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Multi-layered transcriptional control of glycogen metabolism coordinates thermogenic remodeling of white adipocytes in male mice. Nat Commun. 2025 Dec 16; 17(1):809. Fu H, Lee S, Zemke NR, Fan W, Wang Y, Garza J, Tin D, Villao B, Zhang B, Ma X, Zhang J, Dong T, Ren Y, Downes M, Evans RM, Ren B, Saltiel AR. PMID: 41402325; PMCID: PMC12824187.
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Circadian regulator REV-ERBα is a master regulator of tumor lineage plasticity and an effective therapeutic target. Proc Natl Acad Sci U S A. 2025 Nov 18; 122(46):e2513468122. Zhang X, Yang Y, Zou H, Cai D, Corey E, Zoubeidi A, Lo SH, Yu AM, Evans RM, Chen HW. PMID: 41231955; PMCID: PMC12646269.
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Antibody-bottlebrush prodrug conjugates for targeted cancer therapy. Nat Biotechnol. 2025 Sep 09. Liu B, Nguyen HV, Jiang Y, Wang AX, Lensch V, Sun Z, Boyer ZH, Raftopoulos PA, Dai Y, MacNicol PL, Wang Y, Jyotsana N, Wang W, Bhagchandani S, Hemdev S, Shieh P, Kristufek SL, Boucher M, Downes M, Evans RM, MacMillan DWC, Johnson JA. PMID: 40925997; PMCID: PMC12425459.
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Thalamic CGRP neurons define a spinothalamic pathway for affective pain. Proc Natl Acad Sci U S A. 2025 Jul 15; 122(28):e2505889122. Kang SJ, Liu S, Kim JH, Kim DI, Oh TG, Peng J, Ye M, Lee KF, Evans RM, Goulding M, Han S. PMID: 40632570; PMCID: PMC12280894.
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Estrogen-related receptors regulate innate and adaptive muscle mitochondrial energetics through cooperative and distinct actions. Proc Natl Acad Sci U S A. 2025 May 20; 122(20):e2426179122. Fan W, Oh TG, Wang HJ, Crossley L, He M, Robbins H, Koopari C, Dai Y, Truitt ML, Liddle C, Yu RT, Atkins AR, Downes M, Evans RM. PMID: 40354528; PMCID: PMC12107179.
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Sympathetic activation of white adipose tissue recruits neutrophils to limit energy expenditure. Res Sq. 2025 Apr 16. Son S, Xu C, Jang J, Dinh M, Skorobogatko Y, Fu H, Valentine JM, An G, Ying W, Yu RT, Downes M, Evans RM, Saltiel AR. PMID: 40321773; PMCID: PMC12047989.
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BCL6 coordinates muscle mass homeostasis with nutritional states. Proc Natl Acad Sci U S A. 2025 Jan 28; 122(4):e2408896122. Wang HJ, Fan W, Liu S, Kim K, Matsushima A, Ogawa S, Kang HG, Zhu J, Estepa G, He M, Crossley L, Liddle C, Kim MS, Truitt ML, Yu RT, Atkins AR, Downes M, Evans RM. PMID: 39841144; PMCID: PMC11789089.
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The human milk oligosaccharide 3'sialyllactose reduces low-grade inflammation and atherosclerosis development in mice. JCI Insight. 2024 Nov 08; 9(21). Pessentheiner AR, Spann NJ, Autran CA, Oh TG, Grunddal KV, Coker JK, Painter CD, Ramms B, Chiang AW, Wang CY, Hsiao J, Wang Y, Quach A, Booshehri LM, Hammond A, Tognaccini C, Latasiewicz J, Willemsen L, Zengler K, de Winther MP, Hoffman HM, Philpott M, Cribbs AP, Oppermann U, Lewis NE, Witztum JL, Yu R, Atkins AR, Downes M, Evans RM, Glass CK, Bode L, Gordts PL. PMID: 39325548; PMCID: PMC11601559.
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Functional inversion of circadian regulator REV-ERBα leads to tumorigenic gene reprogramming. Proc Natl Acad Sci U S A. 2024 Oct 15; 121(42):e2411321121. Yang Y, Zhang X, Cai D, Zheng X, Zhao X, Zou JX, Zhang J, Borowsky AD, Dall'Era MA, Corey E, Mitsiades N, Kung HJ, Chen X, Li JJ, Downes M, Evans RM, Chen HW. PMID: 39383000; PMCID: PMC11494309.
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Vitamin D Receptor Regulates Liver Regeneration After Partial Hepatectomy in Male Mice. Endocrinology. 2024 Jul 01; 165(8). Elangovan H, Stokes RA, Keane J, Chahal S, Samer C, Agoncillo M, Yu J, Chen J, Downes M, Evans RM, Liddle C, Gunton JE. PMID: 38963813; PMCID: PMC11250209.
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Targeting nuclear receptor corepressors for reversible male contraception. Proc Natl Acad Sci U S A. 2024 Feb 27; 121(9):e2320129121. Hong SH, Castro G, Wang D, Nofsinger R, Kane M, Folias A, Atkins AR, Yu RT, Napoli JL, Sassone-Corsi P, de Rooij DG, Liddle C, Downes M, Evans RM. PMID: 38377195; PMCID: PMC10907271.
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Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation. Nat Metab. 2024 Feb; 6(2):273-289. Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne TE, Qian J, Hung CW, Zhao P, Jones Y, Gao H, Liddle C, Yu RT, Downes M, Evans RM, Rydén M, Wabitsch M, Wang Z, Hakozaki H, Schöneberg J, Reilly SM, Huang J, Saltiel AR. PMID: 38286821; PMCID: PMC10896723.
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A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation. Proc Natl Acad Sci U S A. 2024 Jan 09; 121(2):e2316104121. Abe Y, Kofman ER, Ouyang Z, Cruz-Becerra G, Spann NJ, Seidman JS, Troutman TD, Stender JD, Taylor H, Fan W, Link VM, Shen Z, Sakai J, Downes M, Evans RM, Kadonaga JT, Rosenfeld MG, Glass CK. PMID: 38165941; PMCID: PMC10786282.
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Inhibiting stromal Class I HDACs curbs pancreatic cancer progression. Nat Commun. 2023 12 06; 14(1):7791. Liang G, Oh TG, Hah N, Tiriac H, Shi Y, Truitt ML, Antal CE, Atkins AR, Li Y, Fraser C, Ng S, Pinto AFM, Nelson DC, Estepa G, Bashi S, Banayo E, Dai Y, Liddle C, Yu RT, Hunter T, Engle DD, Han H, Von Hoff DD, Downes M, Evans RM. PMID: 38057326; PMCID: PMC10700526.
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Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function. Circulation. 2024 01 16; 149(3):227-250. Xu W, Billon C, Li H, Wilderman A, Qi L, Graves A, Rideb JRDC, Zhao Y, Hayes M, Yu K, Losby M, Hampton CS, Adeyemi CM, Hong SJ, Nasiotis E, Fu C, Oh TG, Fan W, Downes M, Welch RD, Evans RM, Milosavljevic A, Walker JK, Jensen BC, Pei L, Burris T, Zhang L. PMID: 37961903; PMCID: PMC10842599.
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RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression. Mol Cell. 2023 10 05; 83(19):3421-3437.e11. Abe Y, Kofman ER, Almeida M, Ouyang Z, Ponte F, Mueller JR, Cruz-Becerra G, Sakai M, Prohaska TA, Spann NJ, Resende-Coelho A, Seidman JS, Stender JD, Taylor H, Fan W, Link VM, Cobo I, Schlachetzki JCM, Hamakubo T, Jepsen K, Sakai J, Downes M, Evans RM, Yeo GW, Kadonaga JT, Manolagas SC, Rosenfeld MG, Glass CK. PMID: 37751740; PMCID: PMC10591845.
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Inhibiting Stromal Class I HDACs Curbs Pancreatic Cancer Progression. bioRxiv. 2023 Sep 14. Liang G, Oh TG, Hah N, Tiriac H, Shi Y, Truitt ML, Antal CE, Atkins AR, Li Y, Fraser C, Ng S, Pinto AFM, Nelson DC, Estepa G, Bashi S, Banayo E, Dai Y, Liddle C, Yu RT, Hunter T, Engle DD, Han H, Von Hoff DD, Downes M, Evans RM. PMID: 37745372; PMCID: PMC10515810.
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A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer. Nat Commun. 2023 09 06; 14(1):5195. Antal CE, Oh TG, Aigner S, Luo EC, Yee BA, Campos T, Tiriac H, Rothamel KL, Cheng Z, Jiao H, Wang A, Hah N, Lenkiewicz E, Lumibao JC, Truitt ML, Estepa G, Banayo E, Bashi S, Esparza E, Munoz RM, Diedrich JK, Sodir NM, Mueller JR, Fraser CR, Borazanci E, Propper D, Von Hoff DD, Liddle C, Yu RT, Atkins AR, Han H, Lowy AM, Barrett MT, Engle DD, Evan GI, Yeo GW, Downes M, Evans RM. PMID: 37673892; PMCID: PMC10482938.
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Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progression. Cell Rep. 2023 08 29; 42(8):112997. Fu T, Huan T, Rahman G, Zhi H, Xu Z, Oh TG, Guo J, Coulter S, Tripathi A, Martino C, McCarville JL, Zhu Q, Cayabyab F, Low B, He M, Xing S, Vargas F, Yu RT, Atkins A, Liddle C, Ayres J, Raffatellu M, Dorrestein PC, Downes M, Knight R, Evans RM. PMID: 37611587; PMCID: PMC10903535.
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Silver electroceutical technology to treat sarcopenia. Proc Natl Acad Sci U S A. 2023 08 15; 120(33):e2300036120. Kim MY, Shin HY, Cho SC, Yang S, Intisar A, Woo HJ, Choi YS, You CL, Kang JS, Lee YI, Park SC, Yea K, Oh TG, Downes M, Evans RM, Kim MS. PMID: 37549292; PMCID: PMC10438839.
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Zinc accumulation in Atriplex lentiformis is driven by plant genes and the soil microbiome. Sci Total Environ. 2023 Nov 15; 899:165667. Kushwaha P, Tran A, Quintero D, Song M, Yu Q, Yu R, Downes M, Evans RM, Babst-Kostecka A, Schroeder JI, Maier RM. PMID: 37478925; PMCID: PMC10529914.
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PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress. Proc Natl Acad Sci U S A. 2023 05 23; 120(21):e2217826120. Yoon BK, Kim H, Oh TG, Oh SK, Jo S, Kim M, Chun KH, Hwang N, Lee S, Jin S, Atkins AR, Yu RT, Downes M, Kim JW, Kim H, Evans RM, Cheong JH, Fang S. PMID: 37192160; PMCID: PMC10214193.
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Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023 04 21; 18(4):756-771. Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP. PMID: 36988910; PMCID: PMC11584170.
