterial phosphoenolpyruvate:sugar phosphotransferase system. J Cell Biochem. 1985; 27(1):43-56. Saier MH, Grenier FC, Lee CA, Waygood EB. PMID: 3884637.
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Bacterial phosphotransferase system: regulation of mannitol enzyme II activity by sulfhydryl oxidation. Biochemistry. 1985 Jan 01; 24(1):47-51. Grenier FC, Waygood EB, Saier MH. PMID: 3888258.
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Properties of ATP-dependent protein kinase from Streptococcus pyogenes that phosphorylates a seryl residue in HPr, a phosphocarrier protein of the phosphotransferase system. J Bacteriol. 1984 Oct; 160(1):333-40. Reizer J, Novotny MJ, Hengstenberg W, Saier MH. PMID: 6434522; PMCID: PMC214721.
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Purification and properties of D-mannitol-1-phosphate dehydrogenase and D-glucitol-6-phosphate dehydrogenase from Escherichia coli. J Bacteriol. 1984 Sep; 159(3):986-90. Novotny MJ, Reizer J, Esch F, Saier MH. PMID: 6384188; PMCID: PMC215757.
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Regulation of glycerol uptake by the phosphoenolpyruvate-sugar phosphotransferase system in Bacillus subtilis. J Bacteriol. 1984 Jul; 159(1):243-50. Reizer J, Novotny MJ, Stuiver I, Saier MH. PMID: 6429122; PMCID: PMC215620.
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Genetic evidence for glucitol-specific enzyme III, an essential phosphocarrier protein of the Salmonella typhimurium glucitol phosphotransferase system. J Bacteriol. 1984 Mar; 157(3):953-5. Sarno MV, Tenn LG, Desai A, Chin AM, Grenier FC, Saier MH. PMID: 6365895; PMCID: PMC215355.
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Mechanism, regulation and physiological significance of the loop diuretic-sensitive NaCl/KCl symport system in animal cells. Mol Cell Biochem. 1984; 59(1-2):11-32. Saier MH, Boyden DA. PMID: 6323961.
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ATP-dependent protein kinase-catalyzed phosphorylation of a seryl residue in HPr, a phosphate carrier protein of the phosphotransferase system in Streptococcus pyogenes. Proc Natl Acad Sci U S A. 1983 Nov; 80(22):6790-4. Deutscher J, Saier MH. PMID: 6359157; PMCID: PMC390071.
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Characterization of low potassium-resistant mutants of the Madin-Darby canine kidney cell line with defects in NaCl/KCl symport. J Biol Chem. 1983 Oct 25; 258(20):12320-6. McRoberts JA, Tran CT, Saier MH. PMID: 6630190.
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Mechanism of inducer expulsion in Streptococcus pyogenes: a two-step process activated by ATP. J Bacteriol. 1983 Oct; 156(1):354-61. Reizer J, Novotny MJ, Panos C, Saier MH. PMID: 6225770; PMCID: PMC215089.
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Involvement of lactose enzyme II of the phosphotransferase system in rapid expulsion of free galactosides from Streptococcus pyogenes. J Bacteriol. 1983 Oct; 156(1):236-42. Reizer J, Saier MH. PMID: 6413489; PMCID: PMC215075.
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Mannitol-specific enzyme II of the bacterial phosphotransferase system. III. The nucleotide sequence of the permease gene. J Biol Chem. 1983 Sep 10; 258(17):10761-7. Lee CA, Saier MH. PMID: 6309813.
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Mannitol-specific enzyme II of the bacterial phosphotransferase system. I. Properties of the purified permease. J Biol Chem. 1983 Sep 10; 258(17):10748-56. Jacobson GR, Lee CA, Leonard JE, Saier MH. PMID: 6350293.
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Mannitol-specific enzyme II of the bacterial phosphotransferase system. II. Reconstitution of vectorial transphosphorylation in phospholipid vesicles. J Biol Chem. 1983 Sep 10; 258(17):10757-60. Leonard JE, Saier MH. PMID: 6350294.
