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Claudin 4 Deletion Improves Gut Permeability and Survival in a Murine Model of Abdominal Sepsis. Shock. 2026 Feb 03. Shimazui T, Gutierrez MB, Hayashi Y, Sarmiento S, Liang Z, Oami T, Borok Z, Crandall ED, Burd EM, Koval M, Ford ML, Coopersmith CM. PMID: 41697223.
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Diffuse Parenchymal Lung Disease: Updates in Pathophysiology and Management. Annu Rev Med. 2026 Jan; 77(1):479-492. Joshua J, Borok Z. PMID: 41592933.
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Integrated multiomic analysis identifies TRIP13 as a mediator of alveolar epithelial type II cell dysfunction in idiopathic pulmonary fibrosis. Biochim Biophys Acta Mol Basis Dis. 2025 03; 1871(3):167572. St Pierre L, Berhan A, Sung EK, Alvarez JR, Wang H, Ji Y, Liu Y, Yu H, Meier A, Afshar K, Golts EM, Lin GY, Castaldi A, Calvert BA, Ryan A, Zhou B, Offringa IA, Marconett CN, Borok Z. PMID: 39547519; PMCID: PMC11951472.
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A Dynamic, D-dimer-based Thromboprophylaxis Strategy in Patients with COVID-19. F1000Res. 2024; 13:887. Bhoopat L, Martynova A, Choi A, Pattharanitima P, Han S, Du S, Syed I, Chan C, Oh EE, Borok Z, Liebler J, Wilson ML, Tantiyavarong P, Connell CO. PMID: 39399164; PMCID: PMC11467651.
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Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells. Cell Stem Cell. 2024 10 03; 31(10):1465-1483.e6. Xu L, Tan C, Barr J, Talaba N, Verheyden J, Chin JS, Gaboyan S, Kasaraneni N, Elgamal RM, Gaulton KJ, Lin G, Afshar K, Golts E, Meier A, Crotty Alexander LE, Borok Z, Shen Y, Chung WK, McCulley DJ, Sun X. PMID: 39181129; PMCID: PMC12398276.
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Cell of origin alters myeloid-mediated immunosuppression in lung adenocarcinoma. bioRxiv. 2024 Jun 23. Yang M, Shulkin N, Gonzalez E, Castillo J, Yan C, Zhang K, Arvanitis L, Borok Z, Wallace WD, Raz D, Torres ETR, Marconett CN. PMID: 38948812; PMCID: PMC11213232.
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Viral and Host Factors Are Associated With Mortality in Hospitalized Patients With COVID-19. Clin Infect Dis. 2024 06 14; 78(6):1490-1503. Aggarwal NR, Nordwall J, Braun DL, Chung L, Coslet J, Der T, Eriobu N, Ginde AA, Hayanga AJ, Highbarger H, Holodniy M, Horcajada JP, Jain MK, Kim K, Laverdure S, Lundgren J, Natarajan V, Nguyen HH, Pett SL, Phillips A, Poulakou G, Price DA, Robinson P, Rogers AJ, Sandkovsky U, Shaw-Saliba K, Sturek JM, Trautner BW, Waters M, Reilly C, ACTIV-3/TICO Study Group. PMID: 38376212; PMCID: PMC11175705.
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Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study. Lancet Microbe. 2024 Jun; 5(6):e559-e569. Jensen TO, Murray TA, Grandits GA, Jain MK, Grund B, Shaw-Saliba K, Matthay MA, Abassi M, Ardelt M, Baker JV, Chen P, Dewar RL, Goodman AL, Hatlen TJ, Highbarger HC, Holodniy M, Lallemand P, Laverdure S, Leshnower BG, Looney D, Moschopoulos CD, Mugerwa H, Murray DD, Mylonakis E, Nagy-Agren S, Rehman MT, Rupert A, Stevens R, Turville S, Weintrob A, Wick K, Lundgren J, Ko ER, ACTIV-3/TICO Study Group. PMID: 38815595; PMCID: PMC11181148.
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Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. Immunity. 2024 06 11; 57(6):1378-1393.e14. De Sanctis F, Dusi S, Caligola S, Anselmi C, Petrova V, Rossi B, Angelini G, Erdeljan M, Wöll S, Schlitter AM, Metzler T, Steiger K, Borok Z, Bailey P, Bauer A, Halin C, Boschi F, Giugno R, Canè S, Lawlor R, Corbo V, Scarpa A, Constantin G, Ugel S, Vascotto F, Sahin U, Türeci Ö, Bronte V. PMID: 38749447.
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TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis. Cell Metab. 2024 May 07; 36(5):1030-1043.e7. Isaac R, Bandyopadhyay G, Rohm TV, Kang S, Wang J, Pokhrel N, Sakane S, Zapata R, Libster AM, Vinik Y, Berhan A, Kisseleva T, Borok Z, Zick Y, Telese F, Webster NJG, Olefsky JM. PMID: 38670107; PMCID: PMC11113091.
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RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis. Cell Death Dis. 2024 01 22; 15(1):81. Quiroz EJ, Kim S, Gautam LK, Borok Z, Kintner C, Ryan AL. PMID: 38253523; PMCID: PMC10803754.
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Alveolar type I cells can give rise to KRAS-induced lung adenocarcinoma. Cell Rep. 2023 12 26; 42(12):113286. Yang M, Shen H, Flodby P, Koss MD, Bassiouni R, Liu Y, Jashashvili T, Neely A, Ogbolu E, Castillo J, Stueve TR, Mullen DJ, Ryan AL, Carpten J, Castaldi A, Wallace WD, Zhou B, Borok Z, Marconett CN. PMID: 37995179; PMCID: PMC10842735.
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GRAMD2 + alveolar type I cell plasticity facilitates cell state transitions in organoid culture. bioRxiv. 2023 Oct 18. Shen H, Chen W, Liu Y, Castaldi A, Castillo J, Horie M, Flodby P, Sundar S, Li C, Ji Y, Minoo P, Marconett CN, Zhou B, Borok Z. PMID: 37905051; PMCID: PMC10614891.
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RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis. bioRxiv. 2023 Aug 04. Quiroz EJ, Kim S, Gautam LK, Borok Z, Kintner C, Ryan AL. PMID: 37577572; PMCID: PMC10418160.
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Building Career Paths for Ph.D., Basic and Translational Scientists in Clinical Departments in the United States: An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2023 08; 20(8):1077-1087. Moore BB, Ballinger MN, Bauer NN, Blackwell TS, Borok Z, Budinger GRS, Camoretti-Mercado B, Erzurum SC, Himes BE, Keshamouni VG, Kulkarni HS, Mallampalli RK, Mariani TJ, Martinez FJ, McCombs JE, Newcomb DC, Johnston RA, O'Reilly MA, Prakash YS, Ridge KM, Sime PJ, Sperling AI, Violette S, Wilkes DS, Königshoff M. PMID: 37526479; PMCID: PMC10405615.
