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IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity. Cell. 2025 Oct 30; 188(22):6220-6235.e22. Cortez VS, Viragova S, Koga S, Liu M, O'Leary CE, Ricardo-Gonzalez RR, Schroeder AW, Kochhar N, Vaka D, Boffelli D, Klein OD, Diamond MS, Liang HE, Locksley RM. PMID: 40914159.
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RORγt eTACs mediate oral tolerance and Treg induction. J Exp Med. 2025 Aug 04; 222(8). Sun IH, Qualls AE, Yin HS, Wang J, Arvedson MP, Germino J, Horner NK, Zhong S, Du J, Valdearcos M, Ntranos V, Locksley RM, Ricardo-Gonzalez RR, Gardner JM. PMID: 40298935; PMCID: PMC12039581.
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Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB. Cell. 2025 Apr 17; 188(8):2203-2217.e17. Lee Y, Ishikawa T, Lee H, Lee B, Ryu C, Davila Mejia I, Kim M, Lu G, Hong Y, Feng M, Shin H, Meloche S, Locksley RM, Koltsova E, Grivennikov SI, Heiman M, Choi GB, Huh JR. PMID: 40199322; PMCID: PMC12063771.
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IL-25-induced memory ILC2s mediate long-term small intestinal adaptation. bioRxiv. 2025 Mar 29. Cortez VS, Viragova S, Koga S, Liu M, O'Leary CE, Ricardo-Gonzalez RR, Schroeder AW, Kochhar N, Klein OD, Diamond MS, Liang HE, Locksley RM. PMID: 40196473; PMCID: PMC11974837.
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An ILC2-chitinase circuit restores lung homeostasis after epithelial injury. Sci Immunol. 2024 10 18; 9(100):eadl2986. Jung H, Kim DH, Díaz RE, White JM, Rucknagel S, Mosby L, Wang Y, Reddy S, Winkler ES, Hassan AO, Ying B, Diamond MS, Locksley RM, Fraser JS, Van Dyken SJ. PMID: 39423283; PMCID: PMC11854321.
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Telocytes link epithelial nutrient sensing with amplification of the ILC2-tuft cell circuit. bioRxiv. 2024 Oct 17. Liao C, Ji M, Wang ZE, Drucker DJ, Liang HE, Locksley RM. PMID: 39463951; PMCID: PMC11507662.
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Interleukin-33-activated basophils promote asthma by regulating Th2 cell entry into lung tissue. J Exp Med. 2024 Dec 02; 221(12). Schuijs MJ, Brenis Gomez CM, Bick F, Van Moorleghem J, Vanheerswynghels M, van Loo G, Beyaert R, Voehringer D, Locksley RM, Hammad H, Lambrecht BN. PMID: 39297875; PMCID: PMC11413418.
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Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase. Elife. 2024 Jun 17; 12. Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken S, Locksley RM, Fraser JS. PMID: 38884443; PMCID: PMC11182645.
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Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase. bioRxiv. 2024 Mar 25. Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken SJ, Locksley RM, Fraser JS. PMID: 37398339; PMCID: PMC10312649.
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Colostrum is required for the postnatal ontogeny of small intestine innate lymphoid type 2 cells and successful anti-helminth defences. Allergy. 2024 08; 79(8):2247-2251. Rekima A, van den Elsen L, Isnard C, Smyth DJ, Lynn MA, Yee T, Stevens NE, Machado S, Divakara N, Bhasin M, Tjiam MC, Rowel C, Servant F, Burcelin R, Locksley R, Maizels R, Lynn DJ, Egwang T, Verhasselt V. PMID: 38348877.
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Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. Nat Cell Biol. 2024 Feb; 26(2):250-262. Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD. PMID: 38321203; PMCID: PMC11654995.
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A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development. Nat Commun. 2023 10 28; 14(1):6872. O'Keefe RN, Carli ALE, Baloyan D, Chisanga D, Shi W, Afshar-Sterle S, Eissmann MF, Poh AR, Pal B, Seillet C, Locksley RM, Ernst M, Buchert M. PMID: 37898600; PMCID: PMC10613282.
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Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites. J Exp Med. 2023 12 04; 220(12). Shaikh N, Waterhölter A, Gnirck AC, Becker M, Adamiak V, Henneken L, Wunderlich M, Hartmann W, Linnemann L, Huber TB, Krebs CF, Panzer U, Locksley RM, Wilhelm C, Breloer M, Turner JE. PMID: 37773047; PMCID: PMC10541314.
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Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. bioRxiv. 2023 Sep 22. Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD. PMID: 37790430; PMCID: PMC10542170.
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Immune treatment tackles chronic obstructive pulmonary disease. Nature. 2023 09; 621(7979):476-477. Fahy JV, Locksley RM. PMID: 37587279.
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Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis. bioRxiv. 2023 Apr 28. Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, Locksley RM, Molofsky AB. PMID: 37163060; PMCID: PMC10168323.
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The ins and outs of innate and adaptive type 2 immunity. Immunity. 2023 04 11; 56(4):704-722. Molofsky AB, Locksley RM. PMID: 37044061; PMCID: PMC10120575.
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Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage. Annu Rev Pathol. 2023 01 24; 18:311-335. Kotas ME, O'Leary CE, Locksley RM. PMID: 36351364; PMCID: PMC10443898.
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Innate type 2 immunity controls hair follicle commensalism by Demodex mites. Immunity. 2022 10 11; 55(10):1891-1908.e12. Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, Díaz RE, Fraser JS, Ali N, Ansel KM, Spitzer MH, Liang HE, Locksley RM. PMID: 36044899; PMCID: PMC9561030.
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IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function. JCI Insight. 2022 07 08; 7(13). Kotas ME, Moore CM, Gurrola JG, Pletcher SD, Goldberg AN, Alvarez R, Yamato S, Bratcher PE, Shaughnessy CA, Zeitlin PL, Zhang IH, Li Y, Montgomery MT, Lee K, Cope EK, Locksley RM, Seibold MA, Gordon ED. PMID: 35608904; PMCID: PMC9310525.
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Bile acid-sensitive tuft cells regulate biliary neutrophil influx. Sci Immunol. 2022 03 04; 7(69):eabj1080. O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM. PMID: 35245089; PMCID: PMC9166270.
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ILC2s - development, divergence, dispersal. Curr Opin Immunol. 2022 04; 75:102168. Ricardo-Gonzalez RR, Molofsky AB, Locksley RM. PMID: 35176675; PMCID: PMC9131705.
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Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation. Immunity. 2022 02 08; 55(2):254-271.e7. Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, Molofsky AB. PMID: 35139352; PMCID: PMC8852844.
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Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1. Sci Immunol. 2021 Oct 15; 6(64):eabh0707. Castellanos CA, Ren X, Gonzalez SL, Li HK, Schroeder AW, Liang HE, Laidlaw BJ, Hu D, Mak ACY, Eng C, Rodríguez-Santana JR, LeNoir M, Yan Q, Celedón JC, Burchard EG, Zamvil SS, Ishido S, Locksley RM, Cyster JG, Huang X, Shin JS. PMID: 34652961; PMCID: PMC8736284.
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Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth. J Exp Med. 2021 10 04; 218(10). Gschwend J, Sherman SPM, Ridder F, Feng X, Liang HE, Locksley RM, Becher B, Schneider C. PMID: 34431978; PMCID: PMC8404471.
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CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone. Mucosal Immunol. 2021 11; 14(6):1295-1305. Kotas ME, Mroz NM, Koga S, Liang HE, Schroeder AW, Ricardo-Gonzalez RR, Schneider C, Locksley RM. PMID: 34290377; PMCID: PMC8528700.
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Corrections. Curr Protoc. 2021 Jul; 1(7):e205. O'Leary CE, Feng X, Cortez VS, Locksley RM, Schneider C. PMID: 34242484.
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A role for IL-33-activated ILC2s in eosinophilic vasculitis. JCI Insight. 2021 06 22; 6(12). Kotas ME, Dion J, Van Dyken S, Ricardo-Gonzalez RR, Danel CJ, Taillé C, Mouthon L, Locksley RM, Terrier B. PMID: 33974563; PMCID: PMC8262498.
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A stromal progenitor and ILC2 niche promotes muscle eosinophilia and fibrosis-associated gene expression. Cell Rep. 2021 04 13; 35(2):108997. Kastenschmidt JM, Coulis G, Farahat PK, Pham P, Rios R, Cristal TT, Mannaa AH, Ayer RE, Yahia R, Deshpande AA, Hughes BS, Savage AK, Giesige CR, Harper SQ, Locksley RM, Mozaffar T, Villalta SA. PMID: 33852849; PMCID: PMC8127948.
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Interrogating the Small Intestine Tuft Cell-ILC2 Circuit Using In Vivo Manipulations. Curr Protoc. 2021 Mar; 1(3):e77. O'Leary CE, Feng X, Cortez VS, Locksley RM, Schneider C. PMID: 33740294; PMCID: PMC8082719.
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Skin-resident innate lymphoid cells converge on a pathogenic effector state. Nature. 2021 04; 592(7852):128-132. Bielecki P, Riesenfeld SJ, Hütter JC, Torlai Triglia E, Kowalczyk MS, Ricardo-Gonzalez RR, Lian M, Amezcua Vesely MC, Kroehling L, Xu H, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, Kedaigle AJ, Steach HR, York AG, Skadow MH, Yaghoubi P, Dionne D, Jarret A, McGee HM, Porter CBM, Licona-Limón P, Bailis W, Jackson R, Gagliani N, Gasteiger G, Locksley RM, Regev A, Flavell RA. PMID: 33536623; PMCID: PMC8336632.
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In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors. Immunity. 2020 10 13; 53(4):775-792.e9. Zeis P, Lian M, Fan X, Herman JS, Hernandez DC, Gentek R, Elias S, Symowski C, Knöpper K, Peltokangas N, Friedrich C, Doucet-Ladeveze R, Kabat AM, Locksley RM, Voehringer D, Bajenoff M, Rudensky AY, Romagnani C, Grün D, Gasteiger G. PMID: 33002412; PMCID: PMC7611573.
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Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity. J Exp Med. 2020 04 06; 217(4). Ricardo-Gonzalez RR, Schneider C, Liao C, Lee J, Liang HE, Locksley RM. PMID: 32031571; PMCID: PMC7144525.
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Tissue immunity broadcasts near and far. Nat Rev Immunol. 2020 02; 20(2):93-94. Molofsky AB, Locksley RM. PMID: 31748703.
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Differences in the chitinolytic activity of mammalian chitinases on soluble and insoluble substrates. Protein Sci. 2020 04; 29(4):966-977. Barad BA, Liu L, Diaz RE, Basilio R, Van Dyken SJ, Locksley RM, Fraser JS. PMID: 31930591; PMCID: PMC7096708.
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Production of IFNβ by Conventional Dendritic Cells after Stimulation with Viral Compounds and IFNβ-Independent IFNAR1-Signaling Pathways are Associated with Aggravation of Polymicrobial Sepsis. Int J Mol Sci. 2019 Sep 07; 20(18). Howe M, Bauer J, Schulze A, Kropp S, Locksley RM, Alferink J, Weighardt H, Scheu S. PMID: 31500303; PMCID: PMC6770674.
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Regulation of immune responses by tuft cells. Nat Rev Immunol. 2019 09; 19(9):584-593. Schneider C, O'Leary CE, Locksley RM. PMID: 31114038; PMCID: PMC8331098.
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Making Asthma Crystal Clear. N Engl J Med. 2019 08 29; 381(9):882-884. Fahy JV, Locksley RM. PMID: 31461600.
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ILC2s chew the fat. J Exp Med. 2019 09 02; 216(9):1972-1973. Ricardo-Gonzalez RR, Locksley RM. PMID: 31405894; PMCID: PMC6719424.
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Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming. Immunity. 2019 06 18; 50(6):1425-1438.e5. Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM. PMID: 31128962; PMCID: PMC6645687.
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Tuft Cells-Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry. Annu Rev Immunol. 2019 04 26; 37:47-72. O'Leary CE, Schneider C, Locksley RM. PMID: 30379593; PMCID: PMC8352721.
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Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Nature. 2018 10; 562(7727):E22. Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD. PMID: 30013120.
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Tissue signals imprint ILC2 identity with anticipatory function. Nat Immunol. 2018 10; 19(10):1093-1099. Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM. PMID: 30201992; PMCID: PMC6202223.
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Innate Lymphoid Cells: 10 Years On. Cell. 2018 08 23; 174(5):1054-1066. Vivier E, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie ANJ, Mebius RE, Powrie F, Spits H. PMID: 30142344.
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Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development. Nature. 2018 07; 559(7715):627-631. Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS. PMID: 30022164; PMCID: PMC6062473.
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Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit. Immunity. 2018 07 17; 49(1):33-41.e7. Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J. PMID: 30021144; PMCID: PMC6084797.
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Chitins and chitinase activity in airway diseases. J Allergy Clin Immunol. 2018 08; 142(2):364-369. Van Dyken SJ, Locksley RM. PMID: 29959948; PMCID: PMC6078791.
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Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Nature. 2018 07; 559(7712):109-113. Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD. PMID: 29950724; PMCID: PMC6042247.
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Why Innate Lymphoid Cells? Immunity. 2018 06 19; 48(6):1081-1090. Kotas ME, Locksley RM. PMID: 29924974; PMCID: PMC6145487.
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A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling. Cell. 2018 07 12; 174(2):271-284.e14. Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM. PMID: 29887373; PMCID: PMC6046262.
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Pulmonary neuroendocrine cells amplify allergic asthma responses. Science. 2018 06 08; 360(6393). Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken S, Lashua A, Yu C, Klein BS, Locksley RM, Deutsch G, Sun X. PMID: 29599193; PMCID: PMC6387886.
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Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2017 12 14; 171(7):1707. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. PMID: 29245014; PMCID: PMC5764896.
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MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. J Exp Med. 2017 Dec 04; 214(12):3627-3643. Singh PB, Pua HH, Happ HC, Schneider C, von Moltke J, Locksley RM, Baumjohann D, Ansel KM. PMID: 29122948; PMCID: PMC5716040.
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Turning the light on. Nat Rev Immunol. 2017 10; 17(10):593. Locksley R. PMID: 28757606.
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The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine. J Immunol. 2017 09 01; 199(5):1912-1922. Savage AK, Liang HE, Locksley RM. PMID: 28747343; PMCID: PMC5568484.
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Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy. Cell Stem Cell. 2017 07 06; 21(1):120-134.e7. Lechner AJ, Driver IH, Lee J, Conroy CM, Nagle A, Locksley RM, Rock JR. PMID: 28506464; PMCID: PMC5501755.
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Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. J Exp Med. 2017 01; 214(1):27-37. von Moltke J, O'Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley RM. PMID: 28011865; PMCID: PMC5206504.
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Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLoS One. 2016; 11(12):e0167693. Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL. PMID: 27977701; PMCID: PMC5157987.
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A tissue checkpoint regulates type 2 immunity. Nat Immunol. 2016 Dec; 17(12):1381-1387. Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM. PMID: 27749840; PMCID: PMC5275767.
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Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2016 Aug 11; 166(4):841-854. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A. PMID: 27453471; PMCID: PMC4985267.
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Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis. JCI Insight. 2016 Jul 07; 1(10). Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD. PMID: 27525310; PMCID: PMC4979554.
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Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25. Am J Respir Crit Care Med. 2016 05 01; 193(9):935-6. Gordon ED, Locksley RM, Fahy JV. PMID: 27128698; PMCID: PMC4872659.
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Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature. 2016 Jan 14; 529(7585):221-5. von Moltke J, Ji M, Liang HE, Locksley RM. PMID: 26675736; PMCID: PMC4830391.
