Publications: 1981 – 1990 – Langer Lab

Publications: 1981 – 1990 – Langer Lab
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1990
1990
Mathiowitz, E., Kline, D., Langer, R. “Morphology of Poly(anhydride) Microsphere delivery systems”,
J. Scanning Microscopy
; 4: 329-340, 1990.
Staubli, A., Ron, E., Langer, R. “Hydrolytically degradable amino acid containing polymers”,
J. Am. Chem. Soc.
; 112: 4419-4424, 1990.
Kibat, P., Igari, Y., Wheatley, M., Eisen, H., Langer, R. “Microencapsulated liposomes: a system for enzymatically controlled pulsatile release of biologically active substances”,
FASEB J.
; 4: 2533-2539, 1990.
Moses, M., Sudhalter, J., Langer, R. “Identification of an inhibitor of neovascularization from cartilage”,
Science;
248: 1408 – 1410, 1990.
Langer, R., Bernstein, H., Brown, L., Cima, L. “Medical reactors”,
Chemical Eng. Sci.
; 45: 1967- 1978, 1990.
Mathiowitz, E., Ron, E., Mathiowtiz, G., Amato, C., Langer, R. “Morphological characterization of bioerodible polymers. I. crystallinity of poly(anhydride) copolymers”,
Macromolecules;
23: 3212-3218, 1990.
Kost, J., Langer, R. “Magnetically and ultrasonically modulated drug delivery systems”,
Pulsed and Self-Regulated Drug Del.
; pp. 3-16, 1990.
Ghodsian, F., Brown, L., Langer, R. “Solubility dependent controlled release systems”,
Pulsed and Self-Regulated Drug Del.
; pp. 201-214, 1990.
Laurencin, C., Pierre-Jacques, H., Langer, R. “Toxicology and Biocompatibility Considerations”,
Eval. of Polymeric Mat. for Biomed. Appl.
; 10: 549-570, 1990.
Chasin, M., Domb, A., Ron, E., Mathiowitz, E., Leong, K., Laurencin, C., Brem, H., Grossman, B., Langer, R. “Polyanhydrides as Drug Delivery Systems”,
Biodegradable Polym. as Drug Del. Sys.
; 43-70, 1990.
Aiken, J., Cima, L., Schloo, B., Mooney, D., Johnson, L., Langer, R., Vacanti, J. “Studies in Rat Liver Perfusion for Optimal Harvest of Hepatocytes”,
J. Ped. Surg.
; 25: 140-145, 1990.
Lucas, P., Laurencin, C., Syftestad, G., Domb, A., Goldberg, V., Caplan, A., Langer, R. “Ectopic Induction of Cartilage and Bone by Water-soluble Proteins from Bovine Bone using Polyanhydride Delivery Vehicle”,
J. Biomed. Mat. Res.;
24: 901-911, 1990.
Langer, R. “New methods of drug delivery”,
Science;
249: 1527-1533, 1990.
Cohen, S., Bano, M., Visscher, K., Chow, M., Allcock, H., Langer, R. “Ionically crosslinkable polyphosphazene: a novel polymer for microencapsulation”,
J. Am. Chem. Soc.;
112: 7832-7833, 1990.
Laurencin, C., Domb, A., Morris, C., Brown, V., Chasin, M., McConnell, R., Langer, N., Langer, R. “Poly(anhydride) administration in high doses in vivo: studies of biocompatibility and toxicology”,
J. Biomed. Mat. Res.;
1463-1481, 1990.
Mathiowitz, E., Dor, P., Amato, C., Langer, R. “Polyanhydride microspheres as drug carriers III. morphology and release characterization of microspheres made by solvent removal”,
Polymer
; 31, 547­556, 1990.
Siegel, R., Langer, R. “Mechanistic studies of macromolecular drug release from macroporous polymers. II: models for the slow kinetics of drug release”,
J. Contr. Rel.
; 14: 153-168, 1990.
Langer, R., Cima, L., Tamada, J., Wintermantel, E. “Future directions in biomaterials”,
Biomaterials;
11, 738-745, 1990.
Vacanti, J., Ingber, D., Cima, L., Stein, J., Gilbert, J., Johnson, L., Schloo, B., Langer, R. “Hepatocyte tissue engineering using constructs of synthetic polymer networks and cultured cells.”,
A World J. of Hepatic, Pancreatic and Biliary Surgery
; 185-188, 1990.
Chasin, M., Hollenbeck, G., Brem, H., Grossman, S., Colvin, M., Langer, R. “Interstitial drug therapy for brain tumors: a case study”,
Drug. Dev. Ind. Pharm.
; 16: 2579-2594, 1990.
Igari, Y., Kibat, P., Langer, R. “Optimization of a microencapsulated liposome system for enzymatically controlled release of macromolecules”,
J. Cont. Rel.
; 14: 263-267, 1990.
Langer, R. “Novel drug delivery systems”,
Chem. in Britain
; 26: 232-238, 1990.
Domb, A., Laurencin, C., Israeli, O., Gerhart, R., Langer, R. “The step polymerization of poly(propylene fumarate) for use in bioerodible bone cement composites. “,
J. Poly. Sci.;
28: 973-985, 1990.
