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Innate Immune Phenotypes During Acute High-Altitude Exposure. High Alt Med Biol. 2026 Mar; 27(1):33-41. Vargas A, Penuelas V, Mkrtchyan KG, Pham K, Frost S, Moya EA, Yu JJ, Simonson TS, Heinrich EC. PMID: 41005798.
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Dysregulated Fatty Acid Metabolism in Preeclampsia Among Highland Andeans: Insights Into Adaptive and Maladaptive Placental Metabolic Phenotypes. FASEB J. 2025 Nov 30; 39(22):e71254. O'Brien KA, Toledo-Jaldin L, Gu W, Houck JA, Lazo-Vega L, Miranda-Garrido V, Yung HW, Yasini H, Moore LG, Reisz JA, Simonson TS, Shortt J, Stalker M, D'Alessandro A, Julian CG. PMID: 41273236; PMCID: PMC12639537.
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Genetic adaptations shaping survival, pregnancy, and life at high altitude and sea level. Philos Trans R Soc Lond B Biol Sci. 2025 Aug 21; 380(1933):20240170. Gu W, Lawrence ES, Evans AM, Simonson TS. PMID: 40836810; PMCID: PMC12368535.
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Adaptive PRKAA1 variant in Andeans is associated with improved ventilation and sleep phenotypes. iScience. 2025 Aug 15; 28(8):112911. Lawrence ES, Gu W, Kong MC, Fassardi S, Anza-Ramirez C, Moya EA, Heinrich EC, Yu JJ, Orr JE, Cao SY, Sanchez-Azofra A, Cole AM, Hall JE, Lin A, DeYoung PN, Vizcardo-Galindo G, Macarlupu JL, Figueroa-Mujíca R, Bermudez D, Corante N, Cavalleri GL, Gaio E, Evans AM, Powell FL, Malhotra A, Salem RM, Villafuerte FC, Simonson TS. PMID: 40703441; PMCID: PMC12284296.
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Multidimensional Analysis of Twin Sets During an Intensive Week-Long Meditation Retreat: A Pilot Study. Mindfulness (N Y). 2025; 16(6):1634-1655. Zuniga-Hertz JP, Simpson S, Chitetti R, Hsu CF, Huang HP, Jinich-Diamant A, Chernov AV, Onton JA, Cuomo R, Dispenza J, Davis D, Christov-Moore L, Reggente N, Gu W, Kong M, Bonds JA, Maree J, Simonson TS, Ahn AC, Poirier MA, Moeller-Bertram T, Patel HH. PMID: 40535580; PMCID: PMC12170707.
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Improved oxygen saturation and acclimatization with bacteriotherapy at high altitude. iScience. 2025 Apr 18; 28(4):112053. Yu JJ, Moya EA, Cheng H, Kaya K, Ochoa T, Fassardi S, Gruenberg E, Spenceley A, DeYoung P, Young EV, Barnes LA, Lugo A, Sanchez-Azofra A, Orr JE, Heinrich EC, Malhotra A, Simonson TS. PMID: 40290874; PMCID: PMC12022639.
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The Effects of Nocturnal Hypoxemia on Cognitive Performance in Andean Highlanders. High Alt Med Biol. 2025 Dec; 26(4):347-354. Young EV, Djokic MA, Heinrich EC, Marin T, Anza-Ramirez C, Orr JE, Gilbertson D, DeYoung PN, Vizcardo-Galindo G, Figueroa-Mujica R, Villafuerte FC, Malhotra A, Simonson TS. PMID: 39658027.
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Higher oxygen content and transport characterize high-altitude ethnic Tibetan women with the highest lifetime reproductive success. Proc Natl Acad Sci U S A. 2024 Nov 05; 121(45):e2403309121. Ye S, Sun J, Craig SR, Di Rienzo A, Witonsky D, Yu JJ, Moya EA, Simonson TS, Powell FL, Basnyat B, Strohl KP, Hoit BD, Beall CM. PMID: 39432765; PMCID: PMC11551319.
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Transcriptome meta-analysis of Kawasaki disease in humans and mice. Front Pediatr. 2024; 12:1423958. Gu W, Mirsaidi-Madjdabadi S, Ramirez F, Simonson TS, Makino A. PMID: 39350793; PMCID: PMC11440715.
