Abstract It is well known that fibroblast growth factor receptor 2 ( FGFR2 ) interacts with its ligand of fibroblast growth factor ( FGF ) therefore exerting biological functions on cell proliferation and differentiation. In this study, we first reported that the FGFR2 gene could…

Abstract miR-17 family microRNAs (miRNAs) are crucial for embryo development, however, their role in muscle development is still unclear. miR-20a-5p and miR-20b-5p belong to the miR-17 family and are transcribed from the miR-17~92 and miR-106a~363 clusters respectively. In this s…

Introduction MicroRNAs (miRNAs) are a category of single‐stranded non‐coding RNAs which contain about 20~25 nucleotides in length. They play an important role in the regulation of gene expression at the post‐transcriptional and translational level by binding to the 3′untranslated…

JCI - MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy Go to JCI Insight About Editors Consulting Editors For authors Publication ethics Publication alerts by email Advertising Job board Contact The Journal of Clinical Investigation Current issue …

Abstract Skeletal muscle differentiation can be regulated by various transcription factors and non-coding RNAs. In our previous work, miR-223 is differentially expressed in the skeletal muscle of chicken with different growth rates, but its role, expression and action mechanism i…

Abstract Simple Summary Exosomes are small (40–160 nanometer) extracellular vesicles with significant roles in cancer development and progression. Exosomes are abundantly produced by cancer cells, carry tumor-specific content, such as DNA, RNA, and proteins, and have the potentia…

Introduction Thymic epithelial cells (TECs) are critical mediators of T cell development in the thymus. Cortical thymic epithelial cells (cTECs) facilitate positive selection as thymocytes rearrange and assemble T cell receptors (TCRs) capable of recognizing self-MHC [ 1 ]. Posit…

Abstract Hepatitis C virus (HCV) depends on liver-specific microRNA miR-122 for efficient viral RNA amplification in liver cells. This microRNA interacts with two different conserved sites at the very 5’ end of the viral RNA, enhancing miR-122 stability and promoting replication …

Background MicroRNAs (miRNAs) are one category of small single-stranded non-coding RNA molecule (containing 20~25 nucleotides), which function in regulation of gene expression at the posttranscriptional level [ 1 , 2 ]. Generally, miRNAs could cause mRNAs degradation by binding t…

Europe PMC Funders Group Author Manuscript Nat Cell Biol. Author manuscript; available in PMC 2013 January 01. Published in final edited form as: Nat Cell Biol. ; 14(7): 659–665. doi:10.1038/ncb2521. Europe PMC Funders Author Manuscripts The H19 lincRNA is a developmental reservo…

INTRODUCTION Myelination has evolved in vertebrates to electrically insulate axons to promote rapid, energy efficient action potential propagation. In the central nervous system (CNS), the production of multilamellar myelin sheaths is performed by oligodendrocytes (OLs). The loca…

[ 5 ] Erster Act. Erste Scene. Morgendämmerung. Wohnung des Sokrates. In der Nähe derselben das Haus des Strepsiades, in dessen Schlafgemach man hineinsieht. Strepsiades. Pheidippides. Einige Knechte im Hintergrunde. Alle liegen schlafend auf ihrem Nachtlager. Strepsiades. (erwac…

Tr a n s l a t i o n a l O n c o l o g y Volume 12 Number 1 January 2019 pp. 170–179 170 www.transonc.com MYC-Induced miR-203b-3p and miR-203a-3p Control Bcl-xL Expression and Paclitaxel Sensitivity in Tumor Cells1 Sofia Aakko *, †, Anne Hege Straume ‡, §, Einar Elvbakken Birkela…

miR-23b-24-27b cluster in murine AAA We profiled miRNA expression in the porcine-pancreatic-elastase (PPE) infusion model in 10-week-old male C57BL/6J mice. The incidence, growth rate and size of aneurysmal expansion were measured by ultrasound (US) at 3, 7, 14, 21 and 28 days af…

Abstract Accumulating studies report that microRNAs (miRNAs) are actively involved in skeletal myogenesis. Previously, our study revealed that miR-146b-3p was related to the growth of skeletal muscle. Here, we further report that miR-146b-3p is essential for the proliferation, di…