Leong, K., Domb, A., Ron, E., Langer, R. “Polyanhydrides”,
Second Ed. of the Encycl. Poly. Sci. Eng.
; 648-665, 1990.
1989
1989
Brem, H., Kader, A., Epstein, J., Tamargo, R., Domb, A., Langer, R., Leong, K. “Biocompatibility of a biodegradable controlled-release polymer in the rabbit brain”,
Selective Cancer Therap.
; 5: 55-65, 1989.
Levy, D., Kost, J., Meshulam, Y., Langer, R. “Effect of ultrasound on transdermal drug delivery to rats and guinea pigs”,
J. Clin. Invest.
; 83: 2074-2078, 1989.
Siegel, R., Kost, J., Langer, R. “Mechanistic studies of macromolecular drug release from macroporous polymers. I. experiments and preliminary theory concerning completeness of drug release”,
J. Cont. Rel.
; 8: 223-236, 1989.
Howard, M., Gross, A., Grady, M., Langer, R., Mathiowitz, E., Winn, R., Mayberg, M. “Intracerebral drug delivery in rats with lesion-induced memory deficits. “,
J. Neurosurgery
; 71: 105-112, 1989.
Cima, L., Mooney, D., Vacanti, JP., Langer, R. “Three Dimensional Culture of Primary Mammalian Cells in Porous Biodegradable Polymer Matrices for in vivo Organ Regeneration.”,
American Instititute of Chemical Engineers. Microfiche Proceedings of Annual Conference
; , 1989.
Domb, A., Gallardo, C., Langer, R. “Poly(anhydrides) 3. Poly(anhydrides) based on aliphaticaromatic diacids”,
Macromolecules;
22: 3200-3204, 1989.
Yu, H., Langer, R. “Pseudopoly(amino acids): A study of the synthesis and characterization of poly(acyl-hydroxyproline-esters)”,
Macromolecules;
22: 3250-3255, 1989.
Langer, R. “Biomaterials in Controlled Drug Delivery: New perspectives from biotechnological advances”,
Pharm. Techn.
; 13: 22-30, 1989.
Domb, A, Langer, R. “Solid state and solution stability of poly(anhydrides) and poly(esters)”,
Macromolecules;
22: 2117-2122, 1989.
Kost, J., Leong, K., Langer, R. “Effects of ultrasound on polymer degradation and release of incorporated substances”,
PNAS;
86: 7663-7666, 1989.
Comfort, A., Berkowitz, S., Albert, E., Langer, R. “Immobilized enzyme cellulose hollow fibers: I. immobilization of heparinase”,
Biotech. Bioeng.;
34: 1366-1373, 1989.
Comfort, A., Albert, E., Langer, R. “Immobilized enzyme cellulose hollow fibers: II. kinetic analysis”,
Biotech. Bioeng.;
34: 1374-1382, 1989.
Comfort, A., Berkowitz, S., Albert, E., Langer, R. “Immobilized enzyme cellulose hollow fibers: III. physical properties and in vitro biocompatibility”,
Biotech. Bioeng.;
34: 1383-1390, 1989.
Mullon, C., Tosone, C., Langer, R. “Simulation of bilirubin detoxification in the newborn using an extracorporeal bilirubin oxidase reactor”,
Pediatric Res.
; 26: 452-457, 1989.
Yang, V., Bernstein, H., Langer, R. “Heparinase immobilization”,
Enzyme Engin.
; 9: 515-520, 1989.
Saltzman, W. Langer, R. “Transport rates of proteins in porous materials with known microgeometry”,
Biophys. J.
; 55: 163-171, 1989.
Freese, A., Sabel, B., Saltzman, W., During, M., Langer, R. “Controlled release of dopamine from a polymeric brain implant: in vitro characterization”,
Exp. Neur.
; 103: 234-238, 1989.
During, M., Freese, A., Sabel, B., Saltzman, W., Deutch, A., Roth, R., Langer, R. “Controlled release of dopamine from a polymeric brain implant: in vivo characterization”,
Ann. Neur.
; 25: 351-356, 1989.
1988
1988
Kohn, J., Langer, R. “Backbone modifications of synthetic poly-alpha amino acids”,
Peptides, Chem. and Biology
; pp. 658-661, 1988.
Brown, L., Langer, R. “Transdermal drug delivery systems”,
Ann. Rev. of Med.
; 39: 221-229, 1988.
Mullon, C., Klibanov, A., Langer, R.. “Kinetics of bilirubin oxidase and modeling of an immobilized bilirubin oxidase reactor for bilirubin detoxification”,
Biotech. Bioeng.
; 31: 536-546, 1988.
Domb, A., Ron, E., Langer, R. “Polyanhydrides II. One step polymerization using phosgene or diphosgene as coupling agents”,
Macromolecules;
21: 1925-1929, 1988.
Ghodsian, F., Brown, L., Mathiowitz, E., Brandenburg, D., Langer, R. “Enzymatically controlled drug delivery”,
Proc. Nat. Acad.Sci.
; 85: 2403-2406, 1988.