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Development of multiplexed orthogonal base editor (MOBE) systems. Nat Biotechnol. 2025 Apr; 43(4):593-607. Cowan QT, Gu S, Gu W, Ranzau BL, Simonson TS, Komor AC. PMID: 38773305; PMCID: PMC11579250.
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Tibetans exhibit lower hemoglobin concentration and decreased heart response to hypoxia during poikilocapnia at intermediate altitude relative to Han Chinese. Front Physiol. 2024; 15:1334874. Moya EA, Yu JJ, Brown S, Gu W, Lawrence ES, Carlson R, Brandes A, Wegeng W, Amann K, McIntosh SE, Powell FL, Simonson TS. PMID: 38784113; PMCID: PMC11112024.
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Functional EPAS1/HIF2A missense variant is associated with hematocrit in Andean highlanders. Sci Adv. 2024 02 09; 10(6):eadj5661. Lawrence ES, Gu W, Bohlender RJ, Anza-Ramirez C, Cole AM, Yu JJ, Hu H, Heinrich EC, O'Brien KA, Vasquez CA, Cowan QT, Bruck PT, Mercader K, Alotaibi M, Long T, Hall JE, Moya EA, Bauk MA, Reeves JJ, Kong MC, Salem RM, Vizcardo-Galindo G, Macarlupu JL, Figueroa-Mujíca R, Bermudez D, Corante N, Gaio E, Fox KP, Salomaa V, Havulinna AS, Murray AJ, Malhotra A, Powel FL, Jain M, Komor AC, Cavalleri GL, Huff CD, Villafuerte FC, Simonson TS. PMID: 38335297; PMCID: PMC10857371.
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Genomic Selection Signals in Andean Highlanders Reveal Adaptive Placental Metabolic Phenotypes That Are Disrupted in Preeclampsia. Hypertension. 2024 Feb; 81(2):319-329. O'Brien KA, Gu W, Houck JA, Holzner LMW, Yung HW, Armstrong JL, Sowton AP, Baxter R, Darwin PM, Toledo-Jaldin L, Lazo-Vega L, Moreno-Aramayo AE, Miranda-Garrido V, Shortt JA, Matarazzo CJ, Yasini H, Burton GJ, Moore LG, Simonson TS, Murray AJ, Julian CG. PMID: 38018457; PMCID: PMC10841680.
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Inflammation biomarkers in OSA, chronic obstructive pulmonary disease, and chronic obstructive pulmonary disease/OSA overlap syndrome. J Clin Sleep Med. 2023 08 01; 19(8):1447-1456. Sanchez-Azofra A, Gu W, Masso-Silva JA, Sanz-Rubio D, Marin-Oto M, Cubero P, Gil AV, Moya EA, Barnes LA, Mesarwi OA, Marin T, Simonson TS, Crotty Alexander LE, Marin JM, Malhotra A. PMID: 37082823; PMCID: PMC10394367.
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Energy Metabolism Dysregulation in Chronic Kidney Disease. Kidney360. 2023 08 01; 4(8):1080-1094. Li Y, Gu W, Hepokoski M, Pham H, Tham R, Kim YC, Simonson TS, Singh P. PMID: 37222594; PMCID: PMC10476685.
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Very Low Driving-Pressure Ventilation in Patients With COVID-19 Acute Respiratory Distress Syndrome on Extracorporeal Membrane Oxygenation: A Physiologic Study. J Cardiothorac Vasc Anesth. 2023 03; 37(3):423-431. Odish M, Pollema T, Meier A, Hepokoski M, Yi C, Spragg R, Patel HH, Alexander LEC, Sun XS, Jain S, Simonson TS, Malhotra A, Owens RL. PMID: 36567221; PMCID: PMC9701579.
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Preserved peak exercise capacity in Andean highlanders with excessive erythrocytosis both before and after isovolumic hemodilution. J Appl Physiol (1985). 2023 01 01; 134(1):36-49. Anza-Ramírez C, Gu W, Macarlupú JL, Figueroa-Mujíca RJ, Vizcardo-Galindo GA, Heinrich EC, Tift MS, Wagner HE, Wagner PD, Simonson TS, Villafuerte FC. PMID: 36417198; PMCID: PMC9762978.
