Abstract Overconsumption of sugar-sweetened beverages increases risk factors associated with cardiometabolic disease, in part due to hepatic fructose overload. However, it is not clear whether consumption of beverages containing fructose as naturally occurring sugar produces equi…

Abstract Scope n-3 polyunsaturated fatty acid (n-3 PUFA) intake is associated with protection from obesity, however, the mechanisms of protection remain poorly characterized. The stearoyl CoA desaturase ( SCD ), insulin sensitive glucose transporter ( SLC2A4 ), and sterol regulat…

Abstract Objectives While global measures of cardiovascular (CV) risk are used to guide prevention and treatment decisions, these estimates fail to account for the considerable interindividual variability in pre-clinical risk status. This study investigated heterogeneity in CV ri…

Previously, we reported that inverse associations of high-density lipoprotein (HDL) with cardiovascular disease and diabetes were only observed for HDL that lacked the pro-inflammatory protein apolipoprotein C3 (apoC3). To provide further insight into the cardiometabolic properti…

Abstract Objectives: To identify genomic regions associated with fasting plasma lipid profiles, insulin, glucose, and glycosylated hemoglobin in a Yup’ik study population, and to evaluate whether the observed associations between genetic factors and metabolic traits were modified…

International Journal of Biomedical Research ISSN: 0976-9633 (Online) Journal DOI:10.7439/ijbr CODEN:IJBRFA Research Article Establishment of lipid profile in healthy population of middle district of Southern Tamil Nadu D. D. Venkataraman1, N. Sivaranjani*2, G. Elango1, R. Pravin…

Simple strategies or mental processes involved in making quick decisions Heuristics (from Ancient Greek εὑρίσκω ( heurískō ) ' to find, discover ' ) is the process by which humans use mental shortcuts to arrive at decisions. Heuristics are simple strategies that humans, animals, …

Introduction Shorter leukocyte telomere length (LTL) is significantly associated with increased risk of cardiovascular disease, irrespective of adjustment for conventional risk factors [ 1 ]. A meta-analysis of 24 studies with 43,725 participants and 8,400 patients with cardiovas…

Discovery of the Principal Cystic Fibrosis Mutation (F508del) in Ancient DNA from Iron Age Europeans Philip Farrell1, Cedric Le Marechal2, Claude Ferec2, Malika Siker1, and Maria Teschler-Nicola3 1 Departments of Population Health Sciences and Pediatrics University of Wisconsin, …

Abstract Objective Apolipoprotein C-III (apoC-III) is a key regulator of triglyceride (TG) metabolism. Elevated TG rich lipoproteins and apoC-III levels are causally linked to coronary artery disease (CAD) risk. The mechanism(s) through which apoC-III increases CAD risk remains l…

Abstract Background: High-density lipoprotein (HDL) confers protection against atherosclerosis by several different mechanisms. Although in the general population, increasing levels of HDL are associated with reduced cardiovascular (CV) mortality, this association is not well kno…

German-born American anthropologist (1858–1942) Franz Uri Boas [ a ] (July 9, 1858 – December 21, 1942) was a German-American anthropologist and ethnomusicologist . [ 23 ] He was a pioneer of modern anthropology who has been called the "Father of American Anthropology". [ 24 ] [ …

Abstract Diabetes type-2 and the metabolic syndrome are prevalent in epidemic proportions and result in significant co-morbid disease. Limitations in understanding of dietary effects and cholesterol metabolism exist. Current methods to assess diabetes are essential, though many a…

Effects of climate change are well documented and growing for Earth's natural environment and human societies. Changes to the climate system include an overall warming trend , changes to precipitation patterns , and more extreme weather . As the climate changes it impacts the nat…

Abstract Background Leukocyte telomere length (LTL) is a putative biological marker of immune system age, and there are demonstrated associations between LTL and cardiovascular disease. This may be due in part to the relationship of LTL with other biomarkers associated with cardi…