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Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis. Mucosal Immunol. 2016 Jan; 9(1):275-86. Mohapatra A, Van Dyken SJ, Schneider C, Nussbaum JC, Liang HE, Locksley RM. PMID: 26129648; PMCID: PMC4698110.
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Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation. Immunity. 2015 Jun 16; 42(6):1005-19. Molofsky AB, Savage AK, Locksley RM. PMID: 26084021; PMCID: PMC4471869.
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Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity. 2015 Jul 21; 43(1):161-74. Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM. PMID: 26092469; PMCID: PMC4512852.
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New blood: Creative funding of disease-specific research. Sci Transl Med. 2015 May 20; 7(288):288ed5. Seaman WE, Locksley RM, Welsh MJ. PMID: 25995219.
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Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB-induced Bcl-xL for inhibition of apoptosis. Blood. 2015 Jun 18; 125(25):3896-904. Schwartz C, Willebrand R, Huber S, Rupec RA, Wu D, Locksley R, Voehringer D. PMID: 25862560; PMCID: PMC4473117.
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IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015 Apr 06; 212(4):513-24. Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM. PMID: 25779634; PMCID: PMC4387286.
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A novel model for IFN-γ-mediated autoinflammatory syndromes. J Immunol. 2015 Mar 01; 194(5):2358-68. Reinhardt RL, Liang HE, Bao K, Price AE, Mohrs M, Kelly BL, Locksley RM. PMID: 25637019; PMCID: PMC4337485.
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Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell. 2015 Jan 15; 160(1-2):74-87. Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A. PMID: 25543153; PMCID: PMC4297518.
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Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine. Nat Immunol. 2015 Feb; 16(2):153-60. Bando JK, Liang HE, Locksley RM. PMID: 25501629; PMCID: PMC4297560.
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Allergic inflammation--innately homeostatic. Cold Spring Harb Perspect Biol. 2014 Nov 20; 7(3):a016352. Cheng LE, Locksley RM. PMID: 25414367; PMCID: PMC4355269.
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Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Blood. 2014 Dec 04; 124(24):3572-6. Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley RM, Bluestone JA. PMID: 25323825; PMCID: PMC4256909.
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I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis. Curr Opin Immunol. 2014 Dec; 31:58-65. von Moltke J, Locksley RM. PMID: 25458996; PMCID: PMC4254640.
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Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell. 2014 Jun 05; 157(6):1292-1308. Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian X, Locksley RM, Palmiter RD, Chawla A. PMID: 24906148; PMCID: PMC4129510.
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Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med. 2014 Jun 30; 211(7):1281-8. Patnode ML, Bando JK, Krummel MF, Locksley RM, Rosen SD. PMID: 24889202; PMCID: PMC4076593.
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Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection. Infect Immun. 2014 Aug; 82(8):3199-205. O'Dea EM, Amarsaikhan N, Li H, Downey J, Steele E, Van Dyken SJ, Locksley RM, Templeton SP. PMID: 24842927; PMCID: PMC4136210.
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Asthma and the flu: a tricky two-step. Immunol Cell Biol. 2014 May-Jun; 92(5):389-91. Locksley RM, Fahy JV. PMID: 24687019; PMCID: PMC4396068.
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Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells. Immunity. 2014 Mar 20; 40(3):414-24. Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM. PMID: 24631157; PMCID: PMC4019510.
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Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J Immunol. 2013 Dec 01; 191(11):5349-53. Hams E, Locksley RM, McKenzie AN, Fallon PG. PMID: 24166975; PMCID: PMC3847854.
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Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10; 502(7470):245-8. Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. PMID: 24037376; PMCID: PMC3795960.
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Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung. J Leukoc Biol. 2013 Nov; 94(5):877-84. Bando JK, Nussbaum JC, Liang HE, Locksley RM. PMID: 23924659; PMCID: PMC3800063.
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Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9914-9. Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A. PMID: 23716700; PMCID: PMC3683773.
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Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell. 2013 Apr 11; 153(2):376-88. Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley RM, Rando TA, Chawla A. PMID: 23582327; PMCID: PMC3663598.
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Raggin' on T-bet. Cell Metab. 2013 Apr 02; 17(4):473-4. Locksley RM. PMID: 23562073.
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Innate lymphoid cells--a proposal for uniform nomenclature. Nat Rev Immunol. 2013 Feb; 13(2):145-9. Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie AN, Mebius RE, Powrie F, Vivier E. PMID: 23348417.
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Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse. J Immunol. 2013 Mar 01; 190(5):2229-40. Oghumu S, Dong R, Varikuti S, Shawler T, Kampfrath T, Terrazas CA, Lezama-Davila C, Ahmer BM, Whitacre CC, Rajagopalan S, Locksley R, Sharpe AH, Satoskar AR. PMID: 23338236; PMCID: PMC3683850.
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Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. Annu Rev Immunol. 2013; 31:317-43. Van Dyken SJ, Locksley RM. PMID: 23298208; PMCID: PMC3606684.
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Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013 Jan 24; 38(1):166-75. Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM. PMID: 23290520; PMCID: PMC3576928.
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Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion. J Leukoc Biol. 2012 Nov; 92(5):999-1009. Dickgreber N, Farrand KJ, van Panhuys N, Knight DA, McKee SJ, Chong ML, Miranda-Hernandez S, Baxter AG, Locksley RM, Le Gros G, Hermans IF. PMID: 22941735; PMCID: PMC4050521.
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Marking and quantifying IL-17A-producing cells in vivo. PLoS One. 2012; 7(6):e39750. Price AE, Reinhardt RL, Liang HE, Locksley RM. PMID: 22768117; PMCID: PMC3387253.
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Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med. 2012 Jun 04; 209(6):1183-99. Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. PMID: 22585735; PMCID: PMC3371730.
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Infectious (Non)tolerance--frustrated commensalism gone awry? Cold Spring Harb Perspect Biol. 2012 May 01; 4(5). Nussbaum JC, Locksley RM. PMID: 22456498; PMCID: PMC3331693.
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Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nat Immunol. 2011 Dec 04; 13(1):58-66. Liang HE, Reinhardt RL, Bando JK, Sullivan BM, Ho IC, Locksley RM. PMID: 22138715; PMCID: PMC3242938.
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Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature. 2011 Nov 20; 480(7375):104-8. Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM, Chawla A. PMID: 22101429; PMCID: PMC3371761.
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Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol. 2011 Oct 15; 187(8):4319-30. Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA. PMID: 21918195; PMCID: PMC3186826.
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A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness. Clin Exp Allergy. 2012 Jan; 42(1):144-55. Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV. PMID: 22093101; PMCID: PMC3271792.
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The airway epithelium as a regulator of Th2 responses in asthma. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):390-2. Fahy JV, Locksley RM. PMID: 21844510.
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Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration. J Immunol. 2011 Sep 01; 187(5):2261-7. Van Dyken SJ, Garcia D, Porter P, Huang X, Quinlan PJ, Blanc PD, Corry DB, Locksley RM. PMID: 21824866; PMCID: PMC3159725.
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Genetic analysis of basophil function in vivo. Nat Immunol. 2011 Jun; 12(6):527-35. Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM. PMID: 21552267; PMCID: PMC3271435.
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Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science. 2011 Apr 08; 332(6026):243-7. Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM. PMID: 21436399; PMCID: PMC3144160.
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Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection. Parasite Immunol. 2011 Jan; 33(1):1-11. Svensson M, Bell L, Little MC, DeSchoolmeester M, Locksley RM, Else KJ. PMID: 21155838; PMCID: PMC3058490.
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IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22617-22. Ricardo-Gonzalez RR, Red Eagle A, Odegaard JI, Jouihan H, Morel CR, Heredia JE, Mukundan L, Wu D, Locksley RM, Chawla A. PMID: 21149710; PMCID: PMC3012500.
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Lymphocyte development requires S-nitrosoglutathione reductase. J Immunol. 2010 Dec 01; 185(11):6664-9. Yang Z, Wang ZE, Doulias PT, Wei W, Ischiropoulos H, Locksley RM, Liu L. PMID: 20980633; PMCID: PMC3070165.