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Legacy: a tribute to Terri Grodzicker of Genes & Development. Genes Dev. 2023 Jan 01; 37(1-2):20-21. Evans RM. PMID: 37061954; PMCID: PMC10046438.
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FXR mediates ILC-intrinsic responses to intestinal inflammation. Proc Natl Acad Sci U S A. 2022 12 20; 119(51):e2213041119. Fu T, Li Y, Oh TG, Cayabyab F, He N, Tang Q, Coulter S, Truitt M, Medina P, He M, Yu RT, Atkins A, Zheng Y, Liddle C, Downes M, Evans RM. PMID: 36508655; PMCID: PMC9907109.
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Timed use of cardiac glycoside protects the heart. Nat Cardiovasc Res. 2022 Nov; 1(11):973-975. Wang HJ, Evans RM. PMID: 39195909.
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Chronicle of a discovery: the retinoic acid receptor. J Mol Endocrinol. 2022 11 01; 69(4):T1-T11. Giguère V, Evans RM. PMID: 35900848.
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Autocrine FGF1 signaling promotes glucose uptake in adipocytes. Proc Natl Acad Sci U S A. 2022 10 04; 119(40):e2122382119. Nies VJM, Struik D, Liu S, Liu W, Kruit JK, Downes M, van Zutphen T, Verkade HJ, Evans RM, Jonker JW. PMID: 36161959; PMCID: PMC9546606.
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Gut metagenome-derived signature predicts hepatic decompensation and mortality in NAFLD-related cirrhosis. Aliment Pharmacol Ther. 2022 11; 56(10):1475-1485. Sharpton SR, Oh TG, Madamba E, Wang C, Yu RT, Atkins AR, Huan T, Downes M, Evans RM, Loomba R. PMID: 36164267; PMCID: PMC9746351.
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PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. Cell Metab. 2022 10 04; 34(10):1548-1560.e6. Kim JY, Wang LQ, Sladky VC, Oh TG, Liu J, Trinh K, Eichin F, Downes M, Hosseini M, Jacotot ED, Evans RM, Villunger A, Karin M. PMID: 36041455; PMCID: PMC9547947.
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Shared Mechanisms between Cardiovascular Disease and NAFLD. Semin Liver Dis. 2022 11; 42(4):455-464. Huang DQ, Downes M, Evans RM, Witztum JL, Glass CK, Loomba R. PMID: 36008083; PMCID: PMC9828940.
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Metabolic Messengers: fibroblast growth factor 1. Nat Metab. 2022 06; 4(6):663-671. Gasser E, Sancar G, Downes M, Evans RM. PMID: 35681108; PMCID: PMC9624216.
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Daily running enhances molecular and physiological circadian rhythms in skeletal muscle. Mol Metab. 2022 07; 61:101504. Casanova-Vallve N, Duglan D, Vaughan ME, Pariollaud M, Handzlik MK, Fan W, Yu RT, Liddle C, Downes M, Delezie J, Mello R, Chan AB, Westermark PO, Metallo CM, Evans RM, Lamia KA. PMID: 35470095; PMCID: PMC9079800.
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Obesity alters pathology and treatment response in inflammatory disease. Nature. 2022 04; 604(7905):337-342. Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, Cohen JN, Sturgill JL, Crotty Alexander LE, Suh JM, Liddle C, Atkins AR, Yu RT, Downes M, Liu S, Nikolajczyk BS, Lee IK, Guttman-Yassky E, Ansel KM, Woodruff PG, Fahy JV, Sheppard D, Gallo RL, Ye CJ, Evans RM, Zheng Y, Marson A. PMID: 35355021; PMCID: PMC9165753.
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Oleic acid regulates hippocampal neurogenesis as a TLX ligand. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2203038119. Shi Y, Evans RM, Gage FH. PMID: 35344400; PMCID: PMC9169763.
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Interorgan crosstalk in pancreatic islet function and pathology. FEBS Lett. 2022 03; 596(5):607-619. Evans RM, Wei Z. PMID: 35014695; PMCID: PMC8930530.
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β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity. J Clin Invest. 2022 01 18; 132(2). Valentine JM, Ahmadian M, Keinan O, Abu-Odeh M, Zhao P, Zhou X, Keller MP, Gao H, Yu RT, Liddle C, Downes M, Zhang J, Lusis AJ, Attie AD, Evans RM, Rydén M, Saltiel AR. PMID: 34847077; PMCID: PMC8759781.
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BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4. Proc Natl Acad Sci U S A. 2022 01 04; 119(1). Ahmed NS, Gatchalian J, Ho J, Burns MJ, Hah N, Wei Z, Downes M, Evans RM, Hargreaves DC. PMID: 34983841; PMCID: PMC8740701.
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FGF1 and insulin control lipolysis by convergent pathways. Cell Metab. 2022 01 04; 34(1):171-183.e6. Sancar G, Liu S, Gasser E, Alvarez JG, Moutos C, Kim K, van Zutphen T, Wang Y, Huddy TF, Ross B, Dai Y, Zepeda D, Collins B, Tilley E, Kolar MJ, Yu RT, Atkins AR, van Dijk TH, Saghatelian A, Jonker JW, Downes M, Evans RM. PMID: 34986332; PMCID: PMC8863067.
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Colon cancer checks in when bile acids check out: the bile acid-nuclear receptor axis in colon cancer. Essays Biochem. 2021 12 17; 65(6):1015-1024. Tang Q, Evans RM. PMID: 34414429; PMCID: PMC8628182.
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Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2021 Dec; 600(7889):E18. Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T. PMID: 34848876.
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Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes. Nature. 2021 11; 599(7884):296-301. Keinan O, Valentine JM, Xiao H, Mahata SK, Reilly SM, Abu-Odeh M, Deluca JH, Dadpey B, Cho L, Pan A, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Lusis AJ, Laakso M, Chouchani ET, Rydén M, Saltiel AR. PMID: 34707293; PMCID: PMC9186421.
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Bisphenol A derivatives act as novel coactivator-binding inhibitors for estrogen receptor β. J Biol Chem. 2021 11; 297(5):101173. Iwamoto M, Masuya T, Hosose M, Tagawa K, Ishibashi T, Suyama K, Nose T, Yoshihara E, Downes M, Evans RM, Matsushima A. PMID: 34499926; PMCID: PMC8551653.
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Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity. Proc Natl Acad Sci U S A. 2021 08 31; 118(35). Wang L, Oh TG, Magida J, Estepa G, Obayomi SMB, Chong LW, Gatchalian J, Yu RT, Atkins AR, Hargreaves D, Downes M, Wei Z, Evans RM. PMID: 34446564; PMCID: PMC8536317.
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FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes. Cell Rep. 2021 06 29; 35(13):109331. Abu-Odeh M, Zhang Y, Reilly SM, Ebadat N, Keinan O, Valentine JM, Hafezi-Bakhtiari M, Ashayer H, Mamoun L, Zhou X, Zhang J, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Kliewer SA, Mangelsdorf DJ, Saltiel AR. PMID: 34192547; PMCID: PMC8293281.
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Neural basis of opioid-induced respiratory depression and its rescue. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). Liu S, Kim DI, Oh TG, Pao GM, Kim JH, Palmiter RD, Banghart MR, Lee KF, Evans RM, Han S. PMID: 34074761; PMCID: PMC8201770.
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Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors. Immunity. 2021 07 13; 54(7):1561-1577.e7. Xu S, Chaudhary O, Rodríguez-Morales P, Sun X, Chen D, Zappasodi R, Xu Z, Pinto AFM, Williams A, Schulze I, Farsakoglu Y, Varanasi SK, Low JS, Tang W, Wang H, McDonald B, Tripple V, Downes M, Evans RM, Abumrad NA, Merghoub T, Wolchok JD, Shokhirev MN, Ho PC, Witztum JL, Emu B, Cui G, Kaech SM. PMID: 34102100; PMCID: PMC9273026.
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Proton pump inhibitor use status does not modify the microbiome signature for cirrhosis. Cell Metab. 2021 03 02; 33(3):457. Oh TG, Kim SM, Atkins AR, Yu RT, Downes M, Evans RM, Loomba R. PMID: 33657386.
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Intestinal α1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. Cell Mol Gastroenterol Hepatol. 2021; 12(1):293-320. Zhou R, Llorente C, Cao J, Zaramela LS, Zeng S, Gao B, Li SZ, Welch RD, Huang FQ, Qi LW, Pan C, Huang Y, Zhou P, Beussen I, Zhang Y, Bryam G, Fiehn O, Wang L, Liu EH, Yu RT, Downes M, Evans RM, Goglin K, Fouts DE, Brenner DA, Bode L, Fan X, Zengler K, Schnabl B. PMID: 33631374; PMCID: PMC8166943.
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Publisher Correction: Immune-evasive human islet-like organoids ameliorate diabetes. Nature. 2021 Feb; 590(7844):E27. Yoshihara E, O'Connor C, Gasser E, Wei Z, Oh TG, Tseng TW, Wang D, Cayabyab F, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. PMID: 33469222; PMCID: PMC11332361.
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Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts. Oncogenesis. 2020 Nov 09; 9(11):100. Noel P, Hussein S, Ng S, Antal CE, Lin W, Rodela E, Delgado P, Naveed S, Downes M, Lin Y, Evans RM, Von Hoff DD, Han H. PMID: 33168807; PMCID: PMC7653036.
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A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Cell Metab. 2020 Nov 03; 32(5):901. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin CB, Downes M, Evans RM, Loomba R. PMID: 33147487; PMCID: PMC7891106.
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Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas. Cancer Res. 2020 10 15; 80(20):4324-4334. Lenkiewicz E, Malasi S, Hogenson TL, Flores LF, Barham W, Phillips WJ, Roesler AS, Chambers KR, Rajbhandari N, Hayashi A, Antal CE, Downes M, Grandgenett PM, Hollingsworth MA, Cridebring D, Xiong Y, Lee JH, Ye Z, Yan H, Hernandez MC, Leiting JL, Evans RM, Ordog T, Truty MJ, Borad MJ, Reya T, Von Hoff DD, Fernandez-Zapico ME, Barrett MT. PMID: 32928922; PMCID: PMC7906529.
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Shining Light on the COVID-19 Pandemic: A Vitamin D Receptor Checkpoint in Defense of Unregulated Wound Healing. Cell Metab. 2020 11 03; 32(5):704-709. Evans RM, Lippman SM. PMID: 32941797; PMCID: PMC7486067.
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Immune-evasive human islet-like organoids ameliorate diabetes. Nature. 2020 10; 586(7830):606-611. Yoshihara E, O'Connor C, Gasser E, Wei Z, Oh TG, Tseng TW, Wang D, Cayabyab F, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. PMID: 32814902; PMCID: PMC7872080.
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A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Cell Metab. 2020 11 03; 32(5):878-888.e6. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin CB, Downes M, Evans RM, Loomba R. PMID: 32610095; PMCID: PMC7822714.
