Abstract Background: To examine data quality and reproducibility using ISTHMUS, which has been implemented as the standardized MR spectroscopy sequence for the multi-site Healthy Brain and Child Development (HBCD) study. Methods: ISTHMUS is the consecutive acquisition of short-TE…
Research Article AIDS/HIV Immunology Open Access | 10.1172/jci.insight.136648 TCF-1 regulates HIV-specific CD8 + T cell expansion capacity 1 Department of Medicine, UCSF, San Francisco, California, USA. 2 Institute of Human Genetics, University of the Philippines-National Institu…
ARTICLE https://doi.org/10.1038/s41467-019-11338-y OPEN Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes Amar Singh 1,11, Sabarinathan Ramachandran 1,11, Melanie L. Graham 2,11, Saeed Daneshmandi 3,11, David Heller 1, Wilma Lucia …
Frontiers | Regulatory T cell therapies: from patient data to biological insights MINI REVIEW article Front. Immunol. , 31 October 2025 Sec. T Cell Biology Volume 16 - 2025 | https://doi.org/10.3389/fimmu.2025.1675114 Regulatory T cell therapies: from patient data to biological i…
Research Article Free access | 10.1172/JCI30928 A hypomorphic R229Q Rag2 mouse mutant recapitulates human Omenn syndrome 1 Human Genome Department, Istituto di Tecnologie Biomediche, CNR, Segrate, Milan, Italy. 2 Department of Pathology, University of Brescia, Brescia, Italy. 3 I…
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A Septin Requirement Differentiates Autonomous- and Contact-Facilitated T Cell Proliferation - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755847
Abstract T cell proliferation is initiated by T cell antigen receptor (TCR) triggering and/or by soluble growth factors. In characterizing T cells lacking the septin cytoskeleton, we found that successful cell division has discrete septin-dependent and -independent pathways. Sept…
Abstract Checkpoint inhibitors have demonstrated efficacy in patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). However, the majority of patients do not benefit from these agents. To improve the efficacy of checkpoint inhibitors, intratumoral (i.…
Proceedings of the Prehistoric Society http://journals.cambridge.org/PPR Additional services for Proceedings of the Prehistoric Society: Email alerts: Click here Subscriptions: Click here Commercial reprints: Click here Terms of use : Click here Dating the Dead: a High-Resolution…
Introduction Regulatory T cells (Tregs) are CD4 + CD25 + T cells that maintain tolerance to self‐antigens and non‐harmful foreign antigens. 1 , 2 FOXP3 is a critical transcription factor for Treg function in both mice and human. 3 , 4 Because Tregs exhibit potent immunosuppressiv…
Anton Shmelev - John Innes Centre About Press Papers We're Hiring! Anton Shmelev John Innes Centre Molecular Microbiology Post-Doc Followers Following Co-author Public Views Related Authors Anton O Chugunov Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Roman Efremov She…
Frontiers | NKT Cell Networks in the Regulation of Tumor Immunity REVIEW article Front. Immunol. , 28 October 2014 Sec. Cancer Immunity and Immunotherapy Volume 5 - 2014 | https://doi.org/10.3389/fimmu.2014.00543 NKT Cell Networks in the Regulation of Tumor Immunity F C Faith C. …
Introduction T cells have important functions in conferring immunological protection against infectious pathogens by generating effector cells that mediate antigen control and by forming memory cells that provide long-term protective immunity against recurring infections. Effecto…
Production of IL-1α is a characteristic of human T H cells To investigate the heterogeneity of the human T H 17 cell subset and to reveal distinct functions and their molecular control, we performed single-cell RNA-sequencing (scRNA-seq) of activated human T H 17 cells, which had…
Cell lines The Nalm6 B-ALL cell line was provided by D. Barrett and retrovirally transduced to express GFP and firefly luciferase. 143B osteosarcoma cells were acquired from the American Type Culture Collection (ATCC) and then retrovirally transduced with human CD19. The CHLA-255…
Abstract Therapies that target the programmed death-1 (PD-1) receptor have shown unprecedented rates of durable clinical responses in patients with various cancer types. One mechanism by which cancer tissues limit the host immune response is via upregulation of PD-1 ligand (PD-L1…