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Excitotoxic neuronal death requires superoxide entry into neurons through volume-regulated anion channels. Sci Adv. 2025 Aug 29; 11(35):eadw0424. Harris K, Won SJ, Uruk G, Mai N, Ogut D, Zhao Y, Xie L, Baxter P, Everaerts K, Sah R, Swanson RA. PMID: 40880478; PMCID: PMC12396328.
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PATJ regulates cell stress responses and vascular remodeling post-stroke. Redox Biol. 2025 09; 85:103709. Zhang M, Jiang WI, Arkelius K, Swanson RA, Ma DK, Singhal NS. PMID: 40472775; PMCID: PMC12169792.
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Stress hyperglycemia exacerbates inflammatory brain injury after stroke. bioRxiv. 2024 May 14. Won SJ, Zhang Y, Butler NJ, Kim K, Mocanu E, Nzoutchoum OT, Lakkaraju R, Davis J, Ghosh S, Swanson RA. PMID: 38798486; PMCID: PMC11118312.
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α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway. Cell Death Dis. 2024 04 13; 15(4):264. Oliveira da Silva MI, Santejo M, Babcock IW, Magalhães A, Minamide LS, Won SJ, Castillo E, Gerhardt E, Fahlbusch C, Swanson RA, Outeiro TF, Taipa R, Ruff M, Bamburg JR, Liz MA. PMID: 38615035; PMCID: PMC11016063.
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Cofilactin rod formation mediates inflammation-induced neurite degeneration. Cell Rep. 2024 03 26; 43(3):113914. Uruk G, Mocanu E, Shaw AE, Bamburg JR, Swanson RA. PMID: 38451813; PMCID: PMC11068216.
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Bioenergetic and excitotoxic determinants of cofilactin rod formation. J Neurochem. 2024 05; 168(5):899-909. Mai N, Wu L, Uruk G, Mocanu E, Swanson RA. PMID: 38299375; PMCID: PMC11102304.
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Brain energy metabolism: A roadmap for future research. J Neurochem. 2024 05; 168(5):910-954. Rae CD, Baur JA, Borges K, Dienel G, Díaz-García CM, Douglass SR, Drew K, Duarte JMN, Duran J, Kann O, Kristian T, Lee-Liu D, Lindquist BE, McNay EC, Robinson MB, Rothman DL, Rowlands BD, Ryan TA, Scafidi J, Scafidi S, Shuttleworth CW, Swanson RA, Uruk G, Vardjan N, Zorec R, McKenna MC. PMID: 38183680; PMCID: PMC11102343.
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Use of Botulinum Toxin for Limb Immobilization for Rehabilitation in Rats with Experimental Stroke. Biomolecules. 2023 03 10; 13(3). Zhang H, Liu J, Bingham D, Orr A, Kawabori M, Kim JY, Zheng Z, Lam TI, Massa SM, Swanson RA, Yenari MA. PMID: 36979446; PMCID: PMC10046338.
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Neuronal Oxidative Stress Promotes α-Synuclein Aggregation In Vivo. Antioxidants (Basel). 2022 Dec 15; 11(12). Won SJ, Fong R, Butler N, Sanchez J, Zhang Y, Wong C, Tambou Nzoutchoum O, Huynh A, Pan J, Swanson RA. PMID: 36552674; PMCID: PMC9774295.
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Blast-induced axonal degeneration in the rat cerebellum in the absence of head movement. Sci Rep. 2022 01 07; 12(1):143. Bishop R, Won SJ, Irvine KA, Basu J, Rome ES, Swanson RA. PMID: 34996954; PMCID: PMC8741772.
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Glucose availability limits microglial nitric oxide production. J Neurochem. 2021 12; 159(6):1008-1015. Castillo E, Mocanu E, Uruk G, Swanson RA. PMID: 34587283; PMCID: PMC9059794.
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α-synuclein aggregates induce c-Abl activation and dopaminergic neuronal loss by a feed-forward redox stress mechanism. Prog Neurobiol. 2021 07; 202:102070. Ghosh S, Won SJ, Wang J, Fong R, Butler NJM, Moss A, Wong C, Pan J, Sanchez J, Huynh A, Wu L, Manfredsson FP, Swanson RA. PMID: 33951536; PMCID: PMC8210833.