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Cooperative binding of the sugar substrates and allosteric regulatory protein (enzyme IIIGlc of the phosphotransferase system) to the lactose and melibiose permeases in Escherichia coli and Salmonella typhimurium. J Bacteriol. 1983 Sep; 155(3):1351-7. Saier MH, Novotny MJ, Comeau-Fuhrman D, Osumi T, Desai JD. PMID: 6350268; PMCID: PMC217834.
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Loss of the PGE1 requirement for MDCK cell growth associated with a defect in cyclic AMP phosphodiesterase. J Cell Physiol. 1983 Feb; 114(2):153-61. Taub M, Saier MH, Chuman L, Hiller S. PMID: 6185509.
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Use of cloned mtl genes of Escherichia coli to introduce mtl deletion mutations into the chromosome. J Bacteriol. 1983 Feb; 153(2):685-92. Lee CA, Saier MH. PMID: 6401703; PMCID: PMC221685.
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Growth regulation and amino acid transport in epithelial cells: influence of culture conditions and transformation on A, ASC, and L transport activities. J Cell Physiol. 1982 Nov; 113(2):240-6. Boerner P, Saier MH. PMID: 6757258.
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Continuous growth of proximal tubular kidney epithelial cells in hormone-supplemented serum-free medium. J Cell Biol. 1982 Sep; 94(3):506-10. Chuman L, Fine LG, Cohen AH, Saier MH. PMID: 6182146; PMCID: PMC2112226.
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Furosemide-sensitive salt transport in the Madin-Darby canine kidney cell line. Evidence for the cotransport of Na+, K+, and Cl-. J Biol Chem. 1982 Mar 10; 257(5):2260-6. McRoberts JA, Erlinger S, Rindler MJ, Saier MH. PMID: 6277890.
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Physiological desensitization of carbohydrate permeases and adenylate cyclase to regulation by the phosphoenolpyruvate:sugar phosphotransferase system in Escherichia coli and Salmonella typhimurium. Involvement of adenosine cyclic 3',5'-phosphate and inducer. J Biol Chem. 1982 Mar 10; 257(5):2509-17. Saier MH, Keeler DK, Feucht BU. PMID: 6277902.
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(Na+,K+)-cotransport in the Madin-Darby canine kidney cell line. Kinetic characterization of the interaction between Na+ and K+. J Biol Chem. 1982 Mar 10; 257(5):2254-9. Rindler MJ, McRoberts JA, Saier MH. PMID: 6277889.
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Mechanism of regulation of the lactose permease by the phosphotransferase system in Escherichia coli: evidence for protein-protein interaction. Ann Microbiol (Paris). 1982 Mar-Apr; 133(2):269-73. Osumi T, Saier MH. PMID: 7044217.
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Decrease in protein content and cell volume of cultured dog kidney epithelial cells during growth. In Vitro. 1982 Mar; 18(3 Pt 1):196-202. Erlinger SU, Saier MH. PMID: 7129474.
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Regulation of lactose permease activity by the phosphoenolpyruvate:sugar phosphotransferase system: evidence for direct binding of the glucose-specific enzyme III to the lactose permease. Proc Natl Acad Sci U S A. 1982 Mar; 79(5):1457-61. Osumi T, Saier MH. PMID: 7041121; PMCID: PMC345992.
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Studies on growth regulation and the mechanism of transformation of the kidney epithelial cell line, MDCK: importance of transport function to growth. Prog Clin Biol Res. 1982; 91:569-97. Saier MH, Erlinger S, Boerner P. PMID: 7146013.
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Evidence for the functional association of enzyme I and HPr of the phosphoenolpyruvate-sugar phosphotransferase system with the membrane in sealed vesicles of Escherichia coli. J Cell Biochem. 1982; 18(2):231-8. Saier MH, Cox DF, Feucht BU, Novotny MJ. PMID: 7040430.
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Regulation of lactose transport by the phosphoenolpyruvate-sugar phosphotransferase system in membrane vesicles of Escherichia coli. J Cell Biochem. 1982; 18(2):239-44. Dills SS, Schmidt MR, Saier MH. PMID: 7040431.
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Plasmid-directed synthesis of enzymes required for D-mannitol transport and utilization in Escherichia coli. Proc Natl Acad Sci U S A. 1981 Dec; 78(12):7336-40. Lee CA, Jacobson GR, Saier MH. PMID: 6801648; PMCID: PMC349261.
