Introduction RNA editing refers to the alteration of RNA sequences through insertion, deletion or substitution of nucleotides 1 , 2 . In human cells, the most prevalent type of RNA editing is adenosine to inosine editing (A-to-I editing), catalyzed by the protein family adenosine…

Abstract Through its various metabolites, vitamin A controls essential physiological functions. Both naturally occurring metabolites and novel retinoid analogues have shown effectiveness in many clinical settings that include skin diseases and cancer, and in animal models of huma…

Introduction Facilitated by recent technological advances, numerous human genomes are being sequenced, cataloging an unprecedented amount of genetic variants (GVs) 1 . A major challenge exists in identifying and interpreting potentially functional GVs. Disease-associated GVs ofte…

Generation and compilation of RNA-seq data A summary of RNA-seq data generated for this study or compiled from the public domain is provided in Supplementary Dataset 1 . To determine the dynamics of the mammalian brain transcriptome in depth, we performed RNA-seq using mouse cort…

Animals, Husbandry, and Experimental Diets Animal procedures and experiments were approved by the Case Western Reserve University Animal Care Committee and conformed to recommendations of both the American Veterinary Medical Association Panel on Euthanasia and the ARVO Statement …

Paul A. Khavari, MD, PhD's Profile | Stanford Profiles Paul A. Khavari, MD, PhD Carl J. Herzog Professor of Dermatology in the School of Medicine Practices at Stanford Health Care Web page: Print Profile Email Profile View Stanford-only Profile Tab Menu Bio Research & Scholarship…

Abstract The transcription factor recombination signal binding protein-J (RBP-J) functions immediately downstream of the cell surface receptor Notch and mediates transcriptional activation by the intracellular domain of all four kinds of Notch receptors. To investigate the functi…

Papers by Giuseppe Zanotti Crystal structure of the non-regulatory A4 isoform of spinach chloroplast glyceraldehyde-3-phosphate dehydrogenase complexed with NADP Journal of Molecular Biology , 2001 Here, we report the first crystal structure of a photosynthetic glyceraldehyde-3-p…

Abstract Recent advances in pseudouridine detection reveal a complex pseudouridine landscape that includes messenger RNA and diverse classes of non-coding RNA in human cells. The known molecular functions of pseudouridine, which include stabilizing RNA conformations and destabili…

Frontiers | Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targets ORIGINAL RESEARCH article Front. Cell. Infect. Microbiol. , 25 August 2022 Sec. Parasite and Host Volume 12 - 2022…

ARTICLE IN PRESS Building and Environment 42 (2007) 902–912 www.elsevier.com/locate/buildenv A powerful simulator for moisture transfer in buildings M. Karoglou, A. Moropoulou, M.K. Krokida, Z.B. Maroulis School of Chemical Engineering, National Technical University of Athens, Zo…

Abstract RNA-binding proteins (RBPs) control varied processes, including RNA splicing, stability, transport and translation 1-3 . Dysfunctional RNA-RBP interactions contribute to the pathogenesis of human disease 1,4,5 ; however, characterizing the nature and dynamics of multipro…

Discontinued operating system for Sperry UNIVAC Mainframe computers Operating system VS/9 is a computer operating system for the UNIVAC Series 90 mainframes (90/60, 90/70, and 90/80), used during the late 1960s through 1980s. The 90/60 and 90/70 were repackaged Univac 9700 comput…

Ethics statement All experiments were conducted in accordance with relevant National Institutes of Health (NIH) guidelines and regulations related to the Care and Use of Laboratory Animals. All animal procedures were approved by the Institutional Animal Care and Use Committee of …

Abstract Delta-like 3 (DLL3) is a member of the DSL family of Notch ligands in amniotes. In contrast to DLL1 and DLL4, the other Delta-like proteins in the mouse, DLL3 does not bind in trans to Notch and does not activate the receptor, but shows cis-interaction and cis-inhibitory…