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A tandem activity-based sensing and labeling strategy enables imaging of transcellular hydrogen peroxide signaling. Proc Natl Acad Sci U S A. 2021 03 02; 118(9). Iwashita H, Castillo E, Messina MS, Swanson RA, Chang CJ. PMID: 33622793; PMCID: PMC7936376.
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Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 2021 03; 24(3):312-325. Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A. PMID: 33589835; PMCID: PMC8007081.
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Superoxide and Non-ionotropic Signaling in Neuronal Excitotoxicity. Front Neurosci. 2020; 4:861. Wang J, Swanson RA. PMID: 33013314; PMCID: PMC7497801.
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A thermodynamic function of glycogen in brain and muscle. Prog Neurobiol. 2020 06; 189:101787. Swanson RA. PMID: 32151532; PMCID: PMC11156230.
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Cofilin-actin rod formation in experimental stroke is attenuated by therapeutic hypothermia and overexpression of the inducible 70 kD inducible heat shock protein (Hsp70). Brain Circ. 2019 Oct-Dec; 5(4):225-233. Kurisu K, You J, Zheng Z, Won SJ, Swanson RA, Yenari MA. PMID: 31950099; PMCID: PMC6950512.
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Methodological considerations for studies of brain glycogen. J Neurosci Res. 2019 08; 97(8):914-922. Wu L, Wong CP, Swanson RA. PMID: 30892752; PMCID: PMC6565471.
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Technical and Comparative Aspects of Brain Glycogen Metabolism. Adv Neurobiol. 2019; 23:169-185. Wu L, Butler NJM, Swanson RA. PMID: 31667809.
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Excitotoxic superoxide production and neuronal death require both ionotropic and non-ionotropic NMDA receptor signaling. Sci Rep. 2018 11 30; 8(1):17522. Minnella AM, Zhao JX, Jiang X, Jakobsen E, Lu F, Wu L, El-Benna J, Gray JA, Swanson RA. PMID: 30504838; PMCID: PMC6269523.
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Cofilin-actin rod formation in neuronal processes after brain ischemia. PLoS One. 2018; 13(10):e0198709. Won SJ, Minnella AM, Wu L, Eun CH, Rome E, Herson PS, Shaw AE, Bamburg JR, Swanson RA. PMID: 30325927; PMCID: PMC6191105.
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Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nat Immunol. 2018 11; 19(11):1212-1223. Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K. PMID: 30323343; PMCID: PMC6317891.
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Editorial. Glia. 2018 06; 66(6):1133. Barros F, Brown AM, Swanson RA. PMID: 29663573.
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Effects of Veliparib on Microglial Activation and Functional Outcomes after Traumatic Brain Injury in the Rat and Pig. J Neurotrauma. 2018 Apr 01; 35(7):918-929. Irvine KA, Bishop RK, Won SJ, Xu J, Hamel KA, Coppes V, Singh P, Sondag A, Rome E, Basu J, Cittolin-Santos GF, Panter SS, Swanson RA. PMID: 29285982.
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Glia in brain energy metabolism: A perspective. Glia. 2018 06; 66(6):1134-1137. Barros LF, Brown A, Swanson RA. PMID: 29476554; PMCID: PMC6009848.
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Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell Death Differ. 2018 03; 25(3):542-572. Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM. PMID: 29229998; PMCID: PMC5864235.
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Bioenergetic regulation of microglia. Glia. 2018 06; 66(6):1200-1212. Ghosh S, Castillo E, Frias ES, Swanson RA. PMID: 29219210; PMCID: PMC5903989.
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Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP. Nat Commun. 2017 09 22; 8(1):624. Shen Y, Kapfhamer D, Minnella AM, Kim JE, Won SJ, Chen Y, Huang Y, Low LH, Massa SM, Swanson RA. PMID: 28935892; PMCID: PMC5608947.