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Targeting caveolae to pump bispecific antibody to TGF-β into diseased lungs enables ultra-low dose therapeutic efficacy. PLoS One. 2022; 17(11):e0276462. Kadam AH, Kandasamy K, Buss T, Cederstrom B, Yang C, Narayanapillai S, Rodriguez J, Levin MD, Koziol J, Olenyuk B, Borok Z, Chrastina A, Schnitzer JE. PMID: 36413536; PMCID: PMC9681080.
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Decoding the IGF1 signaling gene regulatory network behind alveologenesis from a mouse model of bronchopulmonary dysplasia. Elife. 2022 10 10; 11. Gao F, Li C, Smith SM, Peinado N, Kohbodi G, Tran E, Loh YE, Li W, Borok Z, Minoo P. PMID: 36214448; PMCID: PMC9581530.
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Wnt5a Promotes AT1 and Represses AT2 Lineage-Specific Gene Expression in a Cell-Context-Dependent Manner. Stem Cells. 2022 07 27; 40(7):691-703. Li C, Peinado N, Smith SM, Zhou J, Gao F, Kohbodi G, Zhou B, Thornton ME, Grubbs BH, Lee MK, Bellusci S, Borok Z, Chen YW, Minoo P. PMID: 35429397; PMCID: PMC9332903.
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Stem cells, cell therapies, and bioengineering in lung biology and disease 2021. Am J Physiol Lung Cell Mol Physiol. 2022 09 01; 323(3):L341-L354. Ikonomou L, Magnusson M, Dries R, Herzog EL, Hynds RE, Borok Z, Park JA, Skolasinski S, Burgess JK, Turner L, Mojarad SM, Mahoney JE, Lynch T, Lehmann M, Thannickal VJ, Hook JL, Vaughan AE, Hoffman ET, Weiss DJ, Ryan AL. PMID: 35762622; PMCID: PMC9484991.
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Hedgehog-responsive PDGFRa(+) fibroblasts maintain a unique pool of alveolar epithelial progenitor cells during alveologenesis. Cell Rep. 2022 04 05; 39(1):110608. Gao F, Li C, Danopoulos S, Al Alam D, Peinado N, Webster S, Borok Z, Kohbodi GA, Bellusci S, Minoo P. PMID: 35385750; PMCID: PMC9199394.
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FOXO1 Couples KGF and PI-3K/AKT Signaling to NKX2.1-Regulated Differentiation of Alveolar Epithelial Cells. Cells. 2022 03 26; 11(7). Zhong Q, Liu Y, Correa MR, Marconett CN, Minoo P, Li C, Ann DK, Zhou B, Borok Z. PMID: 35406686; PMCID: PMC8997990.
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Development of human alveolar epithelial cell models to study distal lung biology and disease. iScience. 2022 Feb 18; 25(2):103780. Tran E, Shi T, Li X, Chowdhury AY, Jiang D, Liu Y, Wang H, Yan C, Wallace WD, Lu R, Ryan AL, Marconett CN, Zhou B, Borok Z, Offringa IA. PMID: 35169685; PMCID: PMC8829779.
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Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for maintenance of distal lung identity. BMC Genomics. 2021 Dec 18; 22(1):906. Zhou B, Stueve TR, Mihalakakos EA, Miao L, Mullen D, Wang Y, Liu Y, Luo J, Tran E, Siegmund KD, Lynch SK, Ryan AL, Offringa IA, Borok Z, Marconett CN. PMID: 34922464; PMCID: PMC8684104.
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A wearable eddy current based pulmonary function sensor for continuous non-contact point-of-care monitoring during the COVID-19 pandemic. Sci Rep. 2021 10 11; 11(1):20144. Shahrestani S, Chou TC, Shang KM, Zada G, Borok Z, Rao AP, Tai YC. PMID: 34635738; PMCID: PMC8505507.
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Categorization of lung mesenchymal cells in development and fibrosis. iScience. 2021 Jun 25; 24(6):102551. Liu X, Rowan SC, Liang J, Yao C, Huang G, Deng N, Xie T, Wu D, Wang Y, Burman A, Parimon T, Borok Z, Chen P, Parks WC, Hogaboam CM, Weigt SS, Belperio J, Stripp BR, Noble PW, Jiang D. PMID: 34151224; PMCID: PMC8188567.
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MMP-2 is a novel histone H3 N-terminal protease necessary for myogenic gene activation. Epigenetics Chromatin. 2021 05 17; 14(1):23. Rice JC, Weekley BH, Kanholm T, Chen Z, Lee S, Fernandez DJ, Abrahamson R, Castaldi A, Borok Z, Dynlacht BD, An W. PMID: 34001241; PMCID: PMC8130154.
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Endoplasmic reticulum chaperone GRP78/BiP is critical for mutant Kras-driven lung tumorigenesis. Oncogene. 2021 05; 40(20):3624-3632. Rangel DF, Dubeau L, Park R, Chan P, Ha DP, Pulido MA, Mullen DJ, Vorobyova I, Zhou B, Borok Z, Offringa IA, Lee AS. PMID: 33931739; PMCID: PMC8179725.
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Vitamin C, Thiamine, and Hydrocortisone in the Treatment of Sepsis: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials. J Intensive Care Med. 2022 Mar; 37(3):327-336. Zayed Y, Alzghoul BN, Banifadel M, Venigandla H, Hyde R, Sutchu S, Khasawneh M, Borok Z, Urbine D, Jantz M, Reddy R. PMID: 33511898.
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Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker. Cells. 2020 11 11; 9(11). Horie M, Castaldi A, Sunohara M, Wang H, Ji Y, Liu Y, Li F, Wilkinson TA, Hung L, Shen H, Kage H, Offringa IA, Marconett CN, Flodby P, Zhou B, Borok Z. PMID: 33187367; PMCID: PMC7697677.
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Protocol for Differentiation of Human iPSCs into Pulmonary Neuroendocrine Cells. STAR Protoc. 2020 09 18; 1(2):100068. Hor P, Ichida JK, Borok Z, Ryan AL. PMID: 33111106; PMCID: PMC7580194.
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Genome-wide integration of microRNA and transcriptomic profiles of differentiating human alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2020 07 01; 319(1):L173-L184. Castaldi A, Horie M, Rieger ME, Dubourd M, Sunohara M, Pandit K, Zhou B, Offringa IA, Marconett CN, Borok Z. PMID: 32432919; PMCID: PMC7468844.
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Efficient Generation and Transcriptomic Profiling of Human iPSC-Derived Pulmonary Neuroendocrine Cells. iScience. 2020 May 22; 23(5):101083. Hor P, Punj V, Calvert BA, Castaldi A, Miller AJ, Carraro G, Stripp BR, Brody SL, Spence JR, Ichida JK, Ryan Firth AL, Borok Z. PMID: 32380423; PMCID: PMC7205764.
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Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung. Dev Cell. 2020 03 09; 52(5):617-630.e6. Vila Ellis L, Cain MP, Hutchison V, Flodby P, Crandall ED, Borok Z, Zhou B, Ostrin EJ, Wythe JD, Chen J. PMID: 32059772; PMCID: PMC7170573.
