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Correction: Selective targeting of 3 repeat Tau with brain penetrating single chain antibodies for the treatment of neurodegenerative disorders. Acta Neuropathol. 2026 Feb 19; 151(1):18. Spencer B, Brüschweiler S, Sealey-Cardona M, Rockenstein E, Adame A, Florio J, Mante M, Trinh I, Rissman RA, Konrat R, Masliah E. PMID: 41711933.
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Sex Differences in P-Tau217, Tau Aggregation, and Cognitive Decline. JAMA Neurol. 2026 Feb 16. Coughlan GT, Ourry V, Townsend D, Klinger H, Brown JA, Cuppels M, Betthauser T, Langhough R, Cody K, Seto M, Birkenbihl C, Li A, Farrell M, Thibault E, Kivisäkk Webb P, Arnold S, Rissman RA, Properzi M, Schultz A, Johnson K, Langford O, Donohue MC, Villeneuve S, Johnson SC, Yang HS, Manson JE, Sperling R, Buckley RF, A4 Study Team, the Alzheimer’s Disease Neuroimaging Initiative, and the PREVENT-AD Research Group. PMID: 41697669; PMCID: PMC12910460.
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The prognostic value of blood-based p-tau217 levels on progression to clinical impairment. medRxiv. 2026 Feb 09. Buckley RF, Townsend DL, Birkenbihl CJ, Cuppels M, Coughlan GT, Seto MT, Brown JA, Properzi MJ, Hönig MC, Li A, Schultz AP, Chhatwal J, Yang HS, Arnold S, Kivisäkk P, James BD, O'Bryant S, Rissman RA, Petersen M, Caldwell JZK, Betthauser T, Oomens JE, Carrigan M, Healy B, Condado JG, Johnson S, Yau WW, Langford O, Farrell M, Amariglio RE, Rentz DM, Papp KV, Hohman TJ, Donohue M, Aisen PS, Johnson KA, Sperling RA. PMID: 41728293; PMCID: PMC12919127.
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Whole blood gene expression moderates associations between AD biomarkers and cognitive decline in cognitively unimpaired older adults. Alzheimers Dement. 2026 Feb; 22(2):e71225. Klinger HM, Seto M, Janve VA, Brown JA, Clifton M, Birkenbihl C, Coughlan GT, Townsend DL, Properzi M, Zyski J, Wang TC, Amariglio RE, Papp KV, Rentz DM, Yang HS, Chhatwal J, Donohue MC, Raman R, Rissman RA, Aisen P, Johnson KA, Sperling RA, Dumitrescu L, Hohman T, Buckley RF. PMID: 41724695; PMCID: PMC12928093.
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Elevated temporal tau PET predicts faster cognitive decline in women than men: A meta-analysis. Alzheimers Dement. 2026 Feb; 22(2):e71031. Li A, Klinger HM, Seto M, Birkenbihl C, Properzi MJ, Farrell M, Thibault E, Schultz AP, Townsend DL, Cuppels M, Brown JA, Papp KV, Amariglio RE, Yang HS, Donohue MC, Rissman RA, Betthauser TJ, Langhough RE, Jonaitis EM, Cody K, Johnson SC, Rentz DM, Johnson KA, Sperling RA, Buckley RF, Coughlan GT, A4 Study Team. PMID: 41705602; PMCID: PMC12914651.
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Retraction Note: Brain-derived exosomes from dementia with lewy bodies propagate α-synuclein pathology. Acta Neuropathol Commun. 2026 Jan 05; 14(1):3. Ngolab J, Trinh I, Rockenstein E, Mante M, Florio J, Trejo M, Masliah D, Adame A, Masliah E, Rissman RA. PMID: 41491554; PMCID: PMC12771716.
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Redirecting microglia phenotype via inhibition of NFAT1 ameliorates deficits in mouse model of synucleinopathies. Exp Mol Med. 2025 Nov; 57(11):2588-2607. Iba M, Lee YJ, Kwon S, Horan-Portelance L, Chang K, Kim M, Landeck N, Rissman RA, Lee SJ, You S, Kim C. PMID: 41258081; PMCID: PMC12686539.
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Transcriptome profiling of cerebrospinal fluid in Alzheimer's disease reveals molecular dysregulations associated with disease. Alzheimers Dement (N Y). 2025 Jul-Sep; 11(3):e70152. De Sota RE, Berghuis BA, Khoury SJ, Zhuang J, Rissman RA, Brewer JB, Quake SR, Sninsky JJ, Toden S. PMID: 40963533; PMCID: PMC12438960.
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Racial and ethnic differences in plasma p-tau217 ratio biomarker eligibility rates in a preclinical AD trial with lecanemab. Alzheimers Dement (Amst). 2025 Jul-Sep; 17(3):e70164. Molina-Henry DP, Raman R, Liu A, Langford O, Braunstein JB, Verghese PB, Venkatesh V, Dhadda S, Irrizary M, Grill JD, Johnson K, Rissman RA, Aisen P, Sperling RA, AHEAD 3-45 Study Team. PMID: 40861822; PMCID: PMC12371446.
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A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies. NPJ Parkinsons Dis. 2025 Aug 22; 11(1):254. An S, McInnis JJ, Kim D, Li Y, Tasdemir-Yilmaz O, Ahn J, Mackness BC, Kwon SH, Bonner JM, Yoo M, Dujardin S, Kim D, Park J, Yun H, Tang Y, Pradier L, Hyeon S, Song D, Sung B, Krishnan R, Spencer B, Rissman RA, Sandhu JK, Haqqani AS, Shin JW, Kim DB, Lee H, Jung J, You WK, Star AT, Delaney CE, Stanimirovic DB, Sardi SP, Lee SH, Kayatekin C. PMID: 40847026; PMCID: PMC12373799.
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Health and Aging Brain Study-Health Disparities (HABS-HD) methods and partner characteristics. Alzheimers Dement (N Y). 2025 Jul-Sep; 11(3):e70140. Petersen ME, Zhou Z, Hall JR, Phillips N, Meeker KL, Borzage MT, Braskie MN, Clark AL, Shi Y, Rissman RA, Zhang F, Vintimilla R, Casas A, Rhodes J, Barber RC, Johnson L, Yaffe K, Toga AW, O'Bryant SE, HABS-HD Study Team. PMID: 40799724; PMCID: PMC12340423.
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Brain transcriptomics highlight abundant gene expression and splicing alterations in non-neuronal cells in aFTLD-U. Acta Neuropathol. 2025 Aug 10; 150(1):17. Alidadiani S, Faura J, Wynants S, Peeters N, Van den Broeck M, De Witte L, Policarpo R, Cheung S, Pottier C, Ghayal NB, Mol MO, van Blitterswijk M, Udine E, DeJesus-Hernandez M, Baker M, Finch NA, Asmann YW, van Rooij JGJ, Nguyen AT, Ross Reichard R, Nana AL, Lopez OL, Boxer AL, Rosen HJ, Spina S, Herms J, Josephs KA, Petersen RC, Rissman RA, Hiniker A, Ang LC, Grinberg LT, Halliday GM, Boeve BF, Graff-Radford NR, Seelaar H, Neumann M, Kofler J, White CL, Seeley WW, van Swieten JC, Dickson DW, Mackenzie IRA, De Coster W, Rademakers R. PMID: 40783910; PMCID: PMC12336083.
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Correction: Nicotine-mediated effects in neuronal and mouse models of synucleinopathy. Front Neurosci. 2025; 19:1662162. Fares MB, Alijevic O, Johne S, Overk C, Hashimoto M, Kondylis A, Adame A, Dulize R, Peric D, Nury C, Battey J, Guedj E, Sierro N, Mc Hugh D, Rockenstein E, Kim C, Rissman RA, Hoeng J, Peitsch MC, Masliah E, Mathis C. PMID: 40822239; PMCID: PMC12355812.
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Neutral pH-Selective Inhibition of Cytosolic Cathepsin B: A Novel Drug Targeting Strategy for Traumatic Brain Injury and Alzheimer's Disease. ACS Chem Biol. 2025 Aug 15; 20(8):1841-1848. Hook V, Podvin S, Yoon MC, Phan VV, Florio J, Spencer B, Mosier C, Cheng A, Ahuett S, Almaliti J, Gerwick WH, Rissman RA, O'Donoghue AJ. PMID: 40700403; PMCID: PMC12362428.
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Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes. Mol Neurodegener. 2025 Jul 06; 20(1):80. Vicente CT, Niranjan T, Coopman E, Faura J, Alidadiani S, Schrauwen C, Matchett BJ, Heeman B, Van den Broeck M, De Coster W, Nguyen T, Lau JS, Baheti S, de Pooter T, De Rijk P, Strazisar M, Baker M, DeJesus-Hernandez M, Finch NA, Pottier C, van Blitterswijk M, Asmann Y, Murray ME, Petrucelli L, King A, Troakes C, Al-Sarraj S, Rissman RA, Hiniker A, Flanagan M, Evers BM, White CL, Cruchaga C, Castellani R, van Rooij JGJ, Mol MO, Seelaar H, van Swieten JC, Oskarsson B, Reichard RR, Nguyen AT, Josephs KA, Petersen RC, Ertekin-Taner N, Boeve BF, Graff-Radford NR, Weckhuysen S, Dickson DW, Rademakers R. PMID: 40619440; PMCID: PMC12232778.
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Amyloid PET and clinical management in a diverse, cognitively impaired population: The New IDEAS Study. Alzheimers Dement. 2025 Jul; 21(7):e70504. Windon CC, Gatsonis C, Carrillo MC, Romanoff J, Hanna L, Glavin E, Gareen I, Gutman R, Hillner BE, March A, O'Bryant S, Rissman RA, Siegel BA, Smith K, Whitmer RA, Whitmer RA, Weber CJ, Wilkins CH, Dilworth-Anderson P, Rabinovici GD. PMID: 40728069; PMCID: PMC12305457.
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A splice-switching antisense oligonucleotide targeting APP reduces accumulation of α-synuclein in a mouse model of Parkinson's disease. Alzheimers Dement (N Y). 2025 Apr-Jun; 11(2):e70117. Ahammad RU, Spencer B, Quach B, Salehi S, Rissman RA. PMID: 40556661; PMCID: PMC12185244.
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Establishing tau-PET cut-points for cognitive diagnosis with 18 F-PI-2620 in a multi-ethnoracial cohort. Imaging Neurosci (Camb). 2025; 3. Tennant VR, Wheeler KV, Lee NN, Terner JA, Hand MW, Ganesan S, Walsh P, Greene A, Berkness T, Lei T, Raman R, Rissman RA, Christian BT, Petersen M, Cohen AD, Ances BM, Meeker KL, Zhou Z, Nandy RR, Yaffe K, O'Bryant SE, Toga AW, Braskie MN. PMID: 40800781; PMCID: PMC12319742.
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Testing the causal impact of plasma amyloid on total Tau using a genetically informative sample of adult male twins. Aging Brain. 2025; 7:100139. Gillespie NA, Neale MC, Panizzon MS, McKenzie RE, Tu XM, Xian H, Reynolds CA, Lyons MJ, Rissman RA, Elman JA, Franz C, Kremen WS. PMID: 40487291; PMCID: PMC12145560.
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Differential roles of human tau isoforms in the modulation of inflammation and development of neuropathology. Neurobiol Dis. 2025 07; 211:106942. Spencer B, Schueler A, Sung D, Rissman RA. PMID: 40348205; PMCID: PMC12178306.
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Anti-Sense Oligonucleotide as a Therapeutic for Synucleinopathies: Pharmacokinetic, Safety and Efficacy Evaluation. bioRxiv. 2025 May 07. Ahammad RU, Spencer B, Quach B, Salehi S, Rissman RA. PMID: 40654713; PMCID: PMC12247940.
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Adverse Social Exposome During the Life Course and Vascular Brain Injury. JAMA Netw Open. 2025 05 01; 8(5):e2512289. Keller SA, DeWitt A, Powell WR, Ketchum FB, Rissman RA, Bendlin BB, Kind AJH. PMID: 40423969; PMCID: PMC12117465.
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Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome. Alzheimers Dement. 2025 May; 21(5):e70022. Chen XQ, Zuo X, Becker A, Mante M, Florio JB, Jadhav SG, Albay R, Johnstone A, Karachentsev D, Rissman R, Zhao H, Dowdy SF, Mobley WC. PMID: 40339155; PMCID: PMC12058459.
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Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing. Nat Commun. 2025 Apr 25; 16(1):3914. Pottier C, Küçükali F, Baker M, Batzler A, Jenkins GD, van Blitterswijk M, Vicente CT, De Coster W, Wynants S, Van de Walle P, Ross OA, Murray ME, Faura J, Haggarty SJ, van Rooij JG, Mol MO, Hsiung GR, Graff C, Öijerstedt L, Neumann M, Asmann Y, McDonnell SK, Baheti S, Josephs KA, Whitwell JL, Bieniek KF, Forsberg L, Heuer H, Lago AL, Geier EG, Yokoyama JS, Oddi AP, Flanagan M, Mao Q, Hodges JR, Kwok JB, Domoto-Reilly K, Synofzik M, Wilke C, Onyike C, Dickerson BC, Evers BM, Dugger BN, Munoz DG, Keith J, Zinman L, Rogaeva E, Suh E, Gefen T, Geula C, Weintraub S, Diehl-Schmid J, Farlow MR, Edbauer D, Woodruff BK, Caselli RJ, Donker Kaat LL, Huey ED, Reiman EM, Mead S, King A, Roeber S, Nana AL, Ertekin-Taner N, Knopman DS, Petersen RC, Petrucelli L, Uitti RJ, Wszolek ZK, Ramos EM, Grinberg LT, Tempini MLG, Rosen HJ, Spina S, Piguet O, Grossman M, Trojanowski JQ, Keene CD, Jin LW, Prudlo J, Geschwind DH, Rissman RA, Cruchaga C, Ghetti B, Halliday GM, Beach TG, Serrano GE, Arzberger T, Herms J, Boxer AL, Honig LS, Vonsattel JP, Lopez OL, Kofler J, White CL, Gearing M, Glass J, Rohrer JD, Irwin DJ, Lee EB, Van Deerlin V, Castellani R, Mesulam MM, Tartaglia MC, Finger EC, Troakes C, Al-Sarraj S, Dalgard CL, Miller BL, Seelaar H, Graff-Radford NR, Boeve BF, Mackenzie IR, van Swieten JC, Seeley WW, Sleegers K, Dickson DW, Biernacka JM, Rademakers R. PMID: 40280976; PMCID: PMC12032271.
