-
L. pneumophila CMP-5,7-di-N-acetyllegionaminic acid synthetase (LpCLS)-involved chemoenzymatic synthesis of sialosides and analogues. Org Biomol Chem. 2020 01 28; 18(4):738-744. McArthur JB, Santra A, Li W, Kooner AS, Liu Z, Yu H, Chen X. PMID: 31912849; PMCID: PMC7098451.
-
Enterococcus faecalis α1-2-mannosidase (EfMan-I): an efficient catalyst for glycoprotein N-glycan modification. FEBS Lett. 2020 02; 594(3):439-451. Li Y, Li R, Yu H, Sheng X, Wang J, Fisher AJ, Chen X. PMID: 31552675; PMCID: PMC7012691.
-
Catalytic Cycle of Neisseria meningitidis CMP-Sialic Acid Synthetase Illustrated by High-Resolution Protein Crystallography. Biochemistry. 2020 09 01; 59(34):3157-3168. Matthews MM, McArthur JB, Li Y, Yu H, Chen X, Fisher AJ. PMID: 31583886; PMCID: PMC7814854.
-
Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides. Front Immunol. 2019; 10:2004. Kooner AS, Yu H, Chen X. PMID: 31555264; PMCID: PMC6724515.
-
Elicited and pre-existing anti-Neu5Gc antibodies differentially affect human endothelial cells transcriptome. Xenotransplantation. 2019 11; 26(6):e12535. Le Berre L, Danger R, Mai HL, Amon R, Leviatan Ben-Arye S, Bruneau S, Senage T, Perreault H, Teraiya M, Nguyen TVH, Le Tourneau T, Yu H, Chen X, Galli C, Roussel JC, Manez R, Costa C, Brouard S, Galinanes M, Harris KM, Gitelman S, Cozzi E, Charreau B, Padler-Karavani V, Soulillou JP. PMID: 31293002.
-
9-Azido-9-deoxy-2,3-difluorosialic Acid as a Subnanomolar Inhibitor against Bacterial Sialidases. J Org Chem. 2019 06 07; 84(11):6697-6708. Li W, Santra A, Yu H, Slack TJ, Muthana MM, Shi D, Liu Y, Chen X. PMID: 31083938; PMCID: PMC6660241.
-
Biochemical characterization of Helicobacter pylori α1-3-fucosyltransferase and its application in the synthesis of fucosylated human milk oligosaccharides. Carbohydr Res. 2019 Jul 01; 480:1-6. Bai J, Wu Z, Sugiarto G, Gadi MR, Yu H, Li Y, Xiao C, Ngo A, Zhao B, Chen X, Guan W. PMID: 31132553; PMCID: PMC6613818.
-
A substrate tagging and two-step enzymatic reaction strategy for large-scale synthesis of 2,7-anhydro-sialic acid. Carbohydr Res. 2019 Jun 01; 479:41-47. Li W, Ghosh T, Bai Y, Santra A, Xiao A, Chen X. PMID: 31132641; PMCID: PMC6660240.
-
Differential Recognition of Diet-Derived Neu5Gc-Neoantigens on Glycan Microarrays by Carbohydrate-Specific Pooled Human IgG and IgA Antibodies. Bioconjug Chem. 2019 05 15; 30(5):1565-1574. Leviatan Ben-Arye S, Schneider C, Yu H, Bashir S, Chen X, von Gunten S, Padler-Karavani V. PMID: 30994337; PMCID: PMC6756923.
-
Biomimetic Glyconanoparticle Vaccine for Cancer Immunotherapy. ACS Nano. 2019 03 26; 13(3):2936-2947. Reuven EM, Leviatan Ben-Arye S, Yu H, Duchi R, Perota A, Conchon S, Bachar Abramovitch S, Soulillou JP, Galli C, Chen X, Padler-Karavani V. PMID: 30840433; PMCID: PMC6756924.
-
Quantitative and qualitative changes in anti-Neu5Gc antibody response following rabbit anti-thymocyte IgG induction in kidney allograft recipients. Eur J Clin Invest. 2019 Apr; 49(4):e13069. Rousse J, Salama A, Leviatan Ben-Arye S, Hruba P, Slatinska J, Evanno G, Duvaux O, Blanchard D, Yu H, Chen X, Bach JM, Padler-Karavani V, Viklicky O, Soulillou JP. PMID: 30620396.
-
Production of Glycopeptide Derivatives for Exploring Substrate Specificity of Human OGA Toward Sugar Moiety. Front Chem. 2018; 6:646. Li S, Wang J, Zang L, Zhu H, Guo J, Zhang J, Wen L, Chen Y, Li Y, Chen X, Wang PG, Li J. PMID: 30693278; PMCID: PMC6340312.
-
Targeting Base Excision Repair Glycosylases with DNA Containing Transition State Mimics Prepared via Click Chemistry. ACS Chem Biol. 2019 01 18; 14(1):27-36. Yuen PK, Green SA, Ashby J, Lay KT, Santra A, Chen X, Horvath MP, David SS. PMID: 30500207; PMCID: PMC6825804.
-
Presentation Mode of Glycans Affect Recognition of Human Serum anti-Neu5Gc IgG Antibodies. Bioconjug Chem. 2019 01 16; 30(1):161-168. Bashir S, Leviatan Ben Arye S, Reuven EM, Yu H, Costa C, Galiñanes M, Bottio T, Chen X, Padler-Karavani V. PMID: 30500162; PMCID: PMC6768799.
-
Facile chemoenzymatic synthesis of Lewis a (Lea) antigen in gram-scale and sialyl Lewis a (sLea) antigens containing diverse sialic acid forms. Carbohydr Res. 2019 Jan 15; 472:115-121. Tasnima N, Yu H, Yan X, Li W, Xiao A, Chen X. PMID: 30562693; PMCID: PMC6417886.
-
Regioselective One-Pot Multienzyme (OPME) Chemoenzymatic Strategies for Systematic Synthesis of Sialyl Core 2 Glycans. ACS Catal. 2019 Jan 04; 9(1):211-215. Santra A, Li Y, Ghosh T, Li R, Yu H, Chen X. PMID: 31304048; PMCID: PMC6625783.
-
Strategies for chemoenzymatic synthesis of carbohydrates. Carbohydr Res. 2019 Jan 15; 472:86-97. Li W, McArthur JB, Chen X. PMID: 30529493; PMCID: PMC6342554.
-
Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. Bioorg Med Chem. 2018 11 15; 26(21):5751-5757. Slack TJ, Li W, Shi D, McArthur JB, Zhao G, Li Y, Xiao A, Khedri Z, Yu H, Liu Y, Chen X. PMID: 30389408; PMCID: PMC6326775.
-
Streptococcus pneumoniae Sialidase SpNanB-Catalyzed One-Pot Multienzyme (OPME) Synthesis of 2,7-Anhydro-Sialic Acids as Selective Sialidase Inhibitors. J Org Chem. 2018 09 21; 83(18):10798-10804. Xiao A, Slack TJ, Li Y, Shi D, Yu H, Li W, Liu Y, Chen X. PMID: 30105908; PMCID: PMC6327951.
-
A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen. Sci Rep. 2018 Jul 17; 8(1):10786. Amon R, Grant OC, Leviatan Ben-Arye S, Makeneni S, Nivedha AK, Marshanski T, Norn C, Yu H, Glushka JN, Fleishman SJ, Chen X, Woods RJ, Padler-Karavani V. PMID: 30018351; PMCID: PMC6050261.
-
Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. PLoS Pathog. 2018 06; 14(6):e1007133. Alisson-Silva F, Liu JZ, Diaz SL, Deng L, Gareau MG, Marchelletta R, Chen X, Nizet V, Varki N, Barrett KE, Varki A. PMID: 29912959; PMCID: PMC6023241.
-
Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk. PLoS One. 2018; 13(6):e0197464. Samraj AN, Bertrand KA, Luben R, Khedri Z, Yu H, Nguyen D, Gregg CJ, Diaz SL, Sawyer S, Chen X, Eliassen H, Padler-Karavani V, Wu K, Khaw KT, Willett W, Varki A. PMID: 29912879; PMCID: PMC6005533.
-
Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens. Org Biomol Chem. 2018 06 06; 16(22):4076-4080. Yu H, Santra A, Li Y, McArthur JB, Ghosh T, Yang X, Wang PG, Chen X. PMID: 29789847; PMCID: PMC5991974.
-
Serine-Rich Repeat Adhesins Mediate Shear-Enhanced Streptococcal Binding to Platelets. Infect Immun. 2018 06; 86(6). Yakovenko O, Nunez J, Bensing B, Yu H, Mount J, Zeng J, Hawkins J, Chen X, Sullam PM, Thomas W. PMID: 29581195; PMCID: PMC5964516.