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WNT5a-ROR Signaling Is Essential for Alveologenesis. Cells. 2020 02 07; 9(2). Li C, Smith SM, Peinado N, Gao F, Li W, Lee MK, Zhou B, Bellusci S, Pryhuber GS, Ho HH, Borok Z, Minoo P. PMID: 32046118; PMCID: PMC7072327.
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Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis. Am J Respir Crit Care Med. 2020 01 15; 201(2):198-211. Borok Z, Horie M, Flodby P, Wang H, Liu Y, Ganesh S, Firth AL, Minoo P, Li C, Beers MF, Lee AS, Zhou B. PMID: 31738079; PMCID: PMC6961744.
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Perspectives on Burnout from Pulmonary, Critical Care, and Sleep Medicine Division Directors. Am J Respir Crit Care Med. 2020 01 01; 201(1):111-114. Rinne ST, Swamy L, Anderson E, Shah T, Dixon AE, Kaminski N, Borok Z, Thomson CC. PMID: 31469580.
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Transcriptional control of lung alveolar type 1 cell development and maintenance by NK homeobox 2-1. Proc Natl Acad Sci U S A. 2019 10 08; 116(41):20545-20555. Little DR, Gerner-Mauro KN, Flodby P, Crandall ED, Borok Z, Akiyama H, Kimura S, Ostrin EJ, Chen J. PMID: 31548395; PMCID: PMC6789920.
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Secondary crest myofibroblast PDGFRα controls the elastogenesis pathway via a secondary tier of signaling networks during alveologenesis. Development. 2019 08 09; 146(15). Li C, Lee MK, Gao F, Webster S, Di H, Duan J, Yang CY, Bhopal N, Peinado N, Pryhuber G, Smith SM, Borok Z, Bellusci S, Minoo P. PMID: 31331942; PMCID: PMC6703710.
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Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice. Cell Mol Life Sci. 2019 Dec; 76(23):4663-4672. Kage H, Flodby P, Zhou B, Borok Z. PMID: 31332482; PMCID: PMC6858953.
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Circulating angiotensin peptides levels in Acute Respiratory Distress Syndrome correlate with clinical outcomes: A pilot study. PLoS One. 2019; 14(3):e0213096. Reddy R, Asante I, Liu S, Parikh P, Liebler J, Borok Z, Rodgers K, Baydur A, Louie SG. PMID: 30845246; PMCID: PMC6405137.
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LINC00261 Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response. Cancer Res. 2019 Jun 15; 79(12):3050-3062. Shahabi S, Kumaran V, Castillo J, Cong Z, Nandagopal G, Mullen DJ, Alvarado A, Correa MR, Saizan A, Goel R, Bhat A, Lynch SK, Zhou B, Borok Z, Marconett CN. PMID: 30796052; PMCID: PMC6571057.
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Addressing Gender Inequality in Our Disciplines: Report from the Association of Pulmonary, Critical Care, and Sleep Division Chiefs. Ann Am Thorac Soc. 2018 12; 15(12):1382-1390. Thomson CC, Riekert KA, Bates CK, Jena AB, Borok Z, McCallister JW, Schnapp LM, Lama VN, Kraft M, Davis SD, Finn P, Carson SS, Beck JM, Powell CA, Tanoue LT, Kaminski N, Dixon AE. PMID: 30153425.
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CLDN18.1 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro. Int J Cancer. 2018 12 15; 143(12):3169-3180. Luo J, Chimge NO, Zhou B, Flodby P, Castaldi A, Firth AL, Liu Y, Wang H, Yang C, Marconett CN, Crandall ED, Offringa IA, Frenkel B, Borok Z. PMID: 30325015; PMCID: PMC6263834.
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Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes. Epigenomics. 2018 09; 10(9):1167-1187. Yang C, Stueve TR, Yan C, Rhie SK, Mullen DJ, Luo J, Zhou B, Borok Z, Marconett CN, Offringa IA. PMID: 30212242; PMCID: PMC6391636.
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CISH is a negative regulator of IL-13-induced CCL26 production in lung fibroblasts. Allergol Int. 2019 Jan; 68(1):101-109. Takeshima H, Horie M, Mikami Y, Makita K, Miyashita N, Matsuzaki H, Noguchi S, Urushiyama H, Hiraishi Y, Mitani A, Borok Z, Nagase T, Yamauchi Y. PMID: 30197185.
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Alveolar epithelial cell processing of nanoparticles activates autophagy and lysosomal exocytosis. Am J Physiol Lung Cell Mol Physiol. 2018 08 01; 315(2):L286-L300. Sipos A, Kim KJ, Chow RH, Flodby P, Borok Z, Crandall ED. PMID: 29722567; PMCID: PMC6139662.
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Vitamin D status in sarcoidosis: a cross-sectional study. Sarcoidosis Vasc Diffuse Lung Dis. 2018; 35(2):154-159. Papanikolaou IC, Tabila B, Tabila K, Borok Z, Sharma O, Gould MK. PMID: 32476896; PMCID: PMC7170088.
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Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest. 2018 03 01; 128(3):970-984. Zhou B, Flodby P, Luo J, Castillo DR, Liu Y, Yu FX, McConnell A, Varghese B, Li G, Chimge NO, Sunohara M, Koss MN, Elatre W, Conti P, Liebler JM, Yang C, Marconett CN, Laird-Offringa IA, Minoo P, Guan K, Stripp BR, Crandall ED, Borok Z. PMID: 29400695; PMCID: PMC5824875.
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Isolation of Rat and Mouse Alveolar Type II Epithelial Cells. Methods Mol Biol. 2018; 1809:69-82. Jansing NL, McClendon J, Kage H, Sunohara M, Alvarez JR, Borok Z, Zemans RL. PMID: 29987783; PMCID: PMC10323965.
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Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L1016-L1029. Lax S, Rayes J, Wichaiyo S, Haining EJ, Lowe K, Grygielska B, Laloo R, Flodby P, Borok Z, Crandall ED, Thickett DR, Watson SP. PMID: 28839100; PMCID: PMC5814702.
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Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2. Pharm Res. 2017 Dec; 34(12):2488-2497. Gukasyan HJ, Uchiyama T, Kim KJ, Ehrhardt C, Wu SK, Borok Z, Crandall ED, Lee VHL. PMID: 28831683.
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Epigenome-wide analysis of DNA methylation in lung tissue shows concordance with blood studies and identifies tobacco smoke-inducible enhancers. Hum Mol Genet. 2017 08 01; 26(15):3014-3027. Stueve TR, Li WQ, Shi J, Marconett CN, Zhang T, Yang C, Mullen D, Yan C, Wheeler W, Hua X, Zhou B, Borok Z, Caporaso NE, Pesatori AC, Duan J, Laird-Offringa IA, Landi MT. PMID: 28854564; PMCID: PMC5886283.
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Astrocytic tight junctions control inflammatory CNS lesion pathogenesis. J Clin Invest. 2017 Aug 01; 127(8):3136-3151. Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw AT, Hara Y, Mariani JN, Sawai S, Flodby P, Crandall ED, Borok Z, Sofroniew MV, Chapouly C, John GR. PMID: 28737509; PMCID: PMC5531407.
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Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis. Oncogene. 2017 10 26; 36(43):6020-6029. Debebe A, Medina V, Chen CY, Mahajan IM, Jia C, Fu D, He L, Zeng N, Stiles BW, Chen CL, Wang M, Aggarwal KR, Peng Z, Huang J, Chen J, Li M, Dong T, Atkins S, Borok Z, Yuan W, Machida K, Ju C, Kahn M, Johnson D, Stiles BL. PMID: 28671671; PMCID: PMC5666317.
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Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation. Sci Rep. 2017 06 14; 7(1):3473. Flodby P, Li C, Liu Y, Wang H, Rieger ME, Minoo P, Crandall ED, Ann DK, Borok Z, Zhou B. PMID: 28615712; PMCID: PMC5471216.
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Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes. Am J Respir Cell Mol Biol. 2017 03; 56(3):310-321. Marconett CN, Zhou B, Sunohara M, Pouldar TM, Wang H, Liu Y, Rieger ME, Tran E, Flodby P, Siegmund KD, Crandall ED, Laird-Offringa IA, Borok Z. PMID: 27749084; PMCID: PMC5359537.
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Region-specific role for Pten in maintenance of epithelial phenotype and integrity. Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L131-L142. Flodby P, Liebler JM, Sunohara M, Castillo DR, McConnell AM, Krishnaveni MS, Banfalvi A, Li M, Stripp B, Zhou B, Crandall ED, Minoo P, Borok Z. PMID: 27864284; PMCID: PMC5283927.
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IL-1R1-MyD88 axis elicits papain-induced lung inflammation. Eur J Immunol. 2016 11; 46(11):2531-2541. Agoro R, Piotet-Morin J, Palomo J, Michaudel C, Vigne S, Maillet I, Chenuet P, Guillou N, Le Bérichel J, Kisielow M, Flodby P, Borok Z, Crandall ED, Le Bert M, Quesniaux V, Muller M, Di Padova F, Ryffel B, Gabay C, Couturier-Maillard A. PMID: 27569535.
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Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance. Am J Respir Cell Mol Biol. 2016 09; 55(3):395-406. Flodby P, Kim YH, Beard LL, Gao D, Ji Y, Kage H, Liebler JM, Minoo P, Kim KJ, Borok Z, Crandall ED. PMID: 27064541; PMCID: PMC5023030.
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Pleiotropic Analysis of Lung Cancer and Blood Triglycerides. J Natl Cancer Inst. 2016 12; 108(12). Zuber V, Marconett CN, Shi J, Hua X, Wheeler W, Yang C, Song L, Dale AM, Laplana M, Risch A, Witoelar A, Thompson WK, Schork AJ, Bettella F, Wang Y, Djurovic S, Zhou B, Borok Z, van der Heijden HF, de Graaf J, Swinkels D, Aben KK, McKay J, Hung RJ, Bikeböller H, Stevens VL, Albanes D, Caporaso NE, Han Y, Wei Y, Panadero MA, Mayordomo JI, Christiani DC, Kiemeney L, Andreassen OA, Houlston R, Amos CI, Chatterjee N, Laird-Offringa IA, Mills IG, Landi MT. PMID: 27565901; PMCID: PMC5241892.
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The importance of detailed epigenomic profiling of different cell types within organs. Epigenomics. 2016 06; 8(6):817-29. Stueve TR, Marconett CN, Zhou B, Borok Z, Laird-Offringa IA. PMID: 27305639; PMCID: PMC5066118.
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An American Thoracic Society Official Research Statement: Future Directions in Lung Fibrosis Research. Am J Respir Crit Care Med. 2016 Apr 01; 193(7):792-800. White ES, Borok Z, Brown KK, Eickelberg O, Guenther A, Jenkins RG, Kolb M, Martinez FJ, Roman J, Sime P, American Thoracic Society Respiratory Cell and Molecular Biology Assembly Working Group on Pulmonary. PMID: 27035782; PMCID: PMC5440092.
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Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate. BMC Biol. 2016 Mar 16; 14:19. Li A, Ma S, Smith SM, Lee MK, Fischer A, Borok Z, Bellusci S, Li C, Minoo P. PMID: 26984772; PMCID: PMC4793501.
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p300/β-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC). J Biol Chem. 2016 Mar 18; 291(12):6569-82. Rieger ME, Zhou B, Solomon N, Sunohara M, Li C, Nguyen C, Liu Y, Pan JH, Minoo P, Crandall ED, Brody SL, Kahn M, Borok Z. PMID: 26833564; PMCID: PMC4813575.
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Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E. Sci Rep. 2015 Dec 18; 5:18233. Smith KA, Zhou B, Avdulov S, Benyumov A, Peterson M, Liu Y, Okon A, Hergert P, Braziunas J, Wagner CR, Borok Z, Bitterman PB. PMID: 26678431; PMCID: PMC4683370.
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Non-canonical WNT signalling in the lung. J Biochem. 2015 Nov; 158(5):355-65. Li C, Bellusci S, Borok Z, Minoo P. PMID: 26261051; PMCID: PMC4751232.
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Progenitors of secondary crest myofibroblasts are developmentally committed in early lung mesoderm. Stem Cells. 2015 Mar; 33(3):999-1012. Li C, Li M, Li S, Xing Y, Yang CY, Li A, Borok Z, De Langhe S, Minoo P. PMID: 25448080; PMCID: PMC4650896.
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A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2263-8. Catalán MA, Kondo Y, Peña-Munzenmayer G, Jaramillo Y, Liu F, Choi S, Crandall E, Borok Z, Flodby P, Shull GE, Melvin JE. PMID: 25646474; PMCID: PMC4343136.
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Transcriptomic Profiling of Primary Alveolar Epithelial Cell Differentiation in Human and Rat. Genom Data. 2014 Dec 01; 2:105-109. Marconett CN, Zhou B, Siegmund KD, Borok Z, Laird-Offringa IA. PMID: 25343132; PMCID: PMC4203668.
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Dynamic involvement of ATG5 in cellular stress responses. Cell Death Dis. 2014 Oct 23; 5:e1478. Lin HH, Lin SM, Chung Y, Vonderfecht S, Camden JM, Flodby P, Borok Z, Limesand KH, Mizushima N, Ann DK. PMID: 25341032; PMCID: PMC4649523.
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Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Oct 01; 307(7):L524-36. Kage H, Flodby P, Gao D, Kim YH, Marconett CN, DeMaio L, Kim KJ, Crandall ED, Borok Z. PMID: 25106430; PMCID: PMC4187039.
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Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. Li G, Flodby P, Luo J, Kage H, Sipos A, Gao D, Ji Y, Beard LL, Marconett CN, DeMaio L, Kim YH, Kim KJ, Laird-Offringa IA, Minoo P, Liebler JM, Zhou B, Crandall ED, Borok Z. PMID: 24588076; PMCID: PMC4148039.
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Alveolar epithelium: beyond the barrier. Am J Respir Cell Mol Biol. 2014 May; 50(5):853-6. Borok Z. PMID: 24783957; PMCID: PMC4068954.
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Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. Nat Commun. 2014 Feb 27; 5:3365. Shi J, Marconett CN, Duan J, Hyland PL, Li P, Wang Z, Wheeler W, Zhou B, Campan M, Lee DS, Huang J, Zhou W, Triche T, Amundadottir L, Warner A, Hutchinson A, Chen PH, Chung BS, Pesatori AC, Consonni D, Bertazzi PA, Bergen AW, Freedman M, Siegmund KD, Berman BP, Borok Z, Chatterjee N, Tucker MA, Caporaso NE, Chanock SJ, Laird-Offringa IA, Landi MT. PMID: 24572595; PMCID: PMC3982882.
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Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med. 2014 Jan 15; 189(2):214-22. Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. PMID: 24160862; PMCID: PMC3983890.
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Deletion of ATG5 shows a role of autophagy in salivary homeostatic control. J Dent Res. 2013 Oct; 92(10):911-7. Morgan-Bathke M, Lin HH, Chibly AM, Zhang W, Sun X, Chen CH, Flodby P, Borok Z, Wu R, Arnett D, Klein RR, Ann DK, Limesand KH. PMID: 23884556; PMCID: PMC3775371.
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Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation. PLoS Genet. 2013 Jun; 9(6):e1003513. Marconett CN, Zhou B, Rieger ME, Selamat SA, Dubourd M, Fang X, Lynch SK, Stueve TR, Siegmund KD, Berman BP, Borok Z, Laird-Offringa IA. PMID: 23818859; PMCID: PMC3688557.
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Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling. PLoS One. 2013; 8(4):e62215. Li A, Chan B, Felix JC, Xing Y, Li M, Brody SL, Borok Z, Li C, Minoo P. PMID: 23646120; PMCID: PMC3639955.
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Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling. Dev Biol. 2013 Jun 01; 378(1):13-24. Li C, Li A, Xing Y, Li M, Chan B, Ouyang R, Taketo MM, Kucherlapati R, Borok Z, Minoo P. PMID: 23562608; PMCID: PMC3838671.
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Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms. Nanomedicine. 2013 Aug; 9(6):786-94. Fazlollahi F, Kim YH, Sipos A, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 23454523; PMCID: PMC3702651.
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Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2. PLoS One. 2013; 8(1):e53342. Wu H, Chen L, Zhang X, Zhou Q, Li JM, Berger S, Borok Z, Zhou B, Xiao Z, Yin H, Liu M, Wang Y, Jin J, Blackburn MR, Xia Y, Zhang W. PMID: 23326416; PMCID: PMC3542343.
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Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype. J Clin Invest. 2012 Nov; 122(11):3862-72. Tiozzo C, Carraro G, Al Alam D, Baptista S, Danopoulos S, Li A, Lavarreda-Pearce M, Li C, De Langhe S, Chan B, Borok Z, Bellusci S, Minoo P. PMID: 23023706; PMCID: PMC3484434.
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EMT and interstitial lung disease: a mysterious relationship. Curr Opin Pulm Med. 2012 Sep; 18(5):517-23. Kage H, Borok Z. PMID: 22854509; PMCID: PMC3914631.
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Troglitazone attenuates TGF-β1-induced EMT in alveolar epithelial cells via a PPARγ-independent mechanism. PLoS One. 2012; 7(6):e38827. Zhou B, Buckley ST, Patel V, Liu Y, Luo J, Krishnaveni MS, Ivan M, DeMaio L, Kim KJ, Ehrhardt C, Crandall ED, Borok Z. PMID: 22745681; PMCID: PMC3380041.
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NOTCH1 is required for regeneration of Clara cells during repair of airway injury. Stem Cells. 2012 May; 30(5):946-55. Xing Y, Li A, Borok Z, Li C, Minoo P. PMID: 22331706; PMCID: PMC4005608.
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Cigarette smoke extract stimulates epithelial-mesenchymal transition through Src activation. Free Radic Biol Med. 2012 Apr 15; 52(8):1437-42. Zhang H, Liu H, Borok Z, Davies KJ, Ursini F, Forman HJ. PMID: 22342303; PMCID: PMC3312989.
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Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP). J Biol Chem. 2012 Mar 02; 287(10):7026-38. Zhou B, Liu Y, Kahn M, Ann DK, Han A, Wang H, Nguyen C, Flodby P, Zhong Q, Krishnaveni MS, Liebler JM, Minoo P, Crandall ED, Borok Z. PMID: 22241478; PMCID: PMC3293544.
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Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2. Breast Cancer Res. 2011; 13(6):R127. Chimge NO, Baniwal SK, Little GH, Chen YB, Kahn M, Tripathy D, Borok Z, Frenkel B. PMID: 22151997; PMCID: PMC3326569.
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Ligand-independent transforming growth factor-β type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition. J Pathol. 2012 Mar; 226(4):633-44. DeMaio L, Buckley ST, Krishnaveni MS, Flodby P, Dubourd M, Banfalvi A, Xing Y, Ehrhardt C, Minoo P, Zhou B, Crandall ED, Borok Z. PMID: 21984393; PMCID: PMC4012689.
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In search of the fibrotic epithelial cell: opportunities for a collaborative network. Thorax. 2012 Feb; 67(2):179-82. Jenkins G, Blanchard A, Borok Z, Bradding P, Ehrhardt C, Fisher A, Hirani N, Johnson S, Königshoff M, Maher TM, Millar A, Parfrey H, Scotton C, Tetley T, Thickett D, Wolters P, ECIPF workshop. PMID: 21680569.
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Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. Proc Am Thorac Soc. 2011 Jun; 8(3):215-22. Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA, Kiley J, Gail D, Hoshizaki D. PMID: 21653526; PMCID: PMC3132783.
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Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc. 2011 Jun; 8(3):223-72. Weiss DJ, Bertoncello I, Borok Z, Kim C, Panoskaltsis-Mortari A, Reynolds S, Rojas M, Stripp B, Warburton D, Prockop DJ. PMID: 21653527; PMCID: PMC3132784.
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Nanomaterial interactions with and trafficking across the lung alveolar epithelial barrier: implications for health effects of air-pollution particles. Air Qual Atmos Health. 2011 Mar 01; 4(1):65-78. Yacobi NR, Fazllolahi F, Kim YH, Sipos A, Borok Z, Kim KJ, Crandall ED. PMID: 25568662; PMCID: PMC4283834.
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Polystyrene nanoparticle trafficking across MDCK-II. Nanomedicine. 2011 Oct; 7(5):588-94. Fazlollahi F, Angelow S, Yacobi NR, Marchelletta R, Yu AS, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 21310266; PMCID: PMC3130091.
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Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):498-509. Zhong Q, Zhou B, Ann DK, Minoo P, Liu Y, Banfalvi A, Krishnaveni MS, Dubourd M, Demaio L, Willis BC, Kim KJ, duBois RM, Crandall ED, Beers MF, Borok Z. PMID: 21169555; PMCID: PMC3175581.
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Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis. J Clin Invest. 2011 Jan; 121(1):277-87. Li M, Krishnaveni MS, Li C, Zhou B, Xing Y, Banfalvi A, Li A, Lombardi V, Akbari O, Borok Z, Minoo P. PMID: 21135509; PMCID: PMC3007138.
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Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair. Dev Dyn. 2010 Aug; 239(8):2288-97. Li A, Xing Y, Chan B, Heisterkamp N, Groffen J, Borok Z, Minoo P, Li C. PMID: 20658693; PMCID: PMC2911649.
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Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14309-14. Henderson WR, Chi EY, Ye X, Nguyen C, Tien YT, Zhou B, Borok Z, Knight DA, Kahn M. PMID: 20660310; PMCID: PMC2922550.
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Signaling via Alk5 controls the ontogeny of lung Clara cells. Development. 2010 Mar; 137(5):825-33. Xing Y, Li C, Li A, Sridurongrit S, Tiozzo C, Bellusci S, Borok Z, Kaartinen V, Minoo P. PMID: 20147383; PMCID: PMC2827691.
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More life for a "terminal" cell. Am J Physiol Lung Cell Mol Physiol. 2009 Dec; 297(6):L1042-4. Borok Z, Crandall ED. PMID: 19837848; PMCID: PMC2793181.
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Directed expression of Cre in alveolar epithelial type 1 cells. Am J Respir Cell Mol Biol. 2010 Aug; 43(2):173-8. Flodby P, Borok Z, Banfalvi A, Zhou B, Gao D, Minoo P, Ann DK, Morrisey EE, Crandall ED. PMID: 19767448; PMCID: PMC2937230.
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Epithelial-mesenchymal transition: potential role in obliterative bronchiolitis? Thorax. 2009 Sep; 64(9):742-3. Willis BC, Borok Z. PMID: 19717708; PMCID: PMC4172368.
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N-acetylcysteine inhibits alveolar epithelial-mesenchymal transition. Am J Physiol Lung Cell Mol Physiol. 2009 Nov; 297(5):L805-12. Felton VM, Borok Z, Willis BC. PMID: 19648289; PMCID: PMC2777496.
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Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury. Am J Respir Crit Care Med. 2009 Oct 15; 180(8):701-12. Tiozzo C, De Langhe S, Yu M, Londhe VA, Carraro G, Li M, Li C, Xing Y, Anderson S, Borok Z, Bellusci S, Minoo P. PMID: 19574443; PMCID: PMC2778148.
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Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14. Yacobi NR, Malmstadt N, Fazlollahi F, DeMaio L, Marchelletta R, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 19574531; PMCID: PMC2874446.
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Characterization of mouse alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L1051-8. Demaio L, Tseng W, Balverde Z, Alvarez JR, Kim KJ, Kelley DG, Senior RM, Crandall ED, Borok Z. PMID: 19329539; PMCID: PMC2692796.
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Conjugation with cationic cell-penetrating peptide increases pulmonary absorption of insulin. Mol Pharm. 2009 Mar-Apr; 6(2):492-503. Patel LN, Wang J, Kim KJ, Borok Z, Crandall ED, Shen WC. PMID: 19228019; PMCID: PMC2798810.
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Role for alpha3 integrin in EMT and pulmonary fibrosis. J Clin Invest. 2009 Jan; 119(1):7-10. Borok Z. PMID: 19104143; PMCID: PMC2613449.
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Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways. J Biol Chem. 2008 Dec 26; 283(52):36257-64. Li M, Li C, Liu YH, Xing Y, Hu L, Borok Z, Kwong KY, Minoo P. PMID: 18990706; PMCID: PMC2605990.
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Progressive recruitment of Runx2 to genomic targets despite decreasing expression during osteoblast differentiation. J Cell Biochem. 2008 Nov 01; 105(4):965-70. Pregizer S, Baniwal SK, Yan X, Borok Z, Frenkel B. PMID: 18821584; PMCID: PMC2591066.
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GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1. Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1141-50. Zhou B, Francis TA, Yang H, Tseng W, Zhong Q, Frenkel B, Morrisey EE, Ann DK, Minoo P, Crandall ED, Borok Z. PMID: 18768929; PMCID: PMC2584994.
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Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells. J Pharm Sci. 2008 Jun; 97(6):2340-9. Patel LN, Uchiyama T, Kim KJ, Borok Z, Crandall ED, Shen WC, Lee VH. PMID: 17854063.
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Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Aug; 295(2):L285-92. Liebler JM, Lutzko C, Banfalvi A, Senadheera D, Aghamohammadi N, Crandall ED, Borok Z. PMID: 18515407; PMCID: PMC2519849.
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Rat aquaporin-5 4.3-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C111-20. Zhou B, Ann DK, Flodby P, Minoo P, Liebler JM, Crandall ED, Borok Z. PMID: 18448628; PMCID: PMC2493550.
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Polystyrene nanoparticle trafficking across alveolar epithelium. Nanomedicine. 2008 Jun; 4(2):139-45. Yacobi NR, Demaio L, Xie J, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 18375191.
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Functional characterization and cloning of amino acid transporter B(0,+) (ATB(0,+)) in primary cultured rat pneumocytes. J Cell Physiol. 2008 Mar; 214(3):645-54. Uchiyama T, Fujita T, Gukasyan HJ, Kim KJ, Borok Z, Crandall ED, Lee VH. PMID: 17960566.
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Characterization of protein factor(s) in rat bronchoalveolar lavage fluid that enhance insulin transport via transcytosis across primary rat alveolar epithelial cell monolayers. Eur J Pharm Biopharm. 2008 Aug; 69(3):808-16. Bahhady R, Kim KJ, Borok Z, Crandall ED, Shen WC. PMID: 18406118; PMCID: PMC3638983.
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Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. Zhou B, Zhong Q, Minoo P, Li C, Ann DK, Frenkel B, Morrisey EE, Crandall ED, Borok Z. PMID: 18239190; PMCID: PMC2396252.
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SMAD3 prevents binding of NKX2.1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains. Nucleic Acids Res. 2008 Jan; 36(1):179-88. Minoo P, Hu L, Zhu N, Borok Z, Bellusci S, Groffen J, Kardassis D, Li C. PMID: 18003659; PMCID: PMC2248754.
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Expression and biological activity of ABCA1 in alveolar epithelial cells. Am J Respir Cell Mol Biol. 2008 Mar; 38(3):283-92. Bates SR, Tao JQ, Yu KJ, Borok Z, Crandall ED, Collins HL, Rothblat GH. PMID: 17884990; PMCID: PMC2258448.