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Genomic insights into TASK-1 reveal functional roles in sleep apnea. Nat Genet. 2022 10; 54(10):1451-1452. Simonson TS, Moya EA, Malhotra A. PMID: 36195756; PMCID: PMC9556092.
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Isovolemic hemodilution in chronic mountain sickness acutely worsens nocturnal oxygenation and sleep apnea severity. J Clin Sleep Med. 2022 10 01; 18(10):2423-2432. Sanchez-Azofra A, Villafuerte FC, DeYoung PN, Gilbertson D, Gu W, Moya EA, Vizcardo-Galindo G, Figueroa-Mujíca R, Anza-Ramirez C, Macarlupú JL, Pham LV, Wagner P, Malhotra A, Simonson TS, Mesarwi OA. PMID: 35855526; PMCID: PMC9516589.
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Time Domains of Hypoxia Responses and -Omics Insights. Front Physiol. 2022; 13:885295. Yu JJ, Non AL, Heinrich EC, Gu W, Alcock J, Moya EA, Lawrence ES, Tift MS, O'Brien KA, Storz JF, Signore AV, Khudyakov JI, Milsom WK, Wilson SM, Beall CM, Villafuerte FC, Stobdan T, Julian CG, Moore LG, Fuster MM, Stokes JA, Milner R, West JB, Zhang J, Shyy JY, Childebayeva A, Vázquez-Medina JP, Pham LV, Mesarwi OA, Hall JE, Cheviron ZA, Sieker J, Blood AB, Yuan JX, Scott GR, Rana BK, Ponganis PJ, Malhotra A, Powell FL, Simonson TS. PMID: 36035495; PMCID: PMC9400701.
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Combined intermittent and sustained hypoxia is a novel and deleterious cardio-metabolic phenotype. Sleep. 2022 06 13; 45(6). Zhen X, Moya EA, Gautane M, Zhao H, Lawrence ES, Gu W, Barnes LA, Yuan JX, Jain PP, Xiong M, Catalan Serra P, Pham LV, Malhotra A, Simonson TS, Mesarwi OA. PMID: 34893914; PMCID: PMC9189937.
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Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice. Elife. 2022 04 12; 11. Moshensky A, Brand CS, Alhaddad H, Shin J, Masso-Silva JA, Advani I, Gunge D, Sharma A, Mehta S, Jahan A, Nilaad S, Olay J, Gu W, Simonson T, Almarghalani D, Pham J, Perera S, Park K, Al-Kolla R, Moon H, Das S, Byun MK, Shah Z, Sari Y, Heller Brown J, Crotty Alexander LE. PMID: 35411847; PMCID: PMC9005188.
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Diagnostic Accuracy of the Progressive Collapsing Foot Deformity (PCFD) Classification. Foot Ankle Int. 2022 06; 43(6):800-809. Li S, Zhu M, Gu W, Hamati M, Hunt KJ, de Cesar Netto C, Simonson TS, Myerson MS. PMID: 35301895.
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Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation. Life (Basel). 2022 Mar 16; 12(3). O'Brien KA, Murray AJ, Simonson TS. PMID: 35330188; PMCID: PMC8954738.
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High-Altitude Erythrocytosis: Mechanisms of Adaptive and Maladaptive Responses. Physiology (Bethesda). 2022 07 01; 37(4):0. Villafuerte FC, Simonson TS, Bermudez D, León-Velarde F. PMID: 35001654; PMCID: PMC9191173.
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Targeting Mitochondria and Metabolism in Acute Kidney Injury. J Clin Med. 2021 Sep 03; 10(17). Li Y, Hepokoski M, Gu W, Simonson T, Singh P. PMID: 34501442; PMCID: PMC8432487.
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Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells. Front Physiol. 2021; 12:714785. Rodriguez M, Chen J, Jain PP, Babicheva A, Xiong M, Li J, Lai N, Zhao T, Hernandez M, Balistrieri A, Parmisano S, Simonson T, Breen E, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Garcia JGN, Makino A, Yuan JX. PMID: 34408668; PMCID: PMC8364962.