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Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3. Nat Metab. 2020 07; 2(7):620-634. Reilly SM, Hung CW, Ahmadian M, Zhao P, Keinan O, Gomez AV, DeLuca JH, Dadpey B, Lu D, Zaid J, Poirier B, Peng X, Yu RT, Downes M, Liddle C, Evans RM, Murphy AN, Saltiel AR. PMID: 32694788; PMCID: PMC7384260.
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Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity. Cell Metab. 2020 06 02; 31(6):1173-1188.e5. Paschoal VA, Walenta E, Talukdar S, Pessentheiner AR, Osborn O, Hah N, Chi TJ, Tye GL, Armando AM, Evans RM, Chi NW, Quehenberger O, Olefsky JM, Oh DY. PMID: 32413335; PMCID: PMC7337476.
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Global chemical effects of the microbiome include new bile-acid conjugations. Nature. 2020 03; 579(7797):123-129. Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Aksenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC. PMID: 32103176; PMCID: PMC7252668.
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RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Nat Commun. 2019 10 11; 10(1):4621. Cai D, Wang J, Gao B, Li J, Wu F, Zou JX, Xu J, Jiang Y, Zou H, Huang Z, Borowsky AD, Bold RJ, Lara PN, Li JJ, Chen X, Lam KS, To KF, Kung HJ, Fiehn O, Zhao R, Evans RM, Chen HW. PMID: 31604910; PMCID: PMC6789042.
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The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease. Proc Natl Acad Sci U S A. 2019 09 10; 116(37):18528-18536. Chang C, Loo CS, Zhao X, Solt LA, Liang Y, Bapat SP, Cho H, Kamenecka TM, Leblanc M, Atkins AR, Yu RT, Downes M, Burris TP, Evans RM, Zheng Y. PMID: 31455731; PMCID: PMC6744854.
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YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):15184-15193. Wang L, Mazagova M, Pan C, Yang S, Brandl K, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B. PMID: 31289229; PMCID: PMC6660779.
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Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2019 05; 569(7754):131-135. Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T. PMID: 30996350; PMCID: PMC6565370.
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A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Nat Commun. 2019 03 29; 10(1):1406. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R, Rizo E, Richards L, Xu ZZ, Downes MR, Evans RM, Brenner DA, Sirlin CB, Knight R, Loomba R. PMID: 30926798; PMCID: PMC6440960.
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β-Catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and α-catenin. Development. 2019 03 19; 146(6). Cui S, Li L, Yu RT, Downes M, Evans RM, Hulin JA, Makarenkova HP, Meech R. PMID: 30683662; PMCID: PMC6451316.
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A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression. Cancer Discov. 2019 05; 9(5):617-627. Auciello FR, Bulusu V, Oon C, Tait-Mulder J, Berry M, Bhattacharyya S, Tumanov S, Allen-Petersen BL, Link J, Kendsersky ND, Vringer E, Schug M, Novo D, Hwang RF, Evans RM, Nixon C, Dorrell C, Morton JP, Norman JC, Sears RC, Kamphorst JJ, Sherman MH. PMID: 30837243; PMCID: PMC6497553.
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FXR Regulates Intestinal Cancer Stem Cell Proliferation. Cell. 2019 02 21; 176(5):1098-1112.e18. Fu T, Coulter S, Yoshihara E, Oh TG, Fang S, Cayabyab F, Zhu Q, Zhang T, Leblanc M, Liu S, He M, Waizenegger W, Gasser E, Schnabl B, Atkins AR, Yu RT, Knight R, Liddle C, Downes M, Evans RM. PMID: 30794774; PMCID: PMC6701863.
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Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease. Cell Rep. 2019 01 29; 26(5):1189-1202.e6. Ward JM, Stoyas CA, Switonski PM, Ichou F, Fan W, Collins B, Wall CE, Adanyeguh I, Niu C, Sopher BL, Kinoshita C, Morrison RS, Durr A, Muotri AR, Evans RM, Mochel F, La Spada AR. PMID: 30699348; PMCID: PMC6420346.
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E47 modulates hepatic glucocorticoid action. Nat Commun. 2019 01 18; 10(1):306. Hemmer MC, Wierer M, Schachtrup K, Downes M, Hübner N, Evans RM, Uhlenhaut NH. PMID: 30659202; PMCID: PMC6338785.
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Loss of Transcriptional Repression by BCL6 Confers Insulin Sensitivity in the Setting of Obesity. Cell Rep. 2018 12 18; 25(12):3283-3298.e6. Senagolage MD, Sommars MA, Ramachandran K, Futtner CR, Omura Y, Allred AL, Wang J, Yang C, Procissi D, Evans RM, Han X, Bederman IR, Barish GD. PMID: 30566857; PMCID: PMC6377366.
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Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):10381-10386. Hong SH, Fang S, Lu BC, Nofsinger R, Kawakami Y, Castro GL, Yin Y, Lin C, Yu RT, Downes M, Izpisúa Belmonte JC, Shilatifard A, Evans RM. PMID: 30254164; PMCID: PMC6187131.
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Author Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2018 09; 561(7721):E1. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29973714; PMCID: PMC7871211.
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Vitamin D Switches BAF Complexes to Protect β Cells. Cell. 2018 May 17; 173(5):1135-1149.e15. Wei Z, Yoshihara E, He N, Hah N, Fan W, Pinto AFM, Huddy T, Wang Y, Ross B, Estepa G, Dai Y, Ding N, Sherman MH, Fang S, Zhao X, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM. PMID: 29754817; PMCID: PMC5987229.
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Rational application of macrophage-specific LXR agonists avoids the pitfalls of SREBP-induced lipogenesis. Proc Natl Acad Sci U S A. 2018 05 15; 115(20):5051-5053. Magida JA, Evans RM. PMID: 29712848; PMCID: PMC5960336.
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Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Hepatology. 2018 06; 67(6):2150-2166. Hartmann P, Hochrath K, Horvath A, Chen P, Seebauer CT, Llorente C, Wang L, Alnouti Y, Fouts DE, Stärkel P, Loomba R, Coulter S, Liddle C, Yu RT, Ling L, Rossi SJ, DePaoli AM, Downes M, Evans RM, Brenner DA, Schnabl B. PMID: 29159825; PMCID: PMC5962369.
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Ligand-Dependent Corepressor (LCoR) Is a Rexinoid-Inhibited Peroxisome Proliferator-Activated Receptor γ-Retinoid X Receptor α Coactivator. Mol Cell Biol. 2018 05 01; 38(9). Shalom-Barak T, Liersemann J, Memari B, Flechner L, Devor CE, Bernardo TM, Kim S, Matsumoto N, Friedman SL, Evans RM, White JH, Barak Y. PMID: 29463649; PMCID: PMC5902596.
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ERRγ Preserves Brown Fat Innate Thermogenic Activity. Cell Rep. 2018 03 13; 22(11):2849-2859. Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM. PMID: 29539415; PMCID: PMC5884669.
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ERRγ Promotes Angiogenesis, Mitochondrial Biogenesis, and Oxidative Remodeling in PGC1α/β-Deficient Muscle. Cell Rep. 2018 03 06; 22(10):2521-2529. Fan W, He N, Lin CS, Wei Z, Hah N, Waizenegger W, He MX, Liddle C, Yu RT, Atkins AR, Downes M, Evans RM. PMID: 29514081; PMCID: PMC5860878.
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Visible light reduces C. elegans longevity. Nat Commun. 2018 03 02; 9(1):927. De Magalhaes Filho CD, Henriquez B, Seah NE, Evans RM, Lapierre LR, Dillin A. PMID: 29500338; PMCID: PMC5834526.
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Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. PLoS One. 2017; 12(12):e0189051. Saison-Ridinger M, DelGiorno KE, Zhang T, Kraus A, French R, Jaquish D, Tsui C, Erikson G, Spike BT, Shokhirev MN, Liddle C, Yu RT, Downes M, Evans RM, Saghatelian A, Lowy AM, Wahl GM. PMID: 29211796; PMCID: PMC5718507.
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PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis. Sci Transl Med. 2017 Dec 06; 9(419). Dickey AS, Sanchez DN, Arreola M, Sampat KR, Fan W, Arbez N, Akimov S, Van Kanegan MJ, Ohnishi K, Gilmore-Hall SK, Flores AL, Nguyen JM, Lomas N, Hsu CL, Lo DC, Ross CA, Masliah E, Evans RM, La Spada AR. PMID: 29212711; PMCID: PMC5748332.
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Erratum: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 12 21; 552(7685):430. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29168501; PMCID: PMC8594569.
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Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 11 16; 551(7680):340-345. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29144460; PMCID: PMC5884449.
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Circadian clock cryptochrome proteins regulate autoimmunity. Proc Natl Acad Sci U S A. 2017 11 21; 114(47):12548-12553. Cao Q, Zhao X, Bai J, Gery S, Sun H, Lin DC, Chen Q, Chen Z, Mack L, Yang H, Deng R, Shi X, Chong LW, Cho H, Xie J, Li QZ, Müschen M, Atkins AR, Liddle C, Yu RT, Alkan S, Said JW, Zheng Y, Downes M, Evans RM, Koeffler HP. PMID: 29109286; PMCID: PMC5703267.
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Metabolic control of regulatory T cell (Treg) survival and function by Lkb1. Proc Natl Acad Sci U S A. 2017 11 21; 114(47):12542-12547. He N, Fan W, Henriquez B, Yu RT, Atkins AR, Liddle C, Zheng Y, Downes M, Evans RM. PMID: 29109251; PMCID: PMC5703326.
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NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection. Nat Commun. 2017 10 16; 8(1):959. Wang J, He N, Zhang N, Quan D, Zhang S, Zhang C, Yu RT, Atkins AR, Zhu R, Yang C, Cui Y, Liddle C, Downes M, Xiao H, Zheng Y, Auwerx J, Evans RM, Leng Q. PMID: 29038463; PMCID: PMC5643384.
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Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8776-8781. Kriebs A, Jordan SD, Soto E, Henriksson E, Sandate CR, Vaughan ME, Chan AB, Duglan D, Papp SJ, Huber AL, Afetian ME, Yu RT, Zhao X, Downes M, Evans RM, Lamia KA. PMID: 28751364; PMCID: PMC5565439.
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Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. Cell Metab. 2017 Jul 05; 26(1):157-170.e7. Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel AR. PMID: 28683283; PMCID: PMC5663294.
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CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity. Cell Metab. 2017 Jul 05; 26(1):243-255.e6. Jordan SD, Kriebs A, Vaughan M, Duglan D, Fan W, Henriksson E, Huber AL, Papp SJ, Nguyen M, Afetian M, Downes M, Yu RT, Kralli A, Evans RM, Lamia KA. PMID: 28683290; PMCID: PMC5546250.
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30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Short reflections on the discovery of the mineralocorticoid receptor. J Endocrinol. 2017 07; 234(1):E1-E2. Evans RM. PMID: 28634263.