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WITHDRAWN: SARS-CoV-2 invades cognitive centers of the brain and induces Alzheimer's-like neuropathology. bioRxiv. 2025 Apr 23. Shen WB, Elahi M, Logue J, Yang P, Baracco L, Albert Reece E, Wang B, Li L, Blanchard TG, Han Z, Rissman RA, Frieman MB, Yang P. PMID: 35132414; PMCID: PMC8820661.
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Effects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study. Alzheimers Dement. 2025 Apr; 21(4):e14586. Baker LD, Pa JA, Katula JA, Aslanyan V, Salmon DP, Jacobs DM, Chmelo EA, Hodge H, Morrison R, Matthews G, Brewer J, Jung Y, Rissman RA, Taylor C, Léger GC, Messer K, Evans AC, Okonkwo OC, Shadyab AH, Zou J, Jin S, Thomas RG, Zhang J, La Croix AZ, Cotman CW, Feldman HH, EXERT Study Group. PMID: 40271888; PMCID: PMC12019696.
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Activation of Cytosolic Cathepsin B Activity in the Brain by Traumatic Brain Injury and Inhibition by the Neutral pH Selective Inhibitor Probe Z-Arg-Lys-AOMK. ACS Chem Neurosci. 2025 Apr 02; 16(7):1297-1308. Podvin S, Florio J, Spencer B, Mante M, Guzman E, Arias C, Mosier C, Phan VV, Yoon MC, Almaliti J, O'Donoghue AJ, Gerwick WH, Rissman RA, Hook V. PMID: 40130579; PMCID: PMC11969537.
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Pharmacokinetic and pharmacodynamic assessment of oral nicotinamide in the NEAT clinical trial for early Alzheimer's disease. Alzheimers Res Ther. 2025 Mar 11; 17(1):59. Ketron GL, Grun F, Grill JD, Feldman HH, Rissman RA, Brewer GJ. PMID: 40069789; PMCID: PMC11895359.
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Characterization of plasma AT(N) biomarkers among a racial and ethnically diverse community-based cohort: an HABS-HD study. Alzheimers Dement (N Y). 2025 Jan-Mar; 11(1):e70045. Petersen ME, Zhang F, Hall J, Brock C, Rissman RA, Como T, Julovich D, Mapstone M, Ances BM, Meeker K, Palmer R, Barber R, Mason D, Johnson L, Yaffe K, Toga AW, Cohen A, O'Bryant SE, HABS-HD Study Team. PMID: 39975470; PMCID: PMC11837735.
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The Alzheimer's Association Global Biomarker Standardization Consortium (GBSC) plasma phospho-tau Round Robin study. Alzheimers Dement. 2025 Feb; 21(2):e14508. Ashton NJ, Keshavan A, Brum WS, Andreasson U, Arslan B, Droescher M, Barghorn S, Vanbrabant J, Lambrechts C, Van Loo M, Stoops E, Iyengar S, Ji H, Xu X, Forrest-Hay A, Zhang B, Luo Y, Jeromin A, Vandijck M, Bastard NL, Kolb H, Triana-Baltzer G, Bali D, Janelidze S, Yang SY, Demos C, Romero D, Sigal G, Wohlstadter J, Malyavantham K, Khare M, Jethwa A, Stoeckl L, Gobom J, Kac PR, Gonzalez-Ortiz F, Montoliu-Gaya L, Hansson O, Rissman RA, Carrillo MC, Shaw LM, Blennow K, Schott JM, Zetterberg H. PMID: 39907496; PMCID: PMC11851162.
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Clinical and neuropathological analysis of Down syndrome over 7 decades of life. J Neuropathol Exp Neurol. 2025 Feb 01; 84(2):168-173. Sukreet S, Goodwill VS, Ngolab J, Kim HY, Leisher S, Salehi S, Rafii MS, Hiniker A, Rissman RA. PMID: 39471466; PMCID: PMC11747220.
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Retraction Notice to "Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy" [Neurobiology of Disease 104 (2017) 85-96]. Neurobiol Dis. 2025 03; 206:106788. El-Agnaf O, Overk C, Rockenstein E, Mante M, Florio J, Adame A, Vaikath N, Majbour N, Lee SJ, Kim C, Masliah E, Rissman RA. PMID: 39818529.
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Clinical criteria for limbic-predominant age-related TDP-43 encephalopathy. Alzheimers Dement. 2025 Jan; 21(1):e14202. Wolk DA, Nelson PT, Apostolova L, Arfanakis K, Boyle PA, Carlsson CM, Corriveau-Lecavalier N, Dacks P, Dickerson BC, Domoto-Reilly K, Dugger BN, Edelmayer R, Fardo DW, Grothe MJ, Hohman TJ, Irwin DJ, Jicha GA, Jones DT, Kawas CH, Lee EB, Lincoln K, Maestre GE, Mormino EC, Onyike CU, Petersen RC, Rabinovici GD, Rademakers R, Raman R, Rascovsky K, Rissman RA, Rogalski E, Scheltens P, Sperling RA, Yang HS, Yu L, Zetterberg H, Schneider JA. PMID: 39807681; PMCID: PMC11772733.
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Guidelines for the standardization of pre-analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group. Alzheimers Dement. 2025 Feb; 21(2):e14420. Ng TKS, Udeh-Momoh C, Lim MA, Gleerup HS, Leifert W, Ajalo C, Ashton N, Zetterberg H, Rissman RA, Winston CN, O' Bryant S, Jenkins R, Carro E, Orive G, Tamburin S, Olvera-Rojas M, Solis-Urra P, Esteban-Cornejo I, Santos GAAD, Rajan KB, Koh D, Simonsen AH, Slowey PD, Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment: Bioflui. PMID: 39737743; PMCID: PMC11848381.
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Phase 2A Proof-of-Concept Double-Blind, Randomized, Placebo-Controlled Trial of Nicotinamide in Early Alzheimer Disease. Neurology. 2025 Jan 14; 104(1):e210152. Grill JD, Tam S, Thai G, Vides B, Pierce AL, Green K, Gillen DL, Teng E, Kremen S, Beigi M, Rissman RA, Léger GC, Balasubramanian A, Revta C, Morrison R, Jennings R, Pa J, Zhang J, Jin S, Messer K, Feldman HH. PMID: 39671543; PMCID: PMC11655133.
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Single step capture and assessment of multiple plasma extracellular vesicle biomarkers in Alzheimer's disease detection. J Alzheimers Dis. 2024 Dec; 102(3):659-669. Lewis JM, Harris DA, Kosmatka J, Mikrut E, Evenson J, Balcer HI, Dhani H, Hinestrosa JP, Rissman R, Billings PR. PMID: 39533951.
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A mutation in the PRKAR1B gene drives pathological mechanisms of neurodegeneration across species. Brain. 2024 Nov 04; 147(11):3890-3905. Benjamin-Zukerman T, Shimon G, Gaine ME, Dakwar A, Peled N, Aboraya M, Masri-Ismail A, Safadi-Safa R, Solomon M, Lev-Ram V, Rissman RA, Mayrhofer JE, Raffeiner A, Mol MO, Argue BMR, McCool S, Doan B, van Swieten J, Stefan E, Abel T, Ilouz R. PMID: 38743596; PMCID: PMC11531844.
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AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer's disease. J Neuroinflammation. 2024 Sep 28; 21(1):245. Kim YS, Choi SH, Kim KY, Navia-Pelaez JM, Perkins GA, Choi S, Kim J, Nazarenkov N, Rissman RA, Ju WK, Ellisman MH, Miller YI. PMID: 39342323; PMCID: PMC11439205.
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Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations. bioRxiv. 2024 Sep 24. Ghandian S, Albarghouthi L, Nava K, Sharma SRR, Minaud L, Beckett L, Saito N, DeCarli C, Rissman RA, Teich AF, Jin LW, Dugger BN, Keiser MJ. PMID: 39386601; PMCID: PMC11463656.
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Cannabis Use and Cannabidiol Modulate HIV-Induced Alterations in TREM2 Expression: Implications for Age-Related Neuropathogenesis. Viruses. 2024 09 24; 16(10). Avalos B, Kulbe JR, Ford MK, Laird AE, Walter K, Mante M, Florio JB, Boustani A, Chaillon A, Schlachetzki JCM, Sundermann EE, Volsky DJ, Rissman RA, Ellis RJ, Letendre SL, Iudicello J, Fields JA. PMID: 39459844; PMCID: PMC11512329.
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Microglial and neuronal fates following inhibition of CSF-1R in synucleinopathy mouse model. Brain Behav Immun. 2025 Jan; 123:254-269. Iba M, Lee YJ, Horan-Portelance L, Chang K, Szabo M, Rissman RA, You S, Masliah E, Kim C. PMID: 39284516.
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Genome-wide association study meta-analysis of neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration. Commun Biol. 2024 09 09; 7(1):1103. Ahmad S, Imtiaz MA, Mishra A, Wang R, Herrera-Rivero M, Bis JC, Fornage M, Roshchupkin G, Hofer E, Logue M, Longstreth WT, Xia R, Bouteloup V, Mosley T, Launer LJ, Khalil M, Kuhle J, Rissman RA, Chene G, Dufouil C, Djoussé L, Lyons MJ, Mukamal KJ, Kremen WS, Franz CE, Schmidt R, Debette S, Breteler MMB, Berger K, Yang Q, Seshadri S, Aziz NA, Ghanbari M, Ikram MA. PMID: 39251807; PMCID: PMC11385583.
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Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups. Acta Neuropathol. 2024 08 23; 148(1):27. Ma Y, Reyes-Dumeyer D, Piriz A, Recio P, Mejia DR, Medrano M, Lantigua RA, Vonsattel JPG, Tosto G, Teich AF, Ciener B, Leskinen S, Sivakumar S, DeTure M, Ranjan D, Dickson D, Murray M, Lee E, Wolk DA, Jin LW, Dugger BN, Hiniker A, Rissman RA, Mayeux R, Vardarajan BN. PMID: 39177846; PMCID: PMC11343944.
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The Alzheimer's Association Global Biomarker Standardization Consortium (GBSC) plasma phospho-tau Round Robin study. medRxiv. 2024 Aug 22. Ashton NJ, Keshavan A, Brum WS, Andreasson U, Arslan B, Droescher M, Barghorn S, Vanbrabant J, Lambrechts C, Van Loo M, Stoops E, Iyengar S, Ji H, Xu X, Forrest-Hay A, Zhang B, Luo Y, Jeromin A, Vandijck M, Bastard NL, Kolb H, Triana-Baltzer G, Bali D, Janelidze S, Yang SY, Demos C, Romero D, Sigal G, Wohlstadter J, Malyavantham K, Khare M, Jethwa A, Stoeckl L, Gobom J, Kac PR, Gonzalez-Ortiz F, Montoliu-Gaya L, Hansson O, Rissman RA, Carillo MC, Shaw LM, Blennow K, Schott JM, Zetterberg H. PMID: 39228740; PMCID: PMC11370527.
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Testing the causal impact of amyloidosis on total Tau using a genetically informative sample of adult male twins. bioRxiv. 2024 Jul 26. Gillespie NA, Neale MC, Panizzon MS, McKenzie RE, Tu XM, Xian H, Reynolds CA, Lyons MJ, Rissman RA, Elman JA, Franz C, Kremen WS. PMID: 39091865; PMCID: PMC11291022.
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A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with early Alzheimer's Disease. Alzheimers Res Ther. 2024 07 05; 16(1):151. Galasko D, Farlow MR, Lucey BP, Honig LS, Elbert D, Bateman R, Momper J, Thomas RG, Rissman RA, Pa J, Aslanyan V, Balasubramanian A, West T, Maccecchini M, Feldman HH. PMID: 38970127; PMCID: PMC11225352.
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Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing. medRxiv. 2024 Jun 25. Pottier C, Küçükali F, Baker M, Batzler A, Jenkins GD, van Blitterswijk M, Vicente CT, De Coster W, Wynants S, Van de Walle P, Ross OA, Murray ME, Faura J, Haggarty SJ, van Rooij JG, Mol MO, Hsiung GR, Graff C, Öijerstedt L, Neumann M, Asmann Y, McDonnell SK, Baheti S, Josephs KA, Whitwell JL, Bieniek KF, Forsberg L, Heuer H, Lago AL, Geier EG, Yokoyama JS, Oddi AP, Flanagan M, Mao Q, Hodges JR, Kwok JB, Domoto-Reilly K, Synofzik M, Wilke C, Onyike C, Dickerson BC, Evers BM, Dugger BN, Munoz DG, Keith J, Zinman L, Rogaeva E, Suh E, Gefen T, Geula C, Weintraub S, Diehl-Schmid J, Farlow MR, Edbauer D, Woodruff BK, Caselli RJ, Donker Kaat LL, Huey ED, Reiman EM, Mead S, King A, Roeber S, Nana AL, Ertekin-Taner N, Knopman DS, Petersen RC, Petrucelli L, Uitti RJ, Wszolek ZK, Ramos EM, Grinberg LT, Gorno Tempini ML, Rosen HJ, Spina S, Piguet O, Grossman M, Trojanowski JQ, Keene DC, Lee-Way J, Prudlo J, Geschwind DH, Rissman RA, Cruchaga C, Ghetti B, Halliday GM, Beach TG, Serrano GE, Arzberger T, Herms J, Boxer AL, Honig LS, Vonsattel JP, Lopez OL, Kofler J, White CL, Gearing M, Glass J, Rohrer JD, Irwin DJ, Lee EB, Van Deerlin V, Castellani R, Mesulam MM, Tartaglia MC, Finger EC, Troakes C, Al-Sarraj S, Miller BL, Seelaar H, Graff-Radford NR, Boeve BF, Mackenzie IR, van Swieten JC, Seeley WW, Sleegers K, Dickson DW, Biernacka JM, Rademakers R. PMID: 38978643; PMCID: PMC11230325.