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Halofuginone, a promising drug for treatment of pulmonary hypertension. Br J Pharmacol. 2021 09; 178(17):3373-3394. Jain PP, Zhao T, Xiong M, Song S, Lai N, Zheng Q, Chen J, Carr SG, Babicheva A, Izadi A, Rodriguez M, Rahimi S, Balistrieri F, Rahimi S, Simonson T, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Makino A, Yuan JX. PMID: 33694155; PMCID: PMC9792225.
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Impacts of Changes in Atmospheric O2 on Human Physiology. Is There a Basis for Concern? Front Physiol. 2021; 12:571137. Keeling RF, Powell FL, Shaffer G, Robbins PA, Simonson TS. PMID: 33737880; PMCID: PMC7960674.
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Silent hypoxaemia in COVID-19 patients. J Physiol. 2021 02; 599(4):1057-1065. Simonson TS, Baker TL, Banzett RB, Bishop T, Dempsey JA, Feldman JL, Guyenet PG, Hodson EJ, Mitchell GS, Moya EA, Nokes BT, Orr JE, Owens RL, Poulin M, Rawling JM, Schmickl CN, Watters JJ, Younes M, Malhotra A. PMID: 33347610; PMCID: PMC7902403.
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Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes. Pulm Circ. 2020 Oct-Dec; 10(4):2045894020968531. Romanoski CE, Qi X, Sangam S, Vanderpool RR, Stearman RS, Conklin A, Gonzalez-Garay M, Rischard F, Ayon RJ, Wang J, Simonson T, Babicheva A, Shi Y, Tang H, Makino A, Kanthi Y, Geraci MW, Garcia JGN, Yuan JX, Desai AA. PMID: 33343881; PMCID: PMC7727059.
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Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension. Pulm Circ. 2020 Jul-Sep; 10(3):2045894020948470. Wu K, Tang H, Lin R, Carr SG, Wang Z, Babicheva A, Ayon RJ, Jain PP, Xiong M, Rodriguez M, Rahimi S, Balistrieri F, Rahimi S, Valdez-Jasso D, Simonson TS, Desai AA, Garcia JGN, Shyy JY, Thistlethwaite PA, Wang J, Makino A, Yuan JX. PMID: 33294172; PMCID: PMC7707860.
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Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia. Front Physiol. 2020; 11:886. Tift MS, Alves de Souza RW, Weber J, Heinrich EC, Villafuerte FC, Malhotra A, Otterbein LE, Simonson TS. PMID: 32792988; PMCID: PMC7387684.
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Cross-Species Insights Into Genomic Adaptations to Hypoxia. Front Genet. 2020; 11:743. Pamenter ME, Hall JE, Tanabe Y, Simonson TS. PMID: 32849780; PMCID: PMC7387696.
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Seq-ing Higher Ground: Functional Investigation of Adaptive Variation Associated With High-Altitude Adaptation. Front Genet. 2020; 11:471. Hall JE, Lawrence ES, Simonson TS, Fox K. PMID: 32528523; PMCID: PMC7247851.
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Relationships Between Chemoreflex Responses, Sleep Quality, and Hematocrit in Andean Men and Women. Front Physiol. 2020; 11:437. Heinrich EC, Orr JE, Gilbertson D, Anza-Ramirez C, DeYoung PN, Djokic MA, Corante N, Vizcardo-Galindo G, Macarlupu JL, Gaio E, Powell FL, Malhotra A, Villafuerte FC, Simonson TS. PMID: 32435207; PMCID: PMC7219107.
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Variability in hypoxic response: Could genetics play a role? J Physiol. 2020 05; 598(10):1805-1806. Simonson TS, Malhotra A. PMID: 32281106; PMCID: PMC7450394.
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Neuronal HIF-1α in the nucleus tractus solitarius contributes to ventilatory acclimatization to hypoxia. J Physiol. 2020 05; 598(10):2021-2034. Moya EA, Go A, Kim CB, Fu Z, Simonson TS, Powell FL. PMID: 32026480; PMCID: PMC7230006.
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Cognitive function and mood at high altitude following acclimatization and use of supplemental oxygen and adaptive servoventilation sleep treatments. PLoS One. 2019; 14(6):e0217089. Heinrich EC, Djokic MA, Gilbertson D, DeYoung PN, Bosompra NO, Wu L, Anza-Ramirez C, Orr JE, Powell FL, Malhotra A, Simonson TS. PMID: 31188839; PMCID: PMC6561544.
