Abstract Purpose We hypothesized that mutations in homologous recombination repair (HRR) genes beyond BRCA1 and BRCA2 improve outcomes for ovarian carcinoma (OC) patients treated with platinum therapy and would impact the relative benefit of adding prolonged bevacizumab. Experime…

Abstract Background For locally advanced rectal cancer (LARC) patients who receive neoadjuvant chemoradiotherapy (nCRT), there are no reliable indicators to accurately predict pathological complete response (pCR) before surgery. For patients with clinical complete response (cCR),…

Utility of ctDNA in predicting response to neoadjuvant chemoradiotherapy and prognosis assessment in locally advanced rectal cancer: A prospective cohort study | PLOS Medicine Article Authors Metrics Comments Media Coverage Reader Comments Figures Figures Abstract Background For …

Herzlich willkommen auf meiner Seite. Kurz und knapp: Armin P. Seit 14. April 2006 und damit seit 7317 Tagen in der Wikipedia angemeldet. Dieser Benutzer wurde hier am 9. Juni 2006 erstmals aktiv und das war am 14. Juni 2022 seine hunderttausendste und am 21. April 2024 seine ein…

The Structural Racism Remedies Repository | Othering & Belonging Institute Register for the 2026 O&B Conference taking place Oct. 9-10 in Louisville, Kentucky Sign up now Othering & Belonging Institute This a repository of policy-based recommendations for addressing structural an…

SSL_CTX_set1_curves NAME SSL_CTX_set1_groups, SSL_CTX_set1_groups_list, SSL_set1_groups, SSL_set1_groups_list, SSL_get1_groups, SSL_get0_iana_groups, SSL_get_shared_group, SSL_get_negotiated_group, SSL_CTX_set1_curves, SSL_CTX_set1_curves_list, SSL_set1_curves, SSL_set1_curves_li…

draft-ietf-tls-esni-14 Internet-Draft TLS Encrypted Client Hello February 2022 Rescorla, et al. Expires 17 August 2022 [Page] Workgroup: tls Internet-Draft: draft-ietf-tls-esni-14 Published: 13 February 2022 Intended Status: Standards Track Expires: 17 August 2022 Authors: E. Res…

Introduction Recent years have witnessed an emergence in the use of human 3D organoids as a methodological complement to conventional 2D cell lines. Organoids represent robust in vitro cultures that preserve tissue architecture, stem cell activity, multilineage differentiation, g…

Frontiers | A generalized equation for predicting peak oxygen consumption during treadmill exercise testing: mitigating the bias from total body mass scaling ORIGINAL RESEARCH article Front. Cardiovasc. Med. , 10 December 2024 Sec. Precision Cardiology Volume 11 - 2024 | https://…

draft-ietf-tls-esni-25 Internet-Draft TLS Encrypted Client Hello June 2025 Rescorla, et al. Expires 16 December 2025 [Page] Workgroup: tls Internet-Draft: draft-ietf-tls-esni-25 Published: 14 June 2025 Intended Status: Standards Track Expires: 16 December 2025 Authors: E. Rescorl…

The introduction of PARP inhibitors (PARPi) has transformed the management of patients with high-grade serous/endometroid (HGS) ovarian, primary peritoneal or fallopian-tube cancer (subsequently referred to as high-grade serous/endometroid ovarian cancer [HGSC]), in both relapsed…

Establishment of CRISPR screening in 3D oncogene-engineered human gastric tumor organoids To test the feasibility of CRISPR-based genetic screening in 3D organoids, we utilized an oncogene-engineered human gastric tumor organoid model. The TP53/APC double knockout (DKO) organoid …

Transport Layer Security (TLS) Extensions Transport Layer Security (TLS) Extensions Created 2005-11-15 2026-04-01 Related Registry Group(s) Transport Layer Security (TLS) Parameters Available Formats XML HTML Plain text Registries Included Below TLS ExtensionType Values TLS Certi…

Shuffling of genetic material A model of meiotic recombination, initiated by a double-strand break or gap, followed by pairing with an homologous chromosome and strand invasion to initiate the recombinational repair process. Repair of the gap can lead to crossover (CO) or non-cro…

Objective: Combination cediranib/olaparib has reported activity in relapsed ovarian cancer. This phase 2 trial investigated the activity of cediranib/olaparib in relapsed ovarian cancer and its association with homologous recombination deficiency (HRD). Methods: Seventy patients …