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Assessment of brain-derived extracellular vesicle enrichment for blood biomarker analysis in age-related neurodegenerative diseases: An international overview. Alzheimers Dement. 2024 07; 20(7):4411-4422. Badhwar A, Hirschberg Y, Valle-Tamayo N, Iulita MF, Udeh-Momoh CT, Matton A, Tarawneh RM, Rissman RA, Ledreux A, Winston CN, Haqqani AS, Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment: Bioflui. PMID: 38864416; PMCID: PMC11247682.
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The neuropathological landscape of small vessel disease and Lewy pathology in a cohort of Hispanic and non-Hispanic White decedents with Alzheimer disease. Acta Neuropathol Commun. 2024 05 24; 12(1):81. Wang HP, Scalco R, Saito N, Beckett L, Nguyen ML, Huie EZ, Honig LS, DeCarli C, Rissman RA, Teich AF, Mungas DM, Jin LW, Dugger BN. PMID: 38790074; PMCID: PMC11127432.
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Associations of plasma neurofilament light chain with cognition and neuroimaging measures in community-dwelling early old age men. Alzheimers Res Ther. 2024 04 25; 16(1):90. Tang R, Buchholz E, Dale AM, Rissman RA, Fennema-Notestine C, Gillespie NA, Hagler DJ, Lyons MJ, Neale MC, Panizzon MS, Puckett OK, Reynolds CA, Franz CE, Kremen WS, Elman JA. PMID: 38664843; PMCID: PMC11044425.
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Racial and ethnic differences in plasma biomarker eligibility for a preclinical Alzheimer's disease trial. Alzheimers Dement. 2024 06; 20(6):3827-3838. Molina-Henry DP, Raman R, Liu A, Langford O, Johnson K, Shum LK, Glover CM, Dhadda S, Irizarry M, Jimenez-Maggiora G, Braunstein JB, Yarasheski K, Venkatesh V, West T, Verghese PB, Rissman RA, Aisen P, Grill JD, Sperling RA. PMID: 38629508; PMCID: PMC11180863.
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Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease. J Neuroinflammation. 2024 Apr 15; 21(1):93. Iba M, Kwon S, Kim C, Szabo M, Horan-Portelance L, Lopez-Ocasio M, Dagur P, Overk C, Rissman RA, Masliah E. PMID: 38622654; PMCID: PMC11017481.
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From understanding to action: Exploring molecular connections of Down syndrome to Alzheimer's disease for targeted therapeutic approach. Alzheimers Dement (Amst). 2024 Apr-Jun; 16(2):e12580. Sukreet S, Rafii MS, Rissman RA. PMID: 38623383; PMCID: PMC11016820.
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Amyloid precursor protein induces reactive astrogliosis. Acta Physiol (Oxf). 2024 06; 240(6):e14142. Velezmoro Jauregui G, Vukic D, Onyango IG, Arias C, Novotný JS, Texlová K, Wang S, Kovacovicova KL, Polakova N, Zelinkova J, Carna M, Lacovich V, Head BP, Havas D, Mistrik M, Zorec R, Verkhratsky A, Keegan L, O'Connell MA, Rissman R, Stokin GB. PMID: 38584589.
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AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer's disease. bioRxiv. 2024 Mar 27. Kim YS, Choi SH, Kim KY, Navia-Pelaez JM, Perkins GA, Choi S, Kim J, Nazarenkov N, Rissman RA, Ju WK, Ellisman MH, Miller YI. PMID: 38586011; PMCID: PMC10996524.
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A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with Early Alzheimer's Disease. medRxiv. 2024 Mar 22. Galasko D, Farlow MR, Lucey BP, Honig LS, Elbert D, Bateman R, Momper J, Thomas R, Rissman RA, Pa J, Aslanyan V, Balasubramanian A, West T, Maccecchini M, Feldman HH. PMID: 38562783; PMCID: PMC10984053.
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Midlife cumulative deficit frailty predicts Alzheimer's disease-related plasma biomarkers in older adults. Age Ageing. 2024 03 01; 53(3). Buchholz E, Gillespie NA, Hunt JF, Reynolds CA, Rissman RA, Schroeder A, Cortes I, Bell T, Lyons MJ, Kremen WS, Franz CE. PMID: 38454901; PMCID: PMC10921085.
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Multi-omics Characterization of Epigenetic and Genetic Risk of Alzheimer Disease in Autopsied Brains from two Ethnic Groups. medRxiv. 2024 Feb 14. Ma Y, Reyes-Dumeyer D, Piriz A, Recio P, Mejia DR, Medrano M, Lantigua RA, Vonsattel JPG, Tosto G, Teich AF, Ciener B, Leskinen S, Sivakumar S, DeTure M, Ranjan D, Dickson D, Murray M, Lee E, Wolk DA, Jin LW, Dugger BN, Hiniker A, Rissman RA, Mayeux R, Vardarajan BN. PMID: 38405911; PMCID: PMC10889011.
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CSF1R-mediated myeloid cell depletion shifts the ratio of motor cortical excitatory to inhibitory neurons in a multiple system atrophy model. Exp Neurol. 2024 Apr; 374:114706. Gauer C, Battis K, Schneider Y, Florio JB, Mante M, Kim HY, Rissman RA, Hoffmann A, Winkler J. PMID: 38311020.
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Correction: GP120 and tenofovir alafenamide alter cannabinoid receptor 1 expression in hippocampus of mice. J Neurovirol. 2024 Feb; 30(1):101-102. Kulbe JR, Le AA, Mante M, Florio J, Laird AE, Swinton MK, Rissman RA, Fields JA. PMID: 38177832; PMCID: PMC11035418.
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Corrigendum to " Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy Body Disease" [Neurobiology of Disease127 (2019) 163-177]. Neurobiol Dis. 2024 Feb; 191:106397. Spencer B, Trinh I, Rockenstein E, Mante M, Florio J, Adame A, El-Agnaf OMA, Kim C, Masliah E, Rissman RA. PMID: 38216383.
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Hippocampal ΔFosB expression is associated with cognitive impairment in a subgroup of patients with childhood epilepsies. Front Neurol. 2023; 14:1331194. Fu CH, You JC, Mohila C, Rissman RA, Yoshor D, Viaene AN, Chin J. PMID: 38274865; PMCID: PMC10808715.
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Amyloid and Tau Prediction of Cognitive and Functional Decline in Unimpaired Older Individuals: Longitudinal Data from the A4 and LEARN Studies. J Prev Alzheimers Dis. 2024; 11(4):802-813. Sperling RA, Donohue MC, Rissman RA, Johnson KA, Rentz DM, Grill JD, Heidebrink JL, Jenkins C, Jimenez-Maggiora G, Langford O, Liu A, Raman R, Yaari R, Holdridge KC, Sims JR, Aisen PS. PMID: 39044488; PMCID: PMC11266444.
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Relationship between Plasma P-Tau217 and Amyloid PET in Racial and Ethnic Underrepresented Groups (RE-URG) Compared with Non RE-URG in LEARN and A4. J Prev Alzheimers Dis. 2024; 11(4):831-837. Molina-Henry D, Langford O, Donohue MC, Raman R, Aisen P, Johnson KA, Rissman RA, Sperling R. PMID: 39044491; PMCID: PMC11266219.
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Longitudinal Phospho-tau217 Predicts Amyloid Positron Emission Tomography in Asymptomatic Alzheimer's Disease. J Prev Alzheimers Dis. 2024; 11(4):823-830. Rissman RA, Donohue MC, Langford O, Raman R, Abdel-Latif S, Yaari R, Holdridge KC, Sims JR, Molina-Henry D, Jimenez-Maggiora G, Johnson KA, Aisen PS, Sperling RA. PMID: 39044490; PMCID: PMC11266279.
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Maximizing the Utility of Alzheimer's Disease Trial Data: Sharing of Baseline A4 and LEARN Data. J Prev Alzheimers Dis. 2024; 11(4):889-894. Jimenez-Maggiora GA, Schulz AP, Donohue MC, Qiu H, Jaiswal SN, Adegoke O, Gallardo R, Baryshnikava O, Rissman RA, Abdel-Latif S, Sperling RA, Aisen PS. PMID: 39044498; PMCID: PMC11266269.
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Characterization of Ptau181 Among a Diverse Community-Based Cohort: A HABS-HD Study. J Alzheimers Dis. 2024; 100(s1):S63-S73. Petersen ME, Zhang F, Hall JR, Julovich D, Rissman RA, Meeker KL, Phillips N, Large S, Ances BM, O'Bryant SE, HABS-HD Study Team. PMID: 39177606.
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The AlzMatch Pilot Study - Feasibility of Remote Blood Collection of Plasma Biomarkers for Preclinical Alzheimer's Disease Trials. J Prev Alzheimers Dis. 2024; 11(5):1435-1444. Walter S, Langford O, Jimenez-Maggiora GA, Abdel-Latif S, Rissman RA, Grill JD, Karlawish J, Atri A, Bruschi S, Hussen K, Donohue MC, Marshall GA, Jicha G, Racke M, Turner RS, van Dyck CH, Venkatesh V, Yarasheski KE, Sperling R, Cummings J, Aisen PS, Raman R. PMID: 39350391; PMCID: PMC11436450.
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Amyloid precursor protein induces reactive astrogliosis. bioRxiv. 2023 Dec 18. Jauregui GV, Vukic D, Onyango IG, Arias C, Novotný JS, Texlová K, Wang S, Kovacovicova KL, Polakova N, Zelinkova J, Carna M, Strašil VL, Head BP, Havas D, Mistrik M, Zorec R, Verkhratsky A, Keegan L, O'Connel M, Rissman R, Stokin GB. PMID: 38187544; PMCID: PMC10769227.
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Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin. Extracell Vesicles Circ Nucl Acids. 2023; 4(4):588-598. Hook V, Podvin S, Mosier C, Boyarko B, Seyffert L, Stringer H, Rissman RA. PMID: 38125374; PMCID: PMC10732590.
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Association between military service and Alzheimer's disease neuropathology at autopsy. Alzheimers Dement. 2024 02; 20(2):1468-1474. Powell WR, Vilen L, Zuelsdorff M, Goutman SA, Salamat S, Rissman RA, Bendlin BB, Kind AJH. PMID: 37965965; PMCID: PMC10917028.
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Plasma Aβ42/Aβ40 and phospho-tau217 concentration ratios increase the accuracy of amyloid PET classification in preclinical Alzheimer's disease. Alzheimers Dement. 2024 02; 20(2):1214-1224. Rissman RA, Langford O, Raman R, Donohue MC, Abdel-Latif S, Meyer MR, Wente-Roth T, Kirmess KM, Ngolab J, Winston CN, Jimenez-Maggiora G, Rafii MS, Sachdev P, West T, Yarasheski KE, Braunstein JB, Irizarry M, Johnson KA, Aisen PS, Sperling RA, AHEAD 3-45 Study team. PMID: 37932961; PMCID: PMC10916957.
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Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions. Alzheimers Dement. 2024 01; 20(1):728-740. Alber J, Bouwman F, den Haan J, Rissman RA, De Groef L, Koronyo-Hamaoui M, Lengyel I, Thal DR, Alzheimer's Association ISTAART “The Eye as a Biomarker for AD” Professional Interest Area. PMID: 37917365; PMCID: PMC10917008.
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GP120 and tenofovir alafenamide alter cannabinoid receptor 1 expression in hippocampus of mice. J Neurovirol. 2023 10; 29(5):564-576. Kulbe JR, Le AA, Mante M, Florio J, Laird AE, Swinton MK, Rissman RA, Fields JA. PMID: 37801175; PMCID: PMC10645617.
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Assessment of brain-derived extracellular vesicle enrichment for blood biomarker analysis in age-related neurodegenerative diseases: An international overview. bioRxiv. 2023 Oct 02. Badhwar A, Hirschberg Y, Tamayo NV, Iulita MF, Udeh-Momoh CT, Matton A, Tarawneh RM, Rissman RA, Ledreux A, Winston CN, Haqqani AS, Alzheimer’s Association International Society to Advance Alzheimer's Research and Treatment, BBB-EWG. PMID: 37873207; PMCID: PMC10592861.
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Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimer's disease. Neurobiol Dis. 2023 10 01; 186:106285. Leitão ADG, Ahammad RU, Spencer B, Wu C, Masliah E, Rissman RA. PMID: 37690676; PMCID: PMC10584037.
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Nicotine-mediated effects in neuronal and mouse models of synucleinopathy. Front Neurosci. 2023; 17:1239009. Fares MB, Alijevic O, Johne S, Overk C, Hashimoto M, Kondylis A, Adame A, Dulize R, Peric D, Nury C, Battey J, Guedj E, Sierro N, Mc Hugh D, Rockenstein E, Kim C, Rissman RA, Hoeng J, Peitsch MC, Masliah E, Mathis C. PMID: 37719154; PMCID: PMC10501483.
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The heritability of blood-based biomarkers related to risk of Alzheimer's disease in a population-based sample of early old-age men. Alzheimers Dement. 2024 01; 20(1):356-365. Gillespie NA, Elman JA, McKenzie RE, Tu XM, Xian H, Reynolds CA, Panizzon MS, Lyons MJ, Eglit GML, Neale MC, Rissman RA, Franz C, Kremen WS. PMID: 37622539; PMCID: PMC10843753.
