Dr. Lamba’s News Stories » Department of Pharmacotherapy and Translational Research » College of Pharmacy » University of Florida These are links to recent news stories featuring Jatinder Lamba, Ph.D., and her research lab. 2025 ASH recognizes eight UF College of Pharmacy trainee…
Dr. Lamba’s News Stories » Department of Pharmacotherapy and Translational Research » College of Pharmacy » University of Florida These are links to recent news stories featuring Jatinder Lamba, Ph.D., and her research lab. 2025 ASH recognizes eight UF College of Pharmacy trainee…
What is a Menin Inhibitor? | Dana-Farber Cancer Institute Skip to content Published: February 3, 2025 Updated: January 12, 2026 Written by Beth Dougherty Medically Reviewed By: Scott Armstrong, MD, PhD, and Matthew Meyerson, MD, PhD Menin, a protein located in the nucleus of vari…
Kimberly Stegmaier, MD - Dana-Farber Cancer Institute | Boston, MA Email Kimberly Stegmaier, MD Pediatric Hematology/Oncology MAKE AN APPOINTMENT Contact Information Fax 617-632-4850 Appointments 617-632-3270 (established patients) 888-733-4662 (new patients) On This Page Biograp…
FDA approves menin inhibitor for patients with acute leukemia with NPM1 mutation, backed by Dana-Farber science | Dana-Farber Cancer Institute Email FDA approves menin inhibitor for patients with acute leukemia with NPM1 mutation, backed by Dana-Farber science Posted date Novembe…
Abstract To identify novel therapeutic targets in acute myeloid leukemia (AML), we examined kinase expression patterns in primary AML samples. We found that the serine/threonine kinase IKBKE, a noncanonical IkB kinase, is expressed at higher levels in myeloid leukemia cells compa…
Abstract Leukemic blasts are immune cells gone awry. We hypothesized that dysregulation of inflammatory pathways contributes to the maintenance of their leukemic state and can be exploited as cell-intrinsic, self-directed immunotherapy. To this end, we applied genome-wide screens…
Abstract We describe the case of a 16 year-old female with mixed phenotype acute leukemia B/myeloid, NOS (formerly biphenotypic leukemia) with masked hypodiploidy and somatic TP53 and CDKN2A/B deletions. She achieved morphologic remission with lymphoid-directed multi-agent chemot…
INTRODUCTION Leukemia is the most common cancer in children and adolescents 0 to 19 years of age (hereafter referred to as “children”), and the highest incidence rates of leukemia have been reported for children of Hispanic ethnicity (Age Adjusted Incidence Rate (AAIR) for 2009–2…
We offer a brief review of important questions concerning modern inference and how these questions relate to classical statistics. Abstract Statistical science provides a wide range of concepts and methods for studying situations subject to unexplained variability. Such considera…
Phase II Daratumumab Pomalidomide & Dexamethasone in Relapsed/Refractory Light Chain Amyloidosis Not Recruiting More This study will test the hypothesis that in patients with previous daratumumab exposure, combination therapy of daratumumab, pomalidomide, and dexamethasone (DPd) …
Abstract Data on outcomes of allogeneic transplantation in children with Down syndrome and acute myelogenous leukemia (DS-AML) are scarce and conflicting. Early reports stress treatment-related mortality as the main barrier; a recent case series points to posttransplantation rela…
The current issue and full text archive of this journal is available on Emerald Insight at: https://www.emerald.com/insight/1359-0790.htm The birth of the new anti-money laundering authority: harnessing the power of EU-wide supervision Power of EU-wide supervision Georgios Pavlid…
Main Text Transcription factor binding to regulatory DNA sequences controls the activity of cis -regulatory elements, which modulate gene expression programs that define cell phenotype. Assays for probing chromatin accessibility have enabled the discovery of cis -regulatory eleme…
Abstract Acute myeloid leukemia (AML) is organized as a cellular hierarchy initiated and maintained by a subset of self-renewing leukemia stem cells (LSC). We hypothesized that increased CD47 expression on human AML LSC contributes to pathogenesis by inhibiting their phagocytosis…