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Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases. Br J Pharmacol. 2018 01; 175(2):192-222. Berger NA, Besson VC, Boulares AH, Bürkle A, Chiarugi A, Clark RS, Curtin NJ, Cuzzocrea S, Dawson TM, Dawson VL, Haskó G, Liaudet L, Moroni F, Pacher P, Radermacher P, Salzman AL, Snyder SH, Soriano FG, Strosznajder RP, Sümegi B, Swanson RA, Szabo C. PMID: 28213892; PMCID: PMC5758399.
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A data-driven approach for evaluating multi-modal therapy in traumatic brain injury. Sci Rep. 2017 02 16; 7:42474. Haefeli J, Ferguson AR, Bingham D, Orr A, Won SJ, Lam TI, Shi J, Hawley S, Liu J, Swanson RA, Massa SM. PMID: 28205533; PMCID: PMC5311970.
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Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions. Brain Inj. 2017; 31(9):1168-1176. Cernak I, Stein DG, Elder GA, Ahlers S, Curley K, DePalma RG, Duda J, Ikonomovic M, Iverson GL, Kobeissy F, Koliatsos VE, Leggieri MJ, Pacifico AM, Smith DH, Swanson R, Thompson FJ, Tortella FC. PMID: 28981339; PMCID: PMC9351990.
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Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration. Elife. 2016 12 12; 5. Ko HR, Kwon IS, Hwang I, Jin EJ, Shin JH, Brennan-Minnella AM, Swanson R, Cho SW, Lee KH, Ahn JY. PMID: 27938661; PMCID: PMC5153247.
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Microglial activation induced by the alarmin S100B is regulated by poly(ADP-ribose) polymerase-1. Glia. 2016 11; 64(11):1869-78. Xu J, Wang H, Won SJ, Basu J, Kapfhamer D, Swanson RA. PMID: 27444121; PMCID: PMC7927976.
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Neuronal Glutathione Content and Antioxidant Capacity can be Normalized In Situ by N-acetyl Cysteine Concentrations Attained in Human Cerebrospinal Fluid. Neurotherapeutics. 2016 Jan; 13(1):217-25. Reyes RC, Cittolin-Santos GF, Kim JE, Won SJ, Brennan-Minnella AM, Katz M, Glass GA, Swanson RA. PMID: 26572666; PMCID: PMC4720670.
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Erratum to: Neuronal Glutathione Content and Antioxidant Capacity can be Normalized In Situ by N-acetyl Cysteine Concentrations Attained in Human Cerebrospinal Fluid. Neurotherapeutics. 2016 Jan; 13(1):239. Reyes RC, Cittolin-Santos GF, Kim JE, Won SJ, Brennan-Minnella AM, Katz M, Glass GA, Swanson RA. PMID: 26659493; PMCID: PMC4720674.
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NF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1. J Neuroinflammation. 2015 Dec 04; 12:229. Vuong B, Hogan-Cann AD, Alano CC, Stevenson M, Chan WY, Anderson CM, Swanson RA, Kauppinen TM. PMID: 26637332; PMCID: PMC4670503.
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Targeted Lipid Profiling Discovers Plasma Biomarkers of Acute Brain Injury. PLoS One. 2015; 10(6):e0129735. Sheth SA, Iavarone AT, Liebeskind DS, Won SJ, Swanson RA. PMID: 26076478; PMCID: PMC4468135.
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Assessment at the single-cell level identifies neuronal glutathione depletion as both a cause and effect of ischemia-reperfusion oxidative stress. J Neurosci. 2015 May 06; 35(18):7143-52. Won SJ, Kim JE, Cittolin-Santos GF, Swanson RA. PMID: 25948264; PMCID: PMC4420782.
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Cerebrospinal fluid concentrations of N-acetylcysteine after oral administration in Parkinson's disease. Parkinsonism Relat Disord. 2015 May; 21(5):500-3. Katz M, Won SJ, Park Y, Orr A, Jones DP, Swanson RA, Glass GA. PMID: 25765302.
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Tat-NR2B9c prevents excitotoxic neuronal superoxide production. J Cereb Blood Flow Metab. 2015 May; 35(5):739-42. Chen Y, Brennan-Minnella AM, Sheth S, El-Benna J, Swanson RA. PMID: 25669908; PMCID: PMC4420863.