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Evaluation of Neighborhood-Level Disadvantage and Cognition in Mexican American and Non-Hispanic White Adults 50 Years and Older in the US. JAMA Netw Open. 2023 08 01; 6(8):e2325325. Wong CG, Miller JB, Zhang F, Rissman RA, Raman R, Hall JR, Petersen M, Yaffe K, Kind AJ, O'Bryant SE, HABS-HD Study Team. PMID: 37647071; PMCID: PMC10469291.
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The neuropathological landscape of Hispanic and non-Hispanic White decedents with Alzheimer disease. Acta Neuropathol Commun. 2023 06 29; 11(1):105. Scalco R, Saito N, Beckett L, Nguyen ML, Huie E, Wang HP, Flaherty DA, Honig LS, DeCarli C, Rissman RA, Teich AF, Jin LW, Dugger BN. PMID: 37386610; PMCID: PMC10311731.
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Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease: Research outline and call for collaboration. Alzheimers Dement. 2023 11; 19(11):5209-5231. Lathe R, Schultek NM, Balin BJ, Ehrlich GD, Auber LA, Perry G, Breitschwerdt EB, Corry DB, Doty RL, Rissman RA, Nara PL, Itzhaki R, Eimer WA, Tanzi RE, Intracell Research Group Consortium Collaborators. PMID: 37283269; PMCID: PMC10918877.
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Clinical utility of an antibody-free LC-MS method to detect brain amyloid deposition in cognitively unimpaired individuals from the screening visit of the A4 Study. Alzheimers Dement (Amst). 2023 Apr-Jun; 15(2):e12451. Allué JA, Pascual-Lucas M, Sarasa L, Castillo S, Sarasa M, Sáez ME, Abdel-Latif S, Rissman RA, Terencio J. PMID: 37274930; PMCID: PMC10236000.
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Inhibition of p38α MAPK restores neuronal p38γ MAPK and ameliorates synaptic degeneration in a mouse model of DLB/PD. Sci Transl Med. 2023 05 10; 15(695):eabq6089. Iba M, Kim C, Kwon S, Szabo M, Horan-Portelance L, Peer CJ, Figg WD, Reed X, Ding J, Lee SJ, Rissman RA, Cookson MR, Overk C, Wrasidlo W, Masliah E. PMID: 37163617; PMCID: PMC12168722.
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Characterization of altered molecular mechanisms in Parkinson's disease through cell type-resolved multiomics analyses. Sci Adv. 2023 04 14; 9(15):eabo2467. Lee AJ, Kim C, Park S, Joo J, Choi B, Yang D, Jun K, Eom J, Lee SJ, Chung SJ, Rissman RA, Chung J, Masliah E, Jung I. PMID: 37058563; PMCID: PMC10104466.
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Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults. Alzheimers Dement (Amst). 2023 Apr-Jun; 15(2):e12419. Adams JN, Márquez F, Larson MS, Janecek JT, Miranda BA, Noche JA, Taylor L, Hollearn MK, McMillan L, Keator DB, Head E, Rissman RA, Yassa MA. PMID: 37035460; PMCID: PMC10075195.
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Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration. J Neurosci. 2023 05 24; 43(21):3970-3984. Lawrence JA, Aguilar-Calvo P, Ojeda-Juárez D, Khuu H, Soldau K, Pizzo DP, Wang J, Malik A, Shay TF, Sullivan EE, Aulston B, Song SM, Callender JA, Sanchez H, Geschwind MD, Roy S, Rissman RA, Trejo J, Tanaka N, Wu C, Chen X, Patrick GN, Sigurdson CJ. PMID: 37019623; PMCID: PMC10219035.
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Missorting of plasma miRNAs in aging and Alzheimer's disease. J Neurochem. 2023 04; 165(2):149-161. Carna M, Novotny JS, Dragišic N, Slavik H, Sheardova K, Geda YE, Vyhnalek M, Laczo J, Hort J, Mao Z, Rissman RA, Hajduch M, Dammer EB, Stokin GB. PMID: 36892419.
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Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS-HD study. Alzheimers Dement (Amst). 2023 Jan-Mar; 15(1):e12394. Jiang X, O'Bryant SE, Johnson LA, Rissman RA, Yaffe K, Health and Aging Brain Study (HABS-HD) Study Team. PMID: 36911361; PMCID: PMC9994160.
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Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus. Alzheimers Dement. 2023 08; 19(8):3537-3554. Carna M, Onyango IG, Katina S, Holub D, Novotny JS, Nezvedova M, Jha D, Nedelska Z, Lacovich V, Vyvere TV, Houbrechts R, Garcia-Mansfield K, Sharma R, David-Dirgo V, Vyhnalek M, Texlova K, Chaves H, Bakkar N, Pertierra L, Vinkler M, Markova H, Laczo J, Sheardova K, Hortova-Kohoutkova M, Fric J, Forte G, Kanovsky P, Belaškova S, Damborsky J, Hort J, Seyfried NT, Bowser R, Sevlever G, Rissman RA, Smith RA, Hajduch M, Pirrotte P, Spacil Z, Dammer EB, Limbäck-Stokin C, Stokin GB. PMID: 36825691; PMCID: PMC10634590.
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The Independent Walking for Brain Health Intervention for Older Adults: Protocol for a Pilot Randomized Controlled Trial. JMIR Res Protoc. 2023 Feb 13; 12:e42980. Hays Weeks CC, Moore AA, Allison M, Patrick K, Bondi MW, Nebeker C, Liu TT, Wing D, Higgins M, Hartman SJ, Rissman RA, Zlatar ZZ. PMID: 36535765; PMCID: PMC9972211.
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D-685 Reverses Motor Deficits and Reduces Accumulation of Human α-Synuclein Protein in Two Different Parkinson's Disease Animal Models. ACS Chem Neurosci. 2023 03 01; 14(5):885-896. Dutta AK, Armstrong C, Luo D, Das B, Spencer B, Rissman RA. PMID: 36749600.
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Overexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy. Neurobiol Dis. 2023 03; 178:106010. Lin S, Leitão ADG, Fang S, Gu Y, Barber S, Gilliard-Telefoni R, Castro A, Sung K, Shen R, Florio JB, Mante ML, Ding J, Spencer B, Masliah E, Rissman RA, Wu C. PMID: 36702318; PMCID: PMC10754494.
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TDP-43 Pathology in the Setting of Intermediate and High Alzheimer's Disease Neuropathologic Changes: A Preliminary Evaluation Across Ethnoracial Groups. J Alzheimers Dis. 2023; 91(4):1291-1301. Huie EZ, Escudero A, Saito N, Harvey D, Nguyen ML, Lucot KL, LaGrande J, Mungas D, DeCarli C, Lamar M, Schneider JA, Kapasi A, Rissman RA, Teich AF, Dugger BN. PMID: 36617779; PMCID: PMC9974776.
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Evaluation of Blood-Based Plasma Biomarkers as Potential Markers of Amyloid Burden in Preclinical Alzheimer's Disease. J Alzheimers Dis. 2023; 92(1):95-107. Winston CN, Langford O, Levin N, Raman R, Yarasheski K, West T, Abdel-Latif S, Donohue M, Nakamura A, Toba K, Masters CL, Doecke J, Sperling RA, Aisen PS, Rissman RA. PMID: 36710683; PMCID: PMC11191492.
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Precision Medicine for Preventing Alzheimer's Disease: Analysis of the ADAPT Study. J Alzheimers Dis. 2023; 95(4):1609-1622. O'Bryant SE, Zhang F, Johnson LA, Hall J, Petersen M, Oh ES, Lyketsos CG, Rissman RA. PMID: 37718801.
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Hippocampal Reduction of α-Synuclein via RNA Interference Improves Neuropathology in Alzheimer's Disease Mice. J Alzheimers Dis. 2023; 95(1):349-361. Leitão ADG, Spencer B, Sarsoza F, Ngolab J, Amalraj J, Masliah E, Wu C, Rissman RA. PMID: 37522208; PMCID: PMC10578232.
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Association of neurofilament light chain with renal function: mechanisms and clinical implications. Alzheimers Res Ther. 2022 12 16; 14(1):189. Tang R, Panizzon MS, Elman JA, Gillespie NA, Hauger RL, Rissman RA, Lyons MJ, Neale MC, Reynolds CA, Franz CE, Kremen WS, Alzheimer’s Disease Neuroimaging Initiative. PMID: 36527130; PMCID: PMC9756450.
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Evaluation of blood-based, extracellular vesicles as biomarkers for aging-related TDP-43 pathology. Alzheimers Dement (Amst). 2022; 14(1):e12365. Winston CN, Sukreet S, Lynch H, Lee VM, Wilcock DM, Nelson PT, Rissman RA. PMID: 36540894; PMCID: PMC9753157.
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LATE-NC staging in routine neuropathologic diagnosis: an update. Acta Neuropathol. 2023 02; 145(2):159-173. Nelson PT, Lee EB, Cykowski MD, Alafuzoff I, Arfanakis K, Attems J, Brayne C, Corrada MM, Dugger BN, Flanagan ME, Ghetti B, Grinberg LT, Grossman M, Grothe MJ, Halliday GM, Hasegawa M, Hokkanen SRK, Hunter S, Jellinger K, Kawas CH, Keene CD, Kouri N, Kovacs GG, Leverenz JB, Latimer CS, Mackenzie IR, Mao Q, McAleese KE, Merrick R, Montine TJ, Murray ME, Myllykangas L, Nag S, Neltner JH, Newell KL, Rissman RA, Saito Y, Sajjadi SA, Schwetye KE, Teich AF, Thal DR, Tomé SO, Troncoso JC, Wang SJ, White CL, Wisniewski T, Yang HS, Schneider JA, Dickson DW, Neumann M. PMID: 36512061; PMCID: PMC9849315.
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Digital Histological Study of Neocortical Grey and White Matter Tau Burden Across Tauopathies. J Neuropathol Exp Neurol. 2022 11 16; 81(12):953-964. Coughlin DG, Hiniker A, Peterson C, Kim Y, Arezoumandan S, Giannini L, Pizzo D, Weintraub D, Siderowf A, Litvan I, Rissman RA, Galasko D, Hansen L, Trojanowski JQ, Lee E, Grossman M, Irwin D. PMID: 36269086; PMCID: PMC9677241.
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Leukocyte surface biomarkers implicate deficits of innate immunity in sporadic Alzheimer's disease. Alzheimers Dement. 2023 05; 19(5):2084-2094. Huang X, Li Y, Fowler C, Doecke JD, Lim YY, Drysdale C, Zhang V, Park K, Trounson B, Pertile K, Rumble R, Pickering JW, Rissman RA, Sarsoza F, Abdel-Latif S, Lin Y, Doré V, Villemagne V, Rowe CC, Fripp J, Martins R, Wiley JS, Maruff P, Mintzer JE, Masters CL, Gu BJ. PMID: 36349985; PMCID: PMC10166765.
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CSF1R-Mediated Myeloid Cell Depletion Prolongs Lifespan But Aggravates Distinct Motor Symptoms in a Model of Multiple System Atrophy. J Neurosci. 2022 10 05; 42(40):7673-7688. Battis K, Florio JB, Mante M, Lana A, Naumann I, Gauer C, Lambrecht V, Müller SJ, Cobo I, Fixsen B, Kim HY, Masliah E, Glass CK, Schlachetzki JCM, Rissman RA, Winkler J, Hoffmann A. PMID: 36333098; PMCID: PMC9546481.
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The AHEAD 3-45 Study: Design of a prevention trial for Alzheimer's disease. Alzheimers Dement. 2023 04; 19(4):1227-1233. Rafii MS, Sperling RA, Donohue MC, Zhou J, Roberts C, Irizarry MC, Dhadda S, Sethuraman G, Kramer LD, Swanson CJ, Li D, Krause S, Rissman RA, Walter S, Raman R, Johnson KA, Aisen PS. PMID: 35971310; PMCID: PMC9929028.
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Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer's Disease Brain. ACS Chem Neurosci. 2022 07 06; 13(13):1992-2005. Podvin S, Jiang Z, Boyarko B, Rossitto LA, O'Donoghue A, Rissman RA, Hook V. PMID: 35758417; PMCID: PMC9264367.
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Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial. JAMA Neurol. 2022 06 01; 79(6):565-574. Rafii MS, Sol O, Mobley WC, Delpretti S, Skotko BG, Burke AD, Sabbagh MN, Yuan SH, Rissman RA, Pulsifer M, Evans C, Evans AC, Beth G, Fournier N, Gray JA, Dos Santos AM, Hliva V, Vukicevic M, Kosco-Vilbois M, Streffer J, Pfeifer A, Feldman HH. PMID: 35532913; PMCID: PMC9086937.
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Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease. Brain. 2022 04 29; 145(3):879-886. Steinkellner T, Conrad WS, Kovacs I, Rissman RA, Lee EB, Trojanowski JQ, Freyberg Z, Roy S, Luk KC, Lee VM, Hnasko TS. PMID: 35258081; PMCID: PMC9050538.
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Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels. Commun Biol. 2022 04 08; 5(1):336. Sarnowski C, Ghanbari M, Bis JC, Logue M, Fornage M, Mishra A, Ahmad S, Beiser AS, Boerwinkle E, Bouteloup V, Chouraki V, Cupples LA, Damotte V, DeCarli CS, DeStefano AL, Djoussé L, Fohner AE, Franz CE, Kautz TF, Lambert JC, Lyons MJ, Mosley TH, Mukamal KJ, Pase MP, Portilla Fernandez EC, Rissman RA, Satizabal CL, Vasan RS, Yaqub A, Debette S, Dufouil C, Launer LJ, Kremen WS, Longstreth WT, Ikram MA, Seshadri S. PMID: 35396452; PMCID: PMC8993877.