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FGF1 - a new weapon to control type 2 diabetes mellitus. Nat Rev Endocrinol. 2017 Oct; 13(10):599-609. Gasser E, Moutos CP, Downes M, Evans RM. PMID: 28664920; PMCID: PMC5839646.
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Use of Angiotensin System Inhibitors Is Associated with Immune Activation and Longer Survival in Nonmetastatic Pancreatic Ductal Adenocarcinoma. Clin Cancer Res. 2017 Oct 01; 23(19):5959-5969. Liu H, Naxerova K, Pinter M, Incio J, Lee H, Shigeta K, Ho WW, Crain JA, Jacobson A, Michelakos T, Dias-Santos D, Zanconato A, Hong TS, Clark JW, Murphy JE, Ryan DP, Deshpande V, Lillemoe KD, Fernandez-Del Castillo C, Downes M, Evans RM, Michaelson J, Ferrone CR, Boucher Y, Jain RK. PMID: 28600474; PMCID: PMC5856249.
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PPARδ Promotes Running Endurance by Preserving Glucose. Cell Metab. 2017 May 02; 25(5):1186-1193.e4. Fan W, Waizenegger W, Lin CS, Sorrentino V, He MX, Wall CE, Li H, Liddle C, Yu RT, Atkins AR, Auwerx J, Downes M, Evans RM. PMID: 28467934; PMCID: PMC5492977.
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Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia. Sci Rep. 2017 04 12; 7(1):846. Doktorova M, Zwarts I, Zutphen TV, Dijk THV, Bloks VW, Harkema L, Bruin A, Downes M, Evans RM, Verkade HJ, Jonker JW. PMID: 28404991; PMCID: PMC5429805.
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Re-engineering the Pancreas Tumor Microenvironment: A "Regenerative Program" Hacked. Clin Cancer Res. 2017 Apr 01; 23(7):1647-1655. Evan GI, Hah N, Littlewood TD, Sodir NM, Campos T, Downes M, Evans RM. PMID: 28373363; PMCID: PMC5381729.
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Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):E2563-E2570. Wu CC, Baiga TJ, Downes M, La Clair JJ, Atkins AR, Richard SB, Fan W, Stockley-Noel TA, Bowman ME, Noel JP, Evans RM. PMID: 28320959; PMCID: PMC5380080.
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Farnesoid X Receptor an Emerging Target to Combat Obesity. Dig Dis. 2017; 35(3):185-190. De Magalhaes Filho CD, Downes M, Evans RM. PMID: 28249279; PMCID: PMC5417073.
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Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1432-E1440. Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Paszek M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. PMID: 28167773; PMCID: PMC5338369.
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Stromal cues regulate the pancreatic cancer epigenome and metabolome. Proc Natl Acad Sci U S A. 2017 01 31; 114(5):1129-1134. Sherman MH, Yu RT, Tseng TW, Sousa CM, Liu S, Truitt ML, He N, Ding N, Liddle C, Atkins AR, Leblanc M, Collisson EA, Asara JM, Kimmelman AC, Downes M, Evans RM. PMID: 28096419; PMCID: PMC5293019.
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Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol. 2017 Jan 02; 216(1):149-165. Chung HK, Ryu D, Kim KS, Chang JY, Kim YK, Yi HS, Kang SG, Choi MJ, Lee SE, Jung SB, Ryu MJ, Kim SJ, Kweon GR, Kim H, Hwang JH, Lee CH, Lee SJ, Wall CE, Downes M, Evans RM, Auwerx J, Shong M. PMID: 27986797; PMCID: PMC5223607.
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Liver Cancer Checks in When Bile Acid Clocks Out. Cancer Cell. 2016 Dec 12; 30(6):827-828. Fu T, Zhao X, Evans RM. PMID: 27960079; PMCID: PMC5439430.
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Exercise Mimetics: Impact on Health and Performance. Cell Metab. 2017 02 07; 25(2):242-247. Fan W, Evans RM. PMID: 27889389; PMCID: PMC5555683.
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Reply to "PPAR-γ regulates pharmacological but not physiological or pathological osteoclast formation". Nat Med. 2016 11 08; 22(11):1205. Evans RM, Wan Y. PMID: 27824815.
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An S116R Phosphorylation Site Mutation in Human Fibroblast Growth Factor-1 Differentially Affects Mitogenic and Glucose-Lowering Activities. J Pharm Sci. 2016 12; 105(12):3507-3519. Xia X, Kumru OS, Blaber SI, Middaugh CR, Li L, Ornitz DM, Suh JM, Atkins AR, Downes M, Evans RM, Tenorio CA, Bienkiewicz E, Blaber M. PMID: 27773526; PMCID: PMC5310217.
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Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. 2016 12 01; 540(7631):150. Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. PMID: 27706144.
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Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. 2016 08 25; 536(7617):479-83. Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. PMID: 27509858; PMCID: PMC5228623.
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Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages. Elife. 2016 07 27; 5. Eichenfield DZ, Troutman TD, Link VM, Lam MT, Cho H, Gosselin D, Spann NJ, Lesch HP, Tao J, Muto J, Gallo RL, Evans RM, Glass CK. PMID: 27462873; PMCID: PMC4963201.
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Corrigendum: ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat Med. 2016 06 07; 22(6):692. Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW. PMID: 27270780.
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Barx2 and Pax7 Regulate Axin2 Expression in Myoblasts by Interaction with β-Catenin and Chromatin Remodelling. Stem Cells. 2016 08; 34(8):2169-82. Hulin JA, Nguyen TD, Cui S, Marri S, Yu RT, Downes M, Evans RM, Makarenkova H, Meech R. PMID: 27144473; PMCID: PMC5019118.
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Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation. Cell. 2016 Jun 16; 165(7):1644-1657. Zhao X, Hirota T, Han X, Cho H, Chong LW, Lamia K, Liu S, Atkins AR, Banayo E, Liddle C, Yu RT, Yates JR, Kay SA, Downes M, Evans RM. PMID: 27238018; PMCID: PMC4912445.
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Nuclear receptors and AMPK: can exercise mimetics cure diabetes? J Mol Endocrinol. 2016 07; 57(1):R49-58. Wall CE, Yu RT, Atkins AR, Downes M, Evans RM. PMID: 27106806; PMCID: PMC4929025.
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ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells. Cell Metab. 2016 Apr 12; 23(4):622-34. Yoshihara E, Wei Z, Lin CS, Fang S, Ahmadian M, Kida Y, Tseng T, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. PMID: 27076077; PMCID: PMC4832237.
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ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat Med. 2016 05; 22(5):488-96. Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW. PMID: 27019329; PMCID: PMC5030109.
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Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration. Elife. 2016 03 23; 5. Zheng X, Boyer L, Jin M, Kim Y, Fan W, Bardy C, Berggren T, Evans RM, Gage FH, Hunter T. PMID: 27008180; PMCID: PMC4846388.
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Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2288-93. Liu W, Struik D, Nies VJ, Jurdzinski A, Harkema L, de Bruin A, Verkade HJ, Downes M, Evans RM, van Zutphen T, Jonker JW. PMID: 26858440; PMCID: PMC4776526.
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Targeting Transcriptional and Epigenetic Reprogramming in Stromal Cells in Fibrosis and Cancer. Cold Spring Harb Symp Quant Biol. 2015; 80:249-55. Hah N, Sherman MH, Yu RT, Downes M, Evans RM. PMID: 26801159.
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Fibroblast Growth Factor Signaling in Metabolic Regulation. Front Endocrinol (Lausanne). 2015; 6:193. Nies VJ, Sancar G, Liu W, van Zutphen T, Struik D, Yu RT, Atkins AR, Evans RM, Jonker JW, Downes MR. PMID: 26834701; PMCID: PMC4718082.
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BRD4 is a novel therapeutic target for liver fibrosis. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):15713-8. Ding N, Hah N, Yu RT, Sherman MH, Benner C, Leblanc M, He M, Liddle C, Downes M, Evans RM. PMID: 26644586; PMCID: PMC4697417.
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PPARδ preserves a high resistance to fatigue in the mouse medial gastrocnemius after spinal cord transection. Muscle Nerve. 2016 Feb; 53(2):287-96. Kim JA, Roy RR, Zhong H, Alaynick WA, Embler E, Jang C, Gomez G, Sonoda T, Evans RM, Edgerton VR. PMID: 26044200; PMCID: PMC4670275.
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Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature. 2015 Dec 03; 528(7580):137-41. Bapat SP, Myoung Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, LeBlanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM, Zheng Y. PMID: 26580014; PMCID: PMC4670283.
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Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling. Science. 2015 Oct 30; 350(6260):558-63. Schieber AM, Lee YM, Chang MW, Leblanc M, Collins B, Downes M, Evans RM, Ayres JS. PMID: 26516283; PMCID: PMC4732872.
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Imaging Fibrosis and Separating Collagens using Second Harmonic Generation and Phasor Approach to Fluorescence Lifetime Imaging. Sci Rep. 2015 Aug 21; 5:13378. Ranjit S, Dvornikov A, Stakic M, Hong SH, Levi M, Evans RM, Gratton E. PMID: 26293987; PMCID: PMC4543938.
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Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer. Mol Cancer Res. 2015 Nov; 13(11):1509-19. Arensman MD, Nguyen P, Kershaw KM, Lay AR, Ostertag-Hill CA, Sherman MH, Downes M, Liddle C, Evans RM, Dawson DW. PMID: 26224368; PMCID: PMC4644680.
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Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice. Hepatology. 2015 Nov; 62(5):1606-18. Jo YS, Ryu D, Maida A, Wang X, Evans RM, Schoonjans K, Auwerx J. PMID: 25998209; PMCID: PMC4618256.
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High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice. Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28):8714-9. Wall CE, Whyte J, Suh JM, Fan W, Collins B, Liddle C, Yu RT, Atkins AR, Naviaux JC, Li K, Bright AT, Alaynick WA, Downes M, Naviaux RK, Evans RM. PMID: 26124126; PMCID: PMC4507233.
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Turning up the heat on membrane fluidity. Cell. 2015 May 21; 161(5):962-963. Fan W, Evans RM. PMID: 26000475.
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ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency. Cell Stem Cell. 2015 May 07; 16(5):547-55. Kida YS, Kawamura T, Wei Z, Sogo T, Jacinto S, Shigeno A, Kushige H, Yoshihara E, Liddle C, Ecker JR, Yu RT, Atkins AR, Downes M, Evans RM. PMID: 25865501; PMCID: PMC4427539.
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Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism. Cell Metab. 2015 Apr 07; 21(4):628-36. Pei L, Mu Y, Leblanc M, Alaynick W, Barish GD, Pankratz M, Tseng TW, Kaufman S, Liddle C, Yu RT, Downes M, Pfaff SL, Auwerx J, Gage FH, Evans RM. PMID: 25863252; PMCID: PMC4393848.
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Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 2015 Apr 16; 520(7547):388. Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM. PMID: 25739500.