Bernstein, H., Yang, V., Cooney, C., Langer, R. “An immobilized heparinase system for blood deheparinization”,
Meth. Enz.
; 137: 515-529, 1988.
Domb, A., Langer, R. “Polyanhydrides: stability and novel composition”,
Makromol. Chem. Macromol. Symp.
; 19: 189-200, 1988.
Comfort, A., Mullon, C., Langer, R. “The influence of bond chemistry on immobilized enzyme systems for ex vivo use”,
Biotech. and Bioeng.;
32: 554-563, 1988.
Bindschacdler, C., Leong, K., Mathiowitz, E. Langer, R. “Polyanydride microsphere formulation by solvent extraction”,
J. Pharm. Sci.;
77: 696-698, 1988.
Domb, A., Cravalho, E.G., Langer, R. ” The synthesis of poly(hydroxamic) from poly(Acrylamide)”,
J. Poly. Sci.;
26: 2623-2630, 1988.
Kost, J., Leong, K., Langer, R. “Ultrasonically controlled colymeric drug delivery”,
Makromol. Chem. Macromol. Symp.
; 19: 275-285, 1988.
Comfort, A., Mullon, C., Koh, J., Albert, E., Tosone, C., Hall, P., Langer, R. “Stability and immunologic activity of immobilized heparinase and bilrubin oxidase”,
ASAIO Transactions
; 34: 538-2542, 1988.
Freed, L., Vunjak, G., Drinker, P., Langer, R. “A novel bioreactor based on suspended particles of agarose-immobilized species”,
ASAIO Transactions
; 34: 732-738, 1988.
Mullon, C., Saltzman, W., Langer, R. “Computer based visualization for quantitative and analysis of the distribution of matrix-bound proteins”,
Bio/Technology
; 6: 927-929, 1988.
Rosen, H., Kohn, J., Leong, K., Langer, R. “Bioerodible polymers for controlled release systems”,
Cont. Rel. Sys.: Fab. Tech.
; Vol. II, Chap. 5, 84-110, 1988.
Yang, V., Bernstein, H., Cooney, C., Langer, R. “The development of an immobilized heparinase reactor in bioreactors, immobilized enzymes and cells, and fundamentals in the applications”,
Elsevier Applied Science
; pp. 83-94, 1988.
Bernstein, H., Langer, R. “Ex vivo model of an immobilized enzyme reactor”,
PNAS;
85: 8751-8755, 1988.
Klein, M., Arensman, R., Weber, T., Mottaghy, K., Langer, R., Nolte, S.H. “Pediatric ECMO: directions for new developments”,
Trans. Am. Soc. Artif. Intern. Organs.
; 34: 978-985, 1988.
Karel, M., Langer, R. “Controlled release of food additives”,
Flavor Encapsulation
; ACS Symp. Ser. 370. 177-191, 1988.
Langer, R. “Controlled release systems”,
Chem. Eng. Ed. in a Changing Environment
; 115-124, 1988.
Leong, K. Langer, R. “Polymeric controlled drug delivery”,
Adv. Drug Del. Rev.;
I, 199- 233, 1988.
Langer, R. “Biodegradable polymers for drug delivery to the brain”,
ASAIO Transactions
; 34: 945-946, 1988.
Larsen, A., Rice, K., Linhardt, R., Wogan, G., Langer, R. “Resistance of heparinase-derived heparin fragments to biotransformation”,
J. Biol. Chem.
; 264: 1570-1577, 1988.
Vacanti, J., Morse, M., Saltzman, M., Domb, A., Perez-Atayde, A., Langer, R. “Selective Cell Transplantation Using Bioabsorbable Artificial Polymers as Matrices”,
J. Ped. Surg.
; 23: 3-9, 1988.
Mathiowitz, E., Saltzman, M., Domb, A., Dor, P, Langer, R. “Polyanhydride Microspheres as Drug Carriers. II Microencapsulation by Solvent Removal”,
J. Appl. Polym. Sci.
; 35: 755-774, 1988.
Chasin, M., Lewis, D., Langer, R. “Polyanhydrides for controlled release”,
Biopharm. Manuf.
; 1: 33-46, 1988.
1987
1987
Yang, V., Bernstein, H., Langer, R. “Heparinase immobilization: characterization and optimization”,
Methods in Enzymology
; 515-520, 1987.
Kohn, J., Langer, R. “Polymerization reactions involving the side chains of a-L-amino acids”,
J. Am. Chem. Soc.;
109: 817-820, 1987.
Edelman, E., Brown, L., Langer, R. “In vitro and in vivo kinetics of regulated drug release from polymer matrices by oscillating magnetic fields”,
J. Biomed. Mat. Sci.
; 21: 339-353, 1987.
Yang, V., Bernstein, H., Langer, R. “Large scale purification of catalytically pure heparinase”,
Biotech. Prog.
; 3: 27-30, 1987.
Yang, V., Langer, R. “A simple and economic technique for pI measurements”,
Biotechniques
; 5: 138-144, 1987.
Leong, K., Simonte, V., Langer, R. “Synthesis of polyanhydrides: melt-polycondensation, dehydrochlorination, and dehydrative coupling”,
Macromolecules;
20: 705-712, 1987.