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Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes. Mucosal Immunol. 2011 May; 4(3):325-34. Duerr CU, Salzman NH, Dupont A, Szabo A, Normark BH, Normark S, Locksley RM, Mellroth P, Hornef MW. PMID: 20980996.
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Murine B cells regulate serum IgE levels in a CD23-dependent manner. J Immunol. 2010 Nov 01; 185(9):5040-7. Cheng LE, Wang ZE, Locksley RM. PMID: 20870945; PMCID: PMC3085987.
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Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11489-94. Price AE, Liang HE, Sullivan BM, Reinhardt RL, Eisley CJ, Erle DJ, Locksley RM. PMID: 20534524; PMCID: PMC2895098.
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Asthma and allergic inflammation. Cell. 2010 Mar 19; 140(6):777-83. Locksley RM. PMID: 20303868; PMCID: PMC3134388.
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Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat Immunol. 2009 Nov; 10(11):1200-7. Barbalat R, Lau L, Locksley RM, Barton GM. PMID: 19801985; PMCID: PMC2821672.
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Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity. 2009 Aug 21; 31(2):197-208. Mingueneau M, Roncagalli R, Grégoire C, Kissenpfennig A, Miazek A, Archambaud C, Wang Y, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B. PMID: 19682930.
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Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates. BMC Biotechnol. 2009 Jul 28; 9:69. Voehringer D, Wu D, Liang HE, Locksley RM. PMID: 19638212; PMCID: PMC2724507.
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Nine lives: plasticity among T helper cell subsets. J Exp Med. 2009 Aug 03; 206(8):1643-6. Locksley RM. PMID: 19635860; PMCID: PMC2722180.
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In situ IL-12/23p40 production during mycobacterial infection is sustained by CD11bhigh dendritic cells localized in tissue sites distinct from those harboring bacilli. J Immunol. 2009 Jun 01; 182(11):6915-25. Rothfuchs AG, Egen JG, Feng CG, Antonelli LR, Bafica A, Winter N, Locksley RM, Sher A. PMID: 19454688; PMCID: PMC2786988.
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IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway. J Leukoc Biol. 2009 Oct; 86(4):769-78. Kroeger KM, Sullivan BM, Locksley RM. PMID: 19451398; PMCID: PMC2752018.
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Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. J Biol Chem. 2009 Jul 17; 284(29):19650-8. Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley RM, Burchard EG. PMID: 19435888; PMCID: PMC2740590.
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Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol. 2009 Apr; 10(4):385-93. Reinhardt RL, Liang HE, Locksley RM. PMID: 19252490; PMCID: PMC2714053.
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The inflammasome and alum-mediated adjuvanticity. F1000 Biol Rep. 2009 Feb 24; 1:15. Kang SJ, Locksley RM. PMID: 20948671; PMCID: PMC2920669.
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Basophils: a nonredundant contributor to host immunity. Immunity. 2009 Jan 16; 30(1):12-20. Sullivan BM, Locksley RM. PMID: 19144314.
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Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20416-21. Scheu S, Dresing P, Locksley RM. PMID: 19088190; PMCID: PMC2629269.
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Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity. 2008 Nov 14; 29(5):819-33. Kang SJ, Liang HE, Reizis B, Locksley RM. PMID: 19006696; PMCID: PMC2858430.
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Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration. J Immunol. 2008 Oct 15; 181(8):5560-7. Robinson RT, Khader SA, Locksley RM, Lien E, Smiley ST, Cooper AM. PMID: 18832714; PMCID: PMC2640496.
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Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol. 2008 Oct 15; 181(8):5374-85. Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL. PMID: 18832694; PMCID: PMC2657555.
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Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell. 2008 Oct 03; 135(1):37-48. Cisse B, Caton ML, Lehner M, Maeda T, Scheu S, Locksley R, Holmberg D, Zweier C, den Hollander NS, Kant SG, Holter W, Rauch A, Zhuang Y, Reizis B. PMID: 18854153; PMCID: PMC2631034.
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Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity. 2008 Jul 18; 29(1):90-100. Jensen KD, Su X, Shin S, Li L, Youssef S, Yamasaki S, Steinman L, Saito T, Locksley RM, Davis MM, Baumgarth N, Chien YH. PMID: 18585064; PMCID: PMC2601709.
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The Roaring Twenties. Immunity. 2008 Apr; 28(4):437-9. Locksley RM. PMID: 18400185.
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Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice. J Immunol. 2008 Apr 01; 180(7):4742-53. Voehringer D, Liang HE, Locksley RM. PMID: 18354198; PMCID: PMC2670614.
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Autoimmunity: altered self-N-glycans trigger innate-mediated autoimmunity. Immunol Cell Biol. 2007 Nov-Dec; 85(8):572-4. Van Dyken SJ, Locksley RM. PMID: 17909561.
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Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science. 2007 Aug 03; 317(5838):670-4. Mueller SN, Hosiawa-Meagher KA, Konieczny BT, Sullivan BM, Bachmann MF, Locksley RM, Ahmed R, Matloubian M. PMID: 17673664.
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A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes. J Immunol. 2007 Jul 15; 179(2):1096-103. Nurieva RI, Chuvpilo S, Wieder ED, Elkon KB, Locksley R, Serfling E, Dong C. PMID: 17617602.
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Different epitopes of the LACK protein are recognized by V beta 4 V alpha 8 CD4+ T cells in H-2b and H-2d mice susceptible to Leishmania major. Microbes Infect. 2007 Sep; 9(11):1260-6. Launois P, Pingel S, Himmelrich H, Locksley R, Louis J. PMID: 17890126.
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Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature. 2007 May 03; 447(7140):92-6. Reese TA, Liang HE, Tager AM, Luster AD, Van Rooijen N, Voehringer D, Locksley RM. PMID: 17450126; PMCID: PMC2527589.
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IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol. 2007 Apr; 8(4):369-77. Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, Cilley GE, Shen F, Eaton SM, Gaffen SL, Swain SL, Locksley RM, Haynes L, Randall TD, Cooper AM. PMID: 17351619.
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Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection. Exp Parasitol. 2007 Aug; 116(4):458-66. Voehringer D, Stanley SA, Cox JS, Completo GC, Lowary TL, Locksley RM. PMID: 17420014; PMCID: PMC2699772.
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Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages. J Leukoc Biol. 2007 Jun; 81(6):1434-44. Voehringer D, van Rooijen N, Locksley RM. PMID: 17339609.
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Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med. 2006 Dec 25; 203(13):2907-17. Xu X, Zhang D, Zhang H, Wolters PJ, Killeen NP, Sullivan BM, Locksley RM, Lowell CA, Caughey GH. PMID: 17158962; PMCID: PMC2118183.
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A failure to launch: fuelling cytokine secretion in iNKT cells. Immunity. 2006 Sep; 25(3):393-5. Locksley RM. PMID: 16979571.
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Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. J Immunol. 2006 Aug 01; 177(3):1618-27. Reinhardt RL, Hong S, Kang SJ, Wang ZE, Locksley RM. PMID: 16849470.
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Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J Clin Invest. 2006 Aug; 116(8):2252-61. Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA. PMID: 16886063; PMCID: PMC1523399.
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LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major. Eur J Immunol. 2006 Jun; 36(6):1465-73. Gumy A, Aseffa A, Rachinel N, Breton M, Otten L, Tacchini-Cottier F, Röcken M, Doyen N, Acha-Orbea H, Locksley RM, MacDonald HR, Launois P, Louis J. PMID: 16637008.
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Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med. 2006 Jun 12; 203(6):1435-46. Voehringer D, Reese TA, Huang X, Shinkai K, Locksley RM. PMID: 16702603; PMCID: PMC2118302.
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Activation of the integrated stress response during T helper cell differentiation. Nat Immunol. 2006 Jun; 7(6):644-51. Scheu S, Stetson DB, Reinhardt RL, Leber JH, Mohrs M, Locksley RM. PMID: 16680145.
