Frontiers | Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity MINI REVIEW article Front. Immunol. , 12 July 2022 Sec. Nutritional Immunology Volume 13 - 2022 | https://doi.org/10.3389/fi…
Journal Pre-proof Clinical and Therapeutic Predictors of Disease Outcomes in AQP4-IgG+ Neuromyelitis Optica Spectrum Disorder Amy Kunchok MBBS, CORe , Charles Malpas PhD, CORe , Petra Nytrova PhD , Eva Kubala Havrdova PhD , Raed Alroughani MD , Murat Terzi MD , Bassem Yamout MD ,…
Abstract To optimize malaria control, WHO has prioritised the need for new indicators to evaluate the efficacy of malaria vector control strategies. The gSG6-P1 peptide from gSG6 protein of Anopheles gambiae salivary glands was previously designed as a specific salivary sequence …
Frontiers | Differential Patterns of IgG Subclass Responses to Plasmodium falciparum Antigens in Relation to Malaria Protection and RTS,S Vaccination ORIGINAL RESEARCH article Front. Immunol. , 15 March 2019 Sec. Microbial Immunology Volume 10 - 2019 | https://doi.org/10.3389/fim…
Abstract Standard entomological methods for evaluating the impact of vector control lack sensitivity in low-malaria-risk areas. The detection of human IgG specific to Anopheles gSG6-P1 salivary antigen reflects a direct measure of human–vector contact. This study aimed to assess …
Abstract Conventional measurement of antibody responses to vaccines largely relies on serum antibodies, which are primarily produced by bone marrow plasma cells and may not represent the entire vaccine-induced B cell repertoire, including important functional components such as t…
Frontiers | R21/Matrix-M malaria vaccine drives diverse immune responses in pre-exposed adults: insights from a phase IIb controlled human malaria infection trial ORIGINAL RESEARCH article Front. Immunol. , 07 July 2025 Sec. Parasite Immunology Volume 16 - 2025 | https://doi.org/…
Abstract Salivary proteins injected by blood feeding arthropods into their hosts evoke a saliva-specific humoral response which can be useful to evaluate exposure to bites of disease vectors. However, saliva of hematophagous arthropods is a complex cocktail of bioactive factors a…
Frontiers | R21/Matrix-M malaria vaccine drives diverse immune responses in pre-exposed adults: insights from a phase IIb controlled human malaria infection trial ORIGINAL RESEARCH article Front. Immunol. , 07 July 2025 Sec. Parasite Immunology Volume 16 - 2025 | Published in Fro…
Abstract Venezuelan equine encephalitis virus replicon particles (VRP) without a transgene (null VRP) have been used to adjuvant effective humoral [ 1 ], cellular [ 2 ], and mucosal [ 3 ] immune responses in mice. To assess the adjuvant activity of null VRP in the context of a li…
Abstract Human antibody (Ab) response to Anopheles whole saliva, used as biomarker of Anopheles exposure, was investigated over a period of two years (2008–2009), in children between 2 to 9 years old, before and after the introduction of three different malaria vector control met…
The RV144 HIV-vaccine trial, which used ALVAC–HIV and AIDSVAX HIV gp120, clade B and E proteins formulated in alum, resulted in limited but significant ( P = 0.04) protection from HIV acquisition 1 . Serum IgG antibodies against Env variable region 1 (V1) and V2 were inversely co…
Abstract Despite the effective suppression of viremia with antiretroviral (ARV) therapy, HIV can still replicate in the CNS. This was a longitudinal study of the CSF and serum dynamics of several biomarkers related to inflammation, the blood brain barrier, neuronal injury as well…
Abstract Assessment of exposure to malaria vectors is important to our understanding of spatial and temporal variations in disease transmission and facilitates the targeting and evaluation of control efforts. Recently, an immunogenic Anopheles gambiae salivary protein (gSG6) was …
1. Introduction Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder characterized by deficits in social communication and interaction, and restricted repetitive behaviors, interests, and activities[ 1 ]. The estimates of ASD prevalence have been steadily…