1. Introduction Developmental disorders, such as Duchenne muscular dystrophy, cerebral palsy, Fragile X syndrome and numerous others, cause devastating outcomes, affect millions of babies each year, and cause tremendous economic and emotional burdens to society [ [1] , [2] , [3] …
INTRODUCTION Dopamine (DA) neuron dysfunction has been implicated in numerous brain disorders, including addiction, depression, schizophrenia, and Parkinson’s disease. Our incomplete understanding of the complex brain circuits in which dopamine neurons participate represents a ma…
Abstract The role of mitofusin 2 (MFN2), a key regulator of mitochondrial morphology and function in the renal stress response is unknown. To assess its role, the MFN2 floxed gene was conditionally deleted in the kidney of mice (MFN2 cKO) by Pax2 promoter driven Cre expression (P…
See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/268512798 A Role for Noncoding Variation in Schizophrenia Article in Cell Reports · November 2014 DOI: 10.1016/j.celrep.2014.10.015 CITATIONS READS 45 135 25 authors, inc…
Abstract The medium spiny neurons (MSNs), which comprise the direct and indirect output pathways from the striatum, use γ-aminobutyric acid (GABA) as their major fact-acting neurotransmitter. We generated mice carrying a conditional allele of the Gad1 gene, which encodes GAD67, o…
Introduction Skeletal muscle development during embryogenesis is a well-defined process that requires precise regulation of a variety of factors in muscle progenitors and differentiated cell types ( Parker et al., 2003 ; Relaix, 2006 ). Skeletal muscle precursors originate in the…
Mechanotransduction, the cellular response to mechanical stimuli, is essential for a wide range of biological processes, from tactile perception to the maintenance of tissue homeostasis ( 1 – 4 ). Although both mechanical cues and chemical ligands influence physiological function…
Abstract DICER is a key enzyme that processes microRNA and small interfering RNA precursors into their short mature forms, enabling them to regulate gene expression. Only a single Dicer gene exists in the mouse genome, and it is broadly expressed in developing tissues. Dicer -nul…
Abstract Protein tyrosine phosphatase 1B (PTP1B), a key negative regulator of leptin and insulin signaling, is positively correlated with adiposity and contributes to insulin resistance. Global PTP1B deletion improves diet-induced obesity and glucose homeostasis via enhanced lept…
Summary Efficient retrograde access to projection neurons for the delivery of sensors and effectors constitutes an important and enabling capability for neural circuit dissection. Such an approach would also be useful for gene therapy, including the treatment of neurodegenerative…
Abstract Objective Smooth muscle cells (SMCs) of the proximal thoracic aorta are embryonically derived from the second heart field (SHF) and cardiac neural crest (CNC). However, distributions of these embryonic origins are not fully defined. The regional distribution of SMCs of d…
Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines - PMC Official websites use .gov .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS lock ) or means you've safely…
JCI - Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines Go to JCI Insight About Editors Consulting Editors For authors Publication ethics Publication alerts by email Advertising Job board Contact The Journal of Clinical Inves…
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain | Nature Neuroscience Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to…
Adeno-Associated Viral Vectors for Mapping, Monitoring, and Manipulating Neural Circuits - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( ) or https://…