-
α2-6-Neosialidase: A Sialyltransferase Mutant as a Sialyl Linkage-Specific Sialidase. ACS Chem Biol. 2018 05 18; 13(5):1228-1234. McArthur JB, Yu H, Tasnima N, Lee CM, Fisher AJ, Chen X. PMID: 29543427; PMCID: PMC5978697.
-
Poor Patient and Graft Outcome After Induction Treatment by Antithymocyte Globulin in Recipients of a Kidney Graft After Nonrenal Organ Transplantation. Transplant Direct. 2018 Apr; 4(4):e357. Mai HL, Treilhaud M, Ben-Arye SL, Yu H, Perreault H, Ang E, Trébern-Launay K, Laurent J, Malard-Castagnet S, Cesbron A, Nguyen TVH, Brouard S, Rostaing L, Houssel-Debry P, Legendre C, Girerd S, Kessler M, Morelon E, Sicard A, Garrigue V, Karam G, Chen X, Giral M, Padler-Karavani V, Soulillou JP. PMID: 29707628; PMCID: PMC5908458.
-
A Diazido Mannose Analogue as a Chemoenzymatic Synthon for Synthesizing Di-N-acetyllegionaminic Acid-Containing Glycosides. Angew Chem Int Ed Engl. 2018 03 05; 57(11):2929-2933. Santra A, Xiao A, Yu H, Li W, Li Y, Ngo L, McArthur JB, Chen X. PMID: 29349857; PMCID: PMC5991975.
-
Interaction of Neisseria meningitidis Group X N-acetylglucosamine-1-phosphotransferase with its donor substrate. Glycobiology. 2018 02 01; 28(2):100-107. Ming SA, Cottman-Thomas E, Black NC, Chen Y, Veeramachineni V, Peterson DC, Chen X, Tedaldi LM, Wagner GK, Cai C, Linhardt RJ, Vann WF. PMID: 29228283.
-
Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus. Nat Commun. 2017 12 19; 8(1):2196. Owen CD, Tailford LE, Monaco S, Šuligoj T, Vaux L, Lallement R, Khedri Z, Yu H, Lecointe K, Walshaw J, Tribolo S, Horrex M, Bell A, Chen X, Taylor GL, Varki A, Angulo J, Juge N. PMID: 29259165; PMCID: PMC5736709.
-
Glycan microarray reveal induced IgGs repertoire shift against a dietary carbohydrate in response to rabbit anti-human thymocyte therapy. Oncotarget. 2017 Dec 22; 8(68):112236-112244. Amon R, Ben-Arye SL, Engler L, Yu H, Lim N, Berre LL, Harris KM, Ehlers MR, Gitelman SE, Chen X, Soulillou JP, Padler-Karavani V. PMID: 29348821; PMCID: PMC5762506.
-
Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates. BMC Evol Biol. 2017 11 23; 17(1):228. Hayakawa T, Khedri Z, Schwarz F, Landig C, Liang SY, Yu H, Chen X, Fujito NT, Satta Y, Varki A, Angata T. PMID: 29169316; PMCID: PMC5701461.
-
Enzymatic and Chemoenzymatic Syntheses of Disialyl Glycans and Their Necrotizing Enterocolitis Preventing Effects. J Org Chem. 2017 12 15; 82(24):13152-13160. Yu H, Yan X, Autran CA, Li Y, Etzold S, Latasiewicz J, Robertson BM, Li J, Bode L, Chen X. PMID: 29124935; PMCID: PMC5764747.
-
Sialidase-catalyzed one-pot multienzyme (OPME) synthesis of sialidase transition-state analogue inhibitors. ACS Catal. 2018 Jan 05; 8(1):43-47. Xiao A, Li Y, Li X, Santra A, Yu H, Li W, Chen X. PMID: 29713561; PMCID: PMC5920526.
-
Evolution of host adaptation in the Salmonella typhoid toxin. Nat Microbiol. 2017 Dec; 2(12):1592-1599. Gao X, Deng L, Stack G, Yu H, Chen X, Naito-Matsui Y, Varki A, Galán JE. PMID: 28993610; PMCID: PMC5705260.
-
H. pylori α1-3/4-fucosyltransferase (Hp3/4FT)-catalyzed one-pot multienzyme (OPME) synthesis of Lewis antigens and human milk fucosides. Chem Commun (Camb). 2017 Oct 05; 53(80):11012-11015. Yu H, Li Y, Wu Z, Li L, Zeng J, Zhao C, Wu Y, Tasnima N, Wang J, Liu H, Gadi MR, Guan W, Wang PG, Chen X. PMID: 28936496; PMCID: PMC5662472.
-
Chemoenzymatic synthesis of Neu5Ac9NAc-containing α2-3- and α2-6-linked sialosides and their use for sialidase substrate specificity studies. Carbohydr Res. 2017 Nov 08; 451:51-58. Li W, Xiao A, Li Y, Yu H, Chen X. PMID: 28961426; PMCID: PMC5662470.
-
Distribution of O-Acetylated Sialic Acids among Target Host Tissues for Influenza Virus. mSphere. 2017 Sep-Oct; 2(5). Wasik BR, Barnard KN, Ossiboff RJ, Khedri Z, Feng KH, Yu H, Chen X, Perez DR, Varki A, Parrish CR. PMID: 28904995; PMCID: PMC5588038.
-
Membrane-enclosed multienzyme (MEME) synthesis of 2,7-anhydro-sialic acid derivatives. Carbohydr Res. 2017 Nov 08; 451:110-117. Monestier M, Latousakis D, Bell A, Tribolo S, Tailford LE, Colquhoun IJ, Le Gall G, Yu H, Chen X, Rejzek M, Dedola S, Field RA, Juge N. PMID: 28851488; PMCID: PMC5667892.
-
The Trypomastigote Small Surface Antigen (TSSA) regulates Trypanosoma cruzi infectivity and differentiation. PLoS Negl Trop Dis. 2017 Aug; 11(8):e0005856. Cámara MLM, Cánepa GE, Lantos AB, Balouz V, Yu H, Chen X, Campetella O, Mucci J, Buscaglia CA. PMID: 28800609; PMCID: PMC5568413.
-
Highly efficient chemoenzymatic synthesis and facile purification of α-Gal pentasaccharyl ceramide Galα3nLc4βCer. Chem Commun (Camb). 2017 Jul 20; 53(59):8280-8283. Santra A, Li Y, Yu H, Slack TJ, Wang PG, Chen X. PMID: 28695219; PMCID: PMC5597046.
-
Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay. J Vis Exp. 2017 07 13; (125). Leviatan Ben-Arye S, Yu H, Chen X, Padler-Karavani V. PMID: 28745644; PMCID: PMC5612302.
-
A general strategy for the synthesis of homogeneous hyaluronan conjugates and their biological applications. Chem Commun (Camb). 2017 Mar 23; 53(25):3555-3558. Fu X, Shang W, Wang S, Liu Y, Qu J, Chen X, Wang PG, Fang J. PMID: 28286894.
-
Converting Pasteurella multocidaα2-3-sialyltransferase 1 (PmST1) to a regioselective α2-6-sialyltransferase by saturation mutagenesis and regioselective screening. Org Biomol Chem. 2017 Feb 21; 15(7):1700-1709. McArthur JB, Yu H, Zeng J, Chen X. PMID: 28134951; PMCID: PMC5333693.
-
Chemoenzymatic synthesis of para-nitrophenol (pNP)-tagged α2-8-sialosides and high-throughput substrate specificity studies of α2-8-sialidases. Org Biomol Chem. 2016 Dec 20; 15(1):160-167. Tasnima N, Yu H, Li Y, Santra A, Chen X. PMID: 27924345; PMCID: PMC5173422.
-
A Chemical Biology Solution to Problems with Studying Biologically Important but Unstable 9-O-Acetyl Sialic Acids. ACS Chem Biol. 2017 01 20; 12(1):214-224. Khedri Z, Xiao A, Yu H, Landig CS, Li W, Diaz S, Wasik BR, Parrish CR, Wang LP, Varki A, Chen X. PMID: 27936566; PMCID: PMC5704959.
-
Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E. J Biol Chem. 2017 01 20; 292(3):1029-1037. Siddiqui S, Schwarz F, Springer S, Khedri Z, Yu H, Deng L, Verhagen A, Naito-Matsui Y, Jiang W, Kim D, Zhou J, Ding B, Chen X, Varki N, Varki A. PMID: 27920204; PMCID: PMC5247637.
-
Enzymatic synthesis of human blood group P1 pentasaccharide antigen. Carbohydr Res. 2017 Jan 13; 438:39-43. Tsering D, Chen C, Ye J, Han Z, Jing BQ, Liu XW, Chen X, Wang F, Ling P, Cao H. PMID: 27960098.
-
Diversity-Oriented Enzymatic Modular Assembly of ABO Histo-blood Group Antigens. ACS Catalysis. 2016 Dec 2; 6(12):8140-8144. Ye YJ, Liu LX, Peng PP, Yi YW, Chen CX, Wang WF, Cao CH. .
-
Identification of the binding roles of terminal and internal glycan epitopes using enzymatically synthesized N-glycans containing tandem epitopes. Org Biomol Chem. 2016 Nov 29; 14(47):11106-11116. Wu Z, Liu Y, Ma C, Li L, Bai J, Byrd-Leotis L, Lasanajak Y, Guo Y, Wen L, Zhu H, Song J, Li Y, Steinhauer DA, Smith DF, Zhao B, Chen X, Guan W, Wang PG. PMID: 27752690; PMCID: PMC5951163.
-
Chemoenzymatic synthesis of tumor-associated antigen N3 minor octasaccharide. Journal of Carbohydrate Chemistry. 2016 Nov 21; 35(8-9):1-11. Han HZ, Chen CC, Meng MC, Gao GT, Peng PP, Chen CX, Wang WF, Cao CH. .
-
Sequential One-Pot Multienzyme Chemoenzymatic Synthesis of Glycosphingolipid Glycans. J Org Chem. 2016 11 18; 81(22):10809-10824. Yu H, Li Y, Zeng J, Thon V, Nguyen DM, Ly T, Kuang HY, Ngo A, Chen X. PMID: 27736072; PMCID: PMC5775905.
-
Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand. Biochemistry. 2016 Oct 25; 55(42):5927-5937. Loukachevitch LV, Bensing BA, Yu H, Zeng J, Chen X, Sullam PM, Iverson TM. PMID: 27685666; PMCID: PMC5388602.
-
Characterization of immunogenic Neu5Gc in bioprosthetic heart valves. Xenotransplantation. 2016 09; 23(5):381-92. Reuven EM, Leviatan Ben-Arye S, Marshanski T, Breimer ME, Yu H, Fellah-Hebia I, Roussel JC, Costa C, Galiñanes M, Mañez R, Le Tourneau T, Soulillou JP, Cozzi E, Chen X, Padler-Karavani V. PMID: 27610947; PMCID: PMC5036590.
-
Effective one-pot multienzyme (OPME) synthesis of monotreme milk oligosaccharides and other sialosides containing 4-O-acetyl sialic acid. Org Biomol Chem. 2016 Sep 28; 14(36):8586-97. Yu H, Zeng J, Li Y, Thon V, Shi B, Chen X. PMID: 27548611; PMCID: PMC5036589.
-
A General Chemoenzymatic Strategy for the Synthesis of Glycosphingolipids. European J Org Chem. 2016 Sep; 2016(25):4315-4320. Liu Y, Wen L, Li L, Gadi MR, Guan W, Huang K, Xiao Z, Wei M, Ma C, Zhang Q, Yu H, Chen X, Wang PG, Fang J. PMID: 28824290; PMCID: PMC5560440.
-
Correction: Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric N-glycans. Org Biomol Chem. 2016 May 21; 14(19):4542. Calderon AD, Liu Y, Li X, Wang X, Chen X, Li L, Wang PG. PMID: 27139574.
-
Substrate specificity of FUT8 and chemoenzymatic synthesis of core-fucosylated asymmetric N-glycans. Org Biomol Chem. 2016 Apr 26; 14(17):4027-31. Calderon AD, Liu Y, Li X, Wang X, Chen X, Li L, Wang PG. PMID: 27080952; PMCID: PMC4852481.
-
Sialic Acid Glycobiology Unveils Trypanosoma cruzi Trypomastigote Membrane Physiology. PLoS Pathog. 2016 Apr; 12(4):e1005559. Lantos AB, Carlevaro G, Araoz B, Ruiz Diaz P, Camara Mde L, Buscaglia CA, Bossi M, Yu H, Chen X, Bertozzi CR, Mucci J, Campetella O. PMID: 27058585; PMCID: PMC4825991.
-
Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins. Glycobiology. 2016 11; 26(11):1222-1234. Bensing BA, Khedri Z, Deng L, Yu H, Prakobphol A, Fisher SJ, Chen X, Iverson TM, Varki A, Sullam PM. PMID: 27037304; PMCID: PMC6086536.
-
One-pot multienzyme (OPME) systems for chemoenzymatic synthesis of carbohydrates. Org Biomol Chem. 2016 Mar 14; 14(10):2809-18. Yu H, Chen X. PMID: 26881499; PMCID: PMC4795158.
-
Donor substrate promiscuity of bacterial β1-3-N-acetylglucosaminyltransferases and acceptor substrate flexibility of β1-4-galactosyltransferases. Bioorg Med Chem. 2016 Apr 15; 24(8):1696-705. Li Y, Xue M, Sheng X, Yu H, Zeng J, Thon V, Chen Y, Muthana MM, Wang PG, Chen X. PMID: 26968649; PMCID: PMC4808627.
-
The one-pot multienzyme (OPME) synthesis of human blood group H antigens and a human milk oligosaccharide (HMOS) with highly active Thermosynechococcus elongates α1-2-fucosyltransferase. Chem Commun (Camb). 2016 Mar 11; 52(20):3899-902. Zhao C, Wu Y, Yu H, Shah IM, Li Y, Zeng J, Liu B, Mills DA, Chen X. PMID: 26864394; PMCID: PMC4775349.
-
Glycosyltransferase engineering for carbohydrate synthesis. Biochem Soc Trans. 2016 Feb; 44(1):129-42. McArthur JB, Chen X. PMID: 26862198; PMCID: PMC5764748.
-
Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin. J Biol Chem. 2016 Apr 01; 291(14):7230-40. Bensing BA, Loukachevitch LV, McCulloch KM, Yu H, Vann KR, Wawrzak Z, Anderson S, Chen X, Sullam PM, Iverson TM. PMID: 26833566; PMCID: PMC4817157.
-
An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism. PLoS Pathog. 2016 Jan; 12(1):e1005411. Song H, Qi J, Khedri Z, Diaz S, Yu H, Chen X, Varki A, Shi Y, Gao GF. PMID: 26816272; PMCID: PMC4729479.
-
Cu-Catalyzed Click Reaction in Carbohydrate Chemistry. Chem Rev. 2016 Mar 09; 116(5):3086-240. Tiwari VK, Mishra BB, Mishra KB, Mishra N, Singh AS, Chen X. PMID: 26796328.
-
Systematic Chemoenzymatic Synthesis of O-Sulfated Sialyl Lewis x Antigens. Chem Sci. 2016 Apr 01; 7(4):2827-2831. Santra A, Yu H, Tasnima N, Muthana MM, Li Y, Zeng J, Kenyond NJ, Louie AY, Chen X. PMID: 28138383; PMCID: PMC5269574.
-
Human Milk Oligosaccharides (HMOS): Structure, Function, and Enzyme-Catalyzed Synthesis. Adv Carbohydr Chem Biochem. 2015; 72:113-90. Chen X. PMID: 26613816; PMCID: PMC9235823.
-
Characterizing non-hydrolyzing Neisseria meningitidis serogroup A UDP-N-acetylglucosamine (UDP-GlcNAc) 2-epimerase using UDP-N-acetylmannosamine (UDP-ManNAc) and derivatives. Carbohydr Res. 2016 Jan; 419:18-28. Zhang L, Muthana MM, Yu H, McArthur JB, Qu J, Chen X. PMID: 26598987; PMCID: PMC4698195.
-
Characterization of Receptor Binding Profiles of Influenza A Viruses Using An Ellipsometry-Based Label-Free Glycan Microarray Assay Platform. Biomolecules. 2015 Jul 16; 5(3):1480-98. Fei Y, Sun YS, Li Y, Yu H, Lau K, Landry JP, Luo Z, Baumgarth N, Chen X, Zhu X. PMID: 26193329; PMCID: PMC4598760.
-
Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms. Chem Commun (Camb). 2015 Jun 28; 51(51):10310-3. Li L, Liu Y, Li T, Wang W, Yu Z, Ma C, Qu J, Zhao W, Chen X, Wang PG. PMID: 26023910; PMCID: PMC4498953.