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Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function. Mol Cell Biol. 2015 Apr; 35(7):1281-98. Wang T, McDonald C, Petrenko NB, Leblanc M, Wang T, Giguere V, Evans RM, Patel VV, Pei L. PMID: 25624346; PMCID: PMC4355525.
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A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. Nat Commun. 2015 Jan 12; 6:6047. Reilly SM, Ahmadian M, Zamarron BF, Chang L, Uhm M, Poirier B, Peng X, Krause DM, Korytnaya E, Neidert A, Liddle C, Yu RT, Lumeng CN, Oral EA, Downes M, Evans RM, Saltiel AR. PMID: 25581158; PMCID: PMC4324568.
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Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs. Proc Natl Acad Sci U S A. 2015 Jan 20; 112(3):E297-302. Hah N, Benner C, Chong LW, Yu RT, Downes M, Evans RM. PMID: 25564661; PMCID: PMC4311831.
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Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. PMID: 25559344; PMCID: PMC4320010.
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Nuclear Receptor Signaling: a home for nuclear receptor and coregulator signaling research. Nucl Recept Signal. 2014; 12:e006. McKenna NJ, Evans RM, O'Malley BW. PMID: 25614732; PMCID: PMC4303009.
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The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17200-5. Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. PMID: 25404284; PMCID: PMC4260592.
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Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. Diabetes. 2015 Apr; 64(4):1120-30. Morinaga H, Mayoral R, Heinrichsdorff J, Osborn O, Franck N, Hah N, Walenta E, Bandyopadhyay G, Pessentheiner AR, Chi TJ, Chung H, Bogner-Strauss JG, Evans RM, Olefsky JM, Oh DY. PMID: 25315009; PMCID: PMC4375077.
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Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 2014 Sep 25; 159(1):80-93. Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM. PMID: 25259922; PMCID: PMC4177038.
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The PML domain of PML-RARα blocks senescence to promote leukemia. Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):12133-8. Korf K, Wodrich H, Haschke A, Ocampo C, Harder L, Gieseke F, Pollmann A, Dierck K, Prall S, Staege H, Ma H, Horstmann MA, Evans RM, Sternsdorf T. PMID: 25092303; PMCID: PMC4143011.
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Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 2014 Sep 18; 513(7518):436-9. Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM. PMID: 25043058; PMCID: PMC4184286.
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The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages. Genes Dev. 2014 Jul 15; 28(14):1562-77. Daniel B, Nagy G, Hah N, Horvath A, Czimmerer Z, Poliska S, Gyuris T, Keirsse J, Gysemans C, Van Ginderachter JA, Balint BL, Evans RM, Barta E, Nagy L. PMID: 25030696; PMCID: PMC4102764.
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Methylome, transcriptome, and PPAR(γ) cistrome analyses reveal two epigenetic transitions in fat cells. Epigenetics. 2014 Sep; 9(9):1195-206. Takada H, Saito Y, Mituyama T, Wei Z, Yoshihara E, Jacinto S, Downes M, Evans RM, Kida YS. PMID: 25093444; PMCID: PMC4169011.
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A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med. 2014 Aug; 20(8):942-7. Oh DY, Walenta E, Akiyama TE, Lagakos WS, Lackey D, Pessentheiner AR, Sasik R, Hah N, Chi TJ, Cox JM, Powels MA, Di Salvo J, Sinz C, Watkins SM, Armando AM, Chung H, Evans RM, Quehenberger O, McNelis J, Bogner-Strauss JG, Olefsky JM. PMID: 24997608; PMCID: PMC4126875.
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Barx2 and Pax7 have antagonistic functions in regulation of wnt signaling and satellite cell differentiation. Stem Cells. 2014 Jun; 32(6):1661-73. Zhuang L, Hulin JA, Gromova A, Tran Nguyen TD, Yu RT, Liddle C, Downes M, Evans RM, Makarenkova HP, Meech R. PMID: 24753152; PMCID: PMC4134105.
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Nuclear receptors rock around the clock. EMBO Rep. 2014 May; 15(5):518-28. Zhao X, Cho H, Yu RT, Atkins AR, Downes M, Evans RM. PMID: 24737872; PMCID: PMC4210094.
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Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity. Diabetes. 2014 Sep; 63(9):2935-48. Lu B, Bridges D, Yang Y, Fisher K, Cheng A, Chang L, Meng ZX, Lin JD, Downes M, Yu RT, Liddle C, Evans RM, Saltiel AR. PMID: 24722244; PMCID: PMC4141363.
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Nuclear Receptors, RXR, and the Big Bang. Cell. 2014 Mar 27; 157(1):255-66. Evans RM, Mangelsdorf DJ. PMID: 24679540; PMCID: PMC4029515.
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Nuclear receptors and metabolism: from feast to famine. Diabetologia. 2014 May; 57(5):860-7. Hong SH, Ahmadian M, Yu RT, Atkins AR, Downes M, Evans RM. PMID: 24619218; PMCID: PMC3980036.
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Metabolism: Tick, tock, a high-fat clock. Nat Rev Endocrinol. 2014 Apr; 10(4):191-2. Liu S, Evans RM. PMID: 24590185.
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Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-δ gene. Am J Physiol Heart Circ Physiol. 2014 Apr 01; 306(7):H1001-10. d'Uscio LV, He T, Santhanam AV, Tai LJ, Evans RM, Katusic ZS. PMID: 24486511; PMCID: PMC3962632.
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Road to exercise mimetics: targeting nuclear receptors in skeletal muscle. J Mol Endocrinol. 2013 Dec; 51(3):T87-T100. Fan W, Atkins AR, Yu RT, Downes M, Evans RM. PMID: 24280961; PMCID: PMC3936671.
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Journal of Molecular Endocrinology 25th anniversary special issue. J Mol Endocrinol. 2013 Dec; 51(3):E1-3. Evans RM. PMID: 24280960.
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Rescue of a primary myelofibrosis model by retinoid-antagonist therapy. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):18820-5. Hong SH, Dvorak-Ewell M, Stevens HY, Barish GD, Castro GL, Nofsinger R, Frangos JA, Shoback D, Evans RM. PMID: 24191050; PMCID: PMC3839709.
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Hepatic actions of vitamin D receptor ligands: a sunshine option for chronic liver disease? Expert Rev Clin Pharmacol. 2013 Nov; 6(6):597-9. Ding N, Liddle C, Evans RM, Downes M. PMID: 24164608; PMCID: PMC4160153.
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Microbiology: Wealth management in the gut. Nature. 2013 Aug 29; 500(7464):538-9. Fang S, Evans RM. PMID: 23985869.
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Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammation. Pharm Res. 2013 Sep; 30(9):2199-208. Kittayaruksakul S, Zhao W, Xu M, Ren S, Lu J, Wang J, Downes M, Evans RM, Venkataramanan R, Chatsudthipong V, Xie W. PMID: 23896737; PMCID: PMC3771640.
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Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature. 2013 Jun 27; 498(7455):511-5. Lam MT, Cho H, Lesch HP, Gosselin D, Heinz S, Tanaka-Oishi Y, Benner C, Kaikkonen MU, Kim AS, Kosaka M, Lee CY, Watt A, Grossman TR, Rosenfeld MG, Evans RM, Glass CK. PMID: 23728303; PMCID: PMC3839578.
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Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8555-60. Du L, Bergsneider M, Mirsadraei L, Young SH, Jonker JW, Downes M, Yong WH, Evans RM, Heaney AP. PMID: 23653479; PMCID: PMC3666748.
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PPARγ signaling and metabolism: the good, the bad and the future. Nat Med. 2013 May; 19(5):557-66. Ahmadian M, Suh JM, Hah N, Liddle C, Atkins AR, Downes M, Evans RM. PMID: 23652116; PMCID: PMC3870016.
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A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. Cell. 2013 Apr 25; 153(3):601-13. Ding N, Yu RT, Subramaniam N, Sherman MH, Wilson C, Rao R, Leblanc M, Coulter S, He M, Scott C, Lau SL, Atkins AR, Barish GD, Gunton JE, Liddle C, Downes M, Evans RM. PMID: 23622244; PMCID: PMC3673534.
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An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar; 19(3):313-21. Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel AR. PMID: 23396211; PMCID: PMC3594079.
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SRF'ing around the clock. Cell. 2013 Jan 31; 152(3):381-2. Zhao X, Cho H, Evans RM. PMID: 23374332.
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Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice. J Lipid Res. 2013 Mar; 54(3):806-815. Chao LC, Soto E, Hong C, Ito A, Pei L, Chawla A, Conneely OM, Tangirala RK, Evans RM, Tontonoz P. PMID: 23288947; PMCID: PMC3617954.
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Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes. Mol Cell. 2013 Jan 10; 49(1):158-71. Uhlenhaut NH, Barish GD, Yu RT, Downes M, Karunasiri M, Liddle C, Schwalie P, Hübner N, Evans RM. PMID: 23159735; PMCID: PMC3640846.
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The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. Elife. 2012 Oct 15; 1:e00065. Zhang Y, Xie Y, Berglund ED, Coate KC, He TT, Katafuchi T, Xiao G, Potthoff MJ, Wei W, Wan Y, Yu RT, Evans RM, Kliewer SA, Mangelsdorf DJ. PMID: 23066506; PMCID: PMC3466591.
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Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. J Lipid Res. 2012 Dec; 53(12):2610-9. Chao LC, Wroblewski K, Ilkayeva OR, Stevens RD, Bain J, Meyer GA, Schenk S, Martinez L, Vergnes L, Narkar VA, Drew BG, Hong C, Boyadjian R, Hevener AL, Evans RM, Reue K, Spencer MJ, Newgard CB, Tontonoz P. PMID: 23028113; PMCID: PMC3494265.
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A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med. 2012 Sep; 18(9):1350-8. Ito K, Carracedo A, Weiss D, Arai F, Ala U, Avigan DE, Schafer ZT, Evans RM, Suda T, Lee CH, Pandolfi PP. PMID: 22902876; PMCID: PMC3566224.
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Targeting the pregnane X receptor in liver injury. Expert Opin Ther Targets. 2012 Nov; 16(11):1075-83. Li T, Yu RT, Atkins AR, Downes M, Tukey RH, Evans RM. PMID: 22913318; PMCID: PMC4319648.
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Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS One. 2012; 7(6):e37705. Yueh MF, Li T, Evans RM, Hammock B, Tukey RH. PMID: 22761658; PMCID: PMC3376094.
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Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice. Hepatology. 2012 Aug; 56(2):658-67. Chen S, Yueh MF, Evans RM, Tukey RH. PMID: 22371261; PMCID: PMC3383890.
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A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature. 2012 May 17; 485(7398):391-4. Jonker JW, Suh JM, Atkins AR, Ahmadian M, Li P, Whyte J, He M, Juguilon H, Yin YQ, Phillips CT, Yu RT, Olefsky JM, Henry RR, Downes M, Evans RM. PMID: 22522926; PMCID: PMC3358516.
