Research Article Immunology Free access | 10.1172/JCI25112 Defective regulatory and effector T cell functions in patients with FOXP3 mutations 1 San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Milan, Italy. 2 Pediatrics Department, “A. Meyer” Children’s Hospital, Un…
The Simplicity of Divine Ideas Michelle Panchuk According to Theistic Conceptual Realism (TCR), divine concepts, conceived of as eternal aspects of the divine mind, do the metaphysical lifting for which abstract universals are posited on platonic realist accounts of abstract obje…
Teaching Curriculum Resources: A Guiding Light for Effective Instruction In the dynamic world of education, teachers play a pivotal role in shaping the minds of future generations. To effectively fulfill this responsibility, they rely on a comprehensive toolkit of resources, incl…
Teaching Curriculum Resources: A Guiding Light for Effective Instruction In the dynamic world of education, teachers play a pivotal role in shaping the minds of future generations. To effectively fulfill this responsibility, they rely on a comprehensive toolkit of resources, incl…
Teaching Curriculum Resources Teaching Curriculum Resources: A Guiding Light for Effective Instruction In the dynamic world of education, teachers play a pivotal role in shaping the minds of future generations. To effectively fulfill this responsibility, they rely on a comprehens…
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(PDF) Genomic Intelligence as Über Bio-Cybersecurity: The Gödel Sentence in Immuno-Cognitive Systems
https://www.academia.edu/108487167/Genomic_Intelligence_as_%C3%9Cber_Bio_Cybersecurity_The…
entropy Article Genomic Intelligence as Über Bio-Cybersecurity: The Gödel Sentence in Immuno-Cognitive Systems Sheri M. Markose Department of Economics, University of Essex, Essex C04 3SQ, UK; [email protected] Abstract: This paper gives formal foundations and evidence from gene …
What is T cell therapy? T cell therapy is a potential treatment for cancer that uses the patient’s own T cells as a “living drug”. T cells are the cells of the immune system responsible for seeking out and destroying unhealthy cells. These unhealthy cells are typically cells infe…
Abstract Background: To examine data quality and reproducibility using ISTHMUS, which has been implemented as the standardized MR spectroscopy sequence for the multi-site Healthy Brain and Child Development (HBCD) study. Methods: ISTHMUS is the consecutive acquisition of short-TE…
Research Article AIDS/HIV Immunology Open Access | 10.1172/jci.insight.136648 TCF-1 regulates HIV-specific CD8 + T cell expansion capacity 1 Department of Medicine, UCSF, San Francisco, California, USA. 2 Institute of Human Genetics, University of the Philippines-National Institu…
ARTICLE https://doi.org/10.1038/s41467-019-11338-y OPEN Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes Amar Singh 1,11, Sabarinathan Ramachandran 1,11, Melanie L. Graham 2,11, Saeed Daneshmandi 3,11, David Heller 1, Wilma Lucia …
Frontiers | Regulatory T cell therapies: from patient data to biological insights MINI REVIEW article Front. Immunol. , 31 October 2025 Sec. T Cell Biology Volume 16 - 2025 | https://doi.org/10.3389/fimmu.2025.1675114 Regulatory T cell therapies: from patient data to biological i…
Research Article Free access | 10.1172/JCI30928 A hypomorphic R229Q Rag2 mouse mutant recapitulates human Omenn syndrome 1 Human Genome Department, Istituto di Tecnologie Biomediche, CNR, Segrate, Milan, Italy. 2 Department of Pathology, University of Brescia, Brescia, Italy. 3 I…
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A Septin Requirement Differentiates Autonomous- and Contact-Facilitated T Cell Proliferation - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755847
Abstract T cell proliferation is initiated by T cell antigen receptor (TCR) triggering and/or by soluble growth factors. In characterizing T cells lacking the septin cytoskeleton, we found that successful cell division has discrete septin-dependent and -independent pathways. Sept…
Introduction Regulatory T cells (Tregs) are CD4 + CD25 + T cells that maintain tolerance to self‐antigens and non‐harmful foreign antigens. 1 , 2 FOXP3 is a critical transcription factor for Treg function in both mice and human. 3 , 4 Because Tregs exhibit potent immunosuppressiv…
Anton Shmelev - John Innes Centre About Press Papers We're Hiring! Anton Shmelev John Innes Centre Molecular Microbiology Post-Doc Followers Following Co-author Public Views Related Authors Anton O Chugunov Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Roman Efremov She…