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Replication initiation from a novel origin identified in the Th2 cytokine cluster locus requires a distant conserved noncoding sequence. J Immunol. 2006 May 01; 176(9):5446-54. Hayashida T, Oda M, Ohsawa K, Yamaguchi A, Hosozawa T, Locksley RM, Giacca M, Masai H, Miyatake S. PMID: 16622012.
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T helper cell effector fates--who, how and where? Curr Opin Immunol. 2006 Jun; 18(3):271-7. Reinhardt RL, Kang SJ, Liang HE, Locksley RM. PMID: 16617008.
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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006 Feb; 24(2):179-89. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. PMID: 16473830.
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Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol. 2006 Jan; 7(1):83-92. Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA. PMID: 16311599; PMCID: PMC3057888.
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Cytokine reporter mouse system for screening novel IL12/23 p40-inducing compounds. Mol Cells. 2005 Oct 31; 20(2):288-96. Im W, Kim H, Yun D, Seo SY, Park SH, Locksley RM, Hong S. PMID: 16267405.
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A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity. 2005 Oct; 23(4):419-29. Mohrs K, Wakil AE, Killeen N, Locksley RM, Mohrs M. PMID: 16226507; PMCID: PMC2826320.
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Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection. Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28):9872-7. Loke P, Zang X, Hsuan L, Waitz R, Locksley RM, Allen JE, Allison JP. PMID: 15994233; PMCID: PMC1175004.
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Interleukin-4 can be a key positive regulator of inflammatory arthritis. Arthritis Rheum. 2005 Jun; 52(6):1866-75. Ohmura K, Nguyen LT, Locksley RM, Mathis D, Benoist C. PMID: 15934072.
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The Leishmania major LACK antigen with an immunodominant epitope at amino acids 156 to 173 is not required for early Th2 development in BALB/c mice. Infect Immun. 2004 Dec; 72(12):6924-31. Kelly BL, Locksley RM. PMID: 15557613; PMCID: PMC529165.
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CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. J Biol Chem. 2004 Dec 24; 279(52):54117-23. Voehringer D, Rosen DB, Lanier LL, Locksley RM. PMID: 15471863.
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Innate immune responses in peptidoglycan recognition protein L-deficient mice. Mol Cell Biol. 2004 Sep; 24(18):7949-57. Xu M, Wang Z, Locksley RM. PMID: 15340057; PMCID: PMC515053.
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Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity. 2004 Mar; 20(3):267-77. Voehringer D, Shinkai K, Locksley RM. PMID: 15030771.
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Th2 cells: orchestrating barrier immunity. Adv Immunol. 2004; 83:163-89. Stetson DB, Voehringer D, Grogan JL, Xu M, Reinhardt RL, Scheu S, Kelly BL, Locksley RM. PMID: 15135631.
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Basal chromatin modification at the IL-4 gene in helper T cells. J Immunol. 2003 Dec 15; 171(12):6672-9. Grogan JL, Wang ZE, Stanley S, Harmon B, Loots GG, Rubin EM, Locksley RM. PMID: 14662870.
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Leishmania major LACK antigen is required for efficient vertebrate parasitization. J Exp Med. 2003 Dec 01; 198(11):1689-98. Kelly BL, Stetson DB, Locksley RM. PMID: 14657221; PMCID: PMC2194132.
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Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med. 2003 Oct 06; 198(7):1069-76. Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, Gapin L, Kronenberg M, Locksley RM. PMID: 14530376; PMCID: PMC2194220.
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Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8395-400. Matsuda JL, Gapin L, Baron JL, Sidobre S, Stetson DB, Mohrs M, Locksley RM, Kronenberg M. PMID: 12829795; PMCID: PMC166240.
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Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. J Immunol. 2003 Jun 01; 170(11):5502-10. Hadeiba H, Locksley RM. PMID: 12759427.
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Stat signals release activated naive Th cells from an anergic checkpoint. J Immunol. 2003 Feb 15; 170(4):1870-6. Mohrs M, Lacy DA, Locksley RM. PMID: 12574353.
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CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nat Immunol. 2003 Feb; 4(2):182-8. Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA. PMID: 12524538.
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Helper T cells regulate type-2 innate immunity in vivo. Nature. 2002 Dec 19-26; 420(6917):825-9. Shinkai K, Mohrs M, Locksley RM. PMID: 12490951.
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Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo. Immunity. 2002 Aug; 17(2):191-200. Stetson DB, Mohrs M, Mallet-Designe V, Teyton L, Locksley RM. PMID: 12196290.
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Blood lines. Nat Immunol. 2002 Aug; 3(8):705-6. Locksley RM. PMID: 12145653.
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T helper cell differentiation: on again, off again. Curr Opin Immunol. 2002 Jun; 14(3):366-72. Grogan JL, Locksley RM. PMID: 11973136.
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Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4(+) T cells in resistant mice treated once with anti-IL-12 or -IFN-gamma antibodies at the onset of infection with Leishmania major instructs Th2 cell development, resulting in nonhealing lesions. J Immunol. 2002 May 01; 168(9):4628-35. Launois P, Gumy A, Himmelrich H, Locksley RM, Röcken M, Louis JA. PMID: 11971011.
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Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity. 2002 Apr; 16(4):583-94. Baron JL, Gardiner L, Nishimura S, Shinkai K, Locksley R, Ganem D. PMID: 11970881.
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Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S. Immunity. 2001 Dec; 15(6):909-19. Riese RJ, Shi GP, Villadangos J, Stetson D, Driessen C, Lennon-Dumenil AM, Chu CL, Naumov Y, Behar SM, Ploegh H, Locksley R, Chapman HA. PMID: 11754813.
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Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes. Science. 2001 Nov 09; 294(5545):1358-61. Davies SJ, Grogan JL, Blank RB, Lim KC, Locksley RM, McKerrow JH. PMID: 11701932.
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Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity. 2001 Aug; 15(2):303-11. Mohrs M, Shinkai K, Mohrs K, Locksley RM. PMID: 11520464.
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Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis. Infect Immun. 2001 May; 69(5):3232-9. Bottrel RL, Dutra WO, Martins FA, Gontijo B, Carvalho E, Barral-Netto M, Barral A, Almeida RP, Mayrink W, Locksley R, Gollob KJ. PMID: 11292745; PMCID: PMC98281.
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Functional plasticity of the LACK-reactive Vbeta4-Valpha8 CD4(+) T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility to Leishmania major in BALB / c mice. Eur J Immunol. 2001 Apr; 31(4):1288-96. Maillard I, Launois P, Himmelrich H, Acha-Orbea H, Diggelmann H, Locksley RM, Louis JA. PMID: 11298356.
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Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity. 2001 Mar; 14(3):205-15. Grogan JL, Mohrs M, Harmon B, Lacy DA, Sedat JW, Locksley RM. PMID: 11290331.
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The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell. 2001 Feb 23; 104(4):487-501. Locksley RM, Killeen N, Lenardo MJ. PMID: 11239407.
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Flying doctors. Nat Immunol. 2000 Dec; 1(6):457-8. Locksley RM. PMID: 11101861.
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Coordinate regulation of the IL-4, IL-13, and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns. J Immunol. 2000 Sep 15; 165(6):2982-6. Kelly BL, Locksley RM. PMID: 10975806.
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Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells. J Immunol. 2000 Jul 15; 165(2):915-24. Gurunathan S, Stobie L, Prussin C, Sacks DL, Glaichenhaus N, Iwasaki A, Fowell DJ, Locksley RM, Chang JT, Wu CY, Seder RA. PMID: 10878366.
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In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease. J Immunol. 2000 May 01; 164(9):4819-25. Himmelrich H, Launois P, Maillard I, Biedermann T, Tacchini-Cottier F, Locksley RM, Röcken M, Louis JA. PMID: 10779790.
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Faithful expression of the human 5q31 cytokine cluster in transgenic mice. J Immunol. 2000 May 01; 164(9):4569-74. Lacy DA, Wang ZE, Symula DJ, McArthur CJ, Rubin EM, Frazer KA, Locksley RM. PMID: 10779759.