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Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist. Proc Natl Acad Sci U S A. 2012 May 22; 109(21):E1369-76. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y, Sirlin C, Yu E, Yu RT, Downes M, Evans RM, Brenner DA, Schnabl B. PMID: 22538808; PMCID: PMC3361396.
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The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. Cell Metab. 2012 Apr 04; 15(4):554-62. Barish GD, Yu RT, Karunasiri MS, Becerra D, Kim J, Tseng TW, Tai LJ, Leblanc M, Diehl C, Cerchietti L, Miller YI, Witztum JL, Melnick AM, Dent AL, Tangirala RK, Evans RM. PMID: 22465074; PMCID: PMC3367511.
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Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature. 2012 Mar 29; 485(7396):123-7. Cho H, Zhao X, Hatori M, Yu RT, Barish GD, Lam MT, Chong LW, DiTacchio L, Atkins AR, Glass CK, Liddle C, Auwerx J, Downes M, Panda S, Evans RM. PMID: 22460952; PMCID: PMC3367514.
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Revascularization of ischemic skeletal muscle by estrogen-related receptor-γ. Circ Res. 2012 Apr 13; 110(8):1087-96. Matsakas A, Yadav V, Lorca S, Evans RM, Narkar VA. PMID: 22415017; PMCID: PMC3610573.
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Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling. Cancer Prev Res (Phila). 2012 Apr; 5(4):553-61. Subramaniam N, Sherman MH, Rao R, Wilson C, Coulter S, Atkins AR, Evans RM, Liddle C, Downes M. PMID: 22406377; PMCID: PMC3324648.
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O-GlcNAc transferase is involved in glucocorticoid receptor-mediated transrepression. J Biol Chem. 2012 Apr 13; 287(16):12904-12. Li MD, Ruan HB, Singh JP, Zhao L, Zhao T, Azarhoush S, Wu J, Evans RM, Yang X. PMID: 22371499; PMCID: PMC3339970.
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Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes. Int Immunopharmacol. 2012 Apr; 12(4):651-6. Noreault-Conti TL, Fellows A, Jacobs JM, Trask HW, Strom SC, Evans RM, Wrighton SA, Sinclair PR, Sinclair JF, Nichols RC. PMID: 22310326; PMCID: PMC3345897.
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SRY-box-containing gene 2 regulation of nuclear receptor tailless (Tlx) transcription in adult neural stem cells. J Biol Chem. 2012 Feb 17; 287(8):5969-78. Shimozaki K, Zhang CL, Suh H, Denli AM, Evans RM, Gage FH. PMID: 22194602; PMCID: PMC3285364.
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Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature. 2011 Dec 14; 480(7378):552-6. Lamia KA, Papp SJ, Yu RT, Barish GD, Uhlenhaut NH, Jonker JW, Downes M, Evans RM. PMID: 22170608; PMCID: PMC3245818.
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Nuclear receptors as modulators of the tumor microenvironment. Cancer Prev Res (Phila). 2012 Jan; 5(1):3-10. Sherman MH, Downes M, Evans RM. PMID: 22135047; PMCID: PMC3408218.
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Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. Proc Natl Acad Sci U S A. 2011 Dec 06; 108(49):19678-82. Krebs P, Fan W, Chen YH, Tobita K, Downes MR, Wood MR, Sun L, Li X, Xia Y, Ding N, Spaeth JM, Moresco EM, Boyer TG, Lo CW, Yen J, Evans RM, Beutler B. PMID: 22106289; PMCID: PMC3241770.
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NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell. 2011 Nov 11; 147(4):827-39. Yamamoto H, Williams EG, Mouchiroud L, Cantó C, Fan W, Downes M, Héligon C, Barish GD, Desvergne B, Evans RM, Schoonjans K, Auwerx J. PMID: 22078881; PMCID: PMC3225739.
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The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming. Cell Res. 2012 Jan; 22(1):168-77. Panopoulos AD, Yanes O, Ruiz S, Kida YS, Diep D, Tautenhahn R, Herrerías A, Batchelder EM, Plongthongkum N, Lutz M, Berggren WT, Zhang K, Evans RM, Siuzdak G, Izpisua Belmonte JC. PMID: 22064701; PMCID: PMC3252494.
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Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome. Nat Med. 2011 Oct 16; 17(11):1466-72. Pei L, Leblanc M, Barish G, Atkins A, Nofsinger R, Whyte J, Gold D, He M, Kawamura K, Li HR, Downes M, Yu RT, Powell HC, Lingrel JB, Evans RM. PMID: 22001906; PMCID: PMC3210920.
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Tumor suppressor protein (p)53, is a regulator of NF-kappaB repression by the glucocorticoid receptor. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17117-22. Murphy SH, Suzuki K, Downes M, Welch GL, De Jesus P, Miraglia LJ, Orth AP, Chanda SK, Evans RM, Verma IM. PMID: 21949408; PMCID: PMC3193198.
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Epigenetic codes of PPARγ in metabolic disease. FEBS Lett. 2011 Jul 07; 585(13):2121-8. Sugii S, Evans RM. PMID: 21605560; PMCID: PMC3129683.
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Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell. 2011 May 13; 145(4):607-21. Mihaylova MM, Vasquez DS, Ravnskjaer K, Denechaud PD, Yu RT, Alvarez JG, Downes M, Evans RM, Montminy M, Shaw RJ. PMID: 21565617; PMCID: PMC3117637.
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Extrahepatic cancer suppresses nuclear receptor-regulated drug metabolism. Clin Cancer Res. 2011 May 15; 17(10):3170-80. Kacevska M, Downes MR, Sharma R, Evans RM, Clarke SJ, Liddle C, Robertson GR. PMID: 21498392; PMCID: PMC3096719.
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Exercise and PGC-1α-independent synchronization of type I muscle metabolism and vasculature by ERRγ. Cell Metab. 2011 Mar 02; 13(3):283-93. Narkar VA, Fan W, Downes M, Yu RT, Jonker JW, Alaynick WA, Banayo E, Karunasiri MS, Lorca S, Evans RM. PMID: 21356518; PMCID: PMC3084588.
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Feeder-dependent and feeder-independent iPS cell derivation from human and mouse adipose stem cells. Nat Protoc. 2011 Mar; 6(3):346-58. Sugii S, Kida Y, Berggren WT, Evans RM. PMID: 21372815; PMCID: PMC3089977.
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Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3412-7. Fang S, Suh JM, Atkins AR, Hong SH, Leblanc M, Nofsinger RR, Yu RT, Downes M, Evans RM. PMID: 21300871; PMCID: PMC3044388.
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Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature. 2011 Mar 03; 471(7336):68-73. Lister R, Pelizzola M, Kida YS, Hawkins RD, Nery JR, Hon G, Antosiewicz-Bourget J, O'Malley R, Castanon R, Klugman S, Downes M, Yu R, Stewart R, Ren B, Thomson JA, Evans RM, Ecker JR. PMID: 21289626; PMCID: PMC3100360.
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Research resource: Comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cells. Mol Endocrinol. 2011 Mar; 25(3):529-45. Diehl CJ, Barish GD, Downes M, Chou MY, Heinz S, Glass CK, Evans RM, Witztum JL. PMID: 21273443; PMCID: PMC3045740.
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Esrrg functions in early branch generation of the ureteric bud and is essential for normal development of the renal papilla. Hum Mol Genet. 2011 Mar 01; 20(5):917-26. Berry R, Harewood L, Pei L, Fisher M, Brownstein D, Ross A, Alaynick WA, Moss J, Hastie ND, Hohenstein P, Davies JA, Evans RM, FitzPatrick DR. PMID: 21138943; PMCID: PMC3033182.
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Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration. Cell Metab. 2010 Dec 01; 12(6):643-53. Reilly SM, Bhargava P, Liu S, Gangl MR, Gorgun C, Nofsinger RR, Evans RM, Qi L, Hu FB, Lee CH. PMID: 21109196; PMCID: PMC3033658.
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STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells. Immunity. 2010 Nov 24; 33(5):699-712. Szanto A, Balint BL, Nagy ZS, Barta E, Dezso B, Pap A, Szeles L, Poliska S, Oros M, Evans RM, Barak Y, Schwabe J, Nagy L. PMID: 21093321; PMCID: PMC3052437.
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Bcl-6 and NF-kappaB cistromes mediate opposing regulation of the innate immune response. Genes Dev. 2010 Dec 15; 24(24):2760-5. Barish GD, Yu RT, Karunasiri M, Ocampo CB, Dixon J, Benner C, Dent AL, Tangirala RK, Evans RM. PMID: 21106671; PMCID: PMC3003193.
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Metabolism: Tick, tock, a beta-cell clock. Nature. 2010 Jul 29; 466(7306):571-2. Lamia KA, Evans RM. PMID: 20671699; PMCID: PMC3610560.
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PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss. Cell Metab. 2010 Jun 09; 11(6):503-16. Wei W, Wang X, Yang M, Smith LC, Dechow PC, Sonoda J, Evans RM, Wan Y. PMID: 20519122; PMCID: PMC3521515.
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Metabolism and cancer in La Jolla. Cancer Res. 2010 May 15; 70(10):3864-9. Shaw RJ, Evans RM, Simon MC. PMID: 20442287; PMCID: PMC2873170.
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Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3558-63. Sugii S, Kida Y, Kawamura T, Suzuki J, Vassena R, Yin YQ, Lutz MK, Berggren WT, Izpisúa Belmonte JC, Evans RM. PMID: 20133714; PMCID: PMC2840462.
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PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22504-9. Sugii S, Olson P, Sears DD, Saberi M, Atkins AR, Barish GD, Hong SH, Castro GL, Yin YQ, Nelson MC, Hsiao G, Greaves DR, Downes M, Yu RT, Olefsky JM, Evans RM. PMID: 20018750; PMCID: PMC2794650.
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Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal. Nat Cell Biol. 2010 Jan; 12(1):31-40; sup pp 1-9. Qu Q, Sun G, Li W, Yang S, Ye P, Zhao C, Yu RT, Gage FH, Evans RM, Shi Y. PMID: 20010817; PMCID: PMC2880892.
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ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. Mol Endocrinol. 2010 Feb; 24(2):299-309. Alaynick WA, Way JM, Wilson SA, Benson WG, Pei L, Downes M, Yu R, Jonker JW, Holt JA, Rajpal DK, Li H, Stuart J, McPherson R, Remlinger KS, Chang CY, McDonnell DP, Evans RM, Billin AN. PMID: 19965931; PMCID: PMC2817599.
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ERRγ Regulates Cardiac, Gastric, and Renal Potassium Homeostasis. Endocr Rev. 2009 Dec 01; 30(7):931. Alaynick WA, Way JM, Wilson SA, Benson WG, Pei L, Downes M, Yu R, Jonker JW, Holt JA, Rajpal DK, Li H, Stuart J, McPherson R, Remlinger KS, Yi-Chang C, McDonnell DP, Evans RM, Billin AN. PMID: 28199598.