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Genetic variants at the EGLN1 locus associated with high-altitude adaptation in Tibetans are absent or found at low frequency in highland Andeans. Ann Hum Genet. 2019 05; 83(3):171-176. Heinrich EC, Wu L, Lawrence ES, Cole AM, Anza-Ramirez C, Villafuerte FC, Simonson TS. PMID: 30719713; PMCID: PMC7920394.
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Giants in Chest Medicine: Emeritus Professor Peter D. Wagner, MD. Chest. 2019 01; 155(1):9-11. Simonson TS. PMID: 30616739.
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Adaptive Servoventilation as Treatment for Central Sleep Apnea Due to High-Altitude Periodic Breathing in Nonacclimatized Healthy Individuals. High Alt Med Biol. 2018 06; 19(2):178-184. Orr JE, Heinrich EC, Djokic M, Gilbertson D, Deyoung PN, Anza-Ramirez C, Villafuerte FC, Powell FL, Malhotra A, Simonson T. PMID: 29641294; PMCID: PMC6014053.
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Evolutionary history of Tibetans inferred from whole-genome sequencing. PLoS Genet. 2017 04; 13(4):e1006675. Hu H, Petousi N, Glusman G, Yu Y, Bohlender R, Tashi T, Downie JM, Roach JC, Cole AM, Lorenzo FR, Rogers AR, Brunkow ME, Cavalleri G, Hood L, Alpatty SM, Prchal JT, Jorde LB, Robbins PA, Simonson TS, Huff CD. PMID: 28448578; PMCID: PMC5407610.
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Measurement of the distribution of ventilation-perfusion ratios in the human lung with proton MRI: comparison with the multiple inert-gas elimination technique. J Appl Physiol (1985). 2017 Jul 01; 123(1):136-146. Sá RC, Henderson AC, Simonson T, Arai TJ, Wagner H, Theilmann RJ, Wagner PD, Prisk GK, Hopkins SR. PMID: 28280105; PMCID: PMC5538816.
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Sea-level haemoglobin concentration is associated with greater exercise capacity in Tibetan males at 4200 m. Exp Physiol. 2015 Nov; 100(11):1256-62. Wagner PD, Simonson TS, Wei G, Wagner HE, Wuren T, Qin G, Yan M, Ge RL. PMID: 26454003.
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Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans. Exp Physiol. 2015 Nov; 100(11):1263-8. Simonson TS, Huff CD, Witherspoon DJ, Prchal JT, Jorde LB. PMID: 26454145.
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Oxygen transport adaptations to exercise in native highland populations. Exp Physiol. 2015 Nov; 100(11):1231-2. Simonson TS, Wagner PD. PMID: 26575339.
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Metabolic aspects of high-altitude adaptation in Tibetans. Exp Physiol. 2015 Nov; 100(11):1247-55. Ge RL, Simonson TS, Gordeuk V, Prchal JT, McClain DA. PMID: 26053282; PMCID: PMC10905973.
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Low haemoglobin concentration in Tibetan males is associated with greater high-altitude exercise capacity. J Physiol. 2015 Jul 15; 593(14):3207-18. Simonson TS, Wei G, Wagner HE, Wuren T, Qin G, Yan M, Wagner PD, Ge RL. PMID: 25988759; PMCID: PMC4532538.
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Altitude Adaptation: A Glimpse Through Various Lenses. High Alt Med Biol. 2015 Jun; 16(2):125-37. Simonson TS. PMID: 26070057; PMCID: PMC4490743.
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Increased blood-oxygen binding affinity in Tibetan and Han Chinese residents at 4200 m. Exp Physiol. 2014 Dec 01; 99(12):1624-35. Simonson TS, Wei G, Wagner HE, Wuren T, Bui A, Fine JM, Qin G, Beltrami FG, Yan M, Wagner PD, Ge RL. PMID: 25172885; PMCID: PMC4272572.
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A genetic mechanism for Tibetan high-altitude adaptation. Nat Genet. 2014 Sep; 46(9):951-6. Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin WG, Koivunen P, Prchal JT. PMID: 25129147; PMCID: PMC4473257.