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NADPH oxidase-2: linking glucose, acidosis, and excitotoxicity in stroke. Antioxid Redox Signal. 2015 Jan 10; 22(2):161-74. Brennan-Minnella AM, Won SJ, Swanson RA. PMID: 24628477; PMCID: PMC4281853.
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NR2B phosphorylation at tyrosine 1472 contributes to brain injury in a rodent model of neonatal hypoxia-ischemia. Stroke. 2014 Oct; 45(10):3040-7. Knox R, Brennan-Minnella AM, Lu F, Yang D, Nakazawa T, Yamamoto T, Swanson RA, Ferriero DM, Jiang X. PMID: 25158771; PMCID: PMC4175024.
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Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13487-92. Cleaver JE, Brennan-Minnella AM, Swanson RA, Fong KW, Chen J, Chou KM, Chen YW, Revet I, Bezrookove V. PMID: 25136123; PMCID: PMC4169934.
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Brain glycogen--vestigial no more. Foreword. Metab Brain Dis. 2015 Feb; 30(1):251-3. Swanson RA. PMID: 25060966.
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Opposing effects of glucose on stroke and reperfusion injury: acidosis, oxidative stress, and energy metabolism. Stroke. 2014 Jun; 45(6):1881-6. Robbins NM, Swanson RA. PMID: 24743441; PMCID: PMC4102697.
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A systematic survey of lipids across mouse tissues. Am J Physiol Endocrinol Metab. 2014 Apr 15; 306(8):E854-68. Jain M, Ngoy S, Sheth SA, Swanson RA, Rhee EP, Liao R, Clish CB, Mootha VK, Nilsson R. PMID: 24518676; PMCID: PMC3989739.
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Glucose, acid, and aspartate: Friends and foes of the axon. Ann Neurol. 2014 Apr; 75(4):490-1. Swanson RA. PMID: 24272667; PMCID: PMC4074545.
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Targeting microglial activation in stroke therapy: pharmacological tools and gender effects. Curr Med Chem. 2014; 21(19):2146-55. Chen Y, Won SJ, Xu Y, Swanson RA. PMID: 24372213; PMCID: PMC4076056.
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Intracellular pH reduction prevents excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):E4362-8. Lam TI, Brennan-Minnella AM, Won SJ, Shen Y, Hefner C, Shi Y, Sun D, Swanson RA. PMID: 24163350; PMCID: PMC3832003.
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Sirtuins in neurodegenerative diseases: an update on potential mechanisms. Front Aging Neurosci. 2013 Sep 25; 5:53. Min SW, Sohn PD, Cho SH, Swanson RA, Gan L. PMID: 24093018; PMCID: PMC3782645.
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Mitochondrial dysfunction induced by nuclear poly(ADP-ribose) polymerase-1: a treatable cause of cell death in stroke. Transl Stroke Res. 2014 Feb; 5(1):136-44. Baxter P, Chen Y, Xu Y, Swanson RA. PMID: 24323707; PMCID: PMC4034530.
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10th International Conference on Brain Energy Metabolism. Preface. J Neurosci Res. 2013 Aug; 91(8):1005-6. Swanson R, Schouboe A, McKenna MC. PMID: 23798354.
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Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation. Biochim Biophys Acta. 2013 Aug; 1833(8):1985-91. Kauppinen TM, Gan L, Swanson RA. PMID: 23597856; PMCID: PMC4041949.
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Activation of neuronal NMDA receptors induces superoxide-mediated oxidative stress in neighboring neurons and astrocytes. J Neurosci. 2012 Sep 12; 32(37):12973-8. Reyes RC, Brennan AM, Shen Y, Baldwin Y, Swanson RA. PMID: 22973021; PMCID: PMC3478885.
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Recurrent/moderate hypoglycemia induces hippocampal dendritic injury, microglial activation, and cognitive impairment in diabetic rats. J Neuroinflammation. 2012 Jul 25; 9:182. Won SJ, Yoo BH, Kauppinen TM, Choi BY, Kim JH, Jang BG, Lee MW, Sohn M, Liu J, Swanson RA, Suh SW. PMID: 22830525; PMCID: PMC3458941.
