Abstract As the SARS-CoV-2 coronavirus continues to evolve and infect the global population, many individuals are likely to suffer from post-acute sequelae of SARS-CoV-2 infection (PASC). Manifestations of PASC include vision symptoms, but little is known about the ability of SAR…

Retinal Pigmented Epithelial Cells Obtained from Human Induced Pluripotent Stem Cells Possess Functional Visual Cycle Enzymes in Vitro and in Vivo - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United Sta…

Risk and Respirators: The Hazardous Trajectories of Soviet Occupational Safety, 1940s-80s 04_Chunikhin 603–33.qxp_03_49.3dobraszczyk 568– 6/27/22 12:34 PM Page 603 F Risk and Respirators The Hazardous Trajectories of Soviet Occupational Safety, 1940s–80s KIRILL CHUNIKHIN ABSTRACT…

ABSTRACT Subretinal fibrosis significantly contributes to vision loss in neovascular age‐related macular degeneration (nAMD). Epithelial‐to‐mesenchymal transition (EMT) in RPE cells is a key early step in subretinal fibrosis. While mitochondrial dysfunction in RPE is involved, th…

Abstract MicroRNAs (miRNAs) regulate multiple genes, often within the same pathway, fine-tuning expression of key factors and stabilizing gene networks against aberrant fluctuations. The demanding physiologic functions of photoreceptor cells and the retinal pigmented epithelium n…

Unique, non-redundant genes encode a vast set of proteins in our visual system which assist in the transduction of light stimuli captured in the retina into electrochemical impulses that are transmitted to the brain and assembled into a coherent visual field. Defects in these gen…

Reduced Expression of VEGF-A in Human Retinal Pigment Epithelial Cells and Human Muller Cells Following CRISPR-Cas9 Ribonucleoprotein-Mediated Gene Disruption - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in th…

Abstract Automated image segmentation is a critical step toward achieving a quantitative evaluation of disease states with imaging techniques. Two-photon fluorescence microscopy (TPM) has been employed to visualize the retinal pigmented epithelium (RPE) and provide images indicat…

Species and environmental control of photoreceptor cell renewal Although daily renewal of OS is required for proper retinal function in all species studied, differences do occur as species have evolved and adjusted to their photopic environments. Elegant experiments performed by …

CS Graduate Student Handbook 2025-26 CS Graduate Student Handbook 2025-26 Updated 4/17/2026 1 Introduction 2 Admissions 2.1 Admission Requirements 2.2 Direct Admission from M.S. to Ph.D. 2.3 Application Deadlines 2.4 Admission Timeline 2.5 Application Requirements 2.6 GRE Score R…

The transparency of the anterior segment of the eye provides a unique opportunity for identifying vital molecular events within the retina and retinal pigment epithelium (RPE) which contribute to human vision in health and disease. Noninvasive optical imaging not only can reveal …

Abstract Purpose This prospective case series investigates the visual and anatomical outcomes including detailed volumetrics of eyes with vascularized pigment epithelial detachments (PED) treated with aflibercept in eyes with neovascular age-related macular degeneration (nAMD) th…

To obtain images of retinoid visual cycle components within the retinas of living animals using low laser power, several critical factors required both innovation and optimization. To minimize pulse duration at the sample, high-order dispersion compensation was integrated with th…

Abstract Loss of photoreceptors and other retinal cells is a common endpoint in retinal degenerate (RD) diseases that cause blindness. Retinal transplantation is a potential therapy to replace damaged retinal cells and improve vision. In this study, we examined the development of…

Abstract The visual (retinoid) cycle is a fundamental metabolic process in vertebrate retina responsible for production of 11- cis -retinal, the chromophore of rhodopsin and cone pigments. 11- cis -Retinal is bound to opsins, forming visual pigments, and when the resulting visual…