Linhardt, R., Langer, R. “New approaches for anticoagulation in extracorporeal therapy”,
Biomat. Art . Cells, Art. Org.
; 15: 91-100, 1987.
Langer, R. “Bioengineering: its role in the changing face of chemical engineering”,
Biotech. Progress
; 3:02, 1987.
Laurencin, C., Langer, R. “Drug delivery systems”,
Clinics in Lab. Med.
; 7: 301-323, 1987.
Kost, J. Langer, R. “Equilibrium swollen hydrogels in controlled release applications”,
Hydrogels in Med. Pharm.
; pp. 95-108, 1987.
Bernstein, H., Yang, V., Langer, R. “The distribution of heparinase covalently immobilized to agarose: experimental and theoretical studies”,
Biotech. Bioeng.
; 30; 196-207, 1987.
Bernstein, H., Yang, V., Langer, R. “Immobilized heparinase in vitro reactor model”,
Biotech. Bioeng.
; 30: 239-250, 1987.
Mathiowitz, E., Langer, R. “Polyanhydride microspheres as drug carriers”,
J. Cont. Rel.
; 1.126388889, 1987.
Saltzman, W., Pasternack, S., and Langer, R. “Microstructural models for diffusive transport in porous polymers”,
Recent Adv. in Cont. Rel. Tech.
; 348: 16-33, 1987.
Saltzman, W., Pasternak, S., Langer, R. “Quantitative image analysis for developing microstructural descriptions of heterogeneous materials”,
Chem. Eng. Sci.
; 42: 1989-2004, 1987.
Bernstein, H., Yang, V., Randawa, M., Lund, D., Harmon, W., Langer, R. “Extracorporeal enzymatic heparin removal: use in a sheep dialysis model”,
Kidney Int.
; 32: 452-463, 1987.
Mathiowitz, E., Cohen, M., Langer, R. “Novel microcapsules for delivery systems”,
Reactive Poly. Ion Exchange Sorbents
; 6: 275-283, 1987.
Mullon, C., Langer, R. “A new method for measuring conjugated and total bilirubin in neonate plasma using bilirubin oxidase”,
Clin Chem.
; 33: 1822-1825, 1987.
Domb, A., Langer, R. “Polyanhydrides: I. preparation of high molecular weight polyanhydrides”,
J. Poly. Sci.
; 25: 3373-3386, 1987.
Kost, J., Wolfrum, J., Langer, R. “Magnetically controlled insulin release in diabetic rats”,
J. Biomed. Mat. Res.;
21: 1367-1373, 1987.
Levy, R., Golomb, G., Langer, R. “Prevention of Cardiovascular calcification with controlled release diphosphate, in Artificial Organs: The W.F. Kolff Festschrift”,
J. Andrade
; p. 657- 670, 1987.
Bernstein H., Langer, R. “An immobilized enzyme system for heparin removal”,
Art. Organs
; p. 333-342, 1987.
Cuenoud, H., Joris, I., Langer, R., Majno, G. “Focal arteriolar insudation: A response of arterioles to Chronic Non-Specific Irritation”,
Amer. J. Path.
; 127: 592-604, 1987.
Laurencin, C., Koh, H., Neenan, T., Alcock, H., Langer, R. “Controlled release using a new bioerodible polyphosphazene matrix system”,
J. Biomed. Mater. Res.
; 21: 1231-1246, 1987.
Yang, V., H. Bernstein, C. Cooney, Langer, R. “Large scale preparation and characterization of mucopolysaccharase contamination free heparinase”,
Appl. Biochem. Biotech.
; 16: 35-50, 1987.
Wheatley, M., Langer, R. “Particles as drug delivery systems”,
Particulate Sci. and Tech.
; 5: 53-65, 1987.
Langer, R., Leong, K., Edelman, E., Siegel, R., Bawa, R. “Zero order release, magnetic control, and polypeptide release”,
Cont. Drug Del. Sys.
; 146-160, 1987.
Thompson, R.W., Folkman, J., Langer, R., Ingber, D. Sudhalter, J. D’Amore, P. “Angiogenic vascular grafts”,
Endothelizilization of Vascular Grafts
; 167-176, 1987.
Bernstein, H., Yang, V., Langer, R. “An investigation of heparinase immobilization”,
Applied Biochem. and Biotech.
; 129-143, 1987.
1986
1986
Leong, K., D’Amore, P., Marletta, M., Langer, R. “Bioerodible polyanhydrides as drug-carrier matrices: II: biocompatibility and chemical reactivity”,
J. Biomed. Mat. Res.;
20: 51-64, 1986.
Brown, L., Edelman, E., Siemer, L., Langer, R. “Controlled-release systems for macromolecules: methods and applications”,
Adv. in Carriers and Adjuvants for Veterinary Biologics
; 133-141, 1986.
Siegel, R., Langer, R. “A new monte carlo approach to diffusion in constricted porous geometrics”,
J. Colloid Interfacial Sci.
; 109: 426-440, 1986.
