My Bibliography - NCBI

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Li K, Rudy MJ, Klose T, Tan H, Wu X, Demssie HA, Anderson JS, Jadhav P, Zhang QY, Clarke P, Kuhn RJ, Tyler KL, Wang J.
Rational design and in vivo validation of capsid inhibitors for enterovirus D68.
Nat Commun
2026 Feb 10;
17
(1)
doi: 10.1038/s41467-026-69351-x.
PubMed PMID:
41667472
; PubMed Central PMCID:
PMC13039317
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Tan H, Chi X, Deng X, Wang J.
Characterization of the Cross-Resistance of SARS-CoV‑2 Main Protease Inhibitors, Ibuzatrelvir, Ensitrelvir, and Nirmatrelvir.
ACS Pharmacol Transl Sci
2026 Feb 13;
(2)
:404-413
doi: 10.1021/acsptsci.5c00681.
eCollection 2026 Feb 13.
PubMed PMID:
41710745
; PubMed Central PMCID:
PMC12910490
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Cai Z, Kohaal N, Georgiou K, Liang X, Chi X, Tan H, Tan B, Li K, Fan G, Lambrinidis G, Kolocouris A, Deng X, Chen Y, Wang J.
Structure-Based Design of Covalent SARS-CoV‑2 Main Protease Inhibitors Targeting the Nirmatrelvir-Resistant E166 Mutants.
JACS Au
2026 Jan 26;
(1)
:233-244
doi: 10.1021/jacsau.5c01178.
eCollection 2026 Jan 26.
PubMed PMID:
41614164
; PubMed Central PMCID:
PMC12848695
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Tan H, Li K, Wang J.
Serial viral passage and reverse genetics protocol for identifying the antiviral drug targets of EV-D68 antivirals.
STAR Protoc
2025 Sep 19;
(3)
:104053
doi: 10.1016/j.xpro.2025.104053.
Epub 2025 Aug 29.
PubMed PMID:
40884790
; PubMed Central PMCID:
PMC12418817
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Li K, Rudy MJ, Hu Y, Tan H, Lambrinidis G, Wu X, Georgiou K, Tan B, Frost J, Wilson C, Clarke P, Kolocouris A, Zhang QY, Tyler KL, Wang J.
A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis.
Nat Commun
2025 Jul 1;
16
(1)
:5987
doi: 10.1038/s41467-025-61083-8.
PubMed PMID:
40593720
; PubMed Central PMCID:
PMC12216181
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Li K, Demssie HA, Wang J.
Design of a Fluorescence Polarization Probe for Enterovirus 2C Proteins.
J Med Chem
2025 Jul 10;
68
(13)
:14041-14053
doi: 10.1021/acs.jmedchem.5c01219.
Epub 2025 Jun 21.
PubMed PMID:
40542722
; PubMed Central PMCID:
PMC12333363
select
Yang W, Wang L, Shi L, Zhang J, Liu H, Wang J, Ma W.
Bat Influenza M2 Shows Functions Similar to Those of Classical Influenza A Viruses.
Pathogens
2025 Jun 18;
14
(6)
doi: 10.3390/pathogens14060599.
PubMed PMID:
40559607
; PubMed Central PMCID:
PMC12195650
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Tan H, Zhang Q, Georgiou K, Zhang S, Li K, Lambrinidis G, Kolocouris A, Deng X, Wang J.
Identification of naturally occurring drug-resistant mutations of SARS-CoV-2 papain-like protease.
Nat Commun
2025 May 16;
16
(1)
:4548
doi: 10.1038/s41467-025-59922-9.
PubMed PMID:
40379662
; PubMed Central PMCID:
PMC12084387
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Li K, Jadhav P, Wen Y, Tan H, Wang J.
Development of a Fluorescence Polarization Assay for the SARS-CoV-2 Papain-like Protease.
ACS Pharmacol Transl Sci
2025 Mar 14;
(3)
:774-784
doi: 10.1021/acsptsci.4c00642.
eCollection 2025 Mar 14.
PubMed PMID:
40109744
; PubMed Central PMCID:
PMC11915184
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Jadhav P, Liang X, Ansari A, Tan B, Tan H, Li K, Chi X, Ford A, Ruiz FX, Arnold E, Deng X, Wang J.
Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates.
Nat Commun
2025 Feb 13;
16
(1)
:1604
doi: 10.1038/s41467-025-56902-x.
PubMed PMID:
39948104
; PubMed Central PMCID:
PMC11825904
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Lewandowski EM, Zhang X, Tan H, Jaskolka-Brown A, Kohaal N, Frazier A, Madsen JJ, Jacobs LMC, Wang J, Chen Y.
