Deletion of PTP1B in cardiomyocytes alters cardiac metabolic signaling to protect against cardiomyopathy induced by a high-fat diet - PMC Official websites use .gov .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS lo…

Introduction Obesity has reached epidemic proportions worldwide and continues to rise at an alarming rate. Projections from the World Health Organization suggest that 50% of the US will be classically defined as obese by the year 2030, with the most jeopardized demographic being …

INTRODUCTION The bed nucleus of the stria terminalis (BNST) coordinates neuroendocrine, autonomic and somatomotor responses to anxiety and emotional aspects of stressful events ( Crestani et al., 2013 ; Dong and Swanson, 2006 ; Moga et al., 1989 ; Walker et al., 2003 ). This area…

Abstract Apolipoprotein C-III (apoC-III) is a critical regulator of triglyceride metabolism and correlates positively with hypertriglyceridemia and cardiovascular disease (CVD). It remains unclear if therapeutic apoC-III lowering reduces CVD risk and if the CVD correlation depend…

Introduction The ability to target genetic manipulations to specific CNS cell types is essential for analysis of genes, cells, and circuits that play key roles in behavior and disease. Limiting genetic manipulations to specific structures, cell types, or developmental periods can…

INTRODUCTION The lung is richly innervated with nerves ( 1 – 5 ). Growing evidence demonstrates that these nerves serve critical functions. Vagus nerves that innervate the airways are essential for airway protective responses, including bronchospasm and cough reflex ( 6 – 9 ). Re…

Myh6 promoter-driven Cre recombinase excises floxed DNA fragments in a subset of male germ line cells - PMC Official websites use .gov .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS lock ) or means you've safely co…

Abstract Deciphering how neural circuits are anatomically organized with regard to input and output is instrumental in understanding how the brain processes information. For example, locus coeruleus norepinephrine (LC-NE) neurons receive input from and send output to broad region…

Abstract Objectives To develop a mouse model for multi-spectral fluorescence imaging of the pancreas and pancreatic microenvironment. Methods Cre/ loxP technology was used to develop this model. We crossed mT/mG indicator mice, engineered to constitutively express a conditional t…

INTRODUCTION Leptin is secreted by adipocytes in proportion to fat stores providing feedback on the status of lipid reserves ( Friedman, 2009 ). Leptin circulates and binds its receptor (LEPR) in the brain where it decreases food intake and promotes energy expenditure ( Myers et …

A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressing Interneurons of the Striatum | eNeuro Previous Next Research Article Research Article: New Research, Sensory and Motor Systems A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressi…

Research Article Nephrology Free access | 10.1172/JCI57301 Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice 1 Career-Path Promotion Unit for Young Life Scientists, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, S…

INTRODUCTION Myelination has evolved in vertebrates to electrically insulate axons to promote rapid, energy efficient action potential propagation. In the central nervous system (CNS), the production of multilamellar myelin sheaths is performed by oligodendrocytes (OLs). The loca…

Main Monogenic diseases arise from genetic mutations that lead to aberrant or absent gene expression, and many lack appropriate therapies. Advances in molecular biology have enabled several treatment approaches to address this unmet medical need and correct the molecular basis of…

Introduction Advances in gene therapy have positioned adeno-associated viruses (AAV) as a ubiquitous delivery tool for treating monogenic inherited disorders 1 – 3 . Their low toxicity and immunogenicity minimize adverse reactions and they produce long-term transgene expression. …