Main Text Transcription factor binding to regulatory DNA sequences controls the activity of cis -regulatory elements, which modulate gene expression programs that define cell phenotype. Assays for probing chromatin accessibility have enabled the discovery of cis -regulatory eleme…

Abstract Acute myeloid leukemia (AML) is organized as a cellular hierarchy initiated and maintained by a subset of self-renewing leukemia stem cells (LSC). We hypothesized that increased CD47 expression on human AML LSC contributes to pathogenesis by inhibiting their phagocytosis…

Research Article Hematology Free access | 10.1172/JCI70739 Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations 1 Division of Cellular Therapy, Advanced Clinical Research Center, and 2 Division of Stem Cell Signaling, Center for Stem Cell Biology …

Frontiers | Chemokines and Chemokine Receptors: New Targets for Cancer Immunotherapy MINI REVIEW article Front. Immunol. , 06 March 2019 Sec. Cytokines and Soluble Mediators in Immunity Volume 10 - 2019 | https://doi.org/10.3389/fimmu.2019.00379 Chemokines and Chemokine Receptors…

…ddiaeth Rhan o'r canlynol wyneb y Ddaear, cyfandir Arwynebedd 8,486,460 km² Cyfesurynnau 13.5°S 176°W Map o'r byd yn dangos Oceania Delwedd loeren gyfansawdd o Oceania Mae Oceania ( /ˌəʊʃiˈeɪniə/ ) – weithiau Ynysoedd y De terminoleg – yn rhanbarth daearyddol , ac yn aml daearwle…

Frontiers | The role of PD-1/PD-L1 and application of immune-checkpoint inhibitors in human cancers REVIEW article Front. Immunol. , 13 September 2022 Sec. Cancer Immunity and Immunotherapy Volume 13 - 2022 | Published in Frontiers in Immunology Cancer Immunity and Immunotherapy …

Recurring mutations found by sequencing an acute myeloid leukemia genome Abstract Background: The full complement of DNA mutations that are responsible for the pathogenesis of acute myeloid leukemia (AML) is not yet known. Methods: We used massively parallel DNA sequencing to obt…

Ulrich G. Steidl, M.D., Ph.D. | Albert Einstein College of Medicine - New York Ulrich G. Steidl, M.D., Ph.D. Professor, Department of Cell Biology Professor, Department of Oncology Professor, Department of Medicine Chair, Department of Cell Biology Edward P. Evans Endowed Profess…

Mohamed H. Zahran - Mansoura University Skip to main content Log In Sign Up About Press Papers Terms Privacy Copyright We're Hiring! Help Center Mohamed H. Zahran Mansoura University , Urology and Nephrology Center , Faculty Member Followers 16 Following 8 Co-authors 5 Public Vie…

Introduction Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a potentially curative therapy for high-risk acute leukemias, including B-cell acute lymphoblastic leukemia (B-ALL) and acute myeloid leukemia (AML).... more Introduction Allogeneic hematopoietic …

Computer firmware interface standard Advanced Configuration and Power Interface ( ACPI ) is an open standard that operating systems can use to discover and configure computer hardware components, to perform power management (e.g. putting unused hardware components to sleep), auto…

Abstract Relapsed acute lymphoblastic leukaemia (ALL) is a leading cause of death due to disease in young people, but the biologic determinants of treatment failure remain poorly understood. Recent genome-wide profiling of structural DNA alterations in ALL have identified multipl…

John W. Pepper - National Cancer Institute Skip to main content Log In Sign Up About Press Papers Terms Privacy Copyright We're Hiring! Help Center John W. Pepper National Cancer Institute , Division of Cancer Prevention , Biologist Santa Fe Institute , (Non-Departmental Institut…

Abstract We consider large-scale studies in which there are hundreds or thousands of correlated cases to investigate, each represented by its own normal variate, typically a z -value. A familiar example is provided by a microarray experiment comparing healthy with sick subjects' …

Abstract Background AML1/RUNX1 is the most frequently mutated gene in leukaemia and is central to the normal biology of hematopoietic stem and progenitor cells. However, the role of different AML1 isoforms within these primitive compartments is unclear. Here we investigate whethe…