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Baseline airway hyperreactivity in A/J mice is not mediated by cells of the adaptive immune system. J Immunol. 2000 May 01; 164(9):4933-40. Hadeiba H, Corry DB, Locksley RM. PMID: 10779804.
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CD1, tuberculosis, and the evolution of major histocompatibility complex molecules. J Exp Med. 2000 Mar 20; 191(6):907-14. Shinkai K, Locksley RM. PMID: 10727453; PMCID: PMC2193123.
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Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). J Immunol. 1999 Dec 15; 163(12):6520-9. Pippig SD, Peña-Rossi C, Long J, Godfrey WR, Fowell DJ, Reiner SL, Birkeland ML, Locksley RM, Barclay AN, Killeen N. PMID: 10586044.
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Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells. Immunity. 1999 Oct; 11(4):399-409. Fowell DJ, Shinkai K, Liao XC, Beebe AM, Coffman RL, Littman DR, Locksley RM. PMID: 10549622.
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Functional screening of an asthma QTL in YAC transgenic mice. Nat Genet. 1999 Oct; 23(2):241-4. Symula DJ, Frazer KA, Ueda Y, Denefle P, Stevens ME, Wang ZE, Locksley R, Rubin EM. PMID: 10508526.
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Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases. Bioessays. 1999 Jun; 21(6):510-8. Fowell DJ, Locksley RM. PMID: 10402957.
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Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope. J Exp Med. 1999 Apr 05; 189(7):1111-20. Pingel S, Launois P, Fowell DJ, Turck CW, Southwood S, Sette A, Glaichenhaus N, Louis JA, Locksley RM. PMID: 10190902; PMCID: PMC2193001.
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Susceptibility to infectious diseases: Leishmania as a paradigm. J Infect Dis. 1999 Mar; 179 Suppl 2:S305-8. Locksley RM, Pingel S, Lacy D, Wakil AE, Bix M, Fowell DJ. PMID: 10081500.
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Construction of polycompetitors for competitive PCR. Methods Mol Med. 1999; 26:253-64. Corry DB, Locksley RM. PMID: 21340883.
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Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism. J Exp Med. 1998 Dec 21; 188(12):2289-99. Bix M, Wang ZE, Thiel B, Schork NJ, Locksley RM. PMID: 9858515; PMCID: PMC2212433.
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Requirement for IL-13 independently of IL-4 in experimental asthma. Science. 1998 Dec 18; 282(5397):2261-3. Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB. PMID: 9856950; PMCID: PMC3897229.
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Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development. J Exp Med. 1998 Nov 02; 188(9):1651-6. Wakil AE, Wang ZE, Ryan JC, Fowell DJ, Locksley RM. PMID: 9802977; PMCID: PMC2212510.
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Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model. Eur Cytokine Netw. 1998 Sep; 9(3 Suppl):102-6. Fowell DJ, Bix M, Shinkai K, Lacy D, Locksley RM. PMID: 9831197.
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Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells. Science. 1998 Aug 28; 281(5381):1352-4. Bix M, Locksley RM. PMID: 9721100.
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Fellowship training in infectious diseases: a report from the regional and national meetings of infectious diseases division chiefs and program directors. Clin Infect Dis. 1998 May; 26(5):1060-5. Joiner KA, Powderly WG, Blaser MJ, Klempner MS, Locksley RM, Mandell GL, Preheim LC, Remington JS, Slama TG, Steigbigel NH, Bartlett JG. PMID: 9597224.
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Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice. Mol Med. 1998 May; 4(5):344-55. Corry DB, Grünig G, Hadeiba H, Kurup VP, Warnock ML, Sheppard D, Rennick DM, Locksley RM. PMID: 9642684; PMCID: PMC2230383.
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Mouse CD1-autoreactive T cells have diverse patterns of reactivity to CD1+ targets. J Immunol. 1998 Apr 15; 160(8):3681-8. Brossay L, Tangri S, Bix M, Cardell S, Locksley R, Kronenberg M. PMID: 9558068.
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Distribution of protein kinase C isoforms after infection of macrophages with Leishmania major. Infect Immun. 1998 Apr; 66(4):1795-9. Pingel S, Wang ZE, Locksley RM. PMID: 9529117; PMCID: PMC108124.
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Macromolecular contrast media-enhanced MRI estimates of microvascular permeability correlate with histopathologic tumor grade. Acad Radiol. 1998 Apr; 5 Suppl 1:S2-5. Brasch RC, Daldrup H, Shames D, Wendland M, Okuhata Y, Rosenau W. PMID: 9561030.
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Control of Leishmania major by a monoclonal alpha beta T cell repertoire. J Immunol. 1998 Jan 15; 160(2):884-9. Reiner SL, Fowell DJ, Moskowitz NH, Swier K, Brown DR, Brown CR, Turck CW, Scott PA, Killeen N, Locksley RM. PMID: 9551925.
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Development of CD4+ effector T cells and susceptibility to infectious diseases. Adv Exp Med Biol. 1998; 452:45-52. Locksley RM, Fowell DJ, Shinkai K, Wakil AE, Lacy D, Bix M. PMID: 9889958.
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Immunological tolerance to a pancreatic antigen as a result of local expression of TNFalpha by islet beta cells. Immunity. 1997 Sep; 7(3):401-9. McSorley SJ, Soldera S, Malherbe L, Carnaud C, Locksley RM, Flavell RA, Glaichenhaus N. PMID: 9324360.
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Altered immune responses in interleukin 10 transgenic mice. J Exp Med. 1997 Jun 16; 185(12):2101-10. Hagenbaugh A, Sharma S, Dubinett SM, Wei SH, Aranda R, Cheroutre H, Fowell DJ, Binder S, Tsao B, Locksley RM, Moore KW, Kronenberg M. PMID: 9182682; PMCID: PMC2196349.
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Impaired Th2 subset development in the absence of CD4. Immunity. 1997 May; 6(5):559-69. Fowell DJ, Magram J, Turck CW, Killeen N, Locksley RM. PMID: 9175834.
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IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Immunity. 1997 May; 6(5):541-9. Launois P, Maillard I, Pingel S, Swihart KG, Xénarios I, Acha-Orbea H, Diggelmann H, Locksley RM, MacDonald HR, Louis JA. PMID: 9175832.
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T helper subset differentiation in the absence of invariant chain. J Exp Med. 1997 Jan 06; 185(1):31-41. Brown DR, Swier K, Moskowitz NH, Naujokas MF, Locksley RM, Reiner SL. PMID: 8996239; PMCID: PMC2196096.
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Exploitation of immune and other defence mechanisms by parasites: an overview. Parasitology. 1997; 115 Suppl:S5-7. Locksley RM. PMID: 9571686.
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Leishmania major: targeting IL-4 in successful immunomodulation of murine infection. Exp Parasitol. 1996 Nov; 84(2):214-22. Wakil AE, Wang ZE, Locksley RM. PMID: 8932771.
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Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses. J Exp Med. 1996 Oct 01; 184(4):1295-304. Brown DR, Fowell DJ, Corry DB, Wynn TA, Moskowitz NH, Cheever AW, Locksley RM, Reiner SL. PMID: 8879201; PMCID: PMC2192844.
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Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10. J Exp Med. 1996 Aug 01; 184(2):539-48. Roth I, Corry DB, Locksley RM, Abrams JS, Litton MJ, Fisher SJ. PMID: 8760807; PMCID: PMC2192727.
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Cytokine production by peripheral blood mononuclear cells in human coccidioidomycosis. J Infect Dis. 1996 Aug; 174(2):440-3. Corry DB, Ampel NM, Christian L, Locksley RM, Galgiani JN. PMID: 8699085.
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The instructive role of innate immunity in the acquired immune response. Science. 1996 Apr 05; 272(5258):50-3. Fearon DT, Locksley RM. PMID: 8600536.
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Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med. 1996 Jan 01; 183(1):109-17. Corry DB, Folkesson HG, Warnock ML, Erle DJ, Matthay MA, Wiener-Kronish JP, Locksley RM. PMID: 8551213; PMCID: PMC2192426.
