Abstract Th17 cells promote a variety of autoimmune diseases, including psoriasis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. TGF-β is required for conversion of naive T cells to Th17 cells, but the mechanisms regulating this process are unknown. In…

The role of retinol dehydrogenase 10 in the cone visual cycle - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( ) or https:// means you've safely connec…

Cortical Excitatory Neurons and Glia, But Not GABAergic Neurons, Are Produced in the Emx1-Expressing Lineage - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A …

HHS Public Access Author manuscript Genesis. Author manuscript; available in PMC 2017 August 01. Author Manuscript Published in final edited form as: Genesis. 2016 August ; 54(8): 439–446. doi:10.1002/dvg.22949. Cre dependent DREADD (Designer Receptors Exclusively Activated by De…

Abstract Mechanistic target of rapamycin ( Mtor) is required for embryonic inner cell mass proliferation during early development. However, Mtor expression levels are very low in the mouse heart during embryogenesis. To determine if Mtor plays a role during mouse cardiac developm…

INTRODUCTION The discovery that recombinant jellyfish green fluorescent protein (GFP) fluoresces when expressed in heterologous cells 1 has led to a vast array of powerful methods for marking and manipulating cells, subcellular compartments and molecules. The discovery or design …

Deficiency of Shank3 in the nucleus accumbens reveals a loss of social-specific motivation - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( ) or https:…

Abstract Coordinated efforts between macrophages and epithelia are considered essential for wound healing, but the macrophage-derived molecules responsible for repair are poorly defined. This work demonstrates that lung macrophages rely upon Trefoil factor 2 to promote epithelial…

Whole-brain input mapping of the lateral versus medial anterodorsal bed nucleus of the stria terminalis in the mouse - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use …

4 Figure S1. Consequences of early postnatal microglia depletion for cortical connectivity, related to Figure 1 (A) Representative images and quantitation of the density and layer distribution of PV cells in control (n = 4) and microglia-depleted (n = 4) mice at P15 after P1-P15 …

SUMMARY Neural inputs from internal organs are essential for normal autonomic function. The vagus nerve is a key body-brain connection that monitors the digestive, cardiovascular, and respiratory systems. Within the gastrointestinal tract, vagal sensory neurons detect gut hormone…

Abstract Recombinant adeno-associated viruses (rAAVs) are commonly used vehicles for in vivo gene transfer 1 - 6 . However, the tropism repertoire of naturally occurring AAVs is limited, prompting a search for novel AAV capsids with desired characteristics 7 - 13 . Here we descri…

FGF receptors control alveolar elastogenesis - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( ) or https:// means you've safely connected to the .gov w…

INTRODUCTION Dopamine (DA) neuron dysfunction has been implicated in numerous brain disorders, including addiction, depression, schizophrenia, and Parkinson’s disease. Our incomplete understanding of the complex brain circuits in which dopamine neurons participate represents a ma…

Introduction Skeletal muscle development during embryogenesis is a well-defined process that requires precise regulation of a variety of factors in muscle progenitors and differentiated cell types ( Parker et al., 2003 ; Relaix, 2006 ). Skeletal muscle precursors originate in the…