-
Chemoenzymatic synthesis of α-dystroglycan core M1 O-mannose glycans. Chem Commun (Camb). 2015 Jul 25; 51(58):11654-7. Zhang Y, Meng C, Jin L, Chen X, Wang F, Cao H. PMID: 26100261; PMCID: PMC4617230.
-
Efficient Chemoenzymatic Synthesis of an N-glycan Isomer Library. Chem Sci. 2015 Oct 01; 6(10):5652-5661. Li L, Liu Y, Ma C, Qu J, Calderon AD, Wu B, Wei N, Wang X, Guo Y, Xiao Z, Song J, Sugiarto G, Li Y, Yu H, Chen X, Wang PG. PMID: 26417422; PMCID: PMC4583208.
-
Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins. Cell Rep. 2015 Jun 30; 11(12):1966-78. Langereis MA, Bakkers MJ, Deng L, Padler-Karavani V, Vervoort SJ, Hulswit RJ, van Vliet AL, Gerwig GJ, de Poot SA, Boot W, van Ederen AM, Heesters BA, van der Loos CM, van Kuppeveld FJ, Yu H, Huizinga EG, Chen X, Varki A, Kamerling JP, de Groot RJ. PMID: 26095364; PMCID: PMC5292239.
-
Facile chemoenzymatic synthesis of biotinylated heparosan hexasaccharide. Org Biomol Chem. 2015 May 14; 13(18):5098-101. Wu B, Wei N, Thon V, Wei M, Yu Z, Xu Y, Chen X, Liu J, Wang PG, Li T. PMID: 25858766; PMCID: PMC4472006.
-
Sequential one-pot multienzyme (OPME) synthesis of lacto-N-neotetraose and its sialyl and fucosyl derivatives. Chem Commun (Camb). 2015 May 04; 51(36):7689-92. Chen C, Zhang Y, Xue M, Liu XW, Li Y, Chen X, Wang PG, Wang F, Cao H. PMID: 25848722.
-
Structures of Bacteroides fragilis uridine 5'-diphosphate-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (BfLpxA). Acta Crystallogr D Biol Crystallogr. 2015 May; 71(Pt 5):1068-76. Ngo A, Fong KT, Cox DL, Chen X, Fisher AJ. PMID: 25945572; PMCID: PMC4427197.
-
Equine and Canine Influenza H3N8 Viruses Show Minimal Biological Differences Despite Phylogenetic Divergence. J Virol. 2015 Jul; 89(13):6860-73. Feng KH, Gonzalez G, Deng L, Yu H, Tse VL, Huang L, Huang K, Wasik BR, Zhou B, Wentworth DE, Holmes EC, Chen X, Varki A, Murcia PR, Parrish CR. PMID: 25903329; PMCID: PMC4468500.
-
Improved one-pot multienzyme (OPME) systems for synthesizing UDP-uronic acids and glucuronides. Chem Commun (Camb). 2015 Mar 18; 51(22):4595-8. Muthana MM, Qu J, Xue M, Klyuchnik T, Siu A, Li Y, Zhang L, Yu H, Li L, Wang PG, Chen X. PMID: 25686901; PMCID: PMC4348237.
-
A Photobacterium sp. α2-6-sialyltransferase (Psp2,6ST) mutant with an increased expression level and improved activities in sialylating Tn antigens. Carbohydr Res. 2015 May 18; 408:127-33. Ding L, Zhao C, Qu J, Li Y, Sugiarto G, Yu H, Wang J, Chen X. PMID: 25593075; PMCID: PMC9416874.
-
Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi. Cell. 2014 Dec 04; 159(6):1290-9. Deng L, Song J, Gao X, Wang J, Yu H, Chen X, Varki N, Naito-Matsui Y, Galán JE, Varki A. PMID: 25480294; PMCID: PMC4258231.
-
Oral streptococci utilize a Siglec-like domain of serine-rich repeat adhesins to preferentially target platelet sialoglycans in human blood. PLoS Pathog. 2014 Dec; 10(12):e1004540. Deng L, Bensing BA, Thamadilok S, Yu H, Lau K, Chen X, Ruhl S, Sullam PM, Varki A. PMID: 25474103; PMCID: PMC4256463.
-
Crystal structures of sialyltransferase from Photobacterium damselae. FEBS Lett. 2014 Dec 20; 588(24):4720-9. Huynh N, Li Y, Yu H, Huang S, Lau K, Chen X, Fisher AJ. PMID: 25451227; PMCID: PMC4268365.
-
Chemoenzymatic synthesis of lacto-N-tetrasaccharide and sialyl lacto-N-tetrasaccharides. Carbohydr Res. 2015 Jan 12; 401:5-10. Yao W, Yan J, Chen X, Wang F, Cao H. PMID: 25464075.
-
Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1. Elife. 2014 Sep 03; 3:e04066. Chen GY, Brown NK, Wu W, Khedri Z, Yu H, Chen X, van de Vlekkert D, D'Azzo A, Zheng P, Liu Y. PMID: 25187624; PMCID: PMC4168287.
-
Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis. Angew Chem Int Ed Engl. 2014 Jun 23; 53(26):6687-91. Yu H, Lau K, Thon V, Autran CA, Jantscher-Krenn E, Xue M, Li Y, Sugiarto G, Qu J, Mu S, Ding L, Bode L, Chen X. PMID: 24848971; PMCID: PMC4147952.
-
Regioselective chemoenzymatic synthesis of ganglioside disialyl tetrasaccharide epitopes. J Am Chem Soc. 2014 Apr 09; 136(14):5205-8. Meng X, Yao W, Cheng J, Zhang X, Jin L, Yu H, Chen X, Wang F, Cao H. PMID: 24649890; PMCID: PMC4210053.
-
Chemoenzymatic synthesis of sialosides containing C7-modified sialic acids and their application in sialidase substrate specificity studies. Carbohydr Res. 2014 May 07; 389:100-11. Khedri Z, Li Y, Muthana S, Muthana MM, Hsiao CW, Yu H, Chen X. PMID: 24680514; PMCID: PMC4074090.
-
Highly efficient one-pot multienzyme (OPME) synthesis of glycans with fluorous-tag assisted purification. Chem Commun (Camb). 2014 Mar 25; 50(24):3159-62. Hwang J, Yu H, Malekan H, Sugiarto G, Li Y, Qu J, Nguyen V, Wu D, Chen X. PMID: 24473465.
-
Profiling of glycan receptors for minute virus of mice in permissive cell lines towards understanding the mechanism of cell recognition. PLoS One. 2014; 9(1):e86909. Halder S, Cotmore S, Heimburg-Molinaro J, Smith DF, Cummings RD, Chen X, Trollope AJ, North SJ, Haslam SM, Dell A, Tattersall P, McKenna R, Agbandje-McKenna M. PMID: 24475195; PMCID: PMC3903596.
-
Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates. FASEB J. 2014 Mar; 28(3):1280-93. Padler-Karavani V, Hurtado-Ziola N, Chang YC, Sonnenburg JL, Ronaghy A, Yu H, Verhagen A, Nizet V, Chen X, Varki N, Varki A, Angata T. PMID: 24308974; PMCID: PMC3929681.
-
Structural basis for substrate specificity and mechanism of N-acetyl-D-neuraminic acid lyase from Pasteurella multocida. Biochemistry. 2013 Nov 26; 52(47):8570-9. Huynh N, Aye A, Li Y, Yu H, Cao H, Tiwari VK, Shin DW, Chen X, Fisher AJ. PMID: 24152047; PMCID: PMC3880309.
-
An optics-based variable-temperature assay system for characterizing thermodynamics of biomolecular reactions on solid support. Rev Sci Instrum. 2013 Nov; 84(11):114102. Fei Y, Landry JP, Li Y, Yu H, Lau K, Huang S, Chokhawala HA, Chen X, Zhu XD. PMID: 24289409; PMCID: PMC3838479.
-
Efficient enzymatic synthesis of guanosine 5'-diphosphate-sugars and derivatives. Org Lett. 2013 Nov 01; 15(21):5528-30. Li L, Liu Y, Wan Y, Li Y, Chen X, Zhao W, Wang PG. PMID: 24117142; PMCID: PMC3915774.
-
Exploration of sialic acid diversity and biology using sialoglycan microarrays. Biopolymers. 2013 Oct; 99(10):650-65. Deng L, Chen X, Varki A. PMID: 23765393; PMCID: PMC7161822.
-
Tailored design and synthesis of heparan sulfate oligosaccharide analogues using sequential one-pot multienzyme systems. Angew Chem Int Ed Engl. 2013 Nov 04; 52(45):11852-6. Chen Y, Li Y, Yu H, Sugiarto G, Thon V, Hwang J, Ding L, Hie L, Chen X. PMID: 24038939; PMCID: PMC3943747.