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Rosiglitazone activation of PPARgamma suppresses fractalkine signaling. J Mol Endocrinol. 2010 Feb; 44(2):135-42. Wan Y, Evans RM. PMID: 19850645; PMCID: PMC2805405.
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AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science. 2009 Oct 16; 326(5951):437-40. Lamia KA, Sachdeva UM, DiTacchio L, Williams EC, Alvarez JG, Egan DF, Vasquez DS, Juguilon H, Panda S, Shaw RJ, Thompson CB, Evans RM. PMID: 19833968; PMCID: PMC2819106.
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Nuclear receptors: past, present, and future. Preface. Prog Mol Biol Transl Sci. 2009; 87:xi-xiii. Evans RM. PMID: 20374698.
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PPARδ activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation. J Invest Dermatol. 2010 Feb; 130(2):511-9. Jiang YJ, Barish G, Lu B, Evans RM, Crumrine D, Schmuth M, Elias PM, Feingold KR. PMID: 19675577.
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Retrofitting fat metabolism. Cell Metab. 2009 Jun; 9(6):483-4. Pei L, Evans RM. PMID: 19490901.
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Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Mol Endocrinol. 2009 Jun; 23(6):740-6. McKenna NJ, Cooney AJ, DeMayo FJ, Downes M, Glass CK, Lanz RB, Lazar MA, Mangelsdorf DJ, Moore DD, Qin J, Steffen DL, Tsai MJ, Tsai SY, Yu R, Margolis RN, Evans RM, O'Malley BW. PMID: 19423650; PMCID: PMC2691684.
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SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):20021-6. Nofsinger RR, Li P, Hong SH, Jonker JW, Barish GD, Ying H, Cheng SY, Leblanc M, Xu W, Pei L, Kang YJ, Nelson M, Downes M, Yu RT, Olefsky JM, Lee CH, Evans RM. PMID: 19066220; PMCID: PMC2598729.
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The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. Mol Endocrinol. 2008 Nov; 22(11):2496-504. Davies BS, Waki H, Beigneux AP, Farber E, Weinstein MM, Wilpitz DC, Tai LJ, Evans RM, Fong LG, Tontonoz P, Young SG. PMID: 18787041; PMCID: PMC2582544.
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AMPK and PPARdelta agonists are exercise mimetics. Cell. 2008 08 08; 134(3):405-15. Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM. PMID: 18674809; PMCID: PMC2706130.
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Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice. Toxicol Appl Pharmacol. 2008 Oct 15; 232(2):337-50. Kleiner HE, Xia X, Sonoda J, Zhang J, Pontius E, Abey J, Evans RM, Moore DD, DiGiovanni J. PMID: 18692084; PMCID: PMC2585982.
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PPARdelta-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis. Proc Natl Acad Sci U S A. 2008 Mar 18; 105(11):4277-82. Takata Y, Liu J, Yin F, Collins AR, Lyon CJ, Lee CH, Atkins AR, Downes M, Barish GD, Evans RM, Hsueh WA, Tangirala RK. PMID: 18337495; PMCID: PMC2393800.
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PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis. Proc Natl Acad Sci U S A. 2008 Mar 18; 105(11):4271-6. Barish GD, Atkins AR, Downes M, Olson P, Chong LW, Nelson M, Zou Y, Hwang H, Kang H, Curtiss L, Evans RM, Lee CH. PMID: 18337509; PMCID: PMC2393796.
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Staying the distance: avoiding the proteasomal trap. Cancer Cell. 2008 Mar; 13(3):184-5. Downes M, Evans RM. PMID: 18328421.
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Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature. 2008 Feb 21; 451(7181):964-9. Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, Kudlow JE, Michell RH, Olefsky JM, Field SJ, Evans RM. PMID: 18288188.
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A role for adult TLX-positive neural stem cells in learning and behaviour. Nature. 2008 Feb 21; 451(7181):1004-7. Zhang CL, Zou Y, He W, Gage FH, Evans RM. PMID: 18235445.
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The ginsenoside metabolite compound K, a novel agonist of glucocorticoid receptor, induces tolerance to endotoxin-induced lethal shock. J Cell Mol Med. 2008 Sep-Oct; 12(5A):1739-53. Yang CS, Ko SR, Cho BG, Shin DM, Yuk JM, Li S, Kim JM, Evans RM, Jung JS, Song DK, Jo EK. PMID: 18053081; PMCID: PMC3918090.
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PPAR-gamma regulates osteoclastogenesis in mice. Nat Med. 2007 Dec; 13(12):1496-503. Wan Y, Chong LW, Evans RM. PMID: 18059282.
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Nuclear receptors: decoding metabolic disease. FEBS Lett. 2008 Jan 09; 582(1):2-9. Sonoda J, Pei L, Evans RM. PMID: 18023286; PMCID: PMC2254310.
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Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15282-7. Sun G, Yu RT, Evans RM, Shi Y. PMID: 17873065; PMCID: PMC2000559.
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Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation. J Invest Dermatol. 2008 Feb; 128(2):370-7. Man MQ, Barish GD, Schmuth M, Crumrine D, Barak Y, Chang S, Jiang Y, Evans RM, Elias PM, Feingold KR. PMID: 17713572.
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Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense. Genes Dev. 2007 Aug 01; 21(15):1909-20. Sonoda J, Laganière J, Mehl IR, Barish GD, Chong LW, Li X, Scheffler IE, Mock DC, Bataille AR, Robert F, Lee CH, Giguère V, Evans RM. PMID: 17671090; PMCID: PMC1935029.
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Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk. Genes Dev. 2007 Aug 01; 21(15):1895-908. Wan Y, Saghatelian A, Chong LW, Zhang CL, Cravatt BF, Evans RM. PMID: 17652179; PMCID: PMC1935028.
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Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage. Cardiovasc Res. 2007 Nov 01; 76(2):269-79. Ding G, Fu M, Qin Q, Lewis W, Kim HW, Fukai T, Bacanamwo M, Chen YE, Schneider MD, Mangelsdorf DJ, Evans RM, Yang Q. PMID: 17678635.
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ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart. Cell Metab. 2007 Jul; 6(1):13-24. Alaynick WA, Kondo RP, Xie W, He W, Dufour CR, Downes M, Jonker JW, Giles W, Naviaux RK, Giguère V, Evans RM. PMID: 17618853.
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Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma. Cell Metab. 2007 May; 5(5):345-56. Dufour CR, Wilson BJ, Huss JM, Kelly DP, Alaynick WA, Downes M, Evans RM, Blanchette M, Giguère V. PMID: 17488637.
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PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5223-8. Sonoda J, Mehl IR, Chong LW, Nofsinger RR, Evans RM. PMID: 17360356; PMCID: PMC1829290.
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The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. Genes Dev. 2007 Jan 15; 21(2):160-74. Yoh SM, Cho H, Pickle L, Evans RM, Jones KA. PMID: 17234882; PMCID: PMC1770899.
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International Union of Pharmacology. LX. Retinoic acid receptors. Pharmacol Rev. 2006 Dec; 58(4):712-25. Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H. PMID: 17132850.
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International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev. 2006 Dec; 58(4):760-72. Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H. PMID: 17132853.
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Nuclear receptor expression links the circadian clock to metabolism. Cell. 2006 Aug 25; 126(4):801-10. Yang X, Downes M, Yu RT, Bookout AL, He W, Straume M, Mangelsdorf DJ, Evans RM. PMID: 16923398.
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Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell. 2006 Aug 25; 126(4):789-99. Bookout AL, Jeong Y, Downes M, Yu RT, Evans RM, Mangelsdorf DJ. PMID: 16923397; PMCID: PMC6211849.
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Benefit of farnesoid X receptor inhibition in obstructive cholestasis. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11323-8. Stedman C, Liddle C, Coulter S, Sonoda J, Alvarez JG, Evans RM, Downes M. PMID: 16844773; PMCID: PMC1544085.
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TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science. 2006 Jun 23; 312(5781):1763-6. Qi L, Heredia JE, Altarejos JY, Screaton R, Goebel N, Niessen S, Macleod IX, Liew CW, Kulkarni RN, Bain J, Newgard C, Nelson M, Evans RM, Yates J, Montminy M. PMID: 16794074.
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Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1. Genes Dev. 2006 May 15; 20(10):1308-20. Zhang CL, Zou Y, Yu RT, Gage FH, Evans RM. PMID: 16702404; PMCID: PMC1472905.
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A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. J Biol Chem. 2006 May 26; 281(21):15013-20. Zhou J, Zhai Y, Mu Y, Gong H, Uppal H, Toma D, Ren S, Evans RM, Xie W. PMID: 16556603; PMCID: PMC4109972.
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PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest. 2006 Mar; 116(3):590-7. Barish GD, Narkar VA, Evans RM. PMID: 16511591; PMCID: PMC1386117.
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Retinoic acid is required early during adult neurogenesis in the dentate gyrus. Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3902-7. Jacobs S, Lie DC, DeCicco KL, Shi Y, DeLuca LM, Gage FH, Evans RM. PMID: 16505366; PMCID: PMC1450163.
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PPARdelta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3444-9. Lee CH, Olson P, Hevener A, Mehl I, Chong LW, Olefsky JM, Gonzalez FJ, Ham J, Kang H, Peters JM, Evans RM. PMID: 16492734; PMCID: PMC1413918.
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Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2434-9. Lee CH, Kang K, Mehl IR, Nofsinger R, Alaynick WA, Chong LW, Rosenfeld JM, Evans RM. PMID: 16467150; PMCID: PMC1413732.
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Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. Cell Metab. 2006 Feb; 3(2):111-22. Wang Z, Qi C, Krones A, Woodring P, Zhu X, Reddy JK, Evans RM, Rosenfeld MG, Hunter T. PMID: 16459312.
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Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia. Cancer Cell. 2006 Feb; 9(2):81-94. Sternsdorf T, Phan VT, Maunakea ML, Ocampo CB, Sohal J, Silletto A, Galimi F, Le Beau MM, Evans RM, Kogan SC. PMID: 16473276.
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Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms. Toxicol Appl Pharmacol. 2005 Dec 01; 209(2):174-82. Noreault TL, Jacobs JM, Nichols RC, Trask HW, Wrighton SA, Sinclair PR, Evans RM, Sinclair JF. PMID: 15907335.
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Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. Mol Cell Biol. 2005 Oct; 25(19):8456-64. Zhao X, Sternsdorf T, Bolger TA, Evans RM, Yao TP. PMID: 16166628; PMCID: PMC1265742.
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Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity. Drug Metab Dispos. 2005 Dec; 33(12):1827-36. Wolf KK, Wood SG, Hunt JA, Walton-Strong BW, Yasuda K, Lan L, Duan SX, Hao Q, Wrighton SA, Jeffery EH, Evans RM, Szakacs JG, von Moltke LL, Greenblatt DJ, Court MH, Schuetz EG, Sinclair PR, Sinclair JF. PMID: 16141365.
