Abstract Recent clinical trials reported that increasing high-density lipoprotein-cholesterol (HDL-C) levels does not improve cardiovascular outcomes. We hypothesize that HDL proteome dynamics determine HDL cardioprotective functions. In this study, we characterized proteome prof…

Patients with rheumatoid arthritis (RA) suffer significantly increased cardiovascular (CV) morbidity and mortality when compared to the general population with a 48% increased risk of incident CV disease ( 1 – 3 ). Levels of systemic inflammation from active RA have been strongly…

We have previously conducted apolipoprotein profiling by mass spectrometry (MS) in fasted plasma of the community-based Bruneck cohort, demonstrating stronger associations of apolipoproteins on TRL (triglyceride-rich lipoproteins) with incidences of atherosclerotic cardiovascular…

Abstract Active rheumatoid arthritis (RA) is associated with increased cardiovascular risk and impaired function of high-density lipoprotein (HDL). Previous work suggests that HDL may become dysfunctional through oxidative modifications within the RA joint. The current work evalu…

Abstract Purpose To characterize HDL’s anti-inflammatory function in patients with rheumatoid arthritis (RA) and to identify specific differences in HDL-associated proteins and enzymes, which distinguish pro-inflammatory HDL (piHDL) from normal, anti-inflammatory HDL (aiHDL). Met…

Elevated high-density lipoprotein cholesterol and cardiovascular mortality in maintenance hemodialysis patients - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS…

Abstract Nephrotic syndrome results in hyperlipidemia and profound alterations in lipid and lipoprotein metabolism. Serum cholesterol, triglycerides, apolipoprotein B (apoB)–containing lipoproteins (very low-density lipoprotein [VLDL], immediate-density lipoprotein [IDL], and low…

Abstract Background Compared to normal high-density lipoprotein (HDL) cholesterol values, very high HDL cholesterol is associated with a higher incidence of mortality and atherosclerotic cardiovascular disease (ASCVD). As such, clinical risk stratification among persons with very…

Abstract Background: Circulating lipids have been implicated as important modulators of immune response and altered lipid levels correlate with the severity of infection. However, long-term prognostic implications of lipid levels regarding future infection risk remain unclear. Th…

Separating the Mechanism-Based and Off-Target Actions of Cholesteryl Ester Transfer Protein Inhibitors With CETP Gene Polymorphisms Reecha Sofat, Aroon D. Hingorani, Liam Smeeth, Steve E. Humphries, Philippa J. Talmud, Jackie Cooper, Tina Shah, Manjinder S. Sandhu, Sally L. Ricke…

Abstract We characterized the relationship between late life cholesterol exposure and neuropathological outcomes in a community-based, older adult cohort. Adult Changes in Thought is a cohort study that enrolls consenting randomly selected non-demented people aged ≥65 from a heal…

Abstract We characterized the relationship between late life cholesterol exposure and neuropathological outcomes in a community-based, older adult cohort. Adult Changes in Thought is a cohort study that enrolls consenting randomly selected non-demented people aged ≥65 from a heal…

Abstract Background and Aims: We aimed to assess the relationship of HDL (high-density lipoprotein)-mediated cholesterol mass efflux capacity (CMEC) with risk of incident peripheral artery disease (PAD). Methods: CMEC was measured in 1458 Multi-Ethnic Study of Atherosclerosis par…

A novel application of LC-MS/MS accurately quantifies the labile redox pools of cellular coenzymes Q9 and Q10. Free Radic Biol Med. 2025 Dec 01; 240:96-107. Jain A, Li VW, Salem J, Reddy ST , Palaskas NJ , Meriwether D . PMID: 40812599. View in: PubMed Mentions: Fields: The intes…

Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock …