Abstract Conventional measurement of antibody responses to vaccines largely relies on serum antibodies, which are primarily produced by bone marrow plasma cells and may not represent the entire vaccine-induced B cell repertoire, including important functional components such as t…
Key Points The iron transporter FPN is rapidly removed from the early phagosomal membrane, thereby preventing iron loading of phagosomes. NEM blocks SNARE-mediated movement of FPN from the phagosome back to the plasmalemma. Abstract Nutrient sequestration is an essential facet of…
Frontiers | R21/Matrix-M malaria vaccine drives diverse immune responses in pre-exposed adults: insights from a phase IIb controlled human malaria infection trial ORIGINAL RESEARCH article Front. Immunol. , 07 July 2025 Sec. Parasite Immunology Volume 16 - 2025 | https://doi.org/…
Abstract Salivary proteins injected by blood feeding arthropods into their hosts evoke a saliva-specific humoral response which can be useful to evaluate exposure to bites of disease vectors. However, saliva of hematophagous arthropods is a complex cocktail of bioactive factors a…
Frontiers | R21/Matrix-M malaria vaccine drives diverse immune responses in pre-exposed adults: insights from a phase IIb controlled human malaria infection trial ORIGINAL RESEARCH article Front. Immunol. , 07 July 2025 Sec. Parasite Immunology Volume 16 - 2025 | Published in Fro…
Introduction The induction of HIV-1 broadly reactive neutralizing antibodies (bnAbs) by experimental vaccines is a critical goal of HIV-1 vaccine development efforts. However, bnAbs cannot be induced by existing HIV-1 vaccine candidates [ 1 ]. The RV144 ALVAC/AIDSVAX B/E HIV-1 va…
Abstract Venezuelan equine encephalitis virus replicon particles (VRP) without a transgene (null VRP) have been used to adjuvant effective humoral [ 1 ], cellular [ 2 ], and mucosal [ 3 ] immune responses in mice. To assess the adjuvant activity of null VRP in the context of a li…
Abstract Human antibody (Ab) response to Anopheles whole saliva, used as biomarker of Anopheles exposure, was investigated over a period of two years (2008–2009), in children between 2 to 9 years old, before and after the introduction of three different malaria vector control met…
The RV144 HIV-vaccine trial, which used ALVAC–HIV and AIDSVAX HIV gp120, clade B and E proteins formulated in alum, resulted in limited but significant ( P = 0.04) protection from HIV acquisition 1 . Serum IgG antibodies against Env variable region 1 (V1) and V2 were inversely co…
Abstract Despite the effective suppression of viremia with antiretroviral (ARV) therapy, HIV can still replicate in the CNS. This was a longitudinal study of the CSF and serum dynamics of several biomarkers related to inflammation, the blood brain barrier, neuronal injury as well…
Abstract CD4 T follicular helper (T fh ) cells are important for the generation of durable and specific humoral protection against viral infections. The degree to which SARS-CoV-2 infection generates T fh cells and stimulates the germinal center response is an important question …
ABSTRACT Accurate, highly specific immunoassays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are needed to evaluate seroprevalence. This study investigated the concordance of results across four immunoassays targeting different antigens for sera collected at t…
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has now caused over 2 million deaths worldwide and continues to expand. Currently, much is unknown about functionally neutralizing human antib…
Abstract Assessment of exposure to malaria vectors is important to our understanding of spatial and temporal variations in disease transmission and facilitates the targeting and evaluation of control efforts. Recently, an immunogenic Anopheles gambiae salivary protein (gSG6) was …
1. Introduction Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder characterized by deficits in social communication and interaction, and restricted repetitive behaviors, interests, and activities[ 1 ]. The estimates of ASD prevalence have been steadily…