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The Nuclear Receptor Signaling Atlas: development of a functional atlas of nuclear receptors. Mol Endocrinol. 2005 Oct; 19(10):2433-6. Margolis RN, Evans RM, O'Malley BW, NURSA Atlas Consortium. PMID: 16051673.
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A Nuclear Receptor Atlas: 3T3-L1 adipogenesis. Mol Endocrinol. 2005 Oct; 19(10):2437-50. Fu M, Sun T, Bookout AL, Downes M, Yu RT, Evans RM, Mangelsdorf DJ. PMID: 16051663.
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A Nuclear Receptor Atlas: macrophage activation. Mol Endocrinol. 2005 Oct; 19(10):2466-77. Barish GD, Downes M, Alaynick WA, Yu RT, Ocampo CB, Bookout AL, Mangelsdorf DJ, Evans RM. PMID: 16051664.
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The nuclear receptor superfamily: a rosetta stone for physiology. Mol Endocrinol. 2005 Jun; 19(6):1429-38. Evans RM. PMID: 15914712.
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Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2063-8. Stedman CA, Liddle C, Coulter SA, Sonoda J, Alvarez JG, Moore DD, Evans RM, Downes M. PMID: 15684063; PMCID: PMC548592.
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Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2198-203. Sonoda J, Chong LW, Downes M, Barish GD, Coulter S, Liddle C, Lee CH, Evans RM. PMID: 15671183; PMCID: PMC548561.
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Development of ecdysone-regulated lentiviral vectors. Mol Ther. 2005 Jan; 11(1):142-8. Galimi F, Saez E, Gall J, Hoong N, Cho G, Evans RM, Verma IM. PMID: 15585415.
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Peroxisome proliferator-activated receptor gamma controls Muc1 transcription in trophoblasts. Mol Cell Biol. 2004 Dec; 24(24):10661-9. Shalom-Barak T, Nicholas JM, Wang Y, Zhang X, Ong ES, Young TH, Gendler SJ, Evans RM, Barak Y. PMID: 15572671; PMCID: PMC533980.
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A nuclear strike against Listeria--the evolving life of LXR. Cell. 2004 Oct 15; 119(2):149-51. Barish GD, Evans RM. PMID: 15479632.
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Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med. 2004 Nov; 10(11):1245-50. Cheng L, Ding G, Qin Q, Huang Y, Lewis W, He N, Evans RM, Schneider MD, Brako FA, Xiao Y, Chen YE, Yang Q. PMID: 15475963.
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The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem. 2004 Nov 19; 279(47):49517-22. Zhang J, Huang W, Qatanani M, Evans RM, Moore DD. PMID: 15358766.
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Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol. 2004 Oct; 2(10):e294. Wang YX, Zhang CL, Yu RT, Cho HK, Nelson MC, Bayuga-Ocampo CR, Ham J, Kang H, Evans RM. PMID: 15328533; PMCID: PMC509410.
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2003 Keio Medical Science Prize commemorative lecture. PPARs and the complex journey to obesity. Keio J Med. 2004 Jun; 53(2):53-8. Evans RM. PMID: 15264367.
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PPARs and LXRs: atherosclerosis goes nuclear. Trends Endocrinol Metab. 2004 May-Jun; 15(4):158-65. Barish GD, Evans RM. PMID: 15109614.
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PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med. 2004 May; 10(5):530-4. Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M. PMID: 15107844.
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PPARs and the complex journey to obesity. Nat Med. 2004 Apr; 10(4):355-61. Evans RM, Barish GD, Wang YX. PMID: 15057233.
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Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4047-52. Tsai CC, Kao HY, Mitzutani A, Banayo E, Rajan H, McKeown M, Evans RM. PMID: 15016912; PMCID: PMC384693.
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Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem. 2004 May 21; 279(21):22250-7. Assem M, Schuetz EG, Leggas M, Sun D, Yasuda K, Reid G, Zelcer N, Adachi M, Strom S, Evans RM, Moore DD, Borst P, Schuetz JD. PMID: 15004017.
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PPAR gamma signaling exacerbates mammary gland tumor development. Genes Dev. 2004 Mar 01; 18(5):528-40. Saez E, Rosenfeld J, Livolsi A, Olson P, Lombardo E, Nelson M, Banayo E, Cardiff RD, Izpisua-Belmonte JC, Evans RM. PMID: 15037548; PMCID: PMC374235.
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A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Mol Pharmacol. 2004 Feb; 65(2):292-300. Saini SP, Sonoda J, Xu L, Toma D, Uppal H, Mu Y, Ren S, Moore DD, Evans RM, Xie W. PMID: 14742670.
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A methylation-mediator complex in hormone signaling. Genes Dev. 2004 Jan 15; 18(2):144-56. Xu W, Cho H, Kadam S, Banayo EM, Anderson S, Yates JR, Emerson BM, Evans RM. PMID: 14729568; PMCID: PMC324421.
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Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature. 2004 Jan 01; 427(6969):78-83. Shi Y, Chichung Lie D, Taupin P, Nakashima K, Ray J, Yu RT, Gage FH, Evans RM. PMID: 14702088.
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Packing, specificity, and mutability at the binding interface between the p160 coactivator and CREB-binding protein. Protein Sci. 2004 Jan; 13(1):203-10. Demarest SJ, Deechongkit S, Dyson HJ, Evans RM, Wright PE. PMID: 14691235; PMCID: PMC2286511.
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Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15712-7. He W, Barak Y, Hevener A, Olson P, Liao D, Le J, Nelson M, Ong E, Olefsky JM, Evans RM. PMID: 14660788; PMCID: PMC307633.
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Peroxisome proliferator-activated receptor-gamma-deficient heterozygous mice develop an exacerbated neural antigen-induced Th1 response and experimental allergic encephalomyelitis. J Immunol. 2003 Dec 01; 171(11):5743-50. Natarajan C, Muthian G, Barak Y, Evans RM, Bright JJ. PMID: 14634082.
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Muscle-specific Pparg deletion causes insulin resistance. Nat Med. 2003 Dec; 9(12):1491-7. Hevener AL, He W, Barak Y, Le J, Bandyopadhyay G, Olson P, Wilkes J, Evans RM, Olefsky J. PMID: 14625542.
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Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science. 2003 Oct 17; 302(5644):453-7. Lee CH, Chawla A, Urbiztondo N, Liao D, Boisvert WA, Evans RM, Curtiss LK. PMID: 12970571.
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Genetic deficiency in Pparg does not alter development of experimental prostate cancer. Nat Med. 2003 Oct; 9(10):1265-6. Saez E, Olson P, Evans RM. PMID: 12960963.
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Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology. 2003 Jun; 144(6):2201-7. Lee CH, Olson P, Evans RM. PMID: 12746275.
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Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell. 2003 Apr 18; 113(2):159-70. Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H, Evans RM. PMID: 12705865.
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Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition. J Mol Biol. 2003 Apr 04; 327(4):819-32. Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE. PMID: 12654265.
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A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003 Apr; 11(4):1079-92. Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou KC, Evans RM. PMID: 12718892; PMCID: PMC6179153.
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Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor. Mol Endocrinol. 2003 Jul; 17(7):1268-82. Rosenfeld JM, Vargas R, Xie W, Evans RM. PMID: 12663745.
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Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. Org Biomol Chem. 2003 Mar 21; 1(6):908-20. Nicolaou KC, Evans RM, Roecker AJ, Hughes R, Downes M, Pfefferkorn JA. PMID: 12929628.
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Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4150-5. Xie W, Yeuh MF, Radominska-Pandya A, Saini SP, Negishi Y, Bottroff BS, Cabrera GY, Tukey RH, Evans RM. PMID: 12644700; PMCID: PMC153063.
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Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. Development. 2003 Mar; 130(6):1113-22. Stenman J, Yu RT, Evans RM, Campbell K. PMID: 12571103.
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Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding. Am J Physiol Endocrinol Metab. 2003 Mar; 284(3):E618-26. Miles PD, Barak Y, Evans RM, Olefsky JM. PMID: 12556354.
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PPARdelta is a very low-density lipoprotein sensor in macrophages. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1268-73. Chawla A, Lee CH, Barak Y, He W, Rosenfeld J, Liao D, Han J, Kang H, Evans RM. PMID: 12540828; PMCID: PMC298762.
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Acetylation and methylation in nuclear receptor gene activation. Methods Enzymol. 2003; 364:205-23. Xu W, Cho H, Evans RM. PMID: 14631847.
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Co-repressor release but not ligand binding is a prerequisite for transcription activation by human retinoid acid receptor alpha ligand-binding domain. J Biol Chem. 2003 Feb 28; 278(9):7366-73. Kao HY, Han CC, Komar AA, Evans RM. PMID: 12468549.
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Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR). Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13801-6. Sonoda J, Xie W, Rosenfeld JM, Barwick JL, Guzelian PS, Evans RM. PMID: 12370413; PMCID: PMC129778.
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Peroxisome proliferator-activated receptor-gamma in macrophage lipid homeostasis. Trends Endocrinol Metab. 2002 Oct; 13(8):331-5. Lee CH, Evans RM. PMID: 12217489.
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Vitamin D receptor as an intestinal bile acid sensor. Science. 2002 May 17; 296(5571):1313-6. Makishima M, Lu TT, Xie W, Whitfield GK, Domoto H, Evans RM, Haussler MR, Mangelsdorf DJ. PMID: 12016314.
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DSF nuclear receptor acts as a repressor in culture and in vivo. Dev Biol. 2002 May 15; 245(2):315-28. Pitman JL, Tsai CC, Edeen PT, Finley KD, Evans RM, McKeown M. PMID: 11977984.
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Pharmaceutical use of mouse models humanized for the xenobiotic receptor. Drug Discov Today. 2002 May 01; 7(9):509-15. Xie W, Evans RM. PMID: 11983567.
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The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2613-8. Shi Y, Hon M, Evans RM. PMID: 11867749; PMCID: PMC122396.
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Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell. 2002 Feb; 9(2):265-77. Tini M, Benecke A, Um SJ, Torchia J, Evans RM, Chambon P. PMID: 11864601.
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Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature. 2002 Jan 31; 415(6871):549-53. Demarest SJ, Martinez-Yamout M, Chung J, Chen H, Xu W, Dyson HJ, Evans RM, Wright PE. PMID: 11823864.
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The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12. J Biol Chem. 2002 Mar 29; 277(13):11385-91. Love JD, Gooch JT, Benko S, Li C, Nagy L, Chatterjee VK, Evans RM, Schwabe JW. PMID: 11782480.
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Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):303-8. Barak Y, Liao D, He W, Ong ES, Nelson MC, Olefsky JM, Boland R, Evans RM. PMID: 11756685; PMCID: PMC117556.
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Isolation and characterization of mammalian HDAC10, a novel histone deacetylase. J Biol Chem. 2002 Jan 04; 277(1):187-93. Kao HY, Lee CH, Komarov A, Han CC, Evans RM. PMID: 11677242.
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