Murray, J., Allison, K., Sudhalter, J., Langer, R. “Purification and partial amino acid sequence of a collagenase Inhibitor from Bovine Cartilage”,
J. Biol. Chem.
; 261: 4154-4159, 1986.
Kost, J., Langer, R. “Magnetically modulated delivery systems”,
Pharm. International
; 7: 60-63, 1986.
Cerbelaud, E., Conway, L., Galliher, P., Langer, R., Cooney, C. “Sulfur regulation of heparinase and sulfatases in Flavo-bacterium heparinum”,
Appl. and Envir. Microbiol.
; 51: 640-646, 1986.
Kohn, J., Langer, R. “Poly(Iminocarbonates) as Potential New Biomaterials”,
Biomaterials;
7: 176-182, 1986.
Larsen, A., Lund, D., Langer, R., Folkman, J. “Oral heparin results in the appearance of heparin fragments in the Plasma of Rats”,
PNAS;
83: 1-5, 1986.
Brown, L., Siemer. L., Langer, R. “Controlled release of insulin from polymer matrices: in vitro kinetics”,
Diabetes
; 35: 684-691, 1986.
Brown, L., Siemer, L, Munoz, C., Edelman, E., Langer, R. “Controlled release of insulin from polymer matrices: control of diabetes in rats”,
Diabetes
; 35: 692-697, 1986.
Edelman, E., Linhardt, R., Bobeck, H., Kost, J., Rosen, H., Langer, R. “Polymer based drug delivery: magnetically nodulated and bioerodible systems”,
Poly. as Biomat.
; p. 279-292, 1986.
Langer, R. “Biopolymers in controlled release systems”,
Polymeric Biomat.
; p. 161-169, 1986.
Klein, M., Langer, R. “Immobilized enzymes in clinical medicine: a new approach to the treatment of disease”,
Trends in Biotech.
; 4: 179-186, 1986.
Sung, S., Lavin, A., Klibanov, A., Langer, R. “An immobilized enzyme reactor for the detoxification of bilirubin”,
Biotech. Bioeng.
; 28: 1531-1539, 1986.
Leong, K., Kost, J., Mathiowitz, E., Langer, R. “Polyanhydrides for the controlled release of bioactive agents”,
Biomaterials;
7: 364-371, 1986.
Kohn, J., Albert, E., Wilchek, M., Langer, R. “Identification and colorimetric determination of organic cyanates (R-O-C=N) in nanomolar quantities”,
Anal. Chem.
; 58: 3184-3188, 1986.
Kohn, J., Niemi, S., Albert, E., Murphy, J., Langer, R., Fox, J. “Single-step immunization using a controlled release, biodegradable polymer with sustained adjuvant activity”,
J. Immuno. Methods
; 95: 31-38, 1986.
Langer, R., Blackshear, P., Chang, T., Klein, M., Schultz, J. “Enzyme and drug delivery systems”,
ASAIO Trans.
; 9: 639-645, 1986.
Blackshear, P., Robbins, D., Rohde, T., Langer, R., Moses, A., Massey, E. “Insulin replacement: current concepts”,
ASAIO Trans.
; 9: 646-655, 1986.
Yang, V., Bernstein, H. Kadam, J., Cooney, C., Langer, R. “Removal of the anticoagulant activities of the low molecular weight heparin fractions and fragments with flavobacterial heparinase”,
Thrombosis Res.
; 44: 599-610, 1986.
Golomb, G., Langer, R., Schoen, F., Smith, M., Choi, Y., Levy, R. “Controlled release of diphosphonate to inhibit bioprosthetic heart valve calcification: dose-response and mechanistic studies”,
J. Cont. Rel.
; 4: 181 – 194, 1986.
Kost, J., Leong, K., Langer, R. “Ultrasonic modulated drug delivery systems in polymers”,
Med., Biom. and Pharm. Appl.
; 387-396, 1986.
Langer, R., Siegel, R., Brown, L., Leong, K., Kost J., Edelman, E. “Controlled release systems: three mechanisms”,
Chemtech
; 16: 108-110, 1986.
1985
1985
Balazs, A., Calef, D., Deutch, J., Siegel, R., Langer, R. “The role of polymer matrix structure & interparticle interactions in diffusion limited drug release”,
Biophys. J.
; 47: 97-104, 1985.
Folkman, J., Ausprunk, D., Langer, R. “Connective tissue: small blood vessels and capillaries”,
Textbook of Rheumatology
; 197-210, 1985.
Yang, V., Linhardt, R., Bernstein, H., Cooney, C., Langer, R. “Purification and characterization of heparinase from flavobacterium heparinum”,
J. Biol. Chem.
; 260: 1849-1857, 1985.
Edelman, E., Kost, J., Bobeck, H., Langer, R. “Regulation of drug release from porous polymer matrices by oscillating magnetic fields”,
J. Biomed. Mat. Res.;
19: 67-83, 1985.
Hsu, T., Langer, R. “Polymers for the controlled release of macromolecules: effect of molecular weight of ethylene-vinyl acetate copolymer”,
J. Biomed. Mat. Res.;
19: 445-460, 1985.
