Frontiers | TCR Signaling Emerges from the Sum of Many Parts REVIEW article Front. Immunol. , 25 June 2012 Sec. T Cell Biology Volume 3 - 2012 | https://doi.org/10.3389/fimmu.2012.00159 TCR Signaling Emerges from the Sum of Many Parts M S Michael S. Kuhns 1,2 * M M Mark M. Davis …

Significance Immune cell signaling is heavily associated with the spatial organization of molecules. Here, we examined the nanoscale organization of coreceptor CD4 and its relative spatial localization to the T-cell receptor and the active form of Src kinase p56lck (Lck), using t…

Summary Using an elaborately evolved language of cytokines and chemokines as well as cell-cell interactions, the different components of the immune system communicate with each other and orchestrate a response (or wind one down). Immunological synapses are a key feature of the sy…

Single-cell analysis can reveal important functional insights that are masked in bulk analysis of cell populations 1 – 3 . Recent technological advances have improved our ability to query expression of multiple genes in single cells simultaneously, thereby helping to resolve the …

Abstract Quantitative metrics for vaccine-induced T-cell responses are an important need for developing correlates of protection and their use in vaccine-based medical management and population health. Molecular TCR analysis is an appealing strategy but currently requires a targe…

SEEDs enable enrichment of cells with transgene integrations To develop a method for cells with transgene integrations to be enriched through negative selection, we designed two reagents: (1) a guide RNA (gRNA) targeting an intron of a surface-expressed protein that generates a D…

Abstract CD4 + T cells play a critical role in antitumor immunity via recognition of peptide antigens presented on MHC class II (MHC-II). Although some solid cancers can be induced to express MHC-II, the extent to which this enables direct recognition by tumor-specific CD4 + T ce…

Abstract While immunotherapeutic strategies are emerging as adjunctive treatments for cancer, sensitive methods of monitoring the immune response after treatment remain to be established. We used a novel next generation sequencing (NGS) approach to determine whether quantitative …

Pre-existing tumor-resident T cells with cytotoxic potential associate with response to neoadjuvant anti-PD-1 in head and neck cancer - PMC Official websites use .gov .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS …

Enhancing and inhibitory motifs regulate CD4 activity | eLife Version of Record July 28, 2022 Accepted Manuscript July 21, 2022 Cite Share Comment Open annotations (there are currently annotations on this page). 1,702 views 343 downloads citations Altmetric provides a collated sc…

Abstract The capacity of T cells to initiate anti-leukemia immune responses is determined by the ability of their receptors (TCRs) to recognize leukemia neoantigens. Epigenetic mechanisms including DNA methylation contribute to shaping the TCR repertoire composition and diversity…

INTRODUCTION CD4+ T cells display immunologic memory of past infections( 1 ), although there is a lack of studies following CD4+ T cell clones through multiple repeated infections in humans to assess their long-term stability, plasticity, and the fidelity of their recall response…

The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions | eLife Version of Record April 19, 2024 Read the peer reviews Reviewed Preprint v2 March 14, 2024 Reviewed Preprint v1 September 28, 2023 Cite S…

T cells are activated in a cellular interaction with APCs. The central activating receptor is the TCR ( 1 ). It recognizes antigenic peptides presented by MHC on the surface of the APC. It is remarkably sensitive to small changes in the affinity of the TCR for peptide-MHC ( 1 ). …

‘Immunological circuits’ as sources of emergent behaviors The idea that circuits of immune cell-cell interactions are primary determinants of the systemic properties of immunity is not new, although our ability to realize it has been limited until recent advances in computation a…