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Association of Neighborhood-Level Disadvantage With Neurofibrillary Tangles on Neuropathological Tissue Assessment. JAMA Netw Open. 2022 04 01; 5(4):e228966. Powell WR, Zuelsdorff M, Keller SA, Betthauser TJ, Rissman RA, Bendlin BB, Kind AJH. PMID: 35482313; PMCID: PMC9051985.
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The Link between APOE4 Presence and Neuropsychological Test Performance among Mexican Americans and Non-Hispanic Whites of the Multiethnic Health & Aging Brain Study - Health Disparities Cohort. Dement Geriatr Cogn Disord. 2022; 51(1):26-31. O'Bryant SE, Barber RC, Philips N, Johnson LA, Hall JR, Subasinghe K, Petersen M, Toga AW, Yaffe K, Rissman RA, HABS-HD Study Team. PMID: 35226898; PMCID: PMC9175651.
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Plasma biomarkers for Alzheimer's Disease in relation to neuropathology and cognitive change. Acta Neuropathol. 2022 04; 143(4):487-503. Smirnov DS, Ashton NJ, Blennow K, Zetterberg H, Simrén J, Lantero-Rodriguez J, Karikari TK, Hiniker A, Rissman RA, Salmon DP, Galasko D. PMID: 35195758; PMCID: PMC8960664.
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Developing Biomarkers of Mild Traumatic Brain Injury: Promise and Progress of CNS-Derived Exosomes. Front Neurol. 2021; 12:698206. Vaughn MN, Winston CN, Levin N, Rissman RA, Risbrough VB. PMID: 35222223; PMCID: PMC8866179.
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Neurodegeneration from the AT(N) framework is different among Mexican Americans compared to non-Hispanic Whites: A Health & Aging Brain among Latino Elders (HABLE) Study. Alzheimers Dement (Amst). 2022; 14(1):e12267. O'Bryant SE, Zhang F, Petersen M, Hall J, Johnson LA, Yaffe K, Braskie M, Rissman RA, Vig R, Toga AW, HABLE Study Team. PMID: 35155729; PMCID: PMC8828994.
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Intranasal insulin modulates cerebrospinal fluid markers of neuroinflammation in mild cognitive impairment and Alzheimer's disease: a randomized trial. Sci Rep. 2022 01 25; 12(1):1346. Kellar D, Register T, Lockhart SN, Aisen P, Raman R, Rissman RA, Brewer J, Craft S. PMID: 35079029; PMCID: PMC8789895.
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Noninvasive Antemortem Detection of Retinal Prions by a Fluorescent Tracer. J Alzheimers Dis. 2022; 88(3):1137-1145. Aguilar-Calvo P, Sevillano AM, Rasool S, Cao KJ, Randolph LM, Rissman RA, Sarraf ST, Yang J, Sigurdson CJ. PMID: 35754278; PMCID: PMC10080909.
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Novel Brain-Penetrating Single Chain Antibodies Directed Against 3RTau for the Treatment of Alzheimer's Disease and Related Dementias. Methods Mol Biol. 2022; 2383:447-457. Spencer B, Rissman RA, Overk C, Masliah E. PMID: 34766306.
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Characterization of Mild Cognitive Impairment and Dementia among Community-Dwelling Mexican Americans and Non-Hispanic Whites. J Alzheimers Dis. 2022; 90(2):905-915. O'Bryant SE, Petersen M, Hall J, Johnson LA, Barber R, Phillips N, Braskie MN, Yaffe K, Rissman R, Toga A, HABS-HD Study Team. PMID: 36189588; PMCID: PMC10117692.
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Proteomic Profiles of Neurodegeneration Among Mexican Americans and Non-Hispanic Whites in the HABS-HD Study. J Alzheimers Dis. 2022; 86(3):1243-1254. O'Bryant SE, Zhang F, Petersen M, Hall JR, Johnson LA, Yaffe K, Braskie M, Vig R, Toga AW, Rissman RA, HABS-HD Study Team. PMID: 35180110; PMCID: PMC9376967.
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Modulation of Amyloid-β and Tau in Alzheimer's Disease Plasma Neuronal-Derived Extracellular Vesicles by Cerebrolysin® and Donepezil. J Alzheimers Dis. 2022; 90(2):705-717. Alvarez XA, Winston CN, Barlow JW, Sarsoza FM, Alvarez I, Aleixandre M, Linares C, García-Fantini M, Kastberger B, Winter S, Rissman RA. PMID: 36155516; PMCID: PMC9697063.
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NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease Progression. Cells. 2021 12 13; 10(12). Mengel D, Mok TH, Nihat A, Liu W, Rissman RA, Galasko D, Zetterberg H, Mead S, Collinge J, Walsh DM. PMID: 34944022; PMCID: PMC8700417.
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Association of Neurofibrillary Tangle Distribution With Age at Onset-Related Clinical Heterogeneity in Alzheimer Disease: An Autopsy Study. Neurology. 2022 02 01; 98(5):e506-e517. Smirnov DS, Salmon DP, Galasko D, Goodwill VS, Hansen LA, Zhao Y, Edland SD, Léger GC, Peavy GM, Jacobs DM, Rissman R, Pizzo DP, Hiniker A. PMID: 34810247; PMCID: PMC8826459.
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Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathol. 2022 01; 143(1):33-53. Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, Whitney K, Dangoor DK, Walsh H, Marcora E, Hefti MM, Casella A, Sissoko CT, Kapoor M, Novikova G, Udine E, Wong G, Tang W, Bhangale T, Hunkapiller J, Ayalon G, Graham RR, Cherry JD, Cortes EP, Borukov VY, McKee AC, Stein TD, Vonsattel JP, Teich AF, Gearing M, Glass J, Troncoso JC, Frosch MP, Hyman BT, Dickson DW, Murray ME, Attems J, Flanagan ME, Mao Q, Mesulam MM, Weintraub S, Woltjer RL, Pham T, Kofler J, Schneider JA, Yu L, Purohit DP, Haroutunian V, Hof PR, Gandy S, Sano M, Beach TG, Poon W, Kawas CH, Corrada MM, Rissman RA, Metcalf J, Shuldberg S, Salehi B, Nelson PT, Trojanowski JQ, Lee EB, Wolk DA, McMillan CT, Keene CD, Latimer CS, Montine TJ, Kovacs GG, Lutz MI, Fischer P, Perrin RJ, Cairns NJ, Franklin EE, Cohen HT, Raj T, Cobos I, Frost B, Goate A, White Iii CL, Crary JF. PMID: 34719765; PMCID: PMC8786260.
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Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression. PLoS One. 2021; 16(9):e0251611. Grundman J, Spencer B, Sarsoza F, Rissman RA. PMID: 34587152; PMCID: PMC8480850.
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Using Fractional Anisotropy Imaging to Detect Mild Cognitive Impairment and Alzheimer's Disease among Mexican Americans and Non-Hispanic Whites: A HABLE Study. Dement Geriatr Cogn Disord. 2021; 50(3):266-273. Hall JR, Johnson LA, Zhang F, Petersen M, Toga AW, Shi Y, Mason D, Rissman RA, Yaffe K, O'Bryant SE, HABLE Study. PMID: 34569492; PMCID: PMC8559764.
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A transcriptome-wide association study of Alzheimer's disease using prediction models of relevant tissues identifies novel candidate susceptibility genes. Genome Med. 2021 09 01; 13(1):141. Sun Y, Zhu J, Zhou D, Canchi S, Wu C, Cox NJ, Rissman RA, Gamazon ER, Wu L. PMID: 34470669; PMCID: PMC8408990.
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Unbalanced Regulation of α7 nAChRs by Ly6h and NACHO Contributes to Neurotoxicity in Alzheimer's Disease. J Neurosci. 2021 10 13; 41(41):8461-8474. Wu M, Liu CZ, Barrall EA, Rissman RA, Joiner WJ. PMID: 34446574; PMCID: PMC8513707.
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Feasibility study for detection of retinal amyloid in clinical trials: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) trial. Alzheimers Dement (Amst). 2021; 13(1):e12199. Ngolab J, Donohue M, Belsha A, Salazar J, Cohen P, Jaiswal S, Tan V, Gessert D, Korouri S, Aggarwal NT, Alber J, Johnson K, Jicha G, van Dyck C, Lah J, Salloway S, Sperling RA, Aisen PS, Rafii MS, Rissman RA. PMID: 34430703; PMCID: PMC8369843.
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Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study. Alzheimers Dement. 2022 02; 18(2):240-250. O'Bryant S, Petersen M, Hall J, Johnson L, Yaffe K, Braskie M, Toga AW, Rissman RA, HABLE study team. PMID: 34310015; PMCID: PMC9228481.
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The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics. Alzheimers Dement (Amst). 2021; 13(1):e12202. O'Bryant SE, Johnson LA, Barber RC, Braskie MN, Christian B, Hall JR, Hazra N, King K, Kothapalli D, Large S, Mason D, Matsiyevskiy E, McColl R, Nandy R, Palmer R, Petersen M, Philips N, Rissman RA, Shi Y, Toga AW, Vintimilla R, Vig R, Zhang F, Yaffe K, HABLE Study Team. PMID: 34189247; PMCID: PMC8215806.
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A blood screening tool for detecting mild cognitive impairment and Alzheimer's disease among community-dwelling Mexican Americans and non-Hispanic Whites: A method for increasing representation of diverse populations in clinical research. Alzheimers Dement. 2022 01; 18(1):77-87. O'Bryant SE, Zhang F, Petersen M, Hall JR, Johnson LA, Yaffe K, Mason D, Braskie M, Barber RA, Rissman RA, Mapstone M, Mielke MM, Toga AW, HABLE Study Team. PMID: 34057802; PMCID: PMC8936163.
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Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons. ACS Omega. 2021 May 25; 6(20):13033-13056. Podvin S, Jones A, Liu Q, Aulston B, Mosier C, Ames J, Winston C, Lietz CB, Jiang Z, O'Donoghue AJ, Ikezu T, Rissman RA, Yuan SH, Hook V. PMID: 34056454; PMCID: PMC8158845.
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Systematic in silico analysis of clinically tested drugs for reducing amyloid-beta plaque accumulation in Alzheimer's disease. Alzheimers Dement. 2021 09; 17(9):1487-1498. Madrasi K, Das R, Mohmmadabdul H, Lin L, Hyman BT, Lauffenburger DA, Albers MW, Rissman RA, Burke JM, Apgar JF, Wille L, Gruenbaum L, Hua F. PMID: 33938131; PMCID: PMC8478725.
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Protein Footprinting via Covalent Protein Painting Reveals Structural Changes of the Proteome in Alzheimer's Disease. J Proteome Res. 2021 05 07; 20(5):2762-2771. Bamberger C, Pankow S, Martínez-Bartolomé S, Ma M, Diedrich J, Rissman RA, Yates JR. PMID: 33872013; PMCID: PMC8477671.
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Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention. J Exp Med. 2021 04 05; 218(4). Rynearson KD, Ponnusamy M, Prikhodko O, Xie Y, Zhang C, Nguyen P, Hug B, Sawa M, Becker A, Spencer B, Florio J, Mante M, Salehi B, Arias C, Galasko D, Head BP, Johnson G, Lin JH, Duddy SK, Rissman RA, Mobley WC, Thinakaran G, Tanzi RE, Wagner SL. PMID: 33651103; PMCID: PMC7931646.
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Plasma Levels of Neuron- and Astrocyte-Derived Exosomal Amyloid Beta1-42, Amyloid Beta1-40, and Phosphorylated Tau Levels in Schizophrenia Patients and Non-psychiatric Comparison Subjects: Relationships With Cognitive Functioning and Psychopathology. Front Psychiatry. 2020; 11:532624. Lee EE, Winston-Gray C, Barlow JW, Rissman RA, Jeste DV. PMID: 33762974; PMCID: PMC7982803.
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Effects of innate immune receptor stimulation on extracellular α-synuclein uptake and degradation by brain resident cells. Exp Mol Med. 2021 02; 53(2):281-290. Kim C, Kwon S, Iba M, Spencer B, Rockenstein E, Mante M, Adame A, Shin SJ, Fields JA, Rissman RA, Lee SJ, Masliah E. PMID: 33594256; PMCID: PMC8080790.
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Mutant three-repeat tau expression initiates retinal ganglion cell death through Caspase-2. Neurobiol Dis. 2021 05; 152:105277. Ngolab J, Canchi S, Rasool S, Elmaarouf A, Thomas K, Sarsoza F, Grundman J, Mante M, Florio J, Nandankar N, Korouri S, Zago W, Masliah E, Rissman RA. PMID: 33516874; PMCID: PMC8373010.
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Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy. J Neuropathol Exp Neurol. 2021 01 20; 80(2):102-111. Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, Budson A, Cairns NJ, Corrada M, Cortes E, Dickson DW, Fischer P, Flanagan ME, Franklin E, Gearing M, Glass J, Hansen LA, Haroutunian V, Hof PR, Honig L, Kawas C, Keene CD, Kofler J, Kovacs GG, Lee EB, Lutz MI, Mao Q, Masliah E, McKee AC, McMillan CT, Mesulam MM, Murray M, Nelson PT, Perrin R, Pham T, Poon W, Purohit DP, Rissman RA, Sakai K, Sano M, Schneider JA, Stein TD, Teich AF, Trojanowski JQ, Troncoso JC, Vonsattel JP, Weintraub S, Wolk DA, Woltjer RL, Yamada M, Yu L, White CL, Crary JF. PMID: 33367843; PMCID: PMC8453611.
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A Precision Medicine Approach to Treating Alzheimer's Disease Using Rosiglitazone Therapy: A Biomarker Analysis of the REFLECT Trials. J Alzheimers Dis. 2021; 81(2):557-568. O'Bryant SE, Zhang F, Petersen M, Johnson L, Hall J, Rissman RA. PMID: 33814447; PMCID: PMC8203239.