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Shared and unique signals of high-altitude adaptation in geographically distinct Tibetan populations. PLoS One. 2014; 9(3):e88252. Wuren T, Simonson TS, Qin G, Xing J, Huff CD, Witherspoon DJ, Jorde LB, Ge RL. PMID: 24642866; PMCID: PMC3958363.
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Less is more: blunted responses to hypoxia revealed in sea-level Tibetans. J Appl Physiol (1985). 2014 Apr 01; 116(7):711-2. Simonson TS, Powell FL. PMID: 24114703.
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Genomic analysis of natural selection and phenotypic variation in high-altitude mongolians. PLoS Genet. 2013; 9(7):e1003634. Xing J, Wuren T, Simonson TS, Watkins WS, Witherspoon DJ, Wu W, Qin G, Huff CD, Jorde LB, Ge RL. PMID: 23874230; PMCID: PMC3715426.
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Metabolic insight into mechanisms of high-altitude adaptation in Tibetans. Mol Genet Metab. 2012 Jun; 106(2):244-7. Ge RL, Simonson TS, Cooksey RC, Tanna U, Qin G, Huff CD, Witherspoon DJ, Xing J, Zhengzhong B, Prchal JT, Jorde LB, McClain DA. PMID: 22503288; PMCID: PMC3437309.
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Genetic determinants of Tibetan high-altitude adaptation. Hum Genet. 2012 Apr; 131(4):527-33. Simonson TS, McClain DA, Jorde LB, Prchal JT. PMID: 22068265.
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Crohn's disease and genetic hitchhiking at IBD5. Mol Biol Evol. 2012 Jan; 29(1):101-11. Huff CD, Witherspoon DJ, Zhang Y, Gatenbee C, Denson LA, Kugathasan S, Hakonarson H, Whiting A, Davis CT, Wu W, Xing J, Watkins WS, Bamshad MJ, Bradfield JP, Bulayeva K, Simonson TS, Jorde LB, Guthery SL. PMID: 21816865; PMCID: PMC3245542.
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Signatures of the preagricultural peopling processes in sub-Saharan Africa as revealed by the phylogeography of early Y chromosome lineages. Mol Biol Evol. 2011 Sep; 28(9):2603-13. Batini C, Ferri G, Destro-Bisol G, Brisighelli F, Luiselli D, Sánchez-Diz P, Rocha J, Simonson T, Brehm A, Montano V, Elwali NE, Spedini G, D'Amato ME, Myres N, Ebbesen P, Comas D, Capelli C. PMID: 21478374.
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Maximum-likelihood estimation of recent shared ancestry (ERSA). Genome Res. 2011 May; 21(5):768-74. Huff CD, Witherspoon DJ, Simonson TS, Xing J, Watkins WS, Zhang Y, Tuohy TM, Neklason DW, Burt RW, Guthery SL, Woodward SR, Jorde LB. PMID: 21324875; PMCID: PMC3083094.
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Ancestry of the Iban is predominantly Southeast Asian: genetic evidence from autosomal, mitochondrial, and Y chromosomes. PLoS One. 2011 Jan 31; 6(1):e16338. Simonson TS, Xing J, Barrett R, Jerah E, Loa P, Zhang Y, Watkins WS, Witherspoon DJ, Huff CD, Woodward S, Mowry B, Jorde LB. PMID: 21305013; PMCID: PMC3031551.
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Toward a more uniform sampling of human genetic diversity: a survey of worldwide populations by high-density genotyping. Genomics. 2010 Oct; 96(4):199-210. Xing J, Watkins WS, Shlien A, Walker E, Huff CD, Witherspoon DJ, Zhang Y, Simonson TS, Weiss RB, Schiffman JD, Malkin D, Woodward SR, Jorde LB. PMID: 20643205; PMCID: PMC2945611.
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Genetic evidence for high-altitude adaptation in Tibet. Science. 2010 Jul 02; 329(5987):72-5. Simonson TS, Yang Y, Huff CD, Yun H, Qin G, Witherspoon DJ, Bai Z, Lorenzo FR, Xing J, Jorde LB, Prchal JT, Ge R. PMID: 20466884.