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Evidence for Na+/H+ antiport in cultured dog kidney cells (MDCK). J Biol Chem. 1981 Nov 10; 256(21):10820-5. Rindler MJ, Saier MH. PMID: 7287736.
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Phosphoenolpyruvate-dependent sugar phosphotransferase activity in Megasphaera elsdenii. Can J Microbiol. 1981 Sep; 27(9):949-52. Dills SS, Lee CA, Saier MH. PMID: 7306882.
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Regulation of methyl-beta-d-thiogalactopyranoside-6-phosphate accumulation in Streptococcus lactis by exclusion and expulsion mechanisms. J Bacteriol. 1981 Jun; 146(3):885-94. Thompson J, Saier MH. PMID: 6787017; PMCID: PMC216940.
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Growth and differentiated properties of a kidney epithelial cell line (MDCK). Am J Physiol. 1981 Mar; 240(3):C106-9. Saier MH. PMID: 6259947.
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Genetic dissection of catalytic activities of the Salmonella typhimurium mannitol enzyme II. J Bacteriol. 1981 Feb; 145(2):1106-9. Leonard JE, Saier MH. PMID: 6257647; PMCID: PMC217227.
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Amiloride-resistant Madin-Darby canine kidney (MDCK) cells exhibit decreased cation transport. J Cell Physiol. 1981 Feb; 106(2):191-9. Taub M, Saier MH. PMID: 6260818.
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Alterations in growth requirements of kidney epithelial cells in defined medium associated with malignant transformation. J Supramol Struct Cell Biochem. 1981; 15(1):63-72. Taub M, U B, Chuman L, Rindler MJ, Saier MH, Sato G. PMID: 6265706.
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Vectorial and nonvectorial transphosphorylation catalyzed by enzymes II of the bacterial phosphotransferase system. J Bacteriol. 1981 Jan; 145(1):391-7. Saier MH, Schmidt MR. PMID: 6780516; PMCID: PMC217284.
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Phosphoryl exchange reaction catalyzed by enzyme I of the bacterial phosphoenolpyruvate: sugar phosphotransferase system. Kinetic characterization. J Biol Chem. 1980 Sep 25; 255(18):8579-84. Saier MH, Schmidt MR, Lin P. PMID: 6997300.
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Substrate specificity and kinetic characterization of sugar uptake and phosphorylation, catalyzed by the mannose enzyme II of the phosphotransferase system in Salmonella typhimurium. J Biol Chem. 1980 Sep 25; 255(18):8585-91. Rephaeli AW, Saier MH. PMID: 6997301.
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Carbohydrate transport in bacteria. Microbiol Rev. 1980 Sep; 44(3):385-418. Dills SS, Apperson A, Schmidt MR, Saier MH. PMID: 6999324; PMCID: PMC373186.
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Tight junction formation in the establishment of intramembranous particle polarity in aggregating MDCK cells. Effect of drug treatment. Exp Cell Res. 1980 Jul; 128(1):223-35. Sang UH, Saier MH, Ellisman MH. PMID: 7408983.
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Physiological function of periplasmic hexose phosphatase in Salmonella typhimurium. J Bacteriol. 1980 Mar; 141(3):1474-7. Rephaeli AW, Artenstein IR, Saier MH. PMID: 6245072; PMCID: PMC293865.
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Fine control of adenylate cyclase by the phosphoenolpyruvate:sugar phosphotransferase systems in Escherichia coli and Salmonella typhimurium. J Bacteriol. 1980 Feb; 141(2):603-10. Feucht BU, Saier MH. PMID: 6245052; PMCID: PMC293665.
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Regulation of carbohydrate transport activities in Salmonella typhimurium: use of the phosphoglycerate transport system to energize solute uptake. J Bacteriol. 1980 Feb; 141(2):611-7. Saier MH, Feucht BU. PMID: 6988388; PMCID: PMC293666.
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Regulation of genes coding for enzyme constituents of the bacterial phosphotransferase system. J Bacteriol. 1980 Feb; 141(2):658-63. Rephaeli AW, Saier MH. PMID: 6245053; PMCID: PMC293672.
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Catalytic activities associated with the enzymes II of the bacterial phosphotransferase system. J Supramol Struct. 1980; 14(3):281-94. Saier MH. PMID: 7012451.