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Prevention of traumatic brain injury-induced neuron death by intranasal delivery of nicotinamide adenine dinucleotide. J Neurotrauma. 2012 May 01; 29(7):1401-9. Won SJ, Choi BY, Yoo BH, Sohn M, Ying W, Swanson RA, Suh SW. PMID: 22352983; PMCID: PMC5972775.
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One cell's poison is another cell's cure. Nat Neurosci. 2012 Mar 27; 15(4):505-6. Swanson RA. PMID: 22449958.
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Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor. J Neuroinflammation. 2012 Feb 15; 9:31. d'Avila JC, Lam TI, Bingham D, Shi J, Won SJ, Kauppinen TM, Massa S, Liu J, Swanson RA. PMID: 22335939; PMCID: PMC3298794.
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Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β. J Neuroinflammation. 2011 Nov 03; 8:152. Kauppinen TM, Suh SW, Higashi Y, Berman AE, Escartin C, Won SJ, Wang C, Cho SH, Gan L, Swanson RA. PMID: 22051244; PMCID: PMC3247192.
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Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by Increasing superoxide production. Ann Neurol. 2011 Oct; 70(4):583-90. Won SJ, Tang XN, Suh SW, Yenari MA, Swanson RA. PMID: 22002675; PMCID: PMC4554391.
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Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression. J Neurosci. 2011 May 18; 31(20):7392-401. Escartin C, Won SJ, Malgorn C, Auregan G, Berman AE, Chen PC, Déglon N, Johnson JA, Suh SW, Swanson RA. PMID: 21593323; PMCID: PMC3339848.
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N-acetylcysteine prevents loss of dopaminergic neurons in the EAAC1-/- mouse. Ann Neurol. 2011 Mar; 69(3):509-20. Berman AE, Chan WY, Brennan AM, Reyes RC, Adler BL, Suh SW, Kauppinen TM, Edling Y, Swanson RA. PMID: 21446024; PMCID: PMC4096233.
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EAAC1 gene deletion alters zinc homeostasis and exacerbates neuronal injury after transient cerebral ischemia. J Neurosci. 2010 Nov 17; 30(46):15409-18. Won SJ, Yoo BH, Brennan AM, Shin BS, Kauppinen TM, Berman AE, Swanson RA, Suh SW. PMID: 21084597; PMCID: PMC6633677.
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Microglial activation in stroke: therapeutic targets. Neurotherapeutics. 2010 Oct; 7(4):378-91. Yenari MA, Kauppinen TM, Swanson RA. PMID: 20880502; PMCID: PMC5084300.
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Digitally quantifying cerebral hemorrhage using Photoshop and Image J. J Neurosci Methods. 2010 Jul 15; 190(2):240-3. Tang XN, Berman AE, Swanson RA, Yenari MA. PMID: 20452374; PMCID: PMC2898728.
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Astrocytic poly(ADP-ribose) polymerase-1 activation leads to bioenergetic depletion and inhibition of glutamate uptake capacity. Glia. 2010 Mar; 58(4):446-57. Tang KS, Suh SW, Alano CC, Shao Z, Hunt WT, Swanson RA, Anderson CM. PMID: 19795500.
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NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death. J Neurosci. 2010 Feb 24; 30(8):2967-78. Alano CC, Garnier P, Ying W, Higashi Y, Kauppinen TM, Swanson RA. PMID: 20181594; PMCID: PMC2864043.
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Pyruvate protects against experimental stroke via an anti-inflammatory mechanism. Neurobiol Dis. 2009 Oct; 36(1):223-31. Wang Q, van Hoecke M, Tang XN, Lee H, Zheng Z, Swanson RA, Yenari MA. PMID: 19635562; PMCID: PMC2742567.
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NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation. Nat Neurosci. 2009 Jul; 12(7):857-63. Brennan AM, Suh SW, Won SJ, Narasimhan P, Kauppinen TM, Lee H, Edling Y, Chan PH, Swanson RA. PMID: 19503084; PMCID: PMC2746760.
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Astrocyte cultures exhibit P2X7 receptor channel opening in the absence of exogenous ligands. Glia. 2009 Apr 15; 57(6):622-33. Nagasawa K, Escartin C, Swanson RA. PMID: 18942742.