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Limited distribution of a cardiomyopathy-associated variant in India. Ann Hum Genet. 2010 Mar; 74(2):184-8. Simonson TS, Zhang Y, Huff CD, Xing J, Watkins WS, Witherspoon DJ, Woodward SR, Jorde LB. PMID: 20201939; PMCID: PMC2901538.
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Genetic adaptation to extreme hypoxia: study of high-altitude pulmonary edema in a three-generation Han Chinese family. Blood Cells Mol Dis. 2009 Nov-Dec; 43(3):221-5. Lorenzo VF, Yang Y, Simonson TS, Nussenzveig R, Jorde LB, Prchal JT, Ge RL. PMID: 19481479; PMCID: PMC3506116.
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Bacillus anthracis in China and its relationship to worldwide lineages. BMC Microbiol. 2009 Apr 15; 9:71. Simonson TS, Okinaka RT, Wang B, Easterday WR, Huynh L, U'Ren JM, Dukerich M, Zanecki SR, Kenefic LJ, Beaudry J, Schupp JM, Pearson T, Wagner DM, Hoffmaster A, Ravel J, Keim P. PMID: 19368722; PMCID: PMC2674057.
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Global genetic population structure of Bacillus anthracis. PLoS One. 2007 May 23; 2(5):e461. Van Ert MN, Easterday WR, Huynh LY, Okinaka RT, Hugh-Jones ME, Ravel J, Zanecki SR, Pearson T, Simonson TS, U'Ren JM, Kachur SM, Leadem-Dougherty RR, Rhoton SD, Zinser G, Farlow J, Coker PR, Smith KL, Wang B, Kenefic LJ, Fraser-Liggett CM, Wagner DM, Keim P. PMID: 17520020; PMCID: PMC1866244.
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Strain-specific single-nucleotide polymorphism assays for the Bacillus anthracis Ames strain. J Clin Microbiol. 2007 Jan; 45(1):47-53. Van Ert MN, Easterday WR, Simonson TS, U'Ren JM, Pearson T, Kenefic LJ, Busch JD, Huynh LY, Dukerich M, Trim CB, Beaudry J, Welty-Bernard A, Read T, Fraser CM, Ravel J, Keim P. PMID: 17093023; PMCID: PMC1828967.
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Use of a real-time PCR TaqMan assay for rapid identification and differentiation of Burkholderia pseudomallei and Burkholderia mallei. J Clin Microbiol. 2005 Nov; 43(11):5771-4. U'Ren JM, Van Ert MN, Schupp JM, Easterday WR, Simonson TS, Okinaka RT, Pearson T, Keim P. PMID: 16272516; PMCID: PMC1287822.
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Use of single nucleotide polymorphisms in the plcR gene for specific identification of Bacillus anthracis. J Clin Microbiol. 2005 Apr; 43(4):1995-7. Easterday WR, Van Ert MN, Simonson TS, Wagner DM, Kenefic LJ, Allender CJ, Keim P. PMID: 15815042; PMCID: PMC1081367.
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Mass spectrometry provides accurate characterization of two genetic marker types in Bacillus anthracis. Biotechniques. 2004 Oct; 37(4):642-4, 646, 648 passim. Van Ert MN, Hofstadler SA, Jiang Y, Busch JD, Wagner DM, Drader JJ, Ecker DJ, Hannis JC, Huynh LY, Schupp JM, Simonson TS, Keim P. PMID: 15517976.
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Phylogenetic discovery bias in Bacillus anthracis using single-nucleotide polymorphisms from whole-genome sequencing. Proc Natl Acad Sci U S A. 2004 Sep 14; 101(37):13536-41. Pearson T, Busch JD, Ravel J, Read TD, Rhoton SD, U'Ren JM, Simonson TS, Kachur SM, Leadem RR, Cardon ML, Van Ert MN, Huynh LY, Fraser CM, Keim P. PMID: 15347815; PMCID: PMC518758.
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Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr. 1998 Sep 01; 54(Pt 5):905-21. Brünger AT, Adams PD, Clore GM, DeLano WL, Gros P, Grosse-Kunstleve RW, Jiang JS, Kuszewski J, Nilges M, Pannu NS, Read RJ, Rice LM, Simonson T, Warren GL. PMID: 9757107.
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