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Regulation of 22Na+ transport by calcium in an established kidney epithelial cell line. J Biol Chem. 1979 Nov 25; 254(22):11440-4. Taub M, Saier MH. PMID: 387772.
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Uptake of 22Na+ by cultured dog kidney cells (MDCK). J Biol Chem. 1979 Nov 25; 254(22):11431-9. Rindler MJ, Taub M, Saier MH. PMID: 500650.
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Tight junction formation is closely linked to the polar redistribution of intramembranous particles in aggregating MDCK epithelia. Exp Cell Res. 1979 Sep; 122(2):384-91. Hoi Sang U, Saier MH, Ellisman MH. PMID: 116860.
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Growth of Madin-Darby canine kidney epithelial cell (MDCK) line in hormone-supplemented, serum-free medium. Proc Natl Acad Sci U S A. 1979 Jul; 76(7):3338-42. Taub M, Chuman L, Saier MH, Sato G. PMID: 291007; PMCID: PMC383820.
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Retention of differentiated properties in an established dog kidney epithelial cell line (MDCK). J Cell Biol. 1979 Jun; 81(3):635-48. Rindler MJ, Chuman LM, Shaffer L, Saier MH. PMID: 222773; PMCID: PMC2110404.
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Growth of nontumorigenic cells in Millipore diffusion chambers implanted in mice and implications for in vivo growth regulation. Cancer Res. 1979 May; 39(5):1467-73. Reid LM, Stiles CD, Saier MH, Rindler MJ. PMID: 427791.
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Purification of the mannitol-specific enzyme II of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system. J Biol Chem. 1979 Jan 25; 254(2):249-52. Jacobson GR, Lee CA, Saier MH. PMID: 368051.
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An established but differentiated kidney epithelial cell line (MDCK). Methods Enzymol. 1979; 58:552-60. Taub M, Saier MH. PMID: 218080.
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Kinetic analyses of the sugar phosphate:sugar transphosphorylation reaction catalyzed by the glucose enzyme II complex of the bacterial phosphotransferase system. J Biol Chem. 1978 Nov 10; 253(21):7595-7. Rephaeli AW, Saier MH. PMID: 359550.
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Regulation of adenosine 3':5'-monophosphate efflux from animal cells. J Biol Chem. 1978 Aug 10; 253(15):5431-6. Rindler MJ, Bashor MM, Spitzer N, Saier MH. PMID: 209041.
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Cyclic AMP-dependent synthesis of fimbriae in Salmonella typhimurium: effects of cya and pts mutations. J Bacteriol. 1978 Apr; 134(1):356-8. Saier MH, Schmidt MR, Leibowitz M. PMID: 206537; PMCID: PMC222255.
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Permease-specific mutations in Salmonella typhimurium and Escherichia coli that release the glycerol, maltose, melibiose, and lactose transport systems from regulation by the phosphoenolpyruvate:sugar phosphotransferase system. J Bacteriol. 1978 Mar; 133(3):1358-67. Saier MH, Straud H, Massman LS, Judice JJ, Newman MJ, Feucht BU. PMID: 346569; PMCID: PMC222173.
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Sugar phosphate: sugar transphosphorylation and exchange group translocation catalyzed by the enzyme 11 complexes of the bacterial phosphoenolpyruvate: sugar phosphotransferase system. J Biol Chem. 1977 Dec 25; 252(24):8899-907. Saier MH, Feucht BU, Mora WK. PMID: 336623.
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Properties of a phosphoenolpyruvate: mannitol phosphotransferase system in Spirochaeta aurantia. J Biol Chem. 1977 Dec 25; 252(24):8890-8. Saier MH, Newman MJ, Rephaeli AW. PMID: 925030.
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Sugar phosphate:sugar transphosphorylation coupled to exchange group translocation catalyzed by the enzyme II complexes of the phosphoenolpyruvate:sugar phosphotransferase system in membrane vesicles of Escherichia coli. J Biol Chem. 1977 Dec 25; 252(24):8908-16. Saier MH, Cox DF, Moczydlowski EG. PMID: 336624.