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Intranasal Insulin Reduces White Matter Hyperintensity Progression in Association with Improvements in Cognition and CSF Biomarker Profiles in Mild Cognitive Impairment and Alzheimer's Disease. J Prev Alzheimers Dis. 2021; 8(3):240-248. Kellar D, Lockhart SN, Aisen P, Raman R, Rissman RA, Brewer J, Craft S. PMID: 34101779; PMCID: PMC10233712.
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Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer's disease. Science. 2021 01 15; 371(6526). Nakamura T, Oh CK, Liao L, Zhang X, Lopez KM, Gibbs D, Deal AK, Scott HR, Spencer B, Masliah E, Rissman RA, Yates JR, Lipton SA. PMID: 33273062; PMCID: PMC8091809.
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LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies. Sci Transl Med. 2020 10 14; 12(565). Kim C, Beilina A, Smith N, Li Y, Kim M, Kumaran R, Kaganovich A, Mamais A, Adame A, Iba M, Kwon S, Lee WJ, Shin SJ, Rissman RA, You S, Lee SJ, Singleton AB, Cookson MR, Masliah E. PMID: 33055242; PMCID: PMC8100991.
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The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease. Nature. 2020 10; 586(7831):735-740. Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM. PMID: 32879487; PMCID: PMC7919141.
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Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial. JAMA Neurol. 2020 09 01; 77(9):1099-1109. Craft S, Raman R, Chow TW, Rafii MS, Sun CK, Rissman RA, Donohue MC, Brewer JB, Jenkins C, Harless K, Gessert D, Aisen PS. PMID: 32568367; PMCID: PMC7309571.
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Correction to: Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology. Acta Neuropathol Commun. 2020 08 04; 8(1):123. Ngolab J, Trinh I, Rockenstein E, Mante M, Florio J, Trejo M, Masliah D, Adame A, Masliah E, Rissman RA. PMID: 32753049; PMCID: PMC7405419.
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Reproductive status impact on tau phosphorylation induced by chronic stress. Neurobiol Stress. 2020 Nov; 13:100241. Muñoz-Mayorga D, Rissman RA, Morales T. PMID: 33344697; PMCID: PMC7739034.
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A missense point mutation in nerve growth factor (NGFR100W) results in selective peripheral sensory neuropathy. Prog Neurobiol. 2020 11; 194:101886. Yang W, Sung K, Xu W, Rodriguez MJ, Wu AC, Santos SA, Fang S, Uber RK, Dong SX, Guillory BC, Orain X, Raus J, Jolivalt C, Calcutt N, Rissman RA, Ding J, Wu C. PMID: 32693191; PMCID: PMC12327444.
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Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models. J Neuroinflammation. 2020 Jul 17; 17(1):214. Iba M, Kim C, Sallin M, Kwon S, Verma A, Overk C, Rissman RA, Sen R, Sen JM, Masliah E. PMID: 32680537; PMCID: PMC7368752.
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DTI-identified microstructural changes in the gray matter of mice overexpressing CRF in the forebrain. Psychiatry Res Neuroimaging. 2020 10 30; 304:111137. Deslauriers J, Toth M, Scadeng M, McKenna BS, Bussell R, Gresack J, Rissman R, Risbrough VB, Brown GG. PMID: 32731113; PMCID: PMC7508966.
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Diverse proteins aggregate in mild cognitive impairment and Alzheimer's disease brain. Alzheimers Res Ther. 2020 06 19; 12(1):75. Kepchia D, Huang L, Dargusch R, Rissman RA, Shokhirev MN, Fischer W, Schubert D. PMID: 32560738; PMCID: PMC7305608.
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Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease. Transl Neurodegener. 2020 06 18; 9(1):26. Shen R, Zhao X, He L, Ding Y, Xu W, Lin S, Fang S, Yang W, Sung K, Spencer B, Rissman RA, Lei M, Ding J, Wu C. PMID: 32552912; PMCID: PMC7301499.
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The Area Deprivation Index: A novel tool for harmonizable risk assessment in Alzheimer's disease research. Alzheimers Dement (N Y). 2020; 6(1):e12039. Zuelsdorff M, Larson JL, Hunt JFV, Kim AJ, Koscik RL, Buckingham WR, Gleason CE, Johnson SC, Asthana S, Rissman RA, Bendlin BB, Kind AJH. PMID: 32548238; PMCID: PMC7293995.
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Association of Neighborhood-Level Disadvantage With Alzheimer Disease Neuropathology. JAMA Netw Open. 2020 06 01; 3(6):e207559. Powell WR, Buckingham WR, Larson JL, Vilen L, Yu M, Salamat MS, Bendlin BB, Rissman RA, Kind AJH. PMID: 32525547; PMCID: PMC7290421.
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Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders. Biochim Biophys Acta Proteins Proteom. 2020 08; 1868(8):140428. Hook V, Yoon M, Mosier C, Ito G, Podvin S, Head BP, Rissman R, O'Donoghue AJ, Hook G. PMID: 32305689; PMCID: PMC7261628.
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Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Mol Cell Proteomics. 2020 06; 19(6):1017-1034. Podvin S, Jones A, Liu Q, Aulston B, Ransom L, Ames J, Shen G, Lietz CB, Jiang Z, O'Donoghue AJ, Winston C, Ikezu T, Rissman RA, Yuan S, Hook V. PMID: 32295833; PMCID: PMC7261814.
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Women can bear a bigger burden: ante- and post-mortem evidence for reserve in the face of tau. Brain Commun. 2020; 2(1):fcaa025. Digma LA, Madsen JR, Rissman RA, Jacobs DM, Brewer JB, Banks SJ, Alzheimer’s Disease Neuroimaging Initiative . PMID: 32337508; PMCID: PMC7166251.
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Transcriptomic analysis of brain tissues identifies a role for CCAAT enhancer binding protein β in HIV-associated neurocognitive disorder. J Neuroinflammation. 2020 Apr 11; 17(1):112. Canchi S, Swinton MK, Rissman RA, Fields JA. PMID: 32276639; PMCID: PMC7149918.
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Association of Neighborhood-Level Disadvantage With Cerebral and Hippocampal Volume. JAMA Neurol. 2020 04 01; 77(4):451-460. Hunt JFV, Buckingham W, Kim AJ, Oh J, Vogt NM, Jonaitis EM, Hunt TK, Zuelsdorff M, Powell R, Norton D, Rissman RA, Asthana S, Okonkwo OC, Johnson SC, Kind AJH, Bendlin BB. PMID: 31904767; PMCID: PMC6990953.
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Role of Alterations in Protein Kinase p38γ in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and α-Synuclein Transgenic Models. Front Neurosci. 2020; 14:286. Iba M, Kim C, Florio J, Mante M, Adame A, Rockenstein E, Kwon S, Rissman R, Masliah E. PMID: 32296304; PMCID: PMC7138105.
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The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer's Disease. J Alzheimers Dis. 2020; 73(4):1541-1554. Prikhodko O, Rynearson KD, Sekhon T, Mante MM, Nguyen PD, Rissman RA, Tanzi RE, Wagner SL. PMID: 31958080.
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The Trial-Ready Cohort for Preclinical/Prodromal Alzheimer's Disease (TRC-PAD) Project: An Overview. J Prev Alzheimers Dis. 2020; 7(4):208-212. Aisen PS, Sperling RA, Cummings J, Donohue MC, Langford O, Jimenez-Maggiora GA, Rissman RA, Rafii MS, Walter S, Clanton T, Raman R. PMID: 32920621; PMCID: PMC7735207.
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Reflections on the Utility of the Retina as a Biomarker for Alzheimer's Disease: A Literature Review. Neurol Ther. 2019 Dec; 8(Suppl 2):57-72. Ngolab J, Honma P, Rissman RA. PMID: 31833024; PMCID: PMC6908534.
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miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients. Front Neurosci. 2019; 13:1208. Cha DJ, Mengel D, Mustapic M, Liu W, Selkoe DJ, Kapogiannis D, Galasko D, Rissman RA, Bennett DA, Walsh DM. PMID: 31849573; PMCID: PMC6902042.
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Brain cell type-specific enhancer-promoter interactome maps and disease-risk association. Science. 2019 11 29; 366(6469):1134-1139. Nott A, Holtman IR, Coufal NG, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O'Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK. PMID: 31727856; PMCID: PMC7028213.
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Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial. JAMA Neurol. 2019 Nov 01; 76(11):1330-1339. Schneider LS, Thomas RG, Hendrix S, Rissman RA, Brewer JB, Salmon DP, Oltersdorf T, Okuda T, Feldman HH, Alzheimer’s Disease Cooperative Study TCAD Study Group. PMID: 31282954; PMCID: PMC6618817.
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High-Throughput Mass Spectrometry Assay for Quantifying β-Amyloid 40 and 42 in Cerebrospinal Fluid. Clin Chem. 2019 12; 65(12):1572-1580. Weber DM, Tran D, Goldman SM, Taylor SW, Ginns EI, Lagier RJ, Rissman RA, Brewer JB, Clarke NJ. PMID: 31628138.
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Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity. Front Neurosci. 2019; 13:1005. Winston CN, Romero HK, Ellisman M, Nauss S, Julovich DA, Conger T, Hall JR, Campana W, O'Bryant SE, Nievergelt CM, Baker DG, Risbrough VB, Rissman RA. PMID: 31680797; PMCID: PMC6797846.
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Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial. JAMA Neurol. 2019 Oct 01; 76(10):1219-1229. van Dyck CH, Nygaard HB, Chen K, Donohue MC, Raman R, Rissman RA, Brewer JB, Koeppe RA, Chow TW, Rafii MS, Gessert D, Choi J, Turner RS, Kaye JA, Gale SA, Reiman EM, Aisen PS, Strittmatter SM. PMID: 31329216; PMCID: PMC6646979.
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Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies-like model. Alzheimers Dement. 2019 09; 15(9):1133-1148. Mandler M, Rockenstein E, Overk C, Mante M, Florio J, Adame A, Kim C, Santic R, Schneeberger A, Mattner F, Schmidhuber S, Galabova G, Spencer B, Masliah E, Rissman RA. PMID: 31378574; PMCID: PMC7503212.
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Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer's Disease. Cell Rep. 2019 07 23; 28(4):1103-1116.e4. Canchi S, Raao B, Masliah D, Rosenthal SB, Sasik R, Fisch KM, De Jager PL, Bennett DA, Rissman RA. PMID: 31340147; PMCID: PMC7503200.
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Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain. 2019 06 01; 142(6):1503-1527. Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Chui HC, Fardo DW, Flanagan ME, Halliday G, Hokkanen SRK, Hunter S, Jicha GA, Katsumata Y, Kawas CH, Keene CD, Kovacs GG, Kukull WA, Levey AI, Makkinejad N, Montine TJ, Murayama S, Murray ME, Nag S, Rissman RA, Seeley WW, Sperling RA, White CL, Yu L, Schneider JA. PMID: 31039256; PMCID: PMC6536849.
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Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease. Acta Neuropathol Commun. 2019 05 17; 7(1):77. Shanbhag NM, Evans MD, Mao W, Nana AL, Seeley WW, Adame A, Rissman RA, Masliah E, Mucke L. PMID: 31101070; PMCID: PMC6524256.
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Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease. Neurobiol Dis. 2019 07; 127:163-177. Spencer B, Trinh I, Rockenstein E, Mante M, Florio J, Adame A, El-Agnaf OMA, Kim C, Masliah E, Rissman RA. PMID: 30849508; PMCID: PMC6588505.
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Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathol. 2019 06; 137(6):879-899. Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, Matchett B, Karydas AM, Hsiung GR, Seelaar H, Mol MO, Finger EC, Graff C, Öijerstedt L, Neumann M, Heutink P, Synofzik M, Wilke C, Prudlo J, Rizzu P, Simon-Sanchez J, Edbauer D, Roeber S, Diehl-Schmid J, Evers BM, King A, Mesulam MM, Weintraub S, Geula C, Bieniek KF, Petrucelli L, Ahern GL, Reiman EM, Woodruff BK, Caselli RJ, Huey ED, Farlow MR, Grafman J, Mead S, Grinberg LT, Spina S, Grossman M, Irwin DJ, Lee EB, Suh E, Snowden J, Mann D, Ertekin-Taner N, Uitti RJ, Wszolek ZK, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Hodges JR, Piguet O, Geier EG, Yokoyama JS, Rissman RA, Rogaeva E, Keith J, Zinman L, Tartaglia MC, Cairns NJ, Cruchaga C, Ghetti B, Kofler J, Lopez OL, Beach TG, Arzberger T, Herms J, Honig LS, Vonsattel JP, Halliday GM, Kwok JB, White CL, Gearing M, Glass J, Rollinson S, Pickering-Brown S, Rohrer JD, Trojanowski JQ, Van Deerlin V, Bigio EH, Troakes C, Al-Sarraj S, Asmann Y, Miller BL, Graff-Radford NR, Boeve BF, Seeley WW, Mackenzie IRA, van Swieten JC, Dickson DW, Biernacka JM, Rademakers R. PMID: 30739198; PMCID: PMC6533145.
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Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia. Alzheimers Dement (Amst). 2019 Dec; 11:61-66. Winston CN, Goetzl EJ, Schwartz JB, Elahi FM, Rissman RA. PMID: 31032394; PMCID: PMC6477776.
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Neuronal Exosome-Derived Human Tau is Toxic to Recipient Mouse Neurons in vivo. J Alzheimers Dis. 2019; 67(2):541-553. Winston CN, Aulston B, Rockenstein EM, Adame A, Prikhodko O, Dave KN, Mishra P, Rissman RA, Yuan SH. PMID: 30584143; PMCID: PMC8373009.
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Plasma Neurofilament Light and Alzheimer's Disease Biomarkers in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI). J Alzheimers Dis. 2019; 70(1):131-138. Rafii MS, Donohue MC, Matthews DC, Muranevici G, Ness S, O'Bryant SE, Rissman RA. PMID: 31156181.