-
Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts. J Immunol. 2013 Sep 15; 191(6):2907-15. Scobie L, Padler-Karavani V, Le Bas-Bernardet S, Crossan C, Blaha J, Matouskova M, Hector RD, Cozzi E, Vanhove B, Charreau B, Blancho G, Bourdais L, Tallacchini M, Ribes JM, Yu H, Chen X, Kracikova J, Broz L, Hejnar J, Vesely P, Takeuchi Y, Varki A, Soulillou JP. PMID: 23945141; PMCID: PMC3782708.
-
Substrate specificity provides insights into the sugar donor recognition mechanism of O-GlcNAc transferase (OGT). PLoS One. 2013; 8(5):e63452. Ma X, Liu P, Yan H, Sun H, Liu X, Zhou F, Li L, Chen Y, Muthana MM, Chen X, Wang PG, Zhang L. PMID: 23700425; PMCID: PMC3660302.
-
Donor substrate promiscuity of the N-acetylglucosaminyltransferase activities of Pasteurella multocida heparosan synthase 2 (PmHS2) and Escherichia coli K5 KfiA. Appl Microbiol Biotechnol. 2014 Feb; 98(3):1127-34. Li Y, Yu H, Thon V, Chen Y, Muthana MM, Qu J, Hie L, Chen X. PMID: 23661084; PMCID: PMC9416980.
-
Quantum dot nanometal surface energy transfer based biosensing of sialic acid compositions and linkages in biological samples. Anal Chem. 2013 Apr 16; 85(8):3864-70. Kikkeri R, Padler-Karavani V, Diaz S, Verhagen A, Yu H, Cao H, Langereis MA, De Groot RJ, Chen X, Varki A. PMID: 23489180; PMCID: PMC5996995.
-
A simple method for assessment of human anti-Neu5Gc antibodies applied to Kawasaki disease. PLoS One. 2013; 8(3):e58443. Padler-Karavani V, Tremoulet AH, Yu H, Chen X, Burns JC, Varki A. PMID: 23520510; PMCID: PMC3592828.
-
One-pot multi-enzyme (OPME) chemoenzymatic synthesis of sialyl-Tn-MUC1 and sialyl-T-MUC1 glycopeptides containing natural or non-natural sialic acid. Bioorg Med Chem. 2013 Aug 15; 21(16):4778-85. Malekan H, Fung G, Thon V, Khedri Z, Yu H, Qu J, Li Y, Ding L, Lam KS, Chen X. PMID: 23535562; PMCID: PMC3722252.
-
Chemoenzymatic synthesis of mono- and di-fluorinated Thomsen-Friedenreich (T) antigens and their sialylated derivatives. Org Biomol Chem. 2013 Feb 07; 11(5):842-8. Yan J, Chen X, Wang F, Cao H. PMID: 23241945; PMCID: PMC3616747.
-
Structural features affecting trafficking, processing, and secretion of Trypanosoma cruzi mucins. J Biol Chem. 2012 Jul 27; 287(31):26365-76. Cánepa GE, Mesías AC, Yu H, Chen X, Buscaglia CA. PMID: 22707724; PMCID: PMC3406720.
-
Synthesis of selective inhibitors against V. cholerae sialidase and human cytosolic sialidase NEU2. Org Biomol Chem. 2012 Aug 14; 10(30):6112-20. Khedri Z, Li Y, Cao H, Qu J, Yu H, Muthana MM, Chen X. PMID: 22641268; PMCID: PMC11302589.
-
A sialyltransferase mutant with decreased donor hydrolysis and reduced sialidase activities for directly sialylating LewisX. ACS Chem Biol. 2012 Jul 20; 7(7):1232-40. Sugiarto G, Lau K, Qu J, Li Y, Lim S, Mu S, Ames JB, Fisher AJ, Chen X. PMID: 22583967; PMCID: PMC3521065.
-
Cross-comparison of protein recognition of sialic acid diversity on two novel sialoglycan microarrays. J Biol Chem. 2012 Jun 29; 287(27):22593-608. Padler-Karavani V, Song X, Yu H, Hurtado-Ziola N, Huang S, Muthana S, Chokhawala HA, Cheng J, Verhagen A, Langereis MA, Kleene R, Schachner M, de Groot RJ, Lasanajak Y, Matsuda H, Schwab R, Chen X, Smith DF, Cummings RD, Varki A. PMID: 22549775; PMCID: PMC3391140.
-
Sialic acid metabolism and sialyltransferases: natural functions and applications. Appl Microbiol Biotechnol. 2012 May; 94(4):887-905. Li Y, Chen X. PMID: 22526796; PMCID: PMC3534974.
-
LC-MS analysis of polyclonal human anti-Neu5Gc xeno-autoantibodies immunoglobulin G Subclass and partial sequence using multistep intravenous immunoglobulin affinity purification and multienzymatic digestion. Anal Chem. 2012 Mar 20; 84(6):2761-8. Lu Q, Padler-Karavani V, Yu H, Chen X, Wu SL, Varki A, Hancock WS. PMID: 22390546; PMCID: PMC4142218.
-
Probe sialidase substrate specificity using chemoenzymatically synthesized sialosides containing C9-modified sialic acid. Chem Commun (Camb). 2012 Apr 04; 48(27):3357-9. Khedri Z, Muthana MM, Li Y, Muthana SM, Yu H, Cao H, Chen X. PMID: 22361713.
-
Efficient one-pot multienzyme synthesis of UDP-sugars using a promiscuous UDP-sugar pyrophosphorylase from Bifidobacterium longum (BLUSP). Chem Commun (Camb). 2012 Mar 11; 48(21):2728-30. Muthana MM, Qu J, Li Y, Zhang L, Yu H, Ding L, Malekan H, Chen X. PMID: 22306833.
-
Erratum: Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction. Nature Biotechnology. 2012 Feb 1; 30(2):193-193. Chen CG, Chen CX, King KS, Cavassani CK, Cheng CJ, Zheng ZX, Cao CH, Yu YH, Qu QJ, Fang FD, Wu WW, Bai BX, Liu LJ, Woodiga WS, Chen CC, Sun SL, Hogaboam HC, Kunkel KS, Zheng ZP, Liu LY. .
-
Surface plasmon resonance imaging analysis of protein binding to a sialoside-based carbohydrate microarray. Methods Mol Biol. 2012; 808:183-94. Linman MJ, Yu H, Chen X, Cheng Q. PMID: 22057526.
-
General consideration on sialic acid chemistry. Methods Mol Biol. 2012; 808:31-56. Cao H, Chen X. PMID: 22057516; PMCID: PMC11288308.
-
PmST3 from Pasteurella multocida encoded by Pm1174 gene is a monofunctional α2-3-sialyltransferase. Appl Microbiol Biotechnol. 2012 May; 94(4):977-85. Thon V, Li Y, Yu H, Lau K, Chen X. PMID: 22075637.
-
Fluorescent labeling agents change binding profiles of glycan-binding proteins. Mol Biosyst. 2011 Dec; 7(12):3343-52. Fei Y, Sun YS, Li Y, Lau K, Yu H, Chokhawala HA, Huang S, Landry JP, Chen X, Zhu X. PMID: 22009201; PMCID: PMC3271732.
-
Pasteurella multocida CMP-sialic acid synthetase and mutants of Neisseria meningitidis CMP-sialic acid synthetase with improved substrate promiscuity. Appl Microbiol Biotechnol. 2012 Mar; 93(6):2411-23. Li Y, Yu H, Cao H, Muthana S, Chen X. PMID: 21968653.
-
Analysis of influenza virus hemagglutinin receptor binding mutants with limited receptor recognition properties and conditional replication characteristics. J Virol. 2011 Dec; 85(23):12387-98. Bradley KC, Galloway SE, Lasanajak Y, Song X, Heimburg-Molinaro J, Yu H, Chen X, Talekar GR, Smith DF, Cummings RD, Steinhauer DA. PMID: 21917953; PMCID: PMC3209400.
-
Molecular diversity of the Trypanosoma cruzi TcSMUG family of mucin genes and proteins. Biochem J. 2011 Sep 01; 438(2):303-13. Urban I, Santurio LB, Chidichimo A, Yu H, Chen X, Mucci J, Agüero F, Buscaglia CA. PMID: 21651499.
-
One-pot three-enzyme synthesis of UDP-GlcNAc derivatives. Chem Commun (Camb). 2011 Oct 14; 47(38):10815-7. Chen Y, Thon V, Li Y, Yu H, Ding L, Lau K, Qu J, Hie L, Chen X. PMID: 21863157; PMCID: PMC11279325.