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Effects of KGF on alveolar epithelial cell transdifferentiation are mediated by JNK signaling. Am J Respir Cell Mol Biol. 2008 Feb; 38(2):239-46. Qiao R, Yan W, Clavijo C, Mehrian-Shai R, Zhong Q, Kim KJ, Ann D, Crandall ED, Borok Z. PMID: 17872496; PMCID: PMC2214671.
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TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol. 2007 Sep; 293(3):L525-34. Willis BC, Borok Z. PMID: 17631612.
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Nanoparticle effects on rat alveolar epithelial cell monolayer barrier properties. Toxicol In Vitro. 2007 Dec; 21(8):1373-81. Yacobi NR, Phuleria HC, Demaio L, Liang CH, Peng CA, Sioutas C, Borok Z, Kim KJ, Crandall ED. PMID: 17555923; PMCID: PMC3855017.
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Enhancement of insulin transport across primary rat alveolar epithelial cell monolayers by endogenous cellular factor(s). Pharm Res. 2007 Sep; 24(9):1713-9. Bahhady R, Kim KJ, Borok Z, Crandall ED, Shen WC. PMID: 17443400.
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Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-beta1. Am J Respir Cell Mol Biol. 2007 Jul; 37(1):38-47. Jain R, Shaul PW, Borok Z, Willis BC. PMID: 17379848; PMCID: PMC1899351.
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Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers. Biochem Biophys Res Commun. 2007 Apr 27; 356(1):26-31. Flodby P, Zhou B, Ann DK, Kim KJ, Minoo P, Crandall ED, Borok Z. PMID: 17339032; PMCID: PMC2366028.
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Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells. Mol Cell Biol. 2007 Mar; 27(6):2155-65. Minoo P, Hu L, Xing Y, Zhu NL, Chen H, Li M, Borok Z, Li C. PMID: 17220277; PMCID: PMC1820505.
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Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1280-90. Zhou B, Ann DK, Li X, Kim KJ, Lin H, Minoo P, Crandall ED, Borok Z. PMID: 17108010.
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Epithelial origin of myofibroblasts during fibrosis in the lung. Proc Am Thorac Soc. 2006 Jun; 3(4):377-82. Willis BC, duBois RM, Borok Z. PMID: 16738204; PMCID: PMC2658689.
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Adult stem cells, lung biology, and lung disease. NHLBI/Cystic Fibrosis Foundation Workshop. Proc Am Thorac Soc. 2006 May; 3(3):193-207. Weiss DJ, Berberich MA, Borok Z, Gail DB, Kolls JK, Penland C, Prockop DJ. PMID: 16636086.
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SUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cells. Am J Pathol. 2006 May; 168(5):1452-63. Nguyen HV, Chen JL, Zhong J, Kim KJ, Crandall ED, Borok Z, Chen Y, Ann DK. PMID: 16651613; PMCID: PMC1606580.
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Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol. 2005 May; 166(5):1321-32. Willis BC, Liebler JM, Luby-Phelps K, Nicholson AG, Crandall ED, du Bois RM, Borok Z. PMID: 15855634; PMCID: PMC1606388.
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Development of a lung slice preparation for recording ion channel activity in alveolar epithelial type I cells. Respir Res. 2005 Apr 27; 6:40. Bourke S, Mason HS, Borok Z, Kim KJ, Crandall ED, Kemp PJ. PMID: 15857506; PMCID: PMC1131928.
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Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells. J Appl Physiol (1985). 2005 Jan; 98(1):322-8. Chen SP, Zhou B, Willis BC, Sandoval AJ, Liebler JM, Kim KJ, Ann DK, Crandall ED, Borok Z. PMID: 15361518.
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Estimation of paracellular conductance of primary rat alveolar epithelial cell monolayers. J Appl Physiol (1985). 2005 Jan; 98(1):138-43. Kim KJ, Borok Z, Ehrhardt C, Willis BC, Lehr CM, Crandall ED. PMID: 15273240.
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Alveolar epithelial type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2. J Histochem Cytochem. 2004 Jun; 52(6):759-67. Liebler JM, Borok Z, Li X, Zhou B, Sandoval AJ, Kim KJ, Crandall ED. PMID: 15150284.
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Net absorption of IgG via FcRn-mediated transcytosis across rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2004 Sep; 287(3):L616-22. Kim KJ, Fandy TE, Lee VH, Ann DK, Borok Z, Crandall ED. PMID: 15169676.
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Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer. Hum Gene Ther. 2004 May; 15(5):457-68. Qiao R, Zhou B, Harboe-Schmidt E, Kasahara N, Kim KJ, Liebler JM, Crandall ED, Borok Z. PMID: 15144576.
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Suppression of the transformed phenotype and induction of differentiation-like characteristics in cultured ovarian tumor cells by chronic treatment with progesterone. Mol Carcinog. 2003 Dec; 38(4):160-9. Blumenthal M, Kardosh A, Dubeau L, Borok Z, Schönthal AH. PMID: 14639655.
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Timeless in lung morphogenesis. Dev Dyn. 2003 Sep; 228(1):82-94. Xiao J, Li C, Zhu NL, Borok Z, Minoo P. PMID: 12950082.
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Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2004 Apr; 286(4):L650-7. You Y, Huang T, Richer EJ, Schmidt JE, Zabner J, Borok Z, Brody SL. PMID: 12818891.
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Modulation of ion conductance and active transport by TGF-beta 1 in alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2003 Dec; 285(6):L1192-200. Willis BC, Kim KJ, Li X, Liebler J, Crandall ED, Borok Z. PMID: 12730080.
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Identification of three genes of known function expressed by alveolar epithelial type I cells. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):98-105. Qiao R, Zhou B, Liebler JM, Li X, Crandall ED, Borok Z. PMID: 12600825.
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Lung edema clearance: 20 years of progress: invited review: role of aquaporin water channels in fluid transport in lung and airways. J Appl Physiol (1985). 2002 Dec; 93(6):2199-206. Borok Z, Verkman AS. PMID: 12433939.
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Wnt5a participates in distal lung morphogenesis. Dev Biol. 2002 Aug 01; 248(1):68-81. Li C, Xiao J, Hormi K, Borok Z, Minoo P. PMID: 12142021.
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Na transport proteins are expressed by rat alveolar epithelial type I cells. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L599-608. Borok Z, Liebler JM, Lubman RL, Foster MJ, Zhou B, Li X, Zabski SM, Kim KJ, Crandall ED. PMID: 11880284.
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Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L659-65. Mairbäurl H, Mayer K, Kim KJ, Borok Z, Bärtsch P, Crandall ED. PMID: 11880290.
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Vesicular stomatitis virus G-pseudotyped lentivirus vectors mediate efficient apical transduction of polarized quiescent primary alveolar epithelial cells. J Virol. 2001 Dec; 75(23):11747-54. Borok Z, Harboe-Schmidt JE, Brody SL, You Y, Zhou B, Li X, Cannon PM, Kim KJ, Crandall ED, Kasahara N. PMID: 11689655; PMCID: PMC114760.