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Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase. PLoS One. 2009; 4(3):e4896. Burns DM, Ying W, Kauppinen TM, Zhu K, Swanson RA. PMID: 19319190; PMCID: PMC2655720.
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Inhibition of poly(ADP-ribose) polymerase suppresses inflammation and promotes recovery after ischemic injury. J Cereb Blood Flow Metab. 2009 Apr; 29(4):820-9. Kauppinen TM, Suh SW, Berman AE, Hamby AM, Swanson RA. PMID: 19190653.
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Glucose and NADPH oxidase drive neuronal superoxide formation in stroke. Ann Neurol. 2008 Dec; 64(6):654-63. Suh SW, Shin BS, Ma H, Van Hoecke M, Brennan AM, Yenari MA, Swanson RA. PMID: 19107988; PMCID: PMC4304737.
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Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death. J Cereb Blood Flow Metab. 2008 Oct; 28(10):1697-706. Suh SW, Hamby AM, Gum ET, Shin BS, Won SJ, Sheline CT, Chan PH, Swanson RA. PMID: 18545258.
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Zinc triggers microglial activation. J Neurosci. 2008 May 28; 28(22):5827-35. Kauppinen TM, Higashi Y, Suh SW, Escartin C, Nagasawa K, Swanson RA. PMID: 18509044; PMCID: PMC2680357.
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Differences among cell types in NAD(+) compartmentalization: a comparison of neurons, astrocytes, and cardiac myocytes. J Neurosci Res. 2007 Nov 15; 85(15):3378-85. Alano CC, Tran A, Tao R, Ying W, Karliner JS, Swanson RA. PMID: 17853438.
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Hypoglycemia, brain energetics, and hypoglycemic neuronal death. Glia. 2007 Sep; 55(12):1280-1286. Suh SW, Hamby AM, Swanson RA. PMID: 17659530.
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Inhibition of mitochondrial function in astrocytes: implications for neuroprotection. J Neurochem. 2007 Aug; 102(4):1383-94. Voloboueva LA, Suh SW, Swanson RA, Giffard RG. PMID: 17488276; PMCID: PMC3175820.
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Zinc inhibits astrocyte glutamate uptake by activation of poly(ADP-ribose) polymerase-1. Mol Med. 2007 Jul-Aug; 13(7-8):344-9. Suh SW, Aoyama K, Alano CC, Anderson CM, Hamby AM, Swanson RA. PMID: 17728843; PMCID: PMC1952665.
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Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase. J Clin Invest. 2007 Apr; 117(4):910-8. Suh SW, Gum ET, Hamby AM, Chan PH, Swanson RA. PMID: 17404617; PMCID: PMC1838937.
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Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes. J Neurochem. 2007 May; 101(4):1002-17. Bourguignon LY, Gilad E, Peyrollier K, Brightman A, Swanson RA. PMID: 17403031.
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Use of a poly(ADP-ribose) polymerase inhibitor to suppress inflammation and neuronal death after cerebral ischemia-reperfusion. Stroke. 2007 Feb; 38(2 Suppl):632-6. Hamby AM, Suh SW, Kauppinen TM, Swanson RA. PMID: 17261705.
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Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide). J Pharmacol Exp Ther. 2007 Apr; 321(1):45-50. Suh SW, Bergher JP, Anderson CM, Treadway JL, Fosgerau K, Swanson RA. PMID: 17251391.
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INTRODUCTION: Immune mechanisms of neurodegeneration. Clin Neurosci Res. 2006 Dec; 6(5):225. Yenari MA, Swanson RA. PMID: 17464366; PMCID: PMC1857289.
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Novel modulators of poly(ADP-ribose) polymerase. Trends Pharmacol Sci. 2006 Dec; 27(12):626-30. Szabo C, Pacher P, Swanson RA. PMID: 17055069; PMCID: PMC2228253.
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Intracerebral hematoma: beyond the mass lesion. Stroke. 2006 Oct; 37(10):2445. Swanson RA. PMID: 16960087.
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Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations. Proc Natl Acad Sci U S A. 2006 Jun 20; 103(25):9685-90. Alano CC, Kauppinen TM, Valls AV, Swanson RA. PMID: 16769901; PMCID: PMC1480467.