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Bacterial phosphoenolpyruvate: sugar phosphotransferase systems: structural, functional, and evolutionary interrelationships. Bacteriol Rev. 1977 Dec; 41(4):856-71. Saier MH. PMID: 339892; PMCID: PMC414030.
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Phosphoenolpyruvate:sugar phosphotransferase system in Ancalomicrobium adetum. J Bacteriol. 1977 Aug; 131(2):716-8. Saier MH, Staley JT. PMID: 328495; PMCID: PMC235489.
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Phosphoprotein phosphatase activity associated with the cytoplasmic membrane of Salmonella typhimurium and Escherichia coli. J Biol Chem. 1977 Jun 25; 252(12):4416-7. Tuttle RC, Saier MH. PMID: 16933.
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Sugar transport. The crr mutation: its effect on repression of enzyme synthesis. J Biol Chem. 1976 Nov 10; 251(21):6598-605. Saier MH, Roseman S. PMID: 789369.
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Sugar transport. 2nducer exclusion and regulation of the melibiose, maltose, glycerol, and lactose transport systems by the phosphoenolpyruvate:sugar phosphotransferase system. J Biol Chem. 1976 Nov 10; 251(21):6606-15. Saier MH, Roseman S. PMID: 789370.
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Sugar transport. Properties of mutant bacteria defective in proteins of the phosphoenolpyruvate: sugar phosphotransferase system. J Biol Chem. 1976 Nov 10; 251(21):6584-97. Simoni RD, Roseman S, Saier MH. PMID: 789368.
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Regulation of carbohydrate permeases and adenylate cyclase in Escherichia coli. Studies with mutant strains in which enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system is thermolabile. J Biol Chem. 1976 Sep 25; 251(18):5522-7. Castro L, Feucht BU, Morse ML, Saier MH. PMID: 184083.
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Relationship of cell growth behavior in vitro to tumorigenicity in athymic nude mice. Cancer Res. 1976 Sep; 36(9 pt.1):3300-5. Stiles CD, Desmond W, Chuman LM, Sato G, Saier MH. PMID: 975091.
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Effects of crp mutations on adenosine 3',5'-monophosphate metabolism in Salmonella typhimurium. J Bacteriol. 1976 Jul; 127(1):120-7. Rephaeli AW, Saier MH. PMID: 179973; PMCID: PMC233041.
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Direct transfer of the phosphoryl moiety of mannitol 1-phosphate to [14C]mannitol catalyzed by the enzyme II complexes of the phosphoenolpyruvate: mannitol phosphotransferase systems in Spirochaeta aurantia and Salmonella typhimurium. J Biol Chem. 1976 Jun 25; 251(12):3834-7. Saier MH, Newman MJ. PMID: 819432.
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Growth control of heterologous tissue culture cells in the congenitally athymic nude mouse. Cancer Res. 1976 Apr; 36(4):1353-60. Stiles CD, Desmond W, Chuman LM, Sato G, Saier MH. PMID: 1260760.
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Regulation of carbohydrate uptake in gram-positive bacteria. J Biol Chem. 1976 Feb 10; 251(3):893-4. Saier MH, Simoni RD. PMID: 1249061.
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Regulation of carbohydrate uptake and adenylate cyclase activity mediated by the enzymes II of the phosphoenolpyruvate: sugar phosphotransferase system in Escherichia coli. J Biol Chem. 1976 Feb 10; 251(3):883-92. Saier MH, Feucht BU, Hofstadter LJ. PMID: 765335.
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Growth regulation and suppression of metastasis in the congenitally athymic nude mouse. Hamatol Bluttransfus. 1976; 19:185-94. Stiles CD, Roberts PE, Saier MH, Sato G. PMID: 188726.
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Failure of human cells transformed by simian virus 40 to form tumors in athymic nude mice. Proc Natl Acad Sci U S A. 1975 Dec; 72(12):4971-5. Stiles CD, Desmond W, Sato G, Saier MH. PMID: 174085; PMCID: PMC388856.
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Regulation of intracellular adenosine cyclic 3':5'-monophosphate levels in Escherichia coli and Salmonella typhimurium. Evidence for energy-dependent excretion of the cyclic nucleotide. J Biol Chem. 1975 Oct 10; 250(19):7593-601. Saier MH, Feucht BU, McCaman MT. PMID: 170265.
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Coordinate regulation of adenylate cyclase and carbohydrate permeases by the phosphoenolpyruvate:sugar phosphotransferase system in Salmonella typhimurium. J Biol Chem. 1975 Sep 10; 250(17):7078-80. Saier MH, Feucht BU. PMID: 169265.
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Culture techniques and glial-neuronal interrelationships in vitro. Exp Neurol. 1975 Sep; 48(3 pt. 2):135-62. Varon S, Saier M. PMID: 241659.
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A transport system for phosphoenolpyruvate, 2-phosphoglycerate, and 3-phosphoglycerate in Salmonella typhimurium. J Biol Chem. 1975 Jul 10; 250(13):5089-96. Saier MH, Wentzel DL, Feucht BU, Judice JJ. PMID: 238977.
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Regulation of adenosine 3' :5'-monophosphate efflux from rat glioma cells in culture*. J Biol Chem. 1975 Jun 10; 250(11):4371-2. Doore BJ, Bashor MM, Spitzer N, Mawe RC, Saier MH. PMID: 165200.
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Characterization of constitutive galactose permease mutants in Salmonella typhimurium. J Bacteriol. 1973 Jan; 113(1):512-4. Saier MH, Bromberg FG, Roseman S. PMID: 4569699; PMCID: PMC251658.
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Inducer exclusion and repression of enzyme synthesis in mutants of Salmonella typhimurium defective in enzyme I of the phosphoenolpyruvate: sugar phosphotransferase system. J Biol Chem. 1972 Feb 10; 247(3):972-5. Saier MH, Roseman S. PMID: 4550766.
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Phosphoenolpyruvate-dependent fructose phosphorylation in photosynthetic bacteria. J Biol Chem. 1971 Dec 25; 246(24):7819-21. Saier MH, Feucht BU, Roseman S. PMID: 5002684.
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Utilization and transport of hexoses by mutant strains of Salmonella typhimurium lacking enzyme I of the phosphoenolpyruvate-dependent phosphotransferase system. J Biol Chem. 1971 Sep 25; 246(18):5838-40. Saier MH, Young WS, Roseman S. PMID: 4938041.
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The physiological behavior of enzyme I and heat-stable protein mutants of a bacterial phosphotransferase system. J Biol Chem. 1970 Nov 10; 245(21):5870-3. Saier MH, Simoni RD, Roseman S. PMID: 4919491.
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The 6-O-methylglucose-containig lipopolysaccharide of Mycobacterium phlei. Complet structure of the polysaccharide. J Biol Chem. 1968 Aug 25; 243(16):4332-41. Saier MH, Ballou CE. PMID: 5679967.
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The 6-O-methylglucose-containing lipopolysaccharide of Mycobacterium phlei. Structure of the reducing end of the polysaccharide. J Biol Chem. 1968 Aug 25; 243(16):4319-31. Saier MH, Ballou CE. PMID: 5679966.
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The 6-O-methylglucose-containing lipopolysaccharide of Mycobacterium phlei. Identification of D-glyceric acid and 3-O-methyl-D-glucose in the polysaccharide. J Biol Chem. 1968 Mar 10; 243(5):992-1005. Saier MH, Ballou CE. PMID: 4295929.
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Alanine aminotransferase. I. Purification and properties. J Biol Chem. 1967 Jan 10; 242(1):91-100. Saier MH, Jenkins WT. PMID: 6016336.
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Alanine aminotransferase. II. The basis for substrate specificity. J Biol Chem. 1967 Jan 10; 242(1):101-8. Saier MH, Jenkins WT. PMID: 6016324.
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Coccidioidomycosis: case report. Am Pract Dig Treat. 1959 Nov; 10:1948-51. SAIER M. PMID: 14440806.
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Treatment of status asthmaticus complicated by vasomotor collapse. J Allergy. 1959 Jan-Feb; 30(1):61-5. SAIER M, HECKER S, KRUPP M. PMID: 13620446.
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Experience with cortisone and ACTH in a private clinic. Calif Med. 1951 Jul; 75(1):6-10. KRUPP MA, SAIER M, KEDDIE F, TANNER R, SNELL AM. PMID: 14848715; PMCID: PMC1520916.
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