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Re-evaluating the Na(+) conductance of adult rat alveolar type II pneumocytes: evidence for the involvement of cGMP-activated cation channels. J Physiol. 2001 Nov 01; 536(Pt 3):693-701. Kemp PJ, Kim KJ, Borok Z, Crandall ED. PMID: 11691865; PMCID: PMC2278905.
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Extracellular glutathione inhibits oxygen-induced permeability changes in alveolar epithelial monolayers. J Appl Physiol (1985). 2001 Aug; 91(2):748-54. Roum JH, Aledia AS, Carungcong LA, Kim KJ, Borok Z. PMID: 11457790.
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4-Hydroxy-2-nonenal increases gamma-glutamylcysteine synthetase gene expression in alveolar epithelial cells. Am J Respir Cell Mol Biol. 2001 Apr; 24(4):499-505. Liu RM, Borok Z, Forman HJ. PMID: 11306445.
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A useful in vitro model for transport studies of alveolar epithelial barrier. Pharm Res. 2001 Mar; 18(3):253-5. Kim KJ, Borok Z, Crandall ED. PMID: 11442260.
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Differential regulation of rat aquaporin-5 promoter/enhancer activities in lung and salivary epithelial cells. J Biol Chem. 2000 Aug 25; 275(34):26507-14. Borok Z, Li X, Fernandes VF, Zhou B, Ann DK, Crandall ED. PMID: 10849430.
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Integrin alpha(3)-subunit expression modulates alveolar epithelial cell monolayer formation. Am J Physiol Lung Cell Mol Physiol. 2000 Jul; 279(1):L183-93. Lubman RL, Zhang XL, Zheng J, Ocampo L, Lopez MZ, Veeraraghavan S, Zabski SM, Danto SI, Borok Z. PMID: 10893217.
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Epidermal growth factor regulation in adult rat alveolar type II cells of amiloride-sensitive cation channels. Am J Physiol. 1999 12; 277(6):C1058-65. Kemp PJ, Borok Z, Kim KJ, Lubman RL, Danto SI, Crandall ED. PMID: 10600757.
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Glutathione aerosol suppresses lung epithelial surface inflammatory cell-derived oxidants in cystic fibrosis. J Appl Physiol (1985). 1999 Jul; 87(1):438-43. Roum JH, Borok Z, McElvaney NG, Grimes GJ, Bokser AD, Buhl R, Crystal RG. PMID: 10409605.
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KGF prevents hyperoxia-induced reduction of active ion transport in alveolar epithelial cells. Am J Physiol. 1999 06; 276(6):C1352-60. Borok Z, Mihyu S, Fernandes VF, Zhang XL, Kim KJ, Lubman RL. PMID: 10362598.
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Mechanisms of EGF-induced stimulation of sodium reabsorption by alveolar epithelial cells. Am J Physiol. 1998 07; 275(1):C82-92. Danto SI, Borok Z, Zhang XL, Lopez MZ, Patel P, Crandall ED, Lubman RL. PMID: 9688838.
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Modulation of t1alpha expression with alveolar epithelial cell phenotype in vitro. Am J Physiol. 1998 07; 275(1):L155-64. Borok Z, Danto SI, Lubman RL, Cao Y, Williams MC, Crandall ED. PMID: 9688947.
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Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin 5. Am J Respir Cell Mol Biol. 1998 Apr; 18(4):554-61. Borok Z, Lubman RL, Danto SI, Zhang XL, Zabski SM, King LS, Lee DM, Agre P, Crandall ED. PMID: 9533944.
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Na(+)-K(+)-ATPase expression in alveolar epithelial cells: upregulation of active ion transport by KGF. Am J Physiol. 1998 01; 274(1):L149-58. Borok Z, Danto SI, Dimen LL, Zhang XL, Lubman RL. PMID: 9458813.
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Identification of Na(+)-K(+)-ATPase beta-subunit in alveolar epithelial cells. Am J Physiol. 1997 Jan; 272(1 Pt 1):L85-94. Zhang XL, Danto SI, Borok Z, Eber JT, Martín-Vasallo P, Lubman RL. PMID: 9038907.
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Effects of EGF on alveolar epithelial junctional permeability and active sodium transport. Am J Physiol. 1996 Apr; 270(4 Pt 1):L559-65. Borok Z, Hami A, Danto SI, Lubman RL, Kim KJ, Crandall ED. PMID: 8928815.
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Reversible transdifferentiation of alveolar epithelial cells. Am J Respir Cell Mol Biol. 1995 May; 12(5):497-502. Danto SI, Shannon JM, Borok Z, Zabski SM, Crandall ED. PMID: 7742013.
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Rat serum inhibits progression of alveolar epithelial cells toward the type I cell phenotype in vitro. Am J Respir Cell Mol Biol. 1995 Jan; 12(1):50-5. Borok Z, Hami A, Danto SI, Zabski SM, Crandall ED. PMID: 7811470.
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Defined medium for primary culture de novo of adult rat alveolar epithelial cells. In Vitro Cell Dev Biol Anim. 1994 Feb; 30A(2):99-104. Borok Z, Danto SI, Zabski SM, Crandall ED. PMID: 8012662.
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Systemic deficiency of glutathione in cystic fibrosis. J Appl Physiol (1985). 1993 Dec; 75(6):2419-24. Roum JH, Buhl R, McElvaney NG, Borok Z, Crystal RG. PMID: 8125859.
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Correction of glutathione deficiency in the lower respiratory tract of HIV seropositive individuals by glutathione aerosol treatment. Thorax. 1993 Oct; 48(10):985-9. Holroyd KJ, Buhl R, Borok Z, Roum JH, Bokser AD, Grimes GJ, Czerski D, Cantin AM, Crystal RG. PMID: 8256245; PMCID: PMC464806.
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Pulmonary Langerhans cell granulomatosis (histiocytosis X). A clinicopathologic study of 48 cases. Am J Surg Pathol. 1993 Oct; 17(10):971-86. Travis WD, Borok Z, Roum JH, Zhang J, Feuerstein I, Ferrans VJ, Crystal RG. PMID: 8372949.
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Activation of alveolar macrophages in asymptomatic HIV-infected individuals. J Immunol. 1993 Feb 01; 150(3):1019-28. Buhl R, Jaffe HA, Holroyd KJ, Borok Z, Roum JH, Mastrangeli A, Wells FB, Kirby M, Saltini C, Crystal RG. PMID: 8380824.
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Augmentation of functional prostaglandin E levels on the respiratory epithelial surface by aerosol administration of prostaglandin E. Am Rev Respir Dis. 1991 Nov; 144(5):1080-4. Borok Z, Gillissen A, Buhl R, Hoyt RF, Hubbard RC, Ozaki T, Rennard SI, Crystal RG. PMID: 1952435.
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Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis. Lancet. 1991 Jul 27; 338(8761):215-6. Borok Z, Buhl R, Grimes GJ, Bokser AD, Hubbard RC, Holroyd KJ, Roum JH, Czerski DB, Cantin AM, Crystal RG. PMID: 1676780.
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