Distal protein-protein interactions contribute to nirmatrelvir resistance.
Nat Commun
2025 Feb 1;
16
(1)
:1266
doi: 10.1038/s41467-025-56651-x.
PubMed PMID:
39893201
; PubMed Central PMCID:
PMC11787374
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Tan H, Pollard B, Li K, Wang J.
Discovery of A-967079 as an Enterovirus D68 Antiviral by Targeting the Viral 2C Protein.
ACS Infect Dis
2024 Dec 13;
10
(12)
:4327-4336
doi: 10.1021/acsinfecdis.4c00678.
Epub 2024 Nov 22.
PubMed PMID:
39578369
; PubMed Central PMCID:
PMC12183799
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Tan B, Liang X, Ansari A, Jadhav P, Tan H, Li K, Ruiz FX, Arnold E, Deng X, Wang J.
Structure-Based Design of Covalent SARS-CoV-2 Papain-like Protease Inhibitors.
J Med Chem
2024 Nov 28;
67
(22)
:20399-20420
doi: 10.1021/acs.jmedchem.4c01872.
Epub 2024 Nov 5.
PubMed PMID:
39499574
; PubMed Central PMCID:
PMC12182049
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Yang P, Gao S, Shen J, Liu T, Lu K, Han X, Wang J, Ni HM, Ding WX, Li H, Pan JA, Peng K, Zong WX.
TRIM21-mediated ubiquitination of SQSTM1/p62 abolishes its Ser403 phosphorylation and enhances palmitic acid cytotoxicity.
Autophagy
2025 Jan;
21
(1)
:178-190
doi: 10.1080/15548627.2024.2394308.
Epub 2024 Sep 10.
PubMed PMID:
39172027
; PubMed Central PMCID:
PMC11702951
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Pankratova Y, McKay MJ, Ma C, Tan H, Wang J, Hong M.
Structure and dynamics of the proton-selective histidine and the gating tryptophan in an inward rectifying hybrid influenza B and A virus M2 proton channel.
Phys Chem Chem Phys
2024 Jul 31;
26
(30)
:20629-20644
doi: 10.1039/d4cp01648c.
PubMed PMID:
39037444
; PubMed Central PMCID:
PMC11290064
select
Atomwise AIMS Program.
AI is a viable alternative to high throughput screening: a 318-target study.
Sci Rep
2024 Apr 2;
14
(1)
:7526
doi: 10.1038/s41598-024-54655-z.
PubMed PMID:
38565852
; PubMed Central PMCID:
PMC10987645
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Tan B, Zhang X, Ansari A, Jadhav P, Tan H, Li K, Chopra A, Ford A, Chi X, Ruiz FX, Arnold E, Deng X, Wang J.
Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model.
Science
2024 Mar 29;
383
(6690)
:1434-1440
doi: 10.1126/science.adm9724.
Epub 2024 Mar 28.
PubMed PMID:
38547259
; PubMed Central PMCID:
PMC12178660
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Jadhav P, Huang B, Osipiuk J, Zhang X, Tan H, Tesar C, Endres M, Jedrzejczak R, Tan B, Deng X, Joachimiak A, Cai J, Wang J.
Structure-based design of SARS-CoV-2 papain-like protease inhibitors.
Eur J Med Chem
2024 Jan 15;
264
:116011
doi: 10.1016/j.ejmech.2023.116011.
Epub 2023 Dec 5.
PubMed PMID:
38065031
; PubMed Central PMCID:
PMC11194760
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Tan B, Liu C, Li K, Jadhav P, Lambrinidis G, Zhu L, Olson L, Tan H, Wen Y, Kolocouris A, Liu W, Wang J.
Structure-Based Lead Optimization of Enterovirus D68 2A Protease Inhibitors.
J Med Chem
2023 Nov 9;
66
(21)
:14544-14563
doi: 10.1021/acs.jmedchem.3c00995.
Epub 2023 Oct 19.
PubMed PMID:
37857371
; PubMed Central PMCID:
PMC11457037
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Somberg NH, Medeiros-Silva J, Jo H, Wang J, DeGrado WF, Hong M.
Hexamethylene amiloride binds the SARS-CoV-2 envelope protein at the protein-lipid interface.
Protein Sci
2023 Oct;
32
(10)
:e4755
doi: 10.1002/pro.4755.
PubMed PMID:
37632140
; PubMed Central PMCID:
PMC10503410
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Ou J, Lewandowski EM, Hu Y, Lipinski AA, Aljasser A, Colon-Ascanio M, Morgan RT, Jacobs LMC, Zhang X, Bikowitz MJ, Langlais PR, Tan H, Wang J, Chen Y, Choy JS.
