Abstract Diabetic retinopathy is a major cause of vision loss worldwide and areas of retinal non-perfusion (RNP) are a key pathologic feature of the vascular component of diabetic retinopathy. While there is a need for a more complete understanding of the natural history of RNP d…

Ribonucleoprotein (RNP) complexes play central roles in essential cellular processes that include translation, rRNA, pre-mRNA and pre-tRNA processing, and telomere maintenance. In the ribosome and the spliceosome, large RNA molecules form a structural framework for the assembly o…

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Introduction Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disorder caused by an expanded CAG repeat in the first exon of the huntingtin gene ( HTT ) encoding a mutant huntingtin (mHtt) protein with an extended stretch of polyglutamines. 1 mHtt aggregates i…

Paul A. Khavari, MD, PhD's Profile | Stanford Profiles Paul A. Khavari, MD, PhD Carl J. Herzog Professor of Dermatology in the School of Medicine Practices at Stanford Health Care Web page: Print Profile Email Profile View Stanford-only Profile Tab Menu Bio Research & Scholarship…

A review on hepatitis D: From virology to new therapies - PMC Official websites use .gov .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS lock ) or means you've safely connected to the .gov website. Share sensitive i…

Abstract RNA-binding proteins (RBPs) control varied processes, including RNA splicing, stability, transport and translation 1-3 . Dysfunctional RNA-RBP interactions contribute to the pathogenesis of human disease 1,4,5 ; however, characterizing the nature and dynamics of multipro…

Enhancers serve as critical regulatory elements for transcrip tional programs by directing development, homeostasis and disease states 1 , 2 . Clusters of enhancers located in a relatively small genomic region, known as super enhancers 3 , 4 or stretch enhancers 5 , exhibit more …

Purpose: Retinal non-perfusion (RNP) is fundamental to disease onset and progression in diabetic retinopathy (DR). Whether anti-vascular endothelial growth factor (anti-VEGF) therapy can modify RNP progression is unclear. This investigation quantified the impact of anti-VEGF ther…

Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C RNA (2002), 8 :188–201+ Cambridge University Press+ Printed in the USA+ Copyright © 2002 RNA Society+ DOI: 10+1017+S135583820101278X Determinants of the recognition of enteroviral clo…

hPSC culture H9 hPSCs (WiCell) 57 were used throughout this entire study, and were validated to be mycoplasma negative and karyotypically normal. Undifferentiated hPSCs were cultured feeder-free in mTeSR1 media (StemCell Technologies) on cell-culture plates that had been pre-coat…

Genome editing across Dictyostelia species enables comparative functional genetics of social amoebas | Scientific Reports Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up…

Abstract Telomerase is a eukaryotic ribonucleoprotein (RNP) whose specialized reverse transcriptase action performs de novo synthesis of one strand of telomeric DNA. The resulting telomerase-mediated elongation of telomeres, which are the protective end-caps for eukaryotic chromo…

T cell isolation and culture Human peripheral blood Leukopaks enriched for peripheral blood mononuclear cells (PBMCs) from deidentified healthy donors were purchased from StemCell Technologies (200-0092). CD3 + T cells were isolated using the EasySep Human T cell isolation kit (1…