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Players in the PARP-1 cell-death pathway: JNK1 joins the cast. Trends Biochem Sci. 2006 Jun; 31(6):309-11. Alano CC, Swanson RA. PMID: 16679020.
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Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. Proc Natl Acad Sci U S A. 2006 May 02; 103(18):7136-41. Kauppinen TM, Chan WY, Suh SW, Wiggins AK, Huang EJ, Swanson RA. PMID: 16627622; PMCID: PMC1459030.
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Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nat Neurosci. 2006 Jan; 9(1):119-26. Aoyama K, Suh SW, Hamby AM, Liu J, Chan WY, Chen Y, Swanson RA. PMID: 16311588.
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NADH can enter into astrocytes and block poly(ADP-ribose) polymerase-1-mediated astrocyte death. Neuroreport. 2005 Aug 01; 16(11):1209-12. Zhu K, Swanson RA, Ying W. PMID: 16012350.
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Poly(ADP-ribose) polymerase-1 activation in a primate model of multiple sclerosis. J Neurosci Res. 2005 Jul 15; 81(2):190-8. Kauppinen TM, Suh SW, Genain CP, Swanson RA. PMID: 15931673.
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Ischemia-induced programmed cell death in astrocytes. Glia. 2005 Jun; 50(4):299-306. Giffard RG, Swanson RA. PMID: 15846803.
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Pyruvate administered after severe hypoglycemia reduces neuronal death and cognitive impairment. Diabetes. 2005 May; 54(5):1452-8. Suh SW, Aoyama K, Matsumori Y, Liu J, Swanson RA. PMID: 15855333.
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Acidosis causes endoplasmic reticulum stress and caspase-12-mediated astrocyte death. J Cereb Blood Flow Metab. 2005 Mar; 25(3):358-70. Aoyama K, Burns DM, Suh SW, Garnier P, Matsumori Y, Shiina H, Swanson RA. PMID: 15689959.
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Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death. J Immunol. 2005 Feb 15; 174(4):2288-96. Kauppinen TM, Swanson RA. PMID: 15699164.
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Hypoglycemia induces transient neurogenesis and subsequent progenitor cell loss in the rat hippocampus. Diabetes. 2005 Feb; 54(2):500-9. Suh SW, Fan Y, Hong SM, Liu Z, Matsumori Y, Weinstein PR, Swanson RA, Liu J. PMID: 15677508.
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NAD+ as a metabolic link between DNA damage and cell death. J Neurosci Res. 2005 Jan 1-15; 79(1-2):216-23. Ying W, Alano CC, Garnier P, Swanson RA. PMID: 15562437.
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Hypoxia induces caspase-9 and caspase-3 activation without neuronal death in gerbil brains. Eur J Neurosci. 2004 Aug; 20(4):937-46. Garnier P, Prigent-Tessier A, Van Hoecke M, Bertrand N, Demougeot C, Sordet O, Swanson RA, Marie C, Beley A. PMID: 15305862.
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Zinc release contributes to hypoglycemia-induced neuronal death. Neurobiol Dis. 2004 Aug; 16(3):538-45. Suh SW, Garnier P, Aoyama K, Chen Y, Swanson RA. PMID: 15262265.
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Vitamin B12 deficiency. Arch Neurol. 2004 Jun; 61(6):960. Nakamura K, Mukherjee P, Swanson RA. PMID: 15210541.
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Astrocyte influences on ischemic neuronal death. Curr Mol Med. 2004 Mar; 4(2):193-205. Swanson RA, Ying W, Kauppinen TM. PMID: 15032713.
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Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition. J Biol Chem. 2004 Apr 30; 279(18):18895-902. Alano CC, Ying W, Swanson RA. PMID: 14960594.
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Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77. J Biol Chem. 2004 Apr 23; 279(17):17543-53. Castro-Obregón S, Rao RV, del Rio G, Chen SF, Poksay KS, Rabizadeh S, Vesce S, Zhang XK, Swanson RA, Bredesen DE. PMID: 14769794.