A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations.
PLoS Pathog
2023 Aug;
19
(8)
:e1011592
doi: 10.1371/journal.ppat.1011592.
eCollection 2023 Aug.
PubMed PMID:
37651467
; PubMed Central PMCID:
PMC10499260
select
Stampolaki Μ, Hoffmann A, Tekwani K, Georgiou K, Tzitzoglaki C, Ma C, Becker S, Schmerer P, Döring K, Stylianakis I, Turcu AL, Wang J, Vázquez S, Andreas LB, Schmidtke M, Kolocouris A.
A Study of the Activity of Adamantyl Amines against Mutant Influenza A M2 Channels Identified a Polycyclic Cage Amine Triple Blocker, Explored by Molecular Dynamics Simulations and Solid-State NMR.
ChemMedChem
2023 Aug 15;
18
(16)
:e202300182
doi: 10.1002/cmdc.202300182.
Epub 2023 Jul 25.
PubMed PMID:
37377066
select
Hu Y, Lewandowski EM, Tan H, Zhang X, Morgan RT, Zhang X, Jacobs LMC, Butler SG, Gongora MV, Choy J, Deng X, Chen Y, Wang J.
Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir.
ACS Cent Sci
2023 Aug 23;
(8)
:1658-1669
doi: 10.1021/acscentsci.3c00538.
eCollection 2023 Aug 23.
PubMed PMID:
37637734
; PubMed Central PMCID:
PMC10451032
select
Tan B, Sacco M, Tan H, Li K, Joyce R, Zhang X, Chen Y, Wang J.
Exploring diverse reactive warheads for the design of SARS-CoV-2 main protease inhibitors.
Eur J Med Chem
2023 Nov 5;
259
:115667
doi: 10.1016/j.ejmech.2023.115667.
Epub 2023 Jul 19.
PubMed PMID:
37482021
; PubMed Central PMCID:
PMC10529912
select
Frost J, Rudy MJ, Leser JS, Tan H, Hu Y, Wang J, Clarke P, Tyler KL.
Telaprevir Treatment Reduces Paralysis in a Mouse Model of Enterovirus D68 Acute Flaccid Myelitis.
J Virol
2023 May 31;
97
(5)
:e0015623
doi: 10.1128/jvi.00156-23.
Epub 2023 May 8.
PubMed PMID:
37154751
; PubMed Central PMCID:
PMC10231134
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Wang L, Ma C, Sacco MD, Xue S, Mahmoud M, Calcul L, Chen Y, Wang J, Cai J.
Development of the Safe and Broad-Spectrum Aldehyde and Ketoamide Mpro inhibitors Derived from the Constrained α, γ-AA Peptide Scaffold.
Chemistry
2023 Jun 22;
29
(35)
:e202300476
doi: 10.1002/chem.202300476.
Epub 2023 May 5.
PubMed PMID:
36920943
; PubMed Central PMCID:
PMC10330001
select
Tan H, Hu Y, Wang J.
FlipGFP protease assay for evaluating in vitro inhibitory activity against SARS-CoV-2 M(pro) and PL(pro).
STAR Protoc
2023 Jun 16;
(2)
:102323
doi: 10.1016/j.xpro.2023.102323.
Epub 2023 May 4.
PubMed PMID:
37329507
; PubMed Central PMCID:
PMC10156985
select
Wang J, Shahed-Ai-Mahmud M, Chen A, Li K, Tan H, Joyce R.
An Overview of Antivirals against Monkeypox Virus and Other Orthopoxviruses.
J Med Chem
2023 Apr 13;
66
(7)
:4468-4490
doi: 10.1021/acs.jmedchem.3c00069.
Epub 2023 Mar 24.
Review.
PubMed PMID:
36961984
select
Tan B, Joyce R, Tan H, Hu Y, Wang J.
SARS-CoV-2 Main Protease Drug Design, Assay Development, and Drug Resistance Studies.
Acc Chem Res
2023 Jan 17;
56
(2)
:157-168
doi: 10.1021/acs.accounts.2c00735.
Epub 2022 Dec 29.
PubMed PMID:
36580641
; PubMed Central PMCID:
PMC9843634
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Potter CJ, Hu Y, Xiong Z, Wang J, McLeod E.
Point-of-care SARS-CoV-2 sensing using lens-free imaging and a deep learning-assisted quantitative agglutination assay.
Lab Chip
2022 Sep 27;
22
(19)
:3744-3754
doi: 10.1039/d2lc00289b.