-
Combinatorial Biosynthesis of Complex Carbohydrates. . 2011 Aug 22; 229-255. Yu YH, Chen CX. .
-
Decreasing the sialidase activity of multifunctional Pasteurella multocida α2-3-sialyltransferase 1 (PmST1) by site-directed mutagenesis. Mol Biosyst. 2011 Nov; 7(11):3021-7. Sugiarto G, Lau K, Li Y, Khedri Z, Yu H, Le DT, Chen X. PMID: 21858283; PMCID: PMC11314589.
-
Substrate promiscuity of N-acetylhexosamine 1-kinases. Molecules. 2011 Jul 28; 16(8):6396-407. Li Y, Yu H, Chen Y, Lau K, Cai L, Cao H, Tiwari VK, Qu J, Thon V, Wang PG, Chen X. PMID: 21799473; PMCID: PMC6264712.
-
A sialylated glycan microarray reveals novel interactions of modified sialic acids with proteins and viruses. J Biol Chem. 2011 Sep 09; 286(36):31610-22. Song X, Yu H, Chen X, Lasanajak Y, Tappert MM, Air GM, Tiwari VK, Cao H, Chokhawala HA, Zheng H, Cummings RD, Smith DF. PMID: 21757734; PMCID: PMC3173124.
-
Measurement of enzymatic activity and specificity of human and avian influenza neuraminidases from whole virus by glycoarray and MALDI-TOF mass spectrometry. Chembiochem. 2011 Sep 05; 12(13):2071-80. Pourceau G, Chevolot Y, Goudot A, Giroux F, Meyer A, Moulés V, Lina B, Cecioni S, Vidal S, Yu H, Chen X, Ferraris O, Praly JP, Souteyrand E, Vasseur JJ, Morvan F. PMID: 21739555.
-
An infant-associated bacterial commensal utilizes breast milk sialyloligosaccharides. Journal of Biological Chemistry. 2011 Jul 1; 286(26):23620-23620. Sela SD, Li LY, Lerno LL, Wu WS, Marcobal MA, German GJ, Chen CX, Lebrilla LC, Mills MD. .
-
Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives. Chem Commun (Camb). 2011 Aug 14; 47(30):8691-3. Ding L, Yu H, Lau K, Li Y, Muthana S, Wang J, Chen X. PMID: 21725542; PMCID: PMC3201767.
-
Chemoenzymatic synthesis of C8-modified sialic acids and related α2-3- and α2-6-linked sialosides. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):5037-40. Yu H, Cao H, Tiwari VK, Li Y, Chen X. PMID: 21592790; PMCID: PMC3156331.
-
PmST2: a novel Pasteurella multocida glycolipid α2-3-sialyltransferase. Glycobiology. 2011 Sep; 21(9):1206-16. Thon V, Lau K, Yu H, Tran BK, Chen X. PMID: 21515586; PMCID: PMC3150114.
-
Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer. Cancer Res. 2011 May 01; 71(9):3352-63. Padler-Karavani V, Hurtado-Ziola N, Pu M, Yu H, Huang S, Muthana S, Chokhawala HA, Cao H, Secrest P, Friedmann-Morvinski D, Singer O, Ghaderi D, Verma IM, Liu YT, Messer K, Chen X, Varki A, Schwab R. PMID: 21505105; PMCID: PMC3085609.
-
High-throughput neuraminidase substrate specificity study of human and avian influenza A viruses. Virology. 2011 Jun 20; 415(1):12-9. Li Y, Cao H, Dao N, Luo Z, Yu H, Chen Y, Xing Z, Baumgarth N, Cardona C, Chen X. PMID: 21501853; PMCID: PMC3114948.
-
Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction. Nat Biotechnol. 2011 May; 29(5):428-35. Chen GY, Chen X, King S, Cavassani KA, Cheng J, Zheng X, Cao H, Yu H, Qu J, Fang D, Wu W, Bai XF, Liu JQ, Woodiga SA, Chen C, Sun L, Hogaboam CM, Kunkel SL, Zheng P, Liu Y. PMID: 21478876; PMCID: PMC4090080.
-
Sequential two-step multienzyme synthesis of tumor-associated sialyl T-antigens and derivatives. Org Biomol Chem. 2011 Apr 21; 9(8):2784-9. Lau K, Yu H, Thon V, Khedri Z, Leon ME, Tran BK, Chen X. PMID: 21359399; PMCID: PMC3114947.
-
An infant-associated bacterial commensal utilizes breast milk sialyloligosaccharides. J Biol Chem. 2011 Apr 08; 286(14):11909-18. Sela DA, Li Y, Lerno L, Wu S, Marcobal AM, German JB, Chen X, Lebrilla CB, Mills DA. PMID: 21288901; PMCID: PMC3069393.
-
Fermenting next generation glycosylated therapeutics. ACS Chem Biol. 2011 Jan 21; 6(1):14-7. Chen X. PMID: 21250649.
-
Identifying selective inhibitors against the human cytosolic sialidase NEU2 by substrate specificity studies. Mol Biosyst. 2011 Apr; 7(4):1060-72. Li Y, Cao H, Yu H, Chen Y, Lau K, Qu J, Thon V, Sugiarto G, Chen X. PMID: 21206954; PMCID: PMC3114945.
-
Chemoenzymatic synthesis of α2-3-sialylated carbohydrate epitopes. Sci China Chem. 2011 Jan; 54(1):117-128. Shengshu H, Hai Y, Xi C. PMID: 21686057; PMCID: PMC3115702.
-
Cloning and characterization of a viral α2-3-sialyltransferase (vST3Gal-I) for the synthesis of sialyl Lewisx. Glycobiology. 2011 Mar; 21(3):387-96. Sugiarto G, Lau K, Yu H, Vuong S, Thon V, Li Y, Huang S, Chen X. PMID: 20978012; PMCID: PMC3033747.
-
Highly efficient chemoenzymatic synthesis of β1-3-linked galactosides. Chem Commun (Camb). 2010 Oct 28; 46(40):7507-9. Yu H, Thon V, Lau K, Cai L, Chen Y, Mu S, Li Y, Wang PG, Chen X. PMID: 20830443; PMCID: PMC3114946.
-
Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid. J Exp Med. 2010 Aug 02; 207(8):1637-46. Taylor RE, Gregg CJ, Padler-Karavani V, Ghaderi D, Yu H, Huang S, Sorensen RU, Chen X, Inostroza J, Nizet V, Varki A. PMID: 20624889; PMCID: PMC2916132.
-
Highly efficient chemoenzymatic synthesis of beta1-4-linked galactosides with promiscuous bacterial beta1-4-galactosyltransferases. Chem Commun (Camb). 2010 Sep 07; 46(33):6066-8. Lau K, Thon V, Yu H, Ding L, Chen Y, Muthana MM, Wong D, Huang R, Chen X. PMID: 20625591; PMCID: PMC3114949.
-
Helicobacter hepaticus Hh0072 gene encodes a novel alpha1-3-fucosyltransferase belonging to CAZy GT11 family. Glycobiology. 2010 Sep; 20(9):1077-88. Zhang L, Lau K, Cheng J, Yu H, Li Y, Sugiarto G, Huang S, Ding L, Thon V, Wang PG, Chen X. PMID: 20466652; PMCID: PMC2948817.
-
Identification of glycoproteins targeted by Trypanosoma cruzi trans-sialidase, a virulence factor that disturbs lymphocyte glycosylation. Glycobiology. 2010 Jul; 20(7):833-42. Muiá RP, Yu H, Prescher JA, Hellman U, Chen X, Bertozzi CR, Campetella O. PMID: 20354005; PMCID: PMC2900898.
-
Advances in the biology and chemistry of sialic acids. ACS Chem Biol. 2010 Feb 19; 5(2):163-76. Chen X, Varki A. PMID: 20020717; PMCID: PMC2825284.
-
Chemoenzymatic synthesis of GD3 oligosaccharides and other disialyl glycans containing natural and non-natural sialic acids. J Am Chem Soc. 2009 Dec 30; 131(51):18467-77. Yu H, Cheng J, Ding L, Khedri Z, Chen Y, Chin S, Lau K, Tiwari VK, Chen X. PMID: 19947630; PMCID: PMC2811049.
-
Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium. Blood. 2009 Dec 10; 114(25):5225-35. Pham T, Gregg CJ, Karp F, Chow R, Padler-Karavani V, Cao H, Chen X, Witztum JL, Varki NM, Varki A. PMID: 19828701; PMCID: PMC2792214.