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Human serum albumin and its N-terminal tetrapeptide (DAHK) block oxidant-induced neuronal death. Stroke. 2004 Feb; 35(2):590-5. Gum ET, Swanson RA, Alano C, Liu J, Hong S, Weinstein PR, Panter SS. PMID: 14726550.
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ATP-induced ATP release from astrocytes. J Neurochem. 2004 Jan; 88(1):246-56. Anderson CM, Bergher JP, Swanson RA. PMID: 14675168.
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Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia. J Neurosci. 2003 Nov 19; 23(33):10681-90. Suh SW, Aoyama K, Chen Y, Garnier P, Matsumori Y, Gum E, Liu J, Swanson RA. PMID: 14627653; PMCID: PMC6740913.
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Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures. Neurosurgery. 2003 Nov; 53(5):1179-87; discussion 1187-8. Tsuchiya D, Hong S, Matsumori Y, Kayama T, Swanson RA, Dillman WH, Liu J, Panter SS, Weinstein PR. PMID: 14580286.
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Expression and activity of poly(ADP-ribose) glycohydrolase in cultured astrocytes, neurons, and C6 glioma cells. Brain Res Mol Brain Res. 2003 Oct 07; 117(2):213-20. Sevigny MB, Silva JM, Lan WC, Alano CC, Swanson RA. PMID: 14559156.
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NAD+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes. Biochem Biophys Res Commun. 2003 Sep 05; 308(4):809-13. Ying W, Garnier P, Swanson RA. PMID: 12927790.
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Ischemic preconditioning by caspase cleavage of poly(ADP-ribose) polymerase-1. J Neurosci. 2003 Sep 03; 23(22):7967-73. Garnier P, Ying W, Swanson RA. PMID: 12954857; PMCID: PMC6740500.
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Cerebral ischemia and infarction from atheroemboli <100 microm in Size. Stroke. 2003 Aug; 34(8):1976-80. Rapp JH, Pan XM, Yu B, Swanson RA, Higashida RT, Simpson P, Saloner D. PMID: 12855822.
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Overexpression of rat heat shock protein 70 is associated with reduction of early mitochondrial cytochrome C release and subsequent DNA fragmentation after permanent focal ischemia. J Cereb Blood Flow Metab. 2003 Jun; 23(6):718-27. Tsuchiya D, Hong S, Matsumori Y, Shiina H, Kayama T, Swanson RA, Dillman WH, Liu J, Panter SS, Weinstein PR. PMID: 12796720.
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Extracellular conversion of guanine-based purines to guanosine specifically enhances astrocyte glutamate uptake. Brain Res. 2003 May 16; 972(1-2):84-9. Frizzo ME, Antunes Soares FA, Dall'Onder LP, Lara DR, Swanson RA, Souza DO. PMID: 12711081.
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The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures. J Neurochem. 2003 Mar; 84(6):1332-9. Chen Y, Swanson RA. PMID: 12614333.
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P2X7 receptor-mediated release of excitatory amino acids from astrocytes. J Neurosci. 2003 Feb 15; 23(4):1320-8. Duan S, Anderson CM, Keung EC, Chen Y, Chen Y, Swanson RA. PMID: 12598620; PMCID: PMC6742264.
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Astrocytes and brain injury. J Cereb Blood Flow Metab. 2003 Feb; 23(2):137-49. Chen Y, Swanson RA. PMID: 12571445.
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Heat shock - induced Hsp70 expression in murine astrocytes does not require poly(ADP-ribose) polymerase activity. Cell Physiol Biochem. 2003; 13(5):297-300. Sevigny M, Garnier P, Kauppinen T, Swanson R. PMID: 14586173.
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Barbiturates induce mitochondrial depolarization and potentiate excitotoxic neuronal death. J Neurosci. 2002 Nov 01; 22(21):9203-9. Anderson CM, Norquist BA, Vesce S, Nicholls DG, Soine WH, Duan S, Swanson RA. PMID: 12417645; PMCID: PMC6758030.
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Tricarboxylic acid cycle substrates prevent PARP-mediated death of neurons and astrocytes. J Cereb Blood Flow Metab. 2002 Jul; 22(7):774-9. Ying W, Chen Y, Alano CC, Swanson RA. PMID: 12142562.
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