1. Michael Sammeth, Stephen B. Montgomery & Ralf Sudbrak

    Present address: Present addresses: Bioinformatics Laboratory, National Laboratory of Scientific Computing (LNCC), Petropolis 25651-075, Rio de Janeiro, Brazil (M.S.); Departments of Pathology and Genetics, Stanford University, Stanford, California 94305-5324, USA (S.B.M.); Alacris Theranostics GmbH, 14195 Berlin, Germany (R.S.).,

  2. Michael Sammeth, Marc R. Friedländer, Peter A. C. ‘t Hoen, Jean Monlong and Manuel A. Rivas: These authors contributed equally to this work.

  1. Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland,

    Tuuli Lappalainen, Thomas Giger, Ismael Padioleau, Halit Ongen, Helena Kilpinen, Stephen B. Montgomery, Stylianos E. Antonarakis & Emmanouil T. Dermitzakis

  2. Institute for Genetics and Genomics in Geneva (iG3), University of Geneva, 1211 Geneva, Switzerland,

    Tuuli Lappalainen, Ismael Padioleau, Halit Ongen, Helena Kilpinen, Stylianos E. Antonarakis & Emmanouil T. Dermitzakis

  3. Swiss Institute of Bioinformatics, 1211 Geneva, Switzerland,

    Tuuli Lappalainen, Ismael Padioleau, Halit Ongen, Helena Kilpinen & Emmanouil T. Dermitzakis

  4. Centro Nacional de Análisis Genómico, 08028 Barcelona, Catalonia, Spain,

    Michael Sammeth, Thasso Griebel, Paolo Ribeca, Sergi Beltran, Marta Gut, Katja Kahlem & Ivo G. Gut

  5. Centre for Genomic Regulation (CRG), 08003 Barcelona, Catalonia, Spain,

    Michael Sammeth, Marc R. Friedländer, Jean Monlong, Pedro G. Ferreira, Gabrielle Bertier, Esther Lizano, Roderic Guigó & Xavier Estivill

  6. Pompeu Fabra University (UPF), 08003 Barcelona, Catalonia, Spain,

    Michael Sammeth, Marc R. Friedländer, Jean Monlong, Pedro G. Ferreira, Gabrielle Bertier, Esther Lizano, Roderic Guigó & Xavier Estivill

  7. CRG Hospital del Mar Research Institute, 08003 Barcelona, Catalonia, Spain,

    Michael Sammeth, Marc R. Friedländer, Jean Monlong, Pedro G. Ferreira, Esther Lizano, Roderic Guigó & Xavier Estivill

  8. CRG CIBERESP, 08003 Barcelona, Catalonia, Spain,

    Marc R. Friedländer, Esther Lizano & Xavier Estivill

  9. Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, the Netherlands,

    Peter A. C. ‘t Hoen, Maarten van Iterson, Irina Pulyakhina, Henk P. J. Buermans & Gert-Jan van Ommen

  10. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK,

    Manuel A. Rivas, Matti Pirinen, Peter Donnelly & Mark I. McCarthy

  11. European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, CB10 1SD, UK,

    Mar Gonzàlez-Porta, Natalja Kurbatova, Liliana Greger, Andrew Tikhonov, Oliver Stegle, Paul Flicek & Alvis Brazma

  12. Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, D-24105 Kiel, Germany,

    Matthias Barann, Daniela Esser, Stefan Schreiber, Robert Häsler & Philip Rosenstiel

  13. Institute of Human Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany,

    Thomas Wieland, Thomas Schwarzmayr, Tim M. Strom & Thomas Meitinger

  14. Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden,

    Jonas Almlöf, Olof Karlberg & Ann-Christine Syvänen

  15. Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany,

    Marc Sultan, Vyacheslav Amstislavskiy, Hans Lehrach & Ralf Sudbrak

  16. Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, 02114, Massachusetts, USA

    Daniel G. MacArthur & Monkol Lek

  17. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, 02142, Massachusetts, USA

    Daniel G. MacArthur & Monkol Lek

  18. Leiden Genome Technology Center, 2300 RC Leiden, the Netherlands,

    Henk P. J. Buermans

  19. Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Oxford OX3 7BN, UK,

    Mark I. McCarthy

  20. Institute of Human Genetics, Technische Universität München, 81675 Munich, Germany,

    Tim M. Strom & Thomas Meitinger

  21. Dahlem Centre for Genome Research and Medical Systems Biology, 14195 Berlin, Germany,

    Hans Lehrach & Ralf Sudbrak

  22. Fundacion Publica Galega de Medicina Xenomica (SERGAS), Genomic Medicine Group, CIBERER, Universidade de Santiago de Compostela, Santiago de Compostela, Spain,

    Ángel Carracedo

  23. Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK), Partner Site Munich Heart Alliance, 81675 Munich, Germany,

    Thomas Meitinger

Designed the study: T.L., T.Gi., S.B.M., P.AC.H., E.L., H.L., S.S., R.S., A.C., S.E.A., R.H., A.-C.S., G.-J.v.O., A.B., T.M., P.Ro., R.G., I.G.G., X.E. and E.T.D. Coordinated the project: T.L., T.Gi., G.B., X.E. and E.T.D. Participated in data production: T.L., T.Gi., I.Pa., M.Su., E.L., S.B., M.G., V.A., K.K., D.E., P.Ri. and O.K. Analysed the data: T.L., M.Sa., M.R.F., P.A.C.H., J.M., M.A.R., M.G.-P., N.K., T.Gr., P.G.F., M.B., T.W., L.G., M.v.I., J.A., P.Ri., I.Pu., D.E., A.T., M.Su., D.G.M., M.L., E.L., H.P.J.B., I.Pa., T.S., O.K., H.O., H.K., S.B., M.G., K.K., V.A., O.S., M.P., P.D., M.I.M., P.F. and T.M.S. Drafted the paper: T.L. and E.T.D. See Supplementary Note for Members of the Geuvadis Consortium.