PubMed PMID:
36047372
; PubMed Central PMCID:
PMC9529856
select
Hu Y, Lewandowski EM, Tan H, Zhang X, Morgan RT, Zhang X, Jacobs LMC, Butler SG, Gongora MV, Choy J, Deng X, Chen Y, Wang J.
Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir.
bioRxiv
2022 Sep 6;
doi: 10.1101/2022.06.28.497978.
PubMed PMID:
36119652
; PubMed Central PMCID:
PMC9479041
select
Joyce RP, Hu VW, Wang J.
The history, mechanism, and perspectives of nirmatrelvir (PF-07321332): an orally bioavailable main protease inhibitor used in combination with ritonavir to reduce COVID-19-related hospitalizations.
Med Chem Res
2022;
31
(10)
:1637-1646
doi: 10.1007/s00044-022-02951-6.
Epub 2022 Aug 30.
Review.
PubMed PMID:
36060104
; PubMed Central PMCID:
PMC9425786
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Sacco MD, Wang S, Adapa SR, Zhang X, Lewandowski EM, Gongora MV, Keramisanou D, Atlas ZD, Townsend JA, Gatdula JR, Morgan RT, Hammond LR, Marty MT, Wang J, Eswara PJ, Gelis I, Jiang RHY, Sun X, Chen Y.
A unique class of Zn(2+)-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile.
Nat Commun
2022 Jul 28;
13
(1)
:4370
doi: 10.1038/s41467-022-32086-6.
PubMed PMID:
35902581
; PubMed Central PMCID:
PMC9334274
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Gomez K, Tang C, Tan B, Perez-Miller S, Ran D, Loya S, Calderon-Rivera A, Stratton HJ, Duran P, Masterson KA, Gabrielsen AT, Alsbiei O, Dorame A, Serafini M, Moutal A, Wang J, Khanna R.
Stereospecific Effects of Benzimidazolonepiperidine Compounds on T-Type Ca(2+) Channels and Pain.
ACS Chem Neurosci
2022 Jul 6;
13
(13)
:2035-2047
doi: 10.1021/acschemneuro.2c00256.
Epub 2022 Jun 7.
PubMed PMID:
35671441
select
Tan H, Hu Y, Jadhav P, Tan B, Wang J.
Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease.
J Med Chem
2022 Jun 9;
65
(11)
:7561-7580
doi: 10.1021/acs.jmedchem.2c00303.
Epub 2022 May 27.
Review.
PubMed PMID:
35620927
; PubMed Central PMCID:
PMC9159073
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Zhou X, Zhu L, Bondy C, Wang J, Luo Q, Chen Y.
AG1478 Elicits a Novel Anti-Influenza Function via an EGFR-Independent, GBF1-Dependent Pathway.
Int J Mol Sci
2022 May 16;
23
(10)
doi: 10.3390/ijms23105557.
PubMed PMID:
35628375
; PubMed Central PMCID:
PMC9145774
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Tan H, Ma C, Wang J.
Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor.
Med Chem Res
2022;
31
(7)
:1147-1153
doi: 10.1007/s00044-022-02903-0.
Epub 2022 May 12.
PubMed PMID:
35578732
; PubMed Central PMCID:
PMC9095416
select
Ma C, Hu Y, Wang Y, Choza J, Wang J.
Drug-Repurposing Screening Identified Tropifexor as a SARS-CoV-2 Papain-like Protease Inhibitor.
ACS Infect Dis
2022 May 13;
(5)
:1022-1030
doi: 10.1021/acsinfecdis.1c00629.
Epub 2022 Apr 11.
PubMed PMID:
35404564
; PubMed Central PMCID:
PMC9017246
select
Wang J, Li H.
Editorial of Special Column on Antiviral Drug Discovery and Pharmacology.
Acta Pharm Sin B
2022 Apr;
12
(4)
:1540-1541
doi: 10.1016/j.apsb.2022.03.005.
Epub 2022 Apr 22.
PubMed PMID:
35474901
; PubMed Central PMCID:
PMC9023784
select
Tan H, Ma C, Wang J.
Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor.
Res Sq
2022 Mar 30;
doi: 10.21203/rs.3.rs-1490282/v1.
PubMed PMID:
35378761
; PubMed Central PMCID:
PMC8978949
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Sacco MD, Hu Y, Gongora MV, Meilleur F, Kemp MT, Zhang X, Wang J, Chen Y.
The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition.
Cell Res
2022 May;
32
(5)
:498-500
doi: 10.1038/s41422-022-00640-y.
Epub 2022 Mar 15.
PubMed PMID:
35292745
; PubMed Central PMCID:
PMC8923085
select
Hu Y, Ma C, Wang J.
