1. Introduction Autism spectrum disorder (ASD) has steadily been on the rise, now impacting 1 in 100 children worldwide [ 1 ]. ASD is a neurodevelopmental disorder, with specific autistic characteristics presenting themselves uniquely in every autistic child. Although autism is a…

Abstract Background Autism spectrum disorders (ASDs) are more prevalent in males, suggesting a multiple threshold liability model in which females are, on average, protected by sex-differential mechanisms. Under this model, autistic females are predicted to carry a more penetrant…

Abstract Background Williams syndrome (WS) and autism spectrum disorder (ASD) are neurodevelopmental disorders that demonstrate overlapping genetic associations, dichotomous sociobehavioral phenotypes, and dichotomous pathological differences in neuronal distribution in key socia…

Abstract The maternal immune system may play a role in offspring neurodevelopment. We examined whether maternal autoimmune disease, asthma, and allergy were associated with child autism spectrum disorder (ASD) and developmental delay without autism (DD) using 560 ASD cases, 391 t…

Abstract Executive functioning (EF) is an overarching term that refers to neuropsychological processes that enable physical, cognitive, and emotional self-control. Deficits in EF are often present in neurodevelopmental disorders, but the specificity of EF deficits and direct comp…

Abstract Prenatal antidepressant exposure has been associated with increased risk for neurodevelopmental disorders in childhood, including autism spectrum disorder (ASD). The current study utilized multi-cohort data from the Environmental influences on Child Health Outcomes (ECHO…

Abstract Social media holds promise as a technology to facilitate social engagement, but may displace social activities. Adolescents with ASD are well suited capitalize on the unique features of social media, requires less decoding of complex social information. this cross-sectio…

1745-0179/20 Send Orders for Reprints to [email protected] 204 Clinical Practice & Epidemiology in Mental Health Content list available at: https://clinical-practice-and-epidemiology-in-mental-health.com RESEARCH ARTICLE Defining the Optimal Threshold Scores for Adult Autism Subt…

Abstract Autism spectrum disorders (ASD’S) are highly heritable. Consequently, gene discovery promises to help illuminate the pathophysiology of these syndromes, yielding important opportunities for the development of novel treatments and a more nuanced understanding of the natur…

SUMMARY Although autism spectrum disorder (ASD) is defined by core behavioral impairments, gastrointestinal (GI) symptoms are commonly reported. Subsets of ASD individuals display dysbiosis of the gut microbiota, and some exhibit increased intestinal permeability. Here we demonst…

Abstract As early intervention is highly effective for young children with autism spectrum disorder (ASD), it is imperative to make accurate diagnosis as early as possible. ASD has often been associated with atypical visual attention and eye gaze data can be collected at a very e…

Gene: SETD5 - Human Gene Module / Chromosome 3 / SETD5 SETD5 SET domain containing 5 SFARI Gene Score 1S High Confidence, Syndromic Criteria 1.1, Syndromic Autism Reports / Total Reports 22 / 52 Rare Variants / Common Variants 177 / 0 EAGLE Score 28.05 Strong Aliases Associated S…

ASD-risk gene mis-splicing in human DM1 prefrontal cortex The prefrontal cortex orchestrates executive functions affected in ASD, and previous studies reported transcriptome-wide changes in this brain region 29, 37 . To test the hypothesis that the DMPK 3'UTR CTG exp mutation lea…

1. B ackground Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic, fluorinated chemicals that have been used in a variety of consumer products, including non-stick cookware, food packaging materials, fabric and carpet treatments, and firefighting foams, since the…

Abstract We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling’s childhood. Associations between glutathione (GSH), glutathione thiol di…