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Extracellular Vesicles Isolated from Familial Alzheimer's Disease Neuronal Cultures Induce Aberrant Tau Phosphorylation in the Wild-Type Mouse Brain. J Alzheimers Dis. 2019; 72(2):575-585. Aulston B, Liu Q, Mante M, Florio J, Rissman RA, Yuan SH. PMID: 31594233; PMCID: PMC8373022.
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Effects of Novel Calpain Inhibitors in Transgenic Animal Model of Parkinson's disease/dementia with Lewy bodies. Sci Rep. 2018 12 27; 8(1):18083. Hassen GW, Kesner L, Stracher A, Shulman A, Rockenstein E, Mante M, Adame A, Overk C, Rissman RA, Masliah E. PMID: 30591714; PMCID: PMC6308237.
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Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need. Alzheimers Dement. 2019 02; 15(2):292-312. Babulal GM, Quiroz YT, Albensi BC, Arenaza-Urquijo E, Astell AJ, Babiloni C, Bahar-Fuchs A, Bell J, Bowman GL, Brickman AM, Chételat G, Ciro C, Cohen AD, Dilworth-Anderson P, Dodge HH, Dreux S, Edland S, Esbensen A, Evered L, Ewers M, Fargo KN, Fortea J, Gonzalez H, Gustafson DR, Head E, Hendrix JA, Hofer SM, Johnson LA, Jutten R, Kilborn K, Lanctôt KL, Manly JJ, Martins RN, Mielke MM, Morris MC, Murray ME, Oh ES, Parra MA, Rissman RA, Roe CM, Santos OA, Scarmeas N, Schneider LS, Schupf N, Sikkes S, Snyder HM, Sohrabi HR, Stern Y, Strydom A, Tang Y, Terrera GM, Teunissen C, Melo van Lent D, Weinborn M, Wesselman L, Wilcock DM, Zetterberg H, O'Bryant SE, International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association. PMID: 30555031; PMCID: PMC6368893.
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Targeted Mutation (R100W) of the Gene Encoding NGF Leads to Deficits in the Peripheral Sensory Nervous System. Front Aging Neurosci. 2018; 10:373. Yang W, Sung K, Zhou F, Xu W, Rissman RA, Ding J, Wu C. PMID: 30524266; PMCID: PMC6262302.
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Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease. Alzheimers Dement. 2019 03; 15(3):487-496. Chen Z, Mengel D, Keshavan A, Rissman RA, Billinton A, Perkinton M, Percival-Alwyn J, Schultz A, Properzi M, Johnson K, Selkoe DJ, Sperling RA, Patel P, Zetterberg H, Galasko D, Schott JM, Walsh DM. PMID: 30419228; PMCID: PMC6476313.
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T-complex protein 1-ring complex enhances retrograde axonal transport by modulating tau phosphorylation. Traffic. 2018 11; 19(11):840-853. Chen XQ, Fang F, Florio JB, Rockenstein E, Masliah E, Mobley WC, Rissman RA, Wu C. PMID: 30120810; PMCID: PMC6191364.
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Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation. Mol Neurodegener. 2018 08 09; 13(1):43. Kim C, Spencer B, Rockenstein E, Yamakado H, Mante M, Adame A, Fields JA, Masliah D, Iba M, Lee HJ, Rissman RA, Lee SJ, Masliah E. PMID: 30092810; PMCID: PMC6085656.
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Selective targeting of 3 repeat Tau with brain penetrating single chain antibodies for the treatment of neurodegenerative disorders. Acta Neuropathol. 2018 07; 136(1):69-87. Spencer B, Brüschweiler S, Sealey-Cardona M, Rockenstein E, Adame A, Florio J, Mante M, Trinh I, Rissman RA, Konrat R, Masliah E. PMID: 29934874; PMCID: PMC6112111.
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Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. Lancet Neurol. 2018 06; 17(6):548-558. Pottier C, Zhou X, Perkerson RB, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, Sánchez-Valle R, Antonell A, Lladó A, Parsons TM, Finch NA, Finger EC, Lippa CF, Huey ED, Neumann M, Heutink P, Synofzik M, Wilke C, Rissman RA, Slawek J, Sitek E, Johannsen P, Nielsen JE, Ren Y, van Blitterswijk M, DeJesus-Hernandez M, Christopher E, Murray ME, Bieniek KF, Evers BM, Ferrari C, Rollinson S, Richardson A, Scarpini E, Fumagalli GG, Padovani A, Hardy J, Momeni P, Ferrari R, Frangipane F, Maletta R, Anfossi M, Gallo M, Petrucelli L, Suh E, Lopez OL, Wong TH, van Rooij JGJ, Seelaar H, Mead S, Caselli RJ, Reiman EM, Noel Sabbagh M, Kjolby M, Nykjaer A, Karydas AM, Boxer AL, Grinberg LT, Grafman J, Spina S, Oblak A, Mesulam MM, Weintraub S, Geula C, Hodges JR, Piguet O, Brooks WS, Irwin DJ, Trojanowski JQ, Lee EB, Josephs KA, Parisi JE, Ertekin-Taner N, Knopman DS, Nacmias B, Piaceri I, Bagnoli S, Sorbi S, Gearing M, Glass J, Beach TG, Black SE, Masellis M, Rogaeva E, Vonsattel JP, Honig LS, Kofler J, Bruni AC, Snowden J, Mann D, Pickering-Brown S, Diehl-Schmid J, Winkelmann J, Galimberti D, Graff C, Öijerstedt L, Troakes C, Al-Sarraj S, Cruchaga C, Cairns NJ, Rohrer JD, Halliday GM, Kwok JB, van Swieten JC, White CL, Ghetti B, Murell JR, Mackenzie IRA, Hsiung GR, Borroni B, Rossi G, Tagliavini F, Wszolek ZK, Petersen RC, Bigio EH, Grossman M, Van Deerlin VM, Seeley WW, Miller BL, Graff-Radford NR, Boeve BF, Dickson DW, Biernacka JM, Rademakers R. PMID: 29724592; PMCID: PMC6237181.
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Growth Hormone-Releasing Hormone Modulation of Neuronal Exosome Biomarkers in Mild Cognitive Impairment. J Alzheimers Dis. 2018; 66(3):971-981. Winston CN, Goetzl EJ, Baker LD, Vitiello MV, Rissman RA. PMID: 30372675; PMCID: PMC6487872.
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A Precision Medicine Model for Targeted NSAID Therapy in Alzheimer's Disease. J Alzheimers Dis. 2018; 66(1):97-104. O'Bryant SE, Zhang F, Johnson LA, Hall J, Edwards M, Grammas P, Oh E, Lyketsos CG, Rissman RA. PMID: 30198872; PMCID: PMC6428063.
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Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau. J Alzheimers Dis. 2018; 61(3):1201-1219. Arner A, Rockenstein E, Mante M, Florio J, Masliah D, Salehi B, Adame A, Overk C, Masliah E, Rissman RA. PMID: 29332037; PMCID: PMC6508863.
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Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies. J Neurosci. 2018 01 24; 38(4):1000-1014. Rockenstein E, Ostroff G, Dikengil F, Rus F, Mante M, Florio J, Adame A, Trinh I, Kim C, Overk C, Masliah E, Rissman RA. PMID: 29246926; PMCID: PMC5783958.
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NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism. Nat Commun. 2017 11 14; 8(1):1488. Tu S, Akhtar MW, Escorihuela RM, Amador-Arjona A, Swarup V, Parker J, Zaremba JD, Holland T, Bansal N, Holohan DR, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, Huang X, Sultan A, McKercher SR, Ambasudhan R, Xu H, Wang Y, Geschwind DH, Roberts AJ, Terskikh AV, Rissman RA, Masliah E, Lipton SA, Nakanishi N. PMID: 29133852; PMCID: PMC5684358.
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Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits. Nat Med. 2017 Nov; 23(11):1377-1383. You JC, Muralidharan K, Park JW, Petrof I, Pyfer MS, Corbett BF, LaFrancois JJ, Zheng Y, Zhang X, Mohila CA, Yoshor D, Rissman RA, Nestler EJ, Scharfman HE, Chin J. PMID: 29035369; PMCID: PMC5747956.
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Corticotropin-releasing factor receptor-1 modulates biomarkers of DNA oxidation in Alzheimer's disease mice. PLoS One. 2017; 12(7):e0181367. Zhang C, Rissman RA. PMID: 28750017; PMCID: PMC5531470.
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Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease. Sci Rep. 2017 06 20; 7(1):3868. Fang F, Yang W, Florio JB, Rockenstein E, Spencer B, Orain XM, Dong SX, Li H, Chen X, Sung K, Rissman RA, Masliah E, Ding J, Wu C. PMID: 28634349; PMCID: PMC5478665.
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Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation. Neurobiol Dis. 2017 Oct; 106:222-234. Reilly P, Winston CN, Baron KR, Trejo M, Rockenstein EM, Akers JC, Kfoury N, Diamond M, Masliah E, Rissman RA, Yuan SH. PMID: 28610892; PMCID: PMC5593133.
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Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology. Acta Neuropathol Commun. 2017 06 09; 5(1):46. Ngolab J, Trinh I, Rockenstein E, Mante M, Florio J, Trejo M, Masliah D, Adame A, Masliah E, Rissman RA. PMID: 28599681; PMCID: PMC5466770.
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Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy. Neurobiol Dis. 2017 Aug; 104:85-96. El-Agnaf O, Overk C, Rockenstein E, Mante M, Florio J, Adame A, Vaikath N, Majbour N, Lee SJ, Kim C, Masliah E, Rissman RA. PMID: 28476636; PMCID: PMC5954414.
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Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 07; 362(1):31-44. Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. PMID: 28416568; PMCID: PMC5454592.
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A phase 3 trial of IV immunoglobulin for Alzheimer disease. Neurology. 2017 May 02; 88(18):1768-1775. Relkin NR, Thomas RG, Rissman RA, Brewer JB, Rafii MS, van Dyck CH, Jack CR, Sano M, Knopman DS, Raman R, Szabo P, Gelmont DM, Fritsch S, Aisen PS, Alzheimer's Disease Cooperative Study. PMID: 28381506; PMCID: PMC5409846.
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Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy. Acta Neuropathol Commun. 2017 01 13; 5(1):7. Spencer B, Valera E, Rockenstein E, Overk C, Mante M, Adame A, Zago W, Seubert P, Barbour R, Schenk D, Games D, Rissman RA, Masliah E. PMID: 28086964; PMCID: PMC5237270.
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Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease. J Neuroinflammation. 2017 01 03; 14(1):1. Moussa C, Hebron M, Huang X, Ahn J, Rissman RA, Aisen PS, Turner RS. PMID: 28086917; PMCID: PMC5234138.
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PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI). J Alzheimers Dis. 2017; 60(2):439-450. Rafii MS, Lukic AS, Andrews RD, Brewer J, Rissman RA, Strother SC, Wernick MN, Pennington C, Mobley WC, Ness S, Matthews DC, Down Syndrome Biomarker Initiative and the Alzheimer’s Disease Neuroimaging Initiative. PMID: 28946567.
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Deleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment. J Alzheimers Dis. 2017; 56(1):229-237. Sokolow S, Li X, Chen L, Taylor KD, Rotter JI, Rissman RA, Aisen PS, Apostolova LG. PMID: 27911294; PMCID: PMC5534361.
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Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic. Alzheimers Dement. 2017 01; 13(1):45-58. O'Bryant SE, Mielke MM, Rissman RA, Lista S, Vanderstichele H, Zetterberg H, Lewczuk P, Posner H, Hall J, Johnson L, Fong YL, Luthman J, Jeromin A, Batrla-Utermann R, Villarreal A, Britton G, Snyder PJ, Henriksen K, Grammas P, Gupta V, Martins R, Hampel H, Biofluid Based Biomarker Professional Interest Area. PMID: 27870940; PMCID: PMC5218961.
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Meditation and vacation effects have an impact on disease-associated molecular phenotypes. Transl Psychiatry. 2016 08 30; 6(8):e880. Epel ES, Puterman E, Lin J, Blackburn EH, Lum PY, Beckmann ND, Zhu J, Lee E, Gilbert A, Rissman RA, Tanzi RE, Schadt EE. PMID: 27576169; PMCID: PMC5022094.
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Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. J Neurosci. 2016 07 27; 36(30):7971-84. Spencer B, Desplats PA, Overk CR, Valera-Martin E, Rissman RA, Wu C, Mante M, Adame A, Florio J, Rockenstein E, Masliah E. PMID: 27466341; PMCID: PMC4961781.
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Lack of Influence of Apolipoprotein E Status on Cognition or Brain Structure in Professional Fighters. J Neurotrauma. 2017 01 15; 34(2):380-384. Banks SJ, Miller JB, Rissman RA, Bernick CB. PMID: 27245878; PMCID: PMC5220568.
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Higher Brain Perfusion May Not Support Memory Functions in Cognitively Normal Carriers of the ApoE ε4 Allele Compared to Non-Carriers. Front Aging Neurosci. 2016; 8:151. Zlatar ZZ, Bischoff-Grethe A, Hays CC, Liu TT, Meloy MJ, Rissman RA, Bondi MW, Wierenga CE. PMID: 27445794; PMCID: PMC4919360.
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Demonstration of safety of intravenous immunoglobulin in geriatric patients in a long-term, placebo-controlled study of Alzheimer's disease. Alzheimers Dement (N Y). 2016 Jun; 2(2):131-139. Gelmont D, Thomas RG, Britt J, Dyck-Jones JA, Doralt J, Fritsch S, Brewer JB, Rissman RA, Aisen P. PMID: 29067300; PMCID: PMC5644268.
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Dissociation of Down syndrome and Alzheimer's disease effects with imaging. Alzheimers Dement (N Y). 2016 Jun; 2(2):69-81. Matthews DC, Lukic AS, Andrews RD, Marendic B, Brewer J, Rissman RA, Mosconi L, Strother SC, Wernick MN, Mobley WC, Ness S, Schmidt ME, Rafii MS. PMID: 28642933; PMCID: PMC5477635.
