Deficiency of Shank3 in the nucleus accumbens reveals a loss of social-specific motivation - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( ) or https:…

Article Free access | 10.1172/JCI7605 Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart 1 Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215,…

Introduction Clinical observations have documented that liver diseases are associated with alterations in the Central Nervous System (CNS) that manifest as behavioral changes such as cognitive dysfunction, mood disorders and sleep disturbance 1 . A large body of work suggests tha…

Abstract Coordinated efforts between macrophages and epithelia are considered essential for wound healing, but the macrophage-derived molecules responsible for repair are poorly defined. This work demonstrates that lung macrophages rely upon Trefoil factor 2 to promote epithelial…

Whole-brain input mapping of the lateral versus medial anterodorsal bed nucleus of the stria terminalis in the mouse - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use …

4 Figure S1. Consequences of early postnatal microglia depletion for cortical connectivity, related to Figure 1 (A) Representative images and quantitation of the density and layer distribution of PV cells in control (n = 4) and microglia-depleted (n = 4) mice at P15 after P1-P15 …

SUMMARY Neural inputs from internal organs are essential for normal autonomic function. The vagus nerve is a key body-brain connection that monitors the digestive, cardiovascular, and respiratory systems. Within the gastrointestinal tract, vagal sensory neurons detect gut hormone…

Abstract Recombinant adeno-associated viruses (rAAVs) are commonly used vehicles for in vivo gene transfer 1 - 6 . However, the tropism repertoire of naturally occurring AAVs is limited, prompting a search for novel AAV capsids with desired characteristics 7 - 13 . Here we descri…

FGF receptors control alveolar elastogenesis - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( ) or https:// means you've safely connected to the .gov w…

Introduction The dentate gyrus (DG) is a critical structure within the hippocampal formation and is considered the first stage of information processing in the excitatory tri-synaptic circuitry of the hippocampus ( Amaral et al., 2007 ; Witter, 2007 ). The excitatory neuronal typ…

1. Introduction Developmental disorders, such as Duchenne muscular dystrophy, cerebral palsy, Fragile X syndrome and numerous others, cause devastating outcomes, affect millions of babies each year, and cause tremendous economic and emotional burdens to society [ [1] , [2] , [3] …

INTRODUCTION Dopamine (DA) neuron dysfunction has been implicated in numerous brain disorders, including addiction, depression, schizophrenia, and Parkinson’s disease. Our incomplete understanding of the complex brain circuits in which dopamine neurons participate represents a ma…

Abstract The medium spiny neurons (MSNs), which comprise the direct and indirect output pathways from the striatum, use γ-aminobutyric acid (GABA) as their major fact-acting neurotransmitter. We generated mice carrying a conditional allele of the Gad1 gene, which encodes GAD67, o…

Introduction Skeletal muscle development during embryogenesis is a well-defined process that requires precise regulation of a variety of factors in muscle progenitors and differentiated cell types ( Parker et al., 2003 ; Relaix, 2006 ). Skeletal muscle precursors originate in the…

Mechanotransduction, the cellular response to mechanical stimuli, is essential for a wide range of biological processes, from tactile perception to the maintenance of tissue homeostasis ( 1 – 4 ). Although both mechanical cues and chemical ligands influence physiological function…