-
Trans-sialidase activity of Photobacterium damsela alpha2,6-sialyltransferase and its application in the synthesis of sialosides. Glycobiology. 2010 Feb; 20(2):260-8. Cheng J, Huang S, Yu H, Li Y, Lau K, Chen X. PMID: 19880425; PMCID: PMC2800248.
-
Sialidase substrate specificity studies using chemoenzymatically synthesized sialosides containing C5-modified sialic acids. Org Biomol Chem. 2009 Dec 21; 7(24):5137-45. Cao H, Li Y, Lau K, Muthana S, Yu H, Cheng J, Chokhawala HA, Sugiarto G, Zhang L, Chen X. PMID: 20024109.
-
Recent progress in chemical and chemoenzymatic synthesis of carbohydrates. Curr Opin Chem Biol. 2009 Dec; 13(5-6):573-81. Muthana S, Cao H, Chen X. PMID: 19833544; PMCID: PMC3097241.
-
Parallel chemoenzymatic synthesis of sialosides containing a C5-diversified sialic acid. Bioorg Med Chem Lett. 2009 Oct 15; 19(20):5869-71. Cao H, Muthana S, Li Y, Cheng J, Chen X. PMID: 19740656; PMCID: PMC2753693.
-
Fabrication and characterization of a sialoside-based carbohydrate microarray biointerface for protein binding analysis with surface plasmon resonance imaging. ACS Appl Mater Interfaces. 2009 Aug; 1(8):1755-62. Linman MJ, Yu H, Chen X, Cheng Q. PMID: 20355792.
-
Chemoenzymatic synthesis of a new class of macrocyclic oligosaccharides. J Org Chem. 2009 Apr 17; 74(8):2928-36. Muthana S, Yu H, Cao H, Cheng J, Chen X. PMID: 19296596.
-
Remodeling bacterial polysaccharides by metabolic pathway engineering. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4207-12. Yi W, Liu X, Li Y, Li J, Xia C, Zhou G, Zhang W, Zhao W, Chen X, Wang PG. PMID: 19251666; PMCID: PMC2657399.
-
Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products. PLoS One. 2009; 4(1):e4241. Diaz SL, Padler-Karavani V, Ghaderi D, Hurtado-Ziola N, Yu H, Chen X, Brinkman-Van der Linden EC, Varki A, Varki NM. PMID: 19156207; PMCID: PMC2626223.
-
Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors. Org Biomol Chem. 2009 Jan 07; 7(1):27-9. Wong JH, Sahni U, Li Y, Chen X, Gervay-Hague J. PMID: 19081938; PMCID: PMC4505548.
-
Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature. 2008 Dec 04; 456(7222):648-52. Byres E, Paton AW, Paton JC, Löfling JC, Smith DF, Wilce MC, Talbot UM, Chong DC, Yu H, Huang S, Chen X, Varki NM, Varki A, Rossjohn J, Beddoe T. PMID: 18971931; PMCID: PMC2723748.
-
Preface. . 2008 Sep 1; 990:ix-xiii. Chen CX, Halcomb HR, Wang WP. .
-
Chemoenzymatic Synthesis of Sialosides and Their Applications. . 2008 Sep 1; 990:96-122. Yu YH, Chokhawala CH, Huang HS, Chen CX. .
-
Combinatorial chemoenzymatic synthesis and high-throughput screening of sialosides. ACS Chem Biol. 2008 Sep 19; 3(9):567-76. Chokhawala HA, Huang S, Lau K, Yu H, Cheng J, Thon V, Hurtado-Ziola N, Guerrero JA, Varki A, Chen X. PMID: 18729452; PMCID: PMC2588434.
-
Chemoenzymatic Syntheses of Tumor-Associated Carbohydrate Antigen Globo-H and Stage-Specific Embryonic Antigen 4. Adv Synth Catal. 2008 Aug 04; 350(11-12):1717-1728. Wang Z, Gilbert M, Eguchi H, Yu H, Cheng J, Muthana S, Zhou L, Wang PG, Chen X, Huang X. PMID: 20305750; PMCID: PMC2842016.
-
Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: potential implications for disease. Glycobiology. 2008 Oct; 18(10):818-30. Padler-Karavani V, Yu H, Cao H, Chokhawala H, Karp F, Varki N, Chen X, Varki A. PMID: 18669916; PMCID: PMC2586336.
-
Chemical preparation of sialyl Lewis x using an enzymatically synthesized sialoside building block. Carbohydr Res. 2008 Nov 24; 343(17):2863-9. Cao H, Huang S, Cheng J, Li Y, Muthana S, Son B, Chen X. PMID: 18639240; PMCID: PMC2783551.
-
Pasteurella multocida sialic acid aldolase: a promising biocatalyst. Appl Microbiol Biotechnol. 2008 Jul; 79(6):963-70. Li Y, Yu H, Cao H, Lau K, Muthana S, Tiwari VK, Son B, Chen X. PMID: 18521592; PMCID: PMC2588431.
-
Multifunctionality of Campylobacter jejuni sialyltransferase CstII: characterization of GD3/GT3 oligosaccharide synthase, GD3 oligosaccharide sialidase, and trans-sialidase activities. Glycobiology. 2008 Sep; 18(9):686-97. Cheng J, Yu H, Lau K, Huang S, Chokhawala HA, Li Y, Tiwari VK, Chen X. PMID: 18509108; PMCID: PMC2588429.
-
Surface plasmon resonance study of protein-carbohydrate interactions using biotinylated sialosides. Anal Chem. 2008 Jun 01; 80(11):4007-13. Linman MJ, Taylor JD, Yu H, Chen X, Cheng Q. PMID: 18461973; PMCID: PMC2586005.
-
N-Terminal 112 amino acid residues are not required for the sialyltransferase activity of Photobacterium damsela alpha2,6-sialyltransferase. Biotechnol Lett. 2008 Apr; 30(4):671-6. Sun M, Li Y, Chokhawala HA, Henning R, Chen X. PMID: 17989925; PMCID: PMC2598773.
-
Chemoenzymatic synthesis of size-defined polysaccharides by sialyltransferase-catalyzed block transfer of oligosaccharides. J Am Chem Soc. 2007 Oct 03; 129(39):11918-9. Muthana S, Yu H, Huang S, Chen X. PMID: 17845050.
-
Enzymatic synthesis of fluorinated mechanistic probes for sialidases and sialyltransferases. J Am Chem Soc. 2007 Sep 05; 129(35):10630-1. Chokhawala HA, Cao H, Yu H, Chen X. PMID: 17696347.
-
The Hd0053 gene of Haemophilus ducreyi encodes an alpha2,3-sialyltransferase. Biochem Biophys Res Commun. 2007 Sep 21; 361(2):555-60. Li Y, Sun M, Huang S, Yu H, Chokhawala HA, Thon V, Chen X. PMID: 17662691; PMCID: PMC2084346.
-
Efficient chemoenzymatic synthesis of biotinylated human serum albumin-sialoglycoside conjugates containing O-acetylated sialic acids. Org Biomol Chem. 2007 Aug 07; 5(15):2458-63. Yu H, Chokhawala HA, Varki A, Chen X. PMID: 17637967; PMCID: PMC2769491.
-
Crystal structures of Pasteurella multocida sialyltransferase complexes with acceptor and donor analogues reveal substrate binding sites and catalytic mechanism. Biochemistry. 2007 May 29; 46(21):6288-98. Ni L, Chokhawala HA, Cao H, Henning R, Ng L, Huang S, Yu H, Chen X, Fisher AJ. PMID: 17487984.
-
Carbohydrate post-glycosylational modifications. Org Biomol Chem. 2007 Mar 21; 5(6):865-72. Yu H, Chen X. PMID: 17340000; PMCID: PMC2769254.
-
High-throughput substrate specificity studies of sialidases by using chemoenzymatically synthesized sialoside libraries. Chembiochem. 2007 Jan 22; 8(2):194-201. Chokhawala HA, Yu H, Chen X. PMID: 17195254; PMCID: PMC2610223.
-
Disaccharides as sialic acid aldolase substrates: synthesis of disaccharides containing a sialic acid at the reducing end. Angew Chem Int Ed Engl. 2007; 46(13):2249-53. Huang S, Yu H, Chen X. PMID: 17309109.
-
Highly efficient chemoenzymatic synthesis of naturally occurring and non-natural alpha-2,6-linked sialosides: a P. damsela alpha-2,6-sialyltransferase with extremely flexible donor-substrate specificity. Angew Chem Int Ed Engl. 2006 Jun 12; 45(24):3938-44. Yu H, Huang S, Chokhawala H, Sun M, Zheng H, Chen X. PMID: 16721893; PMCID: PMC2728590.
