Deletion of PTP1B in cardiomyocytes alters cardiac metabolic signaling to protect against cardiomyopathy induced by a high-fat diet - PMC Official websites use .gov .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS lo…

INTRODUCTION The bed nucleus of the stria terminalis (BNST) coordinates neuroendocrine, autonomic and somatomotor responses to anxiety and emotional aspects of stressful events ( Crestani et al., 2013 ; Dong and Swanson, 2006 ; Moga et al., 1989 ; Walker et al., 2003 ). This area…

Introduction The ability to target genetic manipulations to specific CNS cell types is essential for analysis of genes, cells, and circuits that play key roles in behavior and disease. Limiting genetic manipulations to specific structures, cell types, or developmental periods can…

Myh6 promoter-driven Cre recombinase excises floxed DNA fragments in a subset of male germ line cells - PMC Official websites use .gov .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS lock ) or means you've safely co…

Abstract Deciphering how neural circuits are anatomically organized with regard to input and output is instrumental in understanding how the brain processes information. For example, locus coeruleus norepinephrine (LC-NE) neurons receive input from and send output to broad region…

Abstract Objectives To develop a mouse model for multi-spectral fluorescence imaging of the pancreas and pancreatic microenvironment. Methods Cre/ loxP technology was used to develop this model. We crossed mT/mG indicator mice, engineered to constitutively express a conditional t…

INTRODUCTION Leptin is secreted by adipocytes in proportion to fat stores providing feedback on the status of lipid reserves ( Friedman, 2009 ). Leptin circulates and binds its receptor (LEPR) in the brain where it decreases food intake and promotes energy expenditure ( Myers et …

A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressing Interneurons of the Striatum | eNeuro Previous Next Research Article Research Article: New Research, Sensory and Motor Systems A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressi…

Research Article Nephrology Free access | 10.1172/JCI57301 Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice 1 Career-Path Promotion Unit for Young Life Scientists, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, S…

Introduction Advances in gene therapy have positioned adeno-associated viruses (AAV) as a ubiquitous delivery tool for treating monogenic inherited disorders 1 – 3 . Their low toxicity and immunogenicity minimize adverse reactions and they produce long-term transgene expression. …

Frontiers | Infections Caused by Carbapenem-Resistant Enterobacteriaceae: An Update on Therapeutic Options REVIEW article Front. Microbiol. , 30 January 2019 Sec. Antimicrobials, Resistance and Chemotherapy Volume 10 - 2019 | https://doi.org/10.3389/fmicb.2019.00080 Infections Ca…

A Developmental Switch in the Response of DRG Neurons to ETS Transcription Factor Signaling - PMC Official websites use .gov .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS lock ) or means you've safely connected to…

High-Resolution Labeling and Functional Manipulation of Specific Neuron Types in Mouse Brain by Cre-Activated Viral Gene Expression - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .go…

Research Article Cell biology Pulmonology Free access | 10.1172/JCI85328 Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis 1 Department of Medicine and the Women’s Guild Lung Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. 2 De…

Introduction Altering the mouse genome by Cre-mediated recombination is one of the central technologies of modern mammalian genetics [1] . An important adjunct to this technology has been the development of a method for pharmacologic control of Cre-mediated recombination by fusin…