Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( ) or https://…

Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans - PMC Skip to main content Official websites use .gov A .gov …

Introduction RNA editing refers to the alteration of RNA sequences through insertion, deletion or substitution of nucleotides 1 , 2 . In human cells, the most prevalent type of RNA editing is adenosine to inosine editing (A-to-I editing), catalyzed by the protein family adenosine…

INTRODUCTION RNA molecules have emerged as critical players in nearly every biological process, from cell division to the regulation of chromatin state and gene expression ( 1 , 2 ). Many diseases, ranging from cancer ( 3 , 4 ) to neurological disorders ( 5 ), can be traced back …

International Journal of Environmental Research and Public Health Article Nutrition Education Intervention Increases Fish Consumption among School Children in Indonesia: Results from Behavioral Based Randomized Control Trial Trias Mahmudiono 1,2, * , Triska Susila Nindya 1 , Qoni…

Abstract Through its various metabolites, vitamin A controls essential physiological functions. Both naturally occurring metabolites and novel retinoid analogues have shown effectiveness in many clinical settings that include skin diseases and cancer, and in animal models of huma…

Introduction Facilitated by recent technological advances, numerous human genomes are being sequenced, cataloging an unprecedented amount of genetic variants (GVs) 1 . A major challenge exists in identifying and interpreting potentially functional GVs. Disease-associated GVs ofte…

Vol-512 Copyright © 2009 for the individual papers by the papers' authors. Copying permitted for private and academic purposes. Re-publication of material from this volume requires permission by the copyright owners. This volume is published by its editors. Understanding the User…

Introduction Whole-genome sequencing efforts have revealed the landscape of human non-coding genetic variants 1 . It is increasingly recognized that non-coding variants contribute significantly to human diseases, including cancer 2 – 4 . Despite the substantial progress toward de…

RNA-binding proteins associated with cancer Two lists of RNA-binding proteins (GO terms and census) were compared with the COSMIC (Catalog of Somatic Mutations in Cancer) list of cancer-associated genes 15 to identify 93 RBPs associated with cancer (Fig. 1a ), of which 51 had no …

Generation and compilation of RNA-seq data A summary of RNA-seq data generated for this study or compiled from the public domain is provided in Supplementary Dataset 1 . To determine the dynamics of the mammalian brain transcriptome in depth, we performed RNA-seq using mouse cort…

Animals, Husbandry, and Experimental Diets Animal procedures and experiments were approved by the Case Western Reserve University Animal Care Committee and conformed to recommendations of both the American Veterinary Medical Association Panel on Euthanasia and the ARVO Statement …

Three strategies to treat diseases caused by mutations in retinoid cycle genes have been explored. The first and conceptually simplest strategy is to replace the defective gene by viral gene therapy. RPE cells take up and express recombinant viruses at high efficiency, which repr…

Paul A. Khavari, MD, PhD's Profile | Stanford Profiles Paul A. Khavari, MD, PhD Carl J. Herzog Professor of Dermatology in the School of Medicine Practices at Stanford Health Care Web page: Print Profile Email Profile View Stanford-only Profile Tab Menu Bio Research & Scholarship…

Abstract The transcription factor recombination signal binding protein-J (RBP-J) functions immediately downstream of the cell surface receptor Notch and mediates transcriptional activation by the intracellular domain of all four kinds of Notch receptors. To investigate the functi…