Levy, R., Wolfrum, J., Schoen, F., Hawley, M., Lund, S., Langer, R. “Inhibition of calcification of bioprosthetic heart valves by local controlled release diphosphonate”,
Science;
228: 190-192, 1985.
Yang, V., Langer, R. “A rapid method for isoelectric point estimation”,
Anal. Bio. Chem.
; 147: 148-155, 1985.
Langer, R., Brown, L., Edelman, E. “Controlled release and magnetically modulated release systems for macromolecules”,
Drug and Enz. Targeting. Meth. in Enzym.
; 112: 399-423, 1985.
Langer, R., Siegel, R., Brown, L., Leong, K., Kost, J., Edelman, E. “Controlled release and magnetically modulated systems for macromolecular drug”,
Ann. of the New York Acad. of Sci.
; 446: 1-13, 1985.
Bawa, R., Siegel, R., Marasca, B., Karel, M., Langer, R. “An explanation for the sustained release of macromolecules from polymers”,
J. Cont. Rel.
; l: 259-267, 1985.
Langer, R. “Biomaterials: new perspectives on their use in the controlled delivery of polypeptides”,
Pharm. Techn.
; 9: 37-39, 1985.
Lavin, A., Sung, C., Klibanov, A., Langer, R. “Enzymatic removal of bilirubin from blood: a potential treatment for neonatal jaundice”,
Science;
230: 543-546, 1985.
Kost, J., Noekker, R., Kunica, E., Langer, R. “Magnetically controlled release systems: effect of polymer composition”,
J. Biomed. Mat. Res.;
l9: 935-940, 1985.
Leong, K., Brott, B., Langer, R. “Bioerodible polyanhydrides as drug-carrier matrices: I. characterization, degradation and release characteristics”,
J. Biomed. Mat. Res.;
19: 941-955, 1985.
Yang, V., Morgan, L., McCarthy, M., Langer, R. “Isoelectric points of the polysaccharide degrading enzymes in flavobacterium heparinum”,
Carbo. Res.
; 143: 1-6, 1985.
Langer, R., Larsen, A., Bernstein, H., Yang, V., Lund, D., Tapper, D. “Enzymatic control of anticoagulation”,
ASAIO J.
; 8: 213-214, 1985.
Linhardt, R., Merchant, Z., Rice, K.G., Kam, Y., Fitzgerald, G., Grant, A., Langer, R. “Evidence of random structural features of the heparin polymer”,
Biochemistry
; 24: 7805-7810, 1985.
Levy, R., Golomb, G., Wolfrum, J., Lund, S.A., Schoen, F., Langer, R. “Local controlled release of diphosphonates from ethylenevinyl acetate matrices prevents bio-prosthetic heart valve calcification”,
Am. Soc. Artif. Intern. Organs
; 31: 459-463, 1985.
Sung, C., Lavin, A., Klibanov, A., Langer, R. “An immobilized enzyme reactor for treatment of severe neonatal jaundice”,
ASAIO J.
; 31: 264-268, 1985.
Langer, R., Lund, D., Leong, K., Folkman, J. “Controlled release of macromolecules: biological studies”,
J. Cont. Rel.
; 2: 331-341, 1985.
Niemi, S., Fox, J., Brown, L., Langer, R. “Evaluation of ethylene-vinyl acetate copolymer as a noninflammatory alternative to Freund’s complete adjuvant in rabbits”,
Lab. Animal Sci.
; 35: 609-612, 1985.
Langer, R. “Bioavailability of macromolecular drugs and its control in controlled drug bioavailability”,
Bioavailability Cont. by Drug Del. Sys. Design
; 3: 307-364, 1985.
1984
1984
Siegel, R. Langer, R. “Controlled release of polypeptides and other macromolecules”,
Pharm. Research;
1: 2-10, 1984.
Grant, A., Linhardt, R., Fitzgerald, G., Park J., Langer, R. “Metachromatic activity of heparin and heparin fragments”,
Anal. Biochem.
; 137: 25-28, 1984.
Lee, A., Langer, R. “Shark cartilage contains an inhibitor of tumor neovascularization”,
Biotech. and Genetic Engin. in the Marine Sci.
; 215-220, 1984.
Larsen, A., Linhardt, R., Klein, M., Tapper, D., Langer, R. “Extracorporeal enzymatic deheparinization and its effect on formed blood components”,
Art. Organs
; 8: 198-203, 1984.
Langer, R. “Polymers and drug delivery systems”,
Long-Acting Contraceptive Del. Sys.
; 23-32, 1984.
Murray, J., Brown, L., Langer, R. “Controlled release of nanogram or microgram quantities of macromolecules”,
Cancer Drug Del.
; 1: 119-123, 1984.
Lee, A., Von Beuzekom, M., Glowacki, J., Langer, R. “Inhibitors enzymes, and growth factors from shark cartilage”,
Comp. Physiol & Biochem.
; 78B: 609-616, 1984.
Linhardt, R., Cooney, C., Zannetos, C., Larsen, A., Tapper, D., Langer, R. “An immobilized microbial heparinase for blood deheparinization”,
Appl. Biochem. and Biotech.
; 9: 41-55, 1984.