-
Aldolase-catalyzed synthesis of beta-D-galp-(1-->9)-D-KDN: a novel acceptor for sialyltransferases. Org Lett. 2006 May 25; 8(11):2393-6. Yu H, Chen X. PMID: 16706534.
-
Cytidine 5'-monophosphate (CMP)-induced structural changes in a multifunctional sialyltransferase from Pasteurella multocida. Biochemistry. 2006 Feb 21; 45(7):2139-48. Ni L, Sun M, Yu H, Chokhawala H, Chen X, Fisher AJ. PMID: 16475803.
-
One-pot three-enzyme chemoenzymatic approach to the synthesis of sialosides containing natural and non-natural functionalities. Nat Protoc. 2006; 1(5):2485-92. Yu H, Chokhawala HA, Huang S, Chen X. PMID: 17406495; PMCID: PMC2586341.
-
Characterization of a bifunctional cytidine 5'-monophosphate N-acetylneuraminic acid synthetase cloned from Streptococcus agalactiae. Biotechnol Lett. 2006 Jan; 28(2):107-13. Yu H, Ryan W, Yu H, Chen X. PMID: 16369694.
-
A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries. J Am Chem Soc. 2005 Dec 21; 127(50):17618-9. Yu H, Chokhawala H, Karpel R, Yu H, Wu B, Zhang J, Zhang Y, Jia Q, Chen X. PMID: 16351087.
-
Chemoenzymatic synthesis of CMP-sialic acid derivatives by a one-pot two-enzyme system: comparison of substrate flexibility of three microbial CMP-sialic acid synthetases. Bioorg Med Chem. 2004 Dec 15; 12(24):6427-35. Yu H, Yu H, Karpel R, Chen X. PMID: 15556760.
-
Production of N-sulfated polysaccharides using yeast-expressed N-deacetylase/N-sulfotransferase-1 (NDST-1). Glycobiology. 2004 Dec; 14(12):1217-28. Saribas AS, Mobasseri A, Pristatsky P, Chen X, Barthelson R, Hakes D, Wang J. PMID: 15253930.
-
Large-scale synthesis of globotriose derivatives through recombinant E. coli. Org Biomol Chem. 2003 Sep 07; 1(17):3048-53. Zhang J, Kowal P, Chen X, Wang PG. PMID: 14518127.
-
Glucuronides in anti-cancer therapy. Curr Med Chem Anticancer Agents. 2003 Mar; 3(2):139-50. Chen X, Wu B, Wang PG. PMID: 12678908.
-
Superbeads: immobilization in "sweet" chemistry. Chemistry. 2003 Jan 20; 9(2):372-7. Nahalka J, Liu Z, Chen X, Wang PG. PMID: 12532285.
-
Synthesis of galactose-containing oligosaccharides through superbeads and superbug approaches: substrate recognition along different biosynthetic pathways. Methods Enzymol. 2003; 362:106-24. Zhang J, Chen X, Shao J, Liu Z, Kowal P, Lu Y, Wang PG. PMID: 12968360.
-
Expeditious syntheses of two carbohydrate-linked cisplatin analogs. Carbohydr Res. 2002 Jun 05; 337(11):1043-6. Chen Y, Janczuk A, Chen X, Wang J, Ksebati M, Wang PG. PMID: 12039546.
-
Combined biosynthetic pathway for de novo production of UDP-galactose: catalysis with multiple enzymes immobilized on agarose beads. Chembiochem. 2002 Apr 02; 3(4):348-55. Liu Z, Zhang J, Chen X, Wang PG. PMID: 11933236.
-
Reassembled biosynthetic pathway for large-scale carbohydrate synthesis: alpha-Gal epitope producing "superbug". Chembiochem. 2002 Jan 04; 3(1):47-53. Chen X, Liu Z, Zhang J, Zhang W, Kowal P, Wang PG. PMID: 17590953.
-
Large-scale Synthesis of Carbohydrates for Pharmaceutical Development. Current Organic Chemistry. 2001 Dec 1; 5(12):1169-1176. Zhang ZJ, Wu WB, Liu LZ, Kowal KP, Chen CX, Shao SJ, Wang WP. .
-
Transferring a biosynthetic cycle into a productive Escherichia coli strain: large-scale synthesis of galactosides. J Am Chem Soc. 2001 Sep 12; 123(36):8866-7. Chen X, Zhang J, Kowal P, Liu Z, Andreana PR, Lu Y, Wang PG. PMID: 11535100.
-
Fluorophore-labeled S-nitrosothiols. J Org Chem. 2001 Sep 07; 66(18):6064-73. Chen X, Wen Z, Xian M, Wang K, Ramachandran N, Tang X, Schlegel HB, Mutus B, Wang PG. PMID: 11529732.
-
Sugar nucleotide regeneration beads (superbeads): a versatile tool for the practical synthesis of oligosaccharides. J Am Chem Soc. 2001 Mar 07; 123(9):2081-2. Chen X, Fang J, Zhang J, Liu Z, Shao J, Kowal P, Andreana P, Wang PG. PMID: 11456841.
-
Synthesis of alpha-Gal epitope derivatives with a galactosyltransferase-epimerase fusion enzyme. Carbohydr Res. 2000 Dec 01; 329(4):873-8. Fang J, Chen X, Zhang W, Janczuk A, Wang PG. PMID: 11125830.
-
Large-scale enzymatic synthesis of oligosaccharides. Curr Opin Drug Discov Devel. 2000 Nov; 3(6):756-63. Chen X, Kowal P, Wang PG. PMID: 19649904.
-
Changing the donor cofactor of bovine alpha 1, 3-galactosyltransferase by fusion with UDP-galactose 4-epimerase. More efficient biocatalysis for synthesis of alpha-Gal epitopes. J Biol Chem. 2000 Oct 13; 275(41):31594-600. Chen X, Liu Z, Wang J, Fang J, Fan H, Wang PG. PMID: 10913140.
-
Production of alpha-galactosyl epitopes via combined use of two recombinant whole cells harboring UDP-galactose 4-epimerase and alpha-1,3-galactosyltransferase. Biotechnol Prog. 2000 Jul-Aug; 16(4):595-9. Chen X, Zhang W, Wang J, Fang J, Wang PG. PMID: 10933834.
-
Inhibition of protein tyrosine phosphatases by low-molecular-weight S-nitrosothiols and S-nitrosylated human serum albumin. Biochem Biophys Res Commun. 2000 Feb 16; 268(2):310-4. Xian M, Wang K, Chen X, Hou Y, McGill A, Zhou B, Zhang ZY, Cheng JP, Wang PG. PMID: 10679200.
-
Carbohydrates in transplantation. Curr Opin Chem Biol. 1999 Dec; 3(6):650-8. Chen X, Andreana PR, Wang PG. PMID: 10600719.
-
Cloning, expression and characterization of a UDP-galactose 4-epimerase from Escherichia coli. Biotechnology Letters. 1999 Dec 1; 21(12):1131-1135. Chen CX, Kowal KP, Hamad HS, Fan FH, Wang WP. .
-
Enhanced Inhibition of Human Anti-Gal Antibody Binding to Mammalian Cells by Synthetic a-Gal Epitope Polymers. Journal of the American Chemical Society. 1999 Sep 1; 121(36):8174-8181. Wang WJ, Chen CX, Zhang ZW, Zacharek ZS, Chen CY, Wang WP. .
-
Bacteria targeted by human natural antibodies using alpha-Gal conjugated receptor-specific glycopolymers. Bioorg Med Chem. 1999 Aug; 7(8):1549-58. Li J, Zacharek S, Chen X, Wang J, Zhang W, Janczuk A, Wang PG. PMID: 10482447.
-
A Unique Chemoenzymatic Synthesis of a-Galactosyl Epitope Derivatives Containing Free Amino Groups: Efficient Separation and Further Manipulation. The Journal of Organic Chemistry. 1999 May 1; 64(11):4089-4094. Fang FJ, Chen CX, Zhang ZW, Wang WJ, Andreana AP, Wang WP. .
-
Alpha-Gal oligosaccharides: chemistry and potential biomedical application. Curr Med Chem. 1999 Feb; 6(2):155-64. Janczuk A, Li J, Zhang W, Chen X, Chen Y, Fang J, Wang J, Wang PG. PMID: 10189229.
-
Highly Efficient Chemoenzymatic Synthesis of a-Galactosyl Epitopes with a Recombinant a(1?3)-Galactosyltransferase. Journal of the American Chemical Society. 1998 Jul 1; 120(27):6635-6638. Fang FJ, Li LJ, Chen CX, Zhang ZY, Wang WJ, Guo GZ, Zhang ZW, Yu YL, Brew BK, Wang WP. .
US