Abstract We found that the plasma of patients with active systemic lupus erythematosus (SLE) could induce a human B-cell line (Ramos) to express high levels of immune accessory molecules that are commonly found on blood B cells of patients with active SLE. The ability of SLE plas…
Abstract HopQ is an outer-membrane protein of Helicobacter pylori that binds to human carcinoembryonic antigen-related cell-adhesion molecules (CEACAMs) with high specificity. We aimed to investigate fluorescence targeting of CEACAM-expressing colorectal tumors in patient-derived…
Abstract Here we investigated the role of the Nod/Rip2 pathway in host responses to Chlamydophila pneumoniae –induced pneumonia in mice. Rip2 −/− mice infected with C. pneumoniae exhibited impaired iNOS expression and NO production, and delayed neutrophil recruitment to the lungs…
Abstract The immune system plays key roles in determining the fate of developing cancers by not only functioning as a tumour promoter facilitating cellular transformation, promoting tumour growth and sculpting tumour cell immunogenicity 1 – 6 , but also as an extrinsic tumour sup…
US
Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731190
Abstract Evolutionarily conserved receptor tyrosine kinase–like orphan receptor-1 and -2 (ROR1/2) are considered distinct receptors for Wnt5a and are implicated in noncanonical Wnt signaling in organogenesis and cancer metastasis. We found that Wnt5a enhanced proliferation and mi…
1. Introduction In this report, we present tools we have developed while performing a detailed analysis of the CD4 response to vaccinia virus in humans using peripheral blood mononuclear cells (PBMC) from persons vaccinated with Dryvax ™ , a live, replication-competent, non-clona…
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EBV reprograms autoreactive anti-CNS B cells as antigen presenting cells in multiple sclerosis - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12919047
Summary paragraph Multiple sclerosis (MS) is a chronic autoimmune disease targeting the central nervous system (CNS). MS develops almost exclusively in individuals previously infected with Epstein–Barr virus (EBV) 1 , yet the mechanisms linking EBV infection to MS pathogenesis re…
Disklêriadur hollvedel gwirioù mab-den - Wikimammenn Mont d’an endalc’had Pellgargañ Eus Wikimammenn Broadoù Unanet Disklêriadur hollvedel gwirioù mab-den 1948 DISKLÊRIADUR HOLLVEDEL GWIRIOÙ MAB-DEN Embannet gant ar Broadoù-Unanet d’an 10 a viz Kerzu 1948 Rakger — O vezañ ma’z eo…
Review For reprint orders, please contact: [email protected] State of the art in epitope mapping and opportunities in COVID-19 Samira M Hamed1 , Masarra M Sakr2 , Ghadir S El-Housseiny2 , Reham Wasfi1 ,2 & Khaled M Aboshanab* 1 Department of Microbiology & Immunology, Faculty of …
Introduction Next-generation sequencing has revealed the altered genetic and transcriptional landscape of human cancers 1 , 2 . These data have led to the molecular classification of tumours, and to subsequent tailored treatment regimens that have successfully linked genetic prof…
…erc'h (Merc’h ar boutaouer-koat/Merc’h ar boutaouer-koat — VII.) Ma Farouz Ma Mestrez koant Ma Vijenn Barz Ma Zi Bihan Ma beaj Jeruzalem Ma beaj Jeruzalem/a-bezh Ma beaj Londrez Ma beaj Londrez/a-bezh Ma biniou ! Ma botou koat Ma c’halon a Vreizad zo leun a velkoni Ma c’horn-bro …
Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS …
Journal of Immunological Methods 273 (2003) 125 – 135 www.elsevier.com/locate/jim The SCID-hu Skin mouse as a model to investigate selective chemokine mediated homing of human T-lymphocytes to the skin in vivo José M. Carballido, Tilo Biedermann, Christoph Schwärzler, Jan E. de…
ADAM disintegrin-like domain recognition by the lymphocyte integrins α4β1 and α4β7 - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( ) or https:// means…
When Dr. Joe G.N. “Skip” Garcia, M.D., was director of pulmonary and critical care medicine at Johns Hopkins University, his laboratory identified NAMPT (nicotinamide phosphoribosyltransferase) as a master regulator of inflammation and innate immunity. Inside the cell, NAMPT is a…