Kost, J., Langer, R. “Controlled release of bioactive agents”,
Trends in Biotech.
; 2: 47-51, 1984.
Siegel, R., Cohen, J., Brown, L., Langer, R. “Sintered polymers for sustained macromolecular drug release”,
Rececnt Adv. in Drug Del. Sys.
; 315-320, 1984.
Langer, R., Brown, L., Edelman, E. “Controlled release and magnetically modulated systems for macromolecules: recent advances”,
Rec. Adv. in Drug Del. Sys.
; 249-258, 1984.
Cohen, J., Siegel, R., Langer, R. “Sintering technique for preparation of polymer matrices for the sustained release of macromolecules”,
J. Pharm. Sci.
; 73: 1034-1037, 1984.
Langer, R. “Macromolecular delivery systems for therapeutic applications of controlled drug release”,
Contemp. Biomat.
; 560-572, 1984.
Larsen, A., Hetelekidis, S., Langer, R. “Disposition and anticoagulant activity of biologically active heparin fragments in the rat”,
J. Pharm. & Exper. Ther.
; 231: 373-378, 1984.
Edelman, E., Brown, L., Kost, J., Taylor, J., Langer, R. “Modulated release from polymeric drug delivery systems using oscillating magnetic fields: in vitro and in vivo characteristics=”,
Trans. Amer. Soc. Art. Int. Organs
; 30: 445-447, 1984.
Larsen, A., Hetelekidis, S., Langer, R. “Enzymatic extracorporeal deheparinization: effects of subchronic exposure to heparin fragments”,
Trans. Amer. Soc. Art. Int. Organs
; 30: 298-302, 1984.
Wheatley, M., Langer, R. “Polymeric microsphere for controlled drug delivery”,
Microspheres and drug therapy
; 341-345, 1984.
Sefton, M., Brown, L., Langer, R. “Ethylene-vinyl acetate microspheres for controlled release of macromolecules”,
J. Pharm. Sci.;
73: 1859-1861, 1984.
Kohn, J., Langer, R. “A new approach to the development of Bioerodible Polymers for controlled release applications employing naturally occurring amino acids”,
Proc. ACS Div. Poly. Mat.: Sci. Eng. American Chemical Society
; 51: 119-121, 1984.
1983
1983
Langer, R., Murray, J. “Angiogenesis inhibitors and their delivery systems”,
Appl. Biochem. and Biotech
; 8: 9-24, 1983.
Hsich, D., Rhine, W., Langer, R. “Zero-order controlled release polymer matrices for micromolecules and macromolecules”,
J. Pharm. Sci.;
72: 17-22, 1983.
Rosen, H., Chang, J., Wnek, G., Linhardt. R., Langer, R. “Bioerodible polyanhydrides for controlled drug delivery”,
Biomaterials;
4: 131-133, 1983.
Langer, R. Edelman, E., Hsieh, D. “Magnetically controlled polymeric delivery systems”,
Biocompatible Poly.: Sci. and Tech.
; 585-596, 1983.
Langer, R. “New drug delivery systems”,
Drug Therapy
; 13: 217-231, 1983.
Hsieh, D., Langer, R. “Zero-order drug delivery systems with magnetic control”,
Cont. Rel. of Bioactive Mat.
; 121-131, 1983.
Langer, R. “Implantable controlled release systems”,
Pharm. and Therapeutics
; 21: 35-51, 1983.
Langer, R., Peppas, N. “Chemical and physical structure of polymers as carriers for controlled release of bioactive agents: a review”,
J. Macromol. Sci.
; 23: 61-126, 1983.
Brown, L., Wei, C., Langer, R. “In vitro and in vivo release of macromolecules from polymeric drug delivery systems”,
J. Pharm. Sci.;
72: 1181-1185, 1983.
Lee, A., Langer, R. “Shark cartilage contains inhibitors of tumor angiogenesis”,
Science;
221: 1185-1187, 1983.
Kupchik, H., Langer, R., Haberern, C., El Deriny, S., O’Brien, M. “A new method for the three dimensional in vitro growth of human cancer cells”,
Exper. Cell. Res.;
147: 454-459, 1983.
Folkman, J., Langer, R., Linhardt, R., Haudenschild, C., Taylor, S. “Angiogenesis inhibition and regression of large tumour masses caused by heparin or a heparin fragment in the presence of cortisone”,
Science;
221: 719-725, 1983.
Murray, J., Brown, L., Klagsbrun, M., Langer, R. “A micro sustained release system for epidermal growth factor”,
In Vitro
; 19: 743-748, 1983.
Klein, M., Drongowski, R., Linhardt, R., Cooney, C., Langer, R. “Heparinase: in vivo activity and immunogenicity in rabbits”,
J. Lab. and Clin. Med.
; 102: 828-837, 1983.
1982
1982
Langer, R., Linhardt, R., Klein, M., Flanagan, M., Galliher, P., Cooney, C. “A system for heparin removal”,
Biomaterials: Interfacial Phenomena and Applications
; 493-509, 1982.
Berman, M., Winthrop, S., Ausprunk, D., Rose, J., Langer, R., Gage, J. “Plasminogen activator (urokinase) causes vascularization of the cornea”,
Invest. Ophthal.