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Interleukin-12 in murine leishmaniasis--match, flame or fuel? Res Immunol. 1995 Sep-Oct; 146(7-8):566-75. Fowell DJ, Wakil AE, Locksley RM. PMID: 8839163.
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Natural T cells. Cells that co-express NKRP-1 and TCR. J Immunol. 1995 Aug 01; 155(3):1020-2. Bix M, Locksley RM. PMID: 7636176.
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Expression cloning of a protective Leishmania antigen. Science. 1995 Apr 28; 268(5210):563-6. Mougneau E, Altare F, Wakil AE, Zheng S, Coppola T, Wang ZE, Waldmann R, Locksley RM, Glaichenhaus N. PMID: 7725103.
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The development of effector T cell subsets in murine Leishmania major infection. Ciba Found Symp. 1995; 195:110-7; discussion 117-22. Locksley RM, Wakil AE, Corry DB, Pingel S, Bix M, Fowell DJ. PMID: 8724833.
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The regulation of immunity to Leishmania major. Annu Rev Immunol. 1995; 13:151-77. Reiner SL, Locksley RM. PMID: 7612219.
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Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12932-6. Wang ZE, Zheng S, Corry DB, Dalton DK, Seder RA, Reiner SL, Locksley RM. PMID: 7809149; PMCID: PMC45554.
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Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J Immunol. 1994 Nov 01; 153(9):4142-8. Corry DB, Reiner SL, Linsley PS, Locksley RM. PMID: 7523517.
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Constructing polycompetitor cDNAs for quantitative PCR (J. Immunol. Methods 165 (1993) 37-46; 173(1994) 133). J Immunol Methods. 1994 Oct 14; 175(2):275. Reiner SL, Zheng S, Corry DB, Locksley RM. PMID: 7930655.
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Constructing polycompetitor cDNAs for quantitative PCR (J. Immunol. Methods 165 (1993) 37-46). J Immunol Methods. 1994 Jul 12; 173(1):133. Reiner SL, Zheng S, Corry DB, Locksley RM. PMID: 8034981.
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Th2 cells: help for helminths. J Exp Med. 1994 May 01; 179(5):1405-7. Locksley RM. PMID: 8163928; PMCID: PMC2191475.
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CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. J Exp Med. 1994 Apr 01; 179(4):1367-71. Wang ZE, Reiner SL, Zheng S, Dalton DK, Locksley RM. PMID: 7908325; PMCID: PMC2191434.
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Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. J Exp Med. 1994 Feb 01; 179(2):447-56. Reiner SL, Zheng S, Wang ZE, Stowring L, Locksley RM. PMID: 7905017; PMCID: PMC2191353.
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Cytokines in the differentiation of Th1/Th2 CD4+ subsets in leishmaniasis. J Cell Biochem. 1993 Dec; 53(4):323-8. Reiner SL, Locksley RM. PMID: 7905485.
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Potential role for interleukin-10 in the immunosuppression associated with kala azar. J Clin Invest. 1993 Dec; 92(6):2626-32. Holaday BJ, Pompeu MM, Jeronimo S, Texeira MJ, Sousa Ade A, Vasconcelos AW, Pearson RD, Abrams JS, Locksley RM. PMID: 8254019; PMCID: PMC288459.
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Constructing polycompetitor cDNAs for quantitative PCR. J Immunol Methods. 1993 Sep 27; 165(1):37-46. Reiner SL, Zheng S, Corry DB, Locksley RM. PMID: 8409467.
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Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science. 1993 Sep 10; 261(5127):1448-51. Locksley RM, Reiner SL, Hatam F, Littman DR, Killeen N. PMID: 8367726.
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Reconstitution of Mycobacterium leprae immunity in severe combined immunodeficient mice using a T-cell line. Int J Lepr Other Mycobact Dis. 1993 Sep; 61(3):398-405. Azouaou N, Gelber RH, Abel K, Sasaki DT, Murray LP, Locksley RM, Mohagheghpour N. PMID: 8228438.
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Targeted activation of CD8 cells and infection of beta 2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis. J Immunol. 1993 Aug 15; 151(4):2077-86. Wang ZE, Reiner SL, Hatam F, Heinzel FP, Bouvier J, Turck CW, Locksley RM. PMID: 8102158.
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Interleukin 12 in host defense against microbial pathogens. Proc Natl Acad Sci U S A. 1993 Jul 01; 90(13):5879-80. Locksley RM. PMID: 8100997; PMCID: PMC46829.
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The worm and the protozoa: stereotyped responses or distinct antigens? Parasitol Today. 1993 Jul; 9(7):258-60. Reiner SL, Locksley RM. PMID: 15463773.
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Transfected Leishmania expressing biologically active IFN-gamma. J Immunol. 1993 Jun 01; 150(11):5059-69. Tobin JF, Reiner SL, Hatam F, Zheng S, Leptak CL, Wirth DF, Locksley RM. PMID: 8098724.
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IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts. J Immunol. 1993 May 01; 150(9):3924-31. Heinzel FP, Rerko RM, Hatam F, Locksley RM. PMID: 8473741.
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TH1 and TH2 cell antigen receptors in experimental leishmaniasis. Science. 1993 Mar 05; 259(5100):1457-60. Reiner SL, Wang ZE, Hatam F, Scott P, Locksley RM. PMID: 8451641.
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Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues. J Exp Med. 1992 Oct 01; 176(4):1053-62. Stevenson FT, Bursten SL, Locksley RM, Lovett DH. PMID: 1402651; PMCID: PMC2119375.
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Interleukin 1: the patterns of translation and intracellular distribution support alternative secretory mechanisms. J Cell Physiol. 1992 Aug; 152(2):223-31. Stevenson FT, Torrano F, Locksley RM, Lovett DH. PMID: 1639857.
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Immunology of leishmaniasis. Curr Opin Immunol. 1992 Aug; 4(4):413-8. Locksley RM, Louis JA. PMID: 1356346.
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Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice. Nature. 1992 Apr 16; 356(6370):604-7. Amiri P, Locksley RM, Parslow TG, Sadick M, Rector E, Ritter D, McKerrow JH. PMID: 1560843.
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Lessons from Leishmania: a model for investigations of CD4+ subset differentiation. Infect Agents Dis. 1992 Feb; 1(1):33-42. Reiner SL, Locksley RM. PMID: 1365527.
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Cytokine regulation of murine leishmaniasis: interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice. Infect Immun. 1991 Dec; 59(12):4710-4. Sadick MD, Street N, Mosmann TR, Locksley RM. PMID: 1937832; PMCID: PMC259104.
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Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines. J Immunol. 1991 Sep 01; 147(5):1653-8. Holaday BJ, Sadick MD, Wang ZE, Reiner SL, Heinzel FP, Parslow TG, Locksley RM. PMID: 1831830.
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Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7011-5. Heinzel FP, Sadick MD, Mutha SS, Locksley RM. PMID: 1908085; PMCID: PMC52223.
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Activation of human monocyte--derived macrophages with lipopolysaccharide decreases human immunodeficiency virus replication in vitro at the level of gene expression. J Clin Invest. 1991 Aug; 88(2):540-5. Bernstein MS, Tong-Starksen SE, Locksley RM. PMID: 1907615; PMCID: PMC295381.
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A single peptide from the major outer membrane protein of Chlamydia trachomatis elicits T cell help for the production of antibodies to protective determinants. J Immunol. 1991 Jul 15; 147(2):674-9. Allen JE, Locksley RM, Stephens RS. PMID: 1712817.
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Cytokines in fluids from polycystic kidneys. Kidney Int. 1991 Apr; 39(4):718-24. Gardner KD, Burnside JS, Elzinga LW, Locksley RM. PMID: 2051729.
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Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function. Immunol Today. 1991 Mar; 12(3):A58-61. Locksley RM, Scott P. PMID: 1829891.
