miR-23b-24-27b cluster in murine AAA We profiled miRNA expression in the porcine-pancreatic-elastase (PPE) infusion model in 10-week-old male C57BL/6J mice. The incidence, growth rate and size of aneurysmal expansion were measured by ultrasound (US) at 3, 7, 14, 21 and 28 days af…
Abstract Accumulating studies report that microRNAs (miRNAs) are actively involved in skeletal myogenesis. Previously, our study revealed that miR-146b-3p was related to the growth of skeletal muscle. Here, we further report that miR-146b-3p is essential for the proliferation, di…
Abstract Genome-wide association studies (GWAS) have identified chromosomal loci that affect risk of coronary heart disease (CHD) independent of classical risk factors. One such association signal has been identified at 6q23.2 in both Caucasians and East Asians. The lead CHD-asso…
Abstract MicroRNAs (miRNAs) are small noncoding RNAs that act as potent regulators of gene expression. The discovery of miRNAs with specific temporal and spatial expression patterns revealed a hidden layer of post-transcriptional gene regulation. Furthermore, differential express…
microRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( ) or https:// means yo…
cell biochemistry and function Cell Biochem Funct (2012) Published online in Wiley Online Library (wileyonlinelibrary.com) DOI: 10.1002/cbf.2847 Prostate cancer is known by the companionship with ATM and miRNA it keeps: craftsmen of translation have dual behaviour with tailors of…
Narrative Analysis of the Iyezidi Chirok of Mir Mih : The Iyezidi Epic of Immortality Narrative Analysis of the Iyezidi Chirok of Mir Mih : The Iyezidi Epic of Immortality Lazgin Kheder Barany Rania Qaso Department of English, Department of English , College of Languages, College…
Abstract Although it is well established that tumors initiate an angiogenic switch, the molecular basis of this process remains incompletely understood. Here we show that the miRNA miR-132 acts as an angiogenic switch by targeting p120RasGAP in the endothelium and thereby inducin…
Abstract Background The treatment options for hepatocellular carcinoma (HCC) are limited, and there is no effective drug that can improve long-term survival rates. Complicated cocktails consisting of multiple medications with toxicities are frequently used to treat cancer. The cu…
Abstract Background The treatment options for hepatocellular carcinoma (HCC) are limited, and there is no effective drug that can improve long-term survival rates. Complicated cocktails consisting of multiple medications with toxicities are frequently used to treat cancer. The cu…
INTRODUCTION Malignant melanoma (MM), an aggressive skin malignancy, is the fifth most common malignant tumor in men and the seventh most common malignant tumor in women [ 1 , 2 ]. Recent studies showed that the incidence of MM has increased by 3.1% per year [ 3 ]. Despite signif…
miR-142-3p balances proliferation and differentiation of mesenchymal cells during lung development - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( ) o…
Significance This study highlights a pathogenic role for loss of miR-15/16 in chronic lymphocytic leukemia (CLL). We find that loss of mi R-15/16 promotes overexpression of BCL2 and ROR1 , which each factor in leukemia pathogenesis. Treatment with single-agent venetoclcax, which …
Introduction Since the first microRNA (miRNA) Lin-4 was discovered in nematode in 1993 1 , and the function of miRNA let-7 was subsequently demonstrated 2 , miRNAs began to attract the attention of researchers and subsequently they have become an intense and focused area of biolo…
Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( ) o…