; 22: 191-199, 1982.
Langer, R., Hsich, D., Brown, L. “Polymeric delivery systems for macromolecules: approaches for studying in vivo release kinetics and designing constant rate dsystems”,
Biol. Activities of Polymers
; 186: 95-197, 1982.
Linhardt, R., Fitzgerald, G., Cooney, C., Langer, R. “Mode of action of heparin lyase E.C. 4227 on heparin”,
Biochem. Biophys. Acta.
; 702: 197-203, 1982.
Langer, R. “Controlled release of macromolecules”,
Chemtech
; 12: 98-105, 1982.
Langer, R., Linhardt, R., Cooney, C., Tapper, D., Klein, M. “Immobilized heparinase: production, purification and application in extracorporeal therapy”,
Enzyme Eng.
; 6: 433-441, 1982.
Klein, M., Drongowski, R., Linhardt, R., Langer, R. “A colorimetric assay for chemical heparin in plasma”,
Anal. Biochem.
; 124: 59-64, 1982.
Linhardt, R., Grant, A., Cooney, C., Langer, R. “Differential anticoagulation activity of heparin fragments prepared using microbial heparinase”,
J. Biol. Chem.
; 257: 7310-7313, 1982.
Langer, R., Linhardt, R., Hoffberg, S., Larsen, A., Cooney, C., Tapper, D., Klein, M. “An enzymatic system for removing heparin in extracorporeal therapy”,
Science;
217: 261-263, 1982.
Cooney, C. Galliher, P., Langer, R., Linhardt, R., Conway, L. “Regulation of heparinase synthesis in flavobacteria heparinum”,
Europ. J. Appl. Microbiol.
; 15: 252-257, 1982.
Langer, R., Linhardt, R., Larsen, A., Cooney, C., Tapper, D., Klein, M. “In vivo activity of microbial heparinase”,
Trans. Am. Soc. Art. Int. Organs
; 28: 387-390, 1982.
1981
1981
Folkman, J., Ausprunk, D., Langer, R.”Connective tissue: small blood vessels and capillaries”,
Textbook of Rheumatology
; 210-220, 1981.
Conn, H., Langer, R.”Iodine disinfection of hydrophilic contact lenses”,
Ann. Ophthal.
; 13: 361-364, 1981.
Langer, R.”Polymers for sustained release of macromolecules: their use in a single-step method of immunization”,
Immunological Techniques, Methods in Enz.
; 73: 57-75, 1981.
Hsich, D., Langer, R., Folkman, J.”Magnetic modulation of release of macromolecules from Polymers”,
PNAS;
78: 1863-1867, 1981.
Galliher, P., Cooney, C., Langer, R., Linhardt, R.”Heparinase production by flavobacteria”,
Appl. Env. Microbiology
; 41: 360-365, 1981.
Langer, R., Brem, H., Tapper, D.”Biocompatibility of polymeric delivery systems for macromolecules”,
J. Biomed. Mat. Res.;
15: 267-277, 1981.
Langer, R.”Controlled Release: A new approach to drug delivery”,
Tech. Rev.;
83: 26-34, 1981.
Langer, R., Karel, M.”Controlled release technology: polymers in medicine, food and agriculture”,
Poly. News
; 7: 250-258, 1981.
Langer, R., Hsieh, D., Brown, L., Rhine, W.”Polymers for the sustained release of macromolecules: controlled and magnetically modulated systems”,
Better Therapy With Existing Drugs: New Uses and Del. Sys.
; 179-216, 1981.
Hsieh, D., Langer, R.”Experimental approaches for achieving both zero-order and modulated controlled release from polymer matrix systems”,
Cont. Rel. of Pesticides and Pharm.
; 16-May, 1981.
Langer, R., Folkman, J. “Angiogenesis Inhibitors in molecular actions and targets for cancer chemotherapeutic agents” 511-525, 1981.
Langer, R., Hsich, D., Peil, A., Bawa, R., Rhine, W.”Polymers for sustained macromolecular release: kinetics, applications, external control”,
Cont. and Topical Rel. of Drugs to the Body
; 206: 10-20, 1981.
Mayberg, M., Langer, R., Zervas, N., Moskowitz, M.”Perivascular meningeal projections from at trigeminal ganglia: possible pathway for vascular headaches in man”,
Science;
213: 228-230, 1981.
Moskowitz, M., Mayberg, M., Langer, R.”Controlled release of horseradish peroxidase from polymers: a method to improve histochemical localization and sensitivity”,
Brain Res.
; 212: 460-465, 1981.
Langer, R., Peppas, N.”Present and future applications of biomaterials in controlled drug delivery systems”,
Biomaterials;
2: 195-210, 1981.
Langer, R., Urquhart, J. Blackshear, P.”Implantable drug delivery systems”,
Trans. Am. Soc. Art. Int. Organs
; 27: 648-654, 1981.
Peil, A., Barrett. F., Rha, C., Langer, R.”Retention of micro-nutrients by polymer coatings used to fortify rice”,
J. Food Science
; 47: 260-262, 1981