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Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection. Res Immunol. 1991 Jan; 142(1):28-32. Locksley RM, Heinzel FP, Holaday BJ, Mutha SS, Reiner SL, Sadick MD. PMID: 1829257.
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Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism. J Exp Med. 1990 Jan 01; 171(1):115-27. Sadick MD, Heinzel FP, Holaday BJ, Pu RT, Dawkins RS, Locksley RM. PMID: 2104918; PMCID: PMC2187647.
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The exposure of health care workers to ribavirin aerosol. JAMA. 1989 Apr 07; 261(13):1880-1. Guglielmo BJ, Jacobs RA, Locksley RM. PMID: 2926922.
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Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med. 1989 Jan 01; 169(1):59-72. Heinzel FP, Sadick MD, Holaday BJ, Coffman RL, Locksley RM. PMID: 2521244; PMCID: PMC2189187.
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Release of interleukin 1 inhibitory activity (contra-IL-1) by human monocyte-derived macrophages infected with human immunodeficiency virus in vitro and in vivo. J Clin Invest. 1988 Dec; 82(6):2097-105. Locksley RM, Crowe S, Sadick MD, Heinzel FP, Gardner KD, McGrath MS, Mills J. PMID: 3264291; PMCID: PMC442793.
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Fatal aspergillosis associated with smoking contaminated marijuana, in a marrow transplant recipient. Chest. 1988 Aug; 94(2):432-3. Hamadeh R, Ardehali A, Locksley RM, York MK. PMID: 3293934.
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Leishmania major: analysis of lymphocyte and macrophage cellular phenotypes during infection of susceptible and resistant mice. Exp Parasitol. 1988 Apr; 65(2):258-68. Heinzel FP, Sadick MD, Locksley RM. PMID: 3127233.
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Cutaneous host defense in leishmaniasis: interaction of isolated dermal macrophages and epidermal Langerhans cells with the insect-stage promastigote. Infect Immun. 1988 Feb; 56(2):336-42. Locksley RM, Heinzel FP, Fankhauser JE, Nelson CS, Sadick MD. PMID: 2828237; PMCID: PMC259285.
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Tumor necrosis factors alpha and beta differ in their capacities to generate interleukin 1 release from human endothelial cells. J Immunol. 1987 Sep 15; 139(6):1891-5. Locksley RM, Heinzel FP, Shepard HM, Agosti J, Eessalu TE, Aggarwal BB, Harlan JM. PMID: 3497981.
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Murine cutaneous leishmaniasis: susceptibility correlates with differential expansion of helper T-cell subsets. Ann Inst Pasteur Immunol. 1987 Sep-Oct; 138(5):744-9. Locksley RM, Heinzel FP, Sadick MD, Holaday BJ, Gardner KD. PMID: 2964247.
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Cellular and humoral immunity to Leishmania major in genetically susceptible mice after in vivo depletion of L3T4+ T cells. J Immunol. 1987 Aug 15; 139(4):1303-9. Sadick MD, Heinzel FP, Shigekane VM, Fisher WL, Locksley RM. PMID: 3112230.
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Loss of granule myeloperoxidase during in vitro culture of human monocytes correlates with decay in antiprotozoa activity. Am J Trop Med Hyg. 1987 May; 36(3):541-8. Locksley RM, Nelson CS, Fankhauser JE, Klebanoff SJ. PMID: 3034086.
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Isolation and characterization of the receptor on human neutrophils that mediates cellular adherence. J Biol Chem. 1987 Apr 25; 262(12):5576-80. Hickstein DD, Ozols J, Williams SA, Baenziger JU, Locksley RM, Roth GJ. PMID: 3553180.
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Expression of leukocyte adherence-related glycoproteins during differentiation of HL-60 promyelocytic leukemia cells. J Immunol. 1987 Jan 15; 138(2):513-9. Hickstein DD, Smith A, Fisher W, Beatty PG, Schwartz BR, Harlan JM, Root RK, Locksley RM. PMID: 2947951.
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Monoclonal antibodies binding to the human neutrophil C3bi receptor have disparate functional effects. Blood. 1986 Apr; 67(4):1054-62. Hickstein DD, Locksley RM, Beatty PG, Smith A, Stone DM, Root RK. PMID: 3006829.
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Murine cutaneous leishmaniasis: resistance correlates with the capacity to generate interferon-gamma in response to Leishmania antigens in vitro. J Immunol. 1986 Jan; 136(2):655-61. Sadick MD, Locksley RM, Tubbs C, Raff HV. PMID: 3079789.
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Infection with varicella-zoster virus after marrow transplantation. J Infect Dis. 1985 Dec; 152(6):1172-81. Locksley RM, Flournoy N, Sullivan KM, Meyers JD. PMID: 3905982.
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Alteration of leukotriene release by macrophages ingesting Toxoplasma gondii. Proc Natl Acad Sci U S A. 1985 Oct; 82(20):6922-6. Locksley RM, Fankhauser J, Henderson WR. PMID: 2995993; PMCID: PMC390800.
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Development of cellular immunity in cutaneous leishmaniasis due to Leishmania tropica. J Infect Dis. 1984 Jul; 150(1):135-8. Sadick MD, Locksley RM, Raff HV. PMID: 6611378.
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Interaction of primate alveolar macrophages and Legionella pneumophila. J Clin Invest. 1984 Jun; 73(6):1515-23. Jacobs RF, Locksley RM, Wilson CB, Haas JE, Klebanoff SJ. PMID: 6373825; PMCID: PMC437061.
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Reversal of dementia associated with Whipple's disease by trimethoprim-sulfamethoxazole, drugs that penetrate the blood-brain barrier. Gastroenterology. 1984 Apr; 86(4):745-52. Ryser RJ, Locksley RM, Eng SC, Dobbins WO, Schoenknecht FD, Rubin CE. PMID: 6199255.
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Increased respiratory burst in myeloperoxidase-deficient monocytes. Blood. 1983 Oct; 62(4):902-9. Locksley RM, Wilson CB, Klebanoff SJ. PMID: 6309288.
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Oxidative response of phagocytes to parasite invasion. Ciba Found Symp. 1983; 99:92-112. Klebanoff SJ, Locksley RM, Jong EC, Rosen H. PMID: 6315321.
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Oxygen-dependent microbicidal systems of phagocytes and host defense against intracellular protozoa. J Cell Biochem. 1983; 22(3):173-85. Locksley RM, Klebanoff SJ. PMID: 6365936.
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Susceptibility of Legionella pneumophila to oxygen-dependent microbicidal systems. J Immunol. 1982 Nov; 129(5):2192-7. Locksley RM, Jacobs RF, Wilson CB, Weaver WM, Klebanoff SJ. PMID: 6288801.
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Multiply antibiotic-resistant Staphylococcus aureus: introduction, transmission, and evolution of nosocomial infection. Ann Intern Med. 1982 Sep; 97(3):317-24. Locksley RM, Cohen ML, Quinn TC, Tompkins LS, Coyle MB, Kirihara JM, Counts GW. PMID: 7114628.
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Role for endogenous and acquired peroxidase in the toxoplasmacidal activity of murine and human mononuclear phagocytes. J Clin Invest. 1982 May; 69(5):1099-111. Locksley RM, Wilson CB, Klebanoff SJ. PMID: 7068848; PMCID: PMC370174.
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Thiazide-induced hyponatremia associated with death or neurologic damage in outpatients. Am J Med. 1981 Jun; 70(6):1163-8. Ashraf N, Locksley R, Arieff AI. PMID: 7234886.
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Prognostic grading and significance of ventricular premature beats after recovery from myocardial infarction. Circulation. 1975 Dec; 52(6 Suppl):III204-10. Moss AJ, DeCamilla J, Mietlowski W, Greene WA, Goldstein S, Locksley R. PMID: 52416.
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Two improvements in the preparation of cardiac microsomes. Recent Adv Stud Cardiac Struct Metab. 1974; 4:409-16. Stam AC, Sole M, Locksley R, Weglicki WB, Sonnenblick EH. PMID: 4377613.
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