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Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile. Alzheimers Dement (Amst). 2016; 3:63-72. Winston CN, Goetzl EJ, Akers JC, Carter BS, Rockenstein EM, Galasko D, Masliah E, Rissman RA. PMID: 27408937; PMCID: PMC4925777.
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Functional Impact of Corticotropin-Releasing Factor Exposure on Tau Phosphorylation and Axon Transport. PLoS One. 2016; 11(1):e0147250. Le MH, Weissmiller AM, Monte L, Lin PH, Hexom TC, Natera O, Wu C, Rissman RA. PMID: 26790099; PMCID: PMC4720402.
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Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges. Alzheimers Dement (Amst). 2016; 3:27-34. O'Bryant SE, Lista S, Rissman RA, Edwards M, Zhang F, Hall J, Zetterberg H, Lovestone S, Gupta V, Graff-Radford N, Martins R, Jeromin A, Waring S, Oh E, Kling M, Baker LD, Hampel H. PMID: 27019866; PMCID: PMC4802360.
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Corticotropin-releasing factor receptor-1 antagonism mitigates beta amyloid pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease. Alzheimers Dement. 2016 05; 12(5):527-37. Zhang C, Kuo CC, Moghadam SH, Monte L, Campbell SN, Rice KC, Sawchenko PE, Masliah E, Rissman RA. PMID: 26555315; PMCID: PMC4860182.
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Reproductive Stage and Modulation of Stress-Induced Tau Phosphorylation in Female Rats. J Neuroendocrinol. 2015 Nov; 27(11):827-34. Steinmetz D, Ramos E, Campbell SN, Morales T, Rissman RA. PMID: 26510116; PMCID: PMC4625411.
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The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome. Front Behav Neurosci. 2015; 9:239. Rafii MS, Wishnek H, Brewer JB, Donohue MC, Ness S, Mobley WC, Aisen PS, Rissman RA. PMID: 26441570; PMCID: PMC4568340.
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A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology. 2015 Oct 20; 85(16):1383-91. Turner RS, Thomas RG, Craft S, van Dyck CH, Mintzer J, Reynolds BA, Brewer JB, Rissman RA, Raman R, Aisen PS, Alzheimer's Disease Cooperative Study. PMID: 26362286; PMCID: PMC4626244.
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Oral glucose tolerance testing to modulate plasma amyloid levels: A novel biomarker. Alzheimers Dement (Amst). 2015 Sep; 1(3):311-315. Oh ES, Marano CM, Leoutsakos JM, Lee RW, Rissman RA, Smith GS, Craft S, Lyketsos CG. PMID: 26413562; PMCID: PMC4578701.
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Impact of CRFR1 Ablation on Amyloid-β Production and Accumulation in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2015; 45(4):1175-84. Campbell SN, Zhang C, Roe AD, Lee N, Lao KU, Monte L, Donohue MC, Rissman RA. PMID: 25697705; PMCID: PMC4459491.
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Corticotropin-Releasing Factor Receptor-1 Antagonism Reduces Oxidative Damage in an Alzheimer’s Disease Transgenic Mouse Model. J Alzheimers Dis. 2015; 45(2):639-50. Zhang C, Kuo CC, Moghadam SH, Monte L, Rice KC, Rissman RA. PMID: 25649650; PMCID: PMC4486520.
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Increased tau phosphorylation and aggregation in the hippocampus of mice overexpressing corticotropin-releasing factor. J Alzheimers Dis. 2015; 43(3):967-76. Campbell SN, Zhang C, Monte L, Roe AD, Rice KC, Taché Y, Masliah E, Rissman RA. PMID: 25125464; PMCID: PMC4258165.
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Differential Effects of Meal Challenges on Cognition, Metabolism, and Biomarkers for Apolipoprotein E ɛ4 Carriers and Adults with Mild Cognitive Impairment. J Alzheimers Dis. 2015; 48(1):205-18. Hanson AJ, Bayer JL, Baker LD, Cholerton B, VanFossen B, Trittschuh E, Rissman RA, Donohue MC, Moghadam SH, Plymate SR, Craft S. PMID: 26401941.
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Characterization of ATP alternations in an Alzheimer's disease transgenic mouse model. J Alzheimers Dis. 2015; 44(2):375-8. Zhang C, Rissman RA, Feng J. PMID: 25261448; PMCID: PMC4305018.
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Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials. Alzheimers Dement. 2015 Sep; 11(9):1069-79. Donohue MC, Moghadam SH, Roe AD, Sun CK, Edland SD, Thomas RG, Petersen RC, Sano M, Galasko D, Aisen PS, Rissman RA. PMID: 25301682; PMCID: PMC4387108.
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Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research. Alzheimers Dement. 2015 May; 11(5):549-60. O'Bryant SE, Gupta V, Henriksen K, Edwards M, Jeromin A, Lista S, Bazenet C, Soares H, Lovestone S, Hampel H, Montine T, Blennow K, Foroud T, Carrillo M, Graff-Radford N, Laske C, Breteler M, Shaw L, Trojanowski JQ, Schupf N, Rissman RA, Fagan AM, Oberoi P, Umek R, Weiner MW, Grammas P, Posner H, Martins R, STAR-B and BBBIG working groups. PMID: 25282381; PMCID: PMC4414664.
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Long-Term Electrophysiological and Behavioral Analysis on the Improvement of Visual Working Memory Load, Training Gains, and Transfer Benefits. J Behav Brain Sci. 2014 May 01; 4(5):234-246. Kuo CC, Zhang C, Rissman RA, Chiu AW. PMID: 25045590; PMCID: PMC4101919.
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Detection and quantification of 8-hydroxy-2'-deoxyguanosine in Alzheimer's transgenic mouse urine using capillary electrophoresis. Electrophoresis. 2013 Aug; 34(15):2268-74. Zhang C, Nestorova G, Rissman RA, Feng J. PMID: 23712533; PMCID: PMC3789118.
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CSF biomarker variability in the Alzheimer's Association quality control program. Alzheimers Dement. 2013 May; 9(3):251-61. Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D, Fagan AM, Heegaard NH, Robin Hsiung GY, Hyman B, Iqbal K, Kaeser SA, Käser SA, Lachno DR, Lleó A, Lewczuk P, Molinuevo JL, Parchi P, Regeniter A, Rissman RA, Rissman R, Rosenmann H, Sancesario G, Schröder J, Shaw LM, Teunissen CE, Trojanowski JQ, Vanderstichele H, Vandijck M, Verbeek MM, Zetterberg H, Blennow K, Alzheimer's Association QC Program Work Group. PMID: 23622690; PMCID: PMC3707386.
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Interaction of age and APOE genotype on cerebral blood flow at rest. J Alzheimers Dis. 2013; 34(4):921-35. Wierenga CE, Clark LR, Dev SI, Shin DD, Jurick SM, Rissman RA, Liu TT, Bondi MW. PMID: 23302659; PMCID: PMC4124882.
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Cortical and subcortical cerebrovascular resistance index in mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis. 2013; 36(4):689-98. Nation DA, Wierenga CE, Clark LR, Dev SI, Stricker NH, Jak AJ, Salmon DP, Delano-Wood L, Bangen KJ, Rissman RA, Liu TT, Bondi MW. PMID: 23666173; PMCID: PMC4089500.
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Effect of mild cognitive impairment and APOE genotype on resting cerebral blood flow and its association with cognition. J Cereb Blood Flow Metab. 2012 Aug; 32(8):1589-99. Wierenga CE, Dev SI, Shin DD, Clark LR, Bangen KJ, Jak AJ, Rissman RA, Liu TT, Salmon DP, Bondi MW. PMID: 22549621; PMCID: PMC3421098.
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Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6277-82. Rissman RA, Staup MA, Lee AR, Justice NJ, Rice KC, Vale W, Sawchenko PE. PMID: 22451915; PMCID: PMC3341026.
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Longitudinal plasma amyloid beta as a biomarker of Alzheimer's disease. J Neural Transm (Vienna). 2012 Jul; 119(7):843-50. Rissman RA, Trojanowski JQ, Shaw LM, Aisen PS. PMID: 22354745; PMCID: PMC4305447.
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Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptors. Eur J Neurosci. 2011 Aug; 34(3):448-56. Roe AD, Staup MA, Serrats J, Sawchenko PE, Rissman RA. PMID: 21722209; PMCID: PMC3148267.
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The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers Dement. 2011 Jul; 7(4):386-395.e6. Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, Fagan AM, Forlenza O, Frisoni GB, Galasko D, Galimberti D, Hampel H, Handberg A, Heneka MT, Herskovits AZ, Herukka SK, Holtzman DM, Humpel C, Hyman BT, Iqbal K, Jucker M, Kaeser SA, Kaiser E, Kapaki E, Kidd D, Klivenyi P, Knudsen CS, Kummer MP, Lui J, Lladó A, Lewczuk P, Li QX, Martins R, Masters C, McAuliffe J, Mercken M, Moghekar A, Molinuevo JL, Montine TJ, Nowatzke W, O'Brien R, Otto M, Paraskevas GP, Parnetti L, Petersen RC, Prvulovic D, de Reus HP, Rissman RA, Scarpini E, Stefani A, Soininen H, Schröder J, Shaw LM, Skinningsrud A, Skrogstad B, Spreer A, Talib L, Teunissen C, Trojanowski JQ, Tumani H, Umek RM, Van Broeck B, Vanderstichele H, Vecsei L, Verbeek MM, Windisch M, Zhang J, Zetterberg H, Blennow K. PMID: 21784349; PMCID: PMC3710290.
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Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. J Neurochem. 2011 May; 117(4):613-22. Rissman RA, Mobley WC. PMID: 21388375; PMCID: PMC3127285.
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Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. Science. 2009 Jul 17; 325(5938):328-32. Maji SK, Perrin MH, Sawaya MR, Jessberger S, Vadodaria K, Rissman RA, Singru PS, Nilsson KP, Simon R, Schubert D, Eisenberg D, Rivier J, Sawchenko P, Vale W, Riek R. PMID: 19541956; PMCID: PMC2865899.
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Stress-induced tau phosphorylation: functional neuroplasticity or neuronal vulnerability? J Alzheimers Dis. 2009; 18(2):453-7. Rissman RA. PMID: 19584431; PMCID: PMC2906152.
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GABA(A) receptors in aging and Alzheimer's disease. J Neurochem. 2007 Nov; 103(4):1285-92. Rissman RA, De Blas AL, Armstrong DM. PMID: 17714455.
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Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation. J Neurosci. 2007 Jun 13; 27(24):6552-62. Rissman RA, Lee KF, Vale W, Sawchenko PE. PMID: 17567816; PMCID: PMC6672442.
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Age-related alterations in GABA(A) receptor subunits in the nonhuman primate hippocampus. Brain Res. 2006 Feb 16; 1073-1074:120-30. Rissman RA, Nocera R, Fuller LM, Kordower JH, Armstrong DM. PMID: 16430870.
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Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta Neuropathol. 2005 Aug; 110(2):135-44. Newman J, Rissman RA, Sarsoza F, Kim RC, Dick M, Bennett DA, Cotman CW, Rohn TT, Head E. PMID: 15986225.
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The role of caspase cleavage of tau in Alzheimer disease neuropathology. J Neuropathol Exp Neurol. 2005 Feb; 64(2):104-12. Cotman CW, Poon WW, Rissman RA, Blurton-Jones M. PMID: 15751224.
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Subregional analysis of GABA(A) receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairment. J Chem Neuroanat. 2004 Sep; 28(1-2):17-25. Rissman RA, Bennett DA, Armstrong DM. PMID: 15363487.
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Caspase-mediated degeneration in Alzheimer's disease. Am J Pathol. 2004 Aug; 165(2):353-5. Cribbs DH, Poon WW, Rissman RA, Blurton-Jones M. PMID: 15277211; PMCID: PMC1618562.
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Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest. 2004 Jul; 114(1):121-30. Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW. PMID: 15232619; PMCID: PMC437967.
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Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer's disease patients according to Braak stage. Exp Neurol. 2004 Jun; 187(2):299-309. Carter TL, Rissman RA, Mishizen-Eberz AJ, Wolfe BB, Hamilton RL, Gandy S, Armstrong DM. PMID: 15144856.
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Biochemical and molecular studies of NMDA receptor subunits NR1/2A/2B in hippocampal subregions throughout progression of Alzheimer's disease pathology. Neurobiol Dis. 2004 Feb; 15(1):80-92. Mishizen-Eberz AJ, Rissman RA, Carter TL, Ikonomovic MD, Wolfe BB, Armstrong DM. PMID: 14751773.
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Plasticity of glutamate and GABAA receptors in the hippocampus of patients with Alzheimer's disease. Cell Mol Neurobiol. 2003 Oct; 23(4-5):491-505. Armstrong DM, Sheffield R, Mishizen-Eberz AJ, Carter TL, Rissman RA, Mizukami K, Ikonomovic MD. PMID: 14514010; PMCID: PMC11530205.
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Biochemical analysis of GABA(A) receptor subunits alpha 1, alpha 5, beta 1, beta 2 in the hippocampus of patients with Alzheimer's disease neuropathology. Neuroscience. 2003; 120(3):695-704. Rissman RA, Mishizen-Eberz AJ, Carter TL, Wolfe BB, De Blas AL, Miralles CP, Ikonomovic MD, Armstrong DM. PMID: 12895510.
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Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous. Drug News Perspect. 2002 Nov; 15(9):549-557. Rohn TT, Rissman RA, Head E, Cotman CW. PMID: 12677194.
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Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis. 2002 Nov; 11(2):341-54. Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW, Head E. PMID: 12505426.
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Urocortin expression in rat brain: evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors. J Comp Neurol. 1999 Dec 20; 415(3):285-312. Bittencourt JC, Vaughan J, Arias C, Rissman RA, Vale WW, Sawchenko PE. PMID: 10553117.
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