Cytopathic Effect Assay and Plaque Assay to Evaluate in vitro Activity of Antiviral Compounds Against Human Coronaviruses 229E, OC43, and NL63.
Bio Protoc
2022 Feb 5;
12
(3)
:e4314
doi: 10.21769/BioProtoc.4314.
eCollection 2022 Feb 5.
PubMed PMID:
35284599
; PubMed Central PMCID:
PMC8855088
select
Hu Y, Jo H, DeGrado WF, Wang J.
Brilacidin, a COVID-19 drug candidate, demonstrates broad-spectrum antiviral activity against human coronaviruses OC43, 229E, and NL63 through targeting both the virus and the host cell.
J Med Virol
2022 May;
94
(5)
:2188-2200
doi: 10.1002/jmv.27616.
Epub 2022 Feb 2.
PubMed PMID:
35080027
; PubMed Central PMCID:
PMC8930451
select
Ma C, Wang J.
Validation and Invalidation of SARS-CoV-2 Papain-like Protease Inhibitors.
ACS Pharmacol Transl Sci
2022 Feb 11;
(2)
:102-109
doi: 10.1021/acsptsci.1c00240.
eCollection 2022 Feb 11.
PubMed PMID:
35178512
; PubMed Central PMCID:
PMC8806001
select
Ma C, Xia Z, Sacco MD, Hu Y, Townsend JA, Meng X, Choza J, Tan H, Jang J, Gongora MV, Zhang X, Zhang F, Xiang Y, Marty MT, Chen Y, Wang J.
Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity.
J Am Chem Soc
2021 Dec 15;
143
(49)
:20697-20709
doi: 10.1021/jacs.1c08060.
Epub 2021 Dec 3.
PubMed PMID:
34860011
; PubMed Central PMCID:
PMC8672434
select
Hu Y, Meng X, Zhang F, Xiang Y, Wang J.
The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor.
Emerg Microbes Infect
2021 Dec;
10
(1)
:317-330
doi: 10.1080/22221751.2021.1888660.
PubMed PMID:
33560940
; PubMed Central PMCID:
PMC7919907
select
Cáceres CJ, Hu Y, Cárdenas-García S, Wu X, Tan H, Carnaccini S, Gay LC, Geiger G, Ma C, Zhang QY, Rajao D, Perez DR, Wang J.
Rational design of a deuterium-containing M2-S31N channel blocker UAWJ280 with in vivo antiviral efficacy against both oseltamivir sensitive and -resistant influenza A viruses.
Emerg Microbes Infect
2021 Dec;
10
(1)
:1832-1848
doi: 10.1080/22221751.2021.1972769.
PubMed PMID:
34427541
; PubMed Central PMCID:
PMC8451667
select
Townsend JA, Sanders HM, Rolland AD, Park CK, Horton NC, Prell JS, Wang J, Marty MT.
Influenza AM2 Channel Oligomerization Is Sensitive to Its Chemical Environment.
Anal Chem
2021 Dec 7;
93
(48)
:16273-16281
doi: 10.1021/acs.analchem.1c04660.
Epub 2021 Nov 23.
PubMed PMID:
34813702
; PubMed Central PMCID:
PMC8665133
select
Ma C, Tan H, Choza J, Wang Y, Wang J.
Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays.
Acta Pharm Sin B
2022 Apr;
12
(4)
:1636-1651
doi: 10.1016/j.apsb.2021.10.026.
Epub 2021 Nov 1.
PubMed PMID:
34745850
; PubMed Central PMCID:
PMC8558150
select
Boras B, Jones RM, Anson BJ, Arenson D, Aschenbrenner L, Bakowski MA, Beutler N, Binder J, Chen E, Eng H, Hammond H, Hammond J, Haupt RE, Hoffman R, Kadar EP, Kania R, Kimoto E, Kirkpatrick MG, Lanyon L, Lendy EK, Lillis JR, Logue J, Luthra SA, Ma C, Mason SW, McGrath ME, Noell S, Obach RS, O' Brien MN, O'Connor R, Ogilvie K, Owen D, Pettersson M, Reese MR, Rogers TF, Rosales R, Rossulek MI, Sathish JG, Shirai N, Steppan C, Ticehurst M, Updyke LW, Weston S, Zhu Y, White KM, García-Sastre A, Wang J, Chatterjee AK, Mesecar AD, Frieman MB, Anderson AS, Allerton C.
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Nat Commun
2021 Oct 18;
12
(1)
:6055
doi: 10.1038/s41467-021-26239-2.
PubMed PMID:
34663813
; PubMed Central PMCID:
PMC8523698
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