Introduction The induction of HIV-1 broadly reactive neutralizing antibodies (bnAbs) by experimental vaccines is a critical goal of HIV-1 vaccine development efforts. However, bnAbs cannot be induced by existing HIV-1 vaccine candidates [ 1 ]. The RV144 ALVAC/AIDSVAX B/E HIV-1 va…

1998-1999 The Prosopography of the Neo-Assyrian Empire, volume 1 (= part 1: A and part 2: B-G). Helsinki: The Neo-Assyrian Text Corpus Project, 1998 and 1999. ISBN 9514581636 and ISBN 951458645X. THE PROSOPOGRAPHY OF THE NEO-ASSYRIAN EMPIRE VOLUME 1, PART I: A Using the Electroni…

Introduction Diminished growth hormone (GH) and insulin/insulin-like growth factor-1 (IGF-1) signaling extends lifespan in many laboratory models, including mutations to daf2 in worms 1 , Sch9 in yeast 2 , and Chico in drosophila 3 . Likewise, several dwarf models, including Ames…

Abstract Monoclonal antibodies (MAbs) to the Chlamydia trachomatis mouse pneumonitis (MoPn) major outer membrane protein (MOMP) were characterized for their ability to neutralize the infectivity of this organism in vitro and in vivo. One of the MAbs (MoPn-23) recognizes a nonline…

Abstract Background The malaria parasite Plasmodium falciparum EBA-175 binds its receptor sialic acids on glycophorin A when invading erythrocytes. The receptor-binding region (RII) contains two cysteine-rich domains with similar cysteine motifs (F1 and F2). Functional relationsh…

Abstract Background A large pool of preexisting alloreactive effector T cells can cause allogeneic graft rejection following transplantation. However, it is possible to induce transplant tolerance by altering the balance between effector and regulatory T (Treg) cells. Among the v…

The Journal of Immunology Heligmosomoides polygyrus Elicits a Dominant Nonprotective Antibody Response Directed against Restricted Glycan and Peptide Epitopes James P. Hewitson,*,1 Kara J. Filbey,*,1 John R. Grainger,*,2 Adam A. Dowle,† Mark Pearson,* Janice Murray,* Yvonne Harcu…

Frontiers | Pathogenic Role of Circulating Citrullinated Antigens and Anti-Cyclic Monoclonal Citrullinated Peptide Antibodies in Rheumatoid Arthritis ORIGINAL RESEARCH article Front. Immunol. , 30 June 2021 Sec. Autoimmune and Autoinflammatory Disorders Volume 12 - 2021 | https:/…

Significance Lipoprotein lipase (LPL) plays a central role in plasma lipid metabolism, hydrolyzing the triglycerides in lipoproteins and releasing fatty acid nutrients for vital tissues. LPL is synthesized by adipocytes and myocytes and secreted into the interstitial spaces, wher…

Abstract The neural cell adhesion molecule L1 has been shown to function as a homophilic ligand in a variety of dynamic neurological processes. Here we demonstrate that the sixth immunoglobulin-like domain of human L1 (L1-Ig6) can function as a heterophilic ligand for multiple me…

Abstract Background Cardiac troponin I (cTnI) is the current standard biomarker for diagnosing acute myocardial infarction and for risk-stratification of acute coronary syndromes in patients. However it remains unclear how the epitope specificity of antibodies in immunoassays inf…

Abstract Background There is little information regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA as a predictor for clinical outcomes in outpatients with mild-to-moderate coronavirus disease 2019 (COVID-19). Methods Anterior nasal (AN) and plasma SARS-Co…

Abstract Infection by field strains of Foot-and-mouth disease virus (FMDV) is initiated by binding to certain species of arginine-glycine-aspartic acid (RGD)-dependent integrin including αvβ3 and the epithelial integrin αvβ6. In this report we show that the integrin αvβ1, when ex…

INTRODUCTION During early embryonic development, certain groups of cells, like neural crest cells, can transiently express locomotory properties that allow them to migrate long distances from their